TDR Targets

Basic information

Technical information

TDR Targets ID: 649179
Name: N-[2-(4-methoxyphenyl)ethyl]-N'-phenyloxamide
MW: 298.336 | Formula: C17H18N2O3
H donors: 2 H acceptors: 2 LogP: 2.74 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)CCNC(=O)C(=O)Nc1ccccc1
InChi: 1S/C17H18N2O3/c1-22-15-9-7-13(8-10-15)11-12-18-16(20)17(21)19-14-5-3-2-4-6-14/h2-10H,11-12H2,1H3,(H,18,20)(H,19,21)
InChiKey: DJHGNYORZDICJU-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

N-[2-(4-methoxyphenyl)ethyl]-N'-phenyl-oxamide
N-[2-(4-methoxyphenyl)ethyl]-N'-phenyl-ethanediamide
STK119376
ZINC02864606

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0063	0.0534	0.0043
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.0063	0.0534	1
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0063	0.0534	1
Plasmodium vivax	3-oxoacyl-[acyl-carrier-protein] reductase, putative	0.0063	0.0534	0.0228
Brugia malayi	RNA recognition motif domain containing protein	0.0061	0.0521	0.9765
Trypanosoma brucei	pteridine reductase 1	0.0063	0.0534	1
Mycobacterium tuberculosis	Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase)	0.0063	0.0534	0.0043
Mycobacterium ulcerans	oxidoreductase	0.0063	0.0534	0.0043
Mycobacterium ulcerans	short chain dehydrogenase	0.0063	0.0534	0.0043
Leishmania major	dehydrogenase/oxidoreductase-like protein	0.0063	0.0534	1
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0521	0.1961
Loa Loa (eye worm)	TAR-binding protein	0.0061	0.0521	0.9765
Schistosoma mansoni	protein phosphatase-2b	0.0042	0.0313	0.0909
Entamoeba histolytica	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0063	0.0534	1
Plasmodium falciparum	3-oxoacyl-[acyl-carrier-protein] reductase	0.0063	0.0534	0.0228
Echinococcus granulosus	p2X purinoceptor 4	0.0206	0.211	1
Wolbachia endosymbiont of Brugia malayi	enoyl-ACP reductase	0.0923	1	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0063	0.0534	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0133	0.2501
Mycobacterium ulcerans	3-alpha-hydroxysteroid dehydrogenase	0.0063	0.0534	0.0043
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0061	0.0521	0.9765
Mycobacterium tuberculosis	NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase)	0.0923	1	1
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.0493	0.8164
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0313	0.5867
Mycobacterium ulcerans	20-beta-hydroxysteroid dehydrogenase FabG3	0.0063	0.0534	0.0043
Mycobacterium ulcerans	short chain dehydrogenase	0.0063	0.0534	0.0043
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0063	0.0534	1
Leishmania major	dehydrogenase/oxidoreductase-like protein	0.0063	0.0534	1
Loa Loa (eye worm)	oxidoreductase	0.0063	0.0534	1
Echinococcus granulosus	tar DNA binding protein	0.0061	0.0521	0.1961
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0063	0.0534	0.0043
Echinococcus granulosus	serine:threonine protein phosphatase 2B	0.0042	0.0313	0.0909
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0133	0.2501
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.0493	0.0186
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0063	0.0534	0.0043
Echinococcus granulosus	geminin	0.0164	0.1652	0.7682
Brugia malayi	TAR-binding protein	0.0061	0.0521	0.9765
Echinococcus multilocularis	serine:threonine protein phosphatase 2B	0.0042	0.0313	0.0215
Toxoplasma gondii	2,4-dienoyl CoA reductase 2, peroxisomal family protein	0.0063	0.0534	0.0228
Mycobacterium tuberculosis	Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase)	0.0063	0.0534	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0307	0.5744
Mycobacterium tuberculosis	Possible oxidoreductase	0.0063	0.0534	0.0043
Mycobacterium ulcerans	short chain dehydrogenase	0.0063	0.0534	0.0043
Onchocerca volvulus		0.0063	0.0534	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0493	0.182
Echinococcus granulosus	3 oxoacyl acyl carrier protein reductase	0.0063	0.0534	0.2025
Echinococcus granulosus	serine:threonine protein phosphatase 2B	0.0042	0.0313	0.0909
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0521	0.1961
Trypanosoma brucei	oxidoreductase-like protein	0.0063	0.0534	1
Echinococcus multilocularis	tar DNA binding protein	0.0061	0.0521	0.0464
Plasmodium falciparum	enoyl-acyl carrier reductase	0.0923	1	1
Echinococcus multilocularis	serine:threonine protein phosphatase 2B	0.0042	0.0313	0.0215
Brugia malayi	intermediate filament protein	0.0026	0.0133	0.2501
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0063	0.0534	0.0043
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0063	0.0534	0.0043
Echinococcus multilocularis	p2X purinoceptor 4	0.0206	0.211	0.2366
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0063	0.0534	0.0043
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0063	0.0534	0.0043
Mycobacterium ulcerans	short chain dehydrogenase	0.0063	0.0534	0.0043
Echinococcus multilocularis	geminin	0.0164	0.1652	0.1818
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0063	0.0534	0.0043
Schistosoma mansoni	P2X receptor subunit	0.0206	0.211	1
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.0493	0.182
Schistosoma mansoni	hypothetical protein	0.0164	0.1652	0.7682
Mycobacterium ulcerans	enoyl-(acyl carrier protein) reductase	0.0923	1	1
Leishmania major	pteridine reductase 1	0.0063	0.0534	1
Schistosoma mansoni	P2X receptor subunit	0.0206	0.211	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0063	0.0534	0.0043
Mycobacterium leprae	NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE)	0.0923	1	1
Mycobacterium ulcerans	3-oxoacyl-ACP reductase	0.0063	0.0534	0.0043
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0063	0.0534	0.0043
Toxoplasma gondii	short chain dehydrogenase family protein, putative	0.0063	0.0534	0.0228
Schistosoma mansoni	3-oxoacyl-[ACP] reductase	0.0063	0.0534	0.2025
Trichomonas vaginalis	hypothetical protein	0.0923	1	0.5
Toxoplasma gondii	3-ketoacyl-(acyl-carrier-protein) reductase	0.0063	0.0534	0.0228
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0063	0.0534	0.0043
Echinococcus multilocularis	3 oxoacyl acyl carrier protein reductase	0.0063	0.0534	0.0479
Brugia malayi	RNA binding protein	0.0061	0.0521	0.9765
Schistosoma mansoni	protein phosphatase-2b	0.0042	0.0313	0.0909
Leishmania major	oxidoreductase-like protein	0.0063	0.0534	1
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0521	0.1961
Echinococcus multilocularis	p2X purinoceptor 4	0.0206	0.211	0.2366
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0521	0.1961
Schistosoma mansoni	P2X receptor subunit	0.0206	0.211	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0534	1
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0063	0.0534	0.0043
Schistosoma mansoni	dihydropteridine reductase	0.0063	0.0534	0.2025
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0493	0.182
Echinococcus granulosus	p2X purinoceptor 4	0.0206	0.211	1
Toxoplasma gondii	enoyl-acyl carrier reductase ENR	0.0923	1	1
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0063	0.0534	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0063	0.0534	0.0043
Echinococcus multilocularis	p2X purinoceptor 4	0.0206	0.211	0.2366
Loa Loa (eye worm)	retinol dehydrogenase 12	0.0063	0.0534	1
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0133	0.2501
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0063	0.0534	0.0043
Mycobacterium ulcerans	short chain dehydrogenase	0.0063	0.0534	0.0043
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0063	0.0534	0.0043
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0063	0.0534	0.0043
Onchocerca volvulus		0.0063	0.0534	1
Mycobacterium tuberculosis	Possible oxidoreductase	0.0063	0.0534	0.0043
Mycobacterium ulcerans	short chain dehydrogenase	0.0063	0.0534	0.0043
Mycobacterium ulcerans	short chain dehydrogenase	0.0063	0.0534	0.0043
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0133	0.2501
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0063	0.0534	0.0043
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0063	0.0534	0.0043
Brugia malayi	Serine/threonine protein phosphatase 2B catalytic subunit 2	0.0042	0.0313	0.5867
Mycobacterium ulcerans	short chain dehydrogenase	0.0063	0.0534	0.0043
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.0493	0.0431
Schistosoma mansoni	hypothetical protein	0.0164	0.1652	0.7682
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0128	0.2402
Mycobacterium tuberculosis	Probable oxidoreductase	0.0063	0.0534	0.0043
Schistosoma mansoni	P2X receptor subunit	0.0206	0.211	1
Echinococcus granulosus	p2X purinoceptor 4	0.0206	0.211	1
Loa Loa (eye worm)	RNA binding protein	0.0061	0.0521	0.9765
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0521	0.1961
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0063	0.0534	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0063	0.0534	0.0043
Mycobacterium ulcerans	3-oxoacyl-ACP reductase	0.0063	0.0534	0.0043
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0063	0.0534	0.0043
Leishmania major	3-oxoacyl-ACP reductase, putative	0.0063	0.0534	1
Trypanosoma brucei	beta-ketoacyl-ACP reductase	0.0063	0.0534	1
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0786	0.8489	1
Plasmodium vivax	enoyl-acyl carrier protein reductase	0.0923	1	1
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.0063	0.0534	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 649179