Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0124 | 0.3428 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0654 | 0.0285 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0037 | 0.0719 | 0.0412 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0037 | 0.0719 | 0.0239 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0124 | 0.3428 | 0.5081 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 0.3221 | 0.4774 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0037 | 0.0719 | 0.0412 |
Onchocerca volvulus | 0.0047 | 0.1027 | 0.912 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0974 | 0.0617 |
Brugia malayi | MH2 domain containing protein | 0.0117 | 0.3221 | 0.4774 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.1027 | 0.212 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0334 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0334 | 0.5 |
Echinococcus multilocularis | tumor protein p63 | 0.0335 | 1 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0719 | 0.1065 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0719 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.1537 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.1537 | 0.3796 |
Mycobacterium ulcerans | hypothetical protein | 0.0037 | 0.0719 | 0.0412 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0683 | 0.9085 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0654 | 0.0285 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0037 | 0.0719 | 0.0239 |
Loa Loa (eye worm) | beta-lactamase | 0.0037 | 0.0719 | 0.1065 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0719 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0654 | 0.0898 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0036 | 0.0683 | 0.2905 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0719 | 1 |
Brugia malayi | Inositol-1 | 0.0036 | 0.0683 | 0.1013 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0036 | 0.0683 | 0.0315 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 0.3221 | 0.4774 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0683 | 0.0994 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.1027 | 0.212 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0037 | 0.0719 | 0.0239 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0654 | 0.0898 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0037 | 0.0719 | 0.0351 |
Trichomonas vaginalis | esterase, putative | 0.0037 | 0.0719 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0124 | 0.3428 | 0.5081 |
Loa Loa (eye worm) | TAR-binding protein | 0.0124 | 0.3428 | 0.5081 |
Brugia malayi | hypothetical protein | 0.023 | 0.6746 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.038 | 0.0564 |
Echinococcus multilocularis | tar DNA binding protein | 0.0124 | 0.3428 | 0.3168 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.023 | 0.6746 | 0.6618 |
Brugia malayi | beta-lactamase | 0.0037 | 0.0719 | 0.1065 |
Plasmodium vivax | hypothetical protein, conserved | 0.0037 | 0.0719 | 1 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0654 | 0.097 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0719 | 0.111 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0063 | 0.1537 | 0.152 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0036 | 0.0683 | 1 |
Onchocerca volvulus | 0.0037 | 0.0719 | 0.4772 | |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0037 | 0.0719 | 0.1065 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0974 | 0.1444 |
Schistosoma mansoni | tar DNA-binding protein | 0.0124 | 0.3428 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0037 | 0.0719 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0719 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0683 | 0.9085 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0037 | 0.0719 | 0.0239 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0683 | 0.2905 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0365 | 0.0542 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0063 | 0.1537 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0719 | 0.111 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0037 | 0.0719 | 0.0351 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.0719 | 0.0239 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0974 | 0.0617 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0719 | 0.1065 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0049 | 0.1089 | 0.2325 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.038 | 0.0564 |
Echinococcus granulosus | tar DNA binding protein | 0.0124 | 0.3428 | 0.3168 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0719 | 0.1065 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0037 | 0.0719 | 0.1065 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0719 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.0719 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0063 | 0.1537 | 0.1203 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0719 | 0.1065 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0974 | 0.1948 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.1537 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0037 | 0.0719 | 0.3198 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.038 | 0.0564 |
Schistosoma mansoni | tar DNA-binding protein | 0.0124 | 0.3428 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0037 | 0.0719 | 0.0412 |
Brugia malayi | TAR-binding protein | 0.0124 | 0.3428 | 0.5081 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1089 | 0.1614 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.1537 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.0719 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0719 | 0.1065 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0974 | 0.0617 |
Mycobacterium leprae | Probable lipase LipE | 0.0037 | 0.0719 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0719 | 0.1065 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0063 | 0.1537 | 1 |
Brugia malayi | hypothetical protein | 0.0016 | 0.006 | 0.0089 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0974 | 0.0617 |
Loa Loa (eye worm) | inositol-1 | 0.0036 | 0.0683 | 0.1013 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0037 | 0.0719 | 0.0239 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.038 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.023 | 0.6746 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0719 | 0.1065 |
Leishmania major | hypothetical protein, conserved | 0.0037 | 0.0719 | 0.3198 |
Onchocerca volvulus | 0.0037 | 0.0719 | 0.4772 | |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0036 | 0.0683 | 0.0315 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0037 | 0.0719 | 0.0239 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0974 | 0.1444 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0237 | 0.6956 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0683 | 0.9085 |
Onchocerca volvulus | 0.0037 | 0.0719 | 0.4772 | |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.1027 | 0.1522 |
Mycobacterium leprae | conserved hypothetical protein | 0.0037 | 0.0719 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.038 | 0.0564 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0334 | 0.0495 |
Schistosoma mansoni | tar DNA-binding protein | 0.0124 | 0.3428 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.1537 | 0.3796 |
Schistosoma mansoni | tar DNA-binding protein | 0.0124 | 0.3428 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0124 | 0.3428 | 0.5081 |
Mycobacterium ulcerans | beta-lactamase | 0.0037 | 0.0719 | 0.0412 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0334 | 0.0495 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0719 | 0.1065 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.0719 | 0.0239 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0974 | 0.1948 |
Onchocerca volvulus | 0.0049 | 0.1089 | 1 | |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0036 | 0.0683 | 0.5 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0037 | 0.0719 | 0.0239 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0974 | 0.1948 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0063 | 0.1537 | 0.1203 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.0719 | 0.0239 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.023 | 0.6746 | 0.6618 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0683 | 0.0994 |
Brugia malayi | RNA binding protein | 0.0124 | 0.3428 | 0.5081 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.