Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0091 | 0.2904 | 1 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0059 | 0.1652 | 0.3329 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.6067 | 0.6067 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0091 | 0.2904 | 0.5 |
Brugia malayi | RNA binding protein | 0.0142 | 0.4963 | 0.4963 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0091 | 0.2904 | 1 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0059 | 0.1652 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0142 | 0.4963 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0091 | 0.2904 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0116 | 0.3916 | 0.7891 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0091 | 0.2904 | 0.5852 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0054 | 0.142 | 0.2861 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0091 | 0.2904 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0054 | 0.142 | 0.2861 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0059 | 0.1652 | 0.3329 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.142 | 0.2861 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0059 | 0.1652 | 0.4744 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.3916 | 0.3916 |
Brugia malayi | TAR-binding protein | 0.0142 | 0.4963 | 0.4963 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0091 | 0.2904 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0142 | 0.4963 | 0.4963 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.142 | 0.2861 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0091 | 0.2904 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0268 | 1 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0054 | 0.142 | 0.2861 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0091 | 0.2904 | 0.5852 |
Schistosoma mansoni | tar DNA-binding protein | 0.0142 | 0.4963 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.017 | 0.6067 | 0.6067 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0142 | 0.4963 | 0.4963 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0054 | 0.142 | 0.142 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.142 | 0.142 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0054 | 0.142 | 0.142 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.2904 | 0.2904 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0091 | 0.2904 | 0.5 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0059 | 0.1652 | 0.5 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0091 | 0.2904 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0142 | 0.4963 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0091 | 0.2904 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0116 | 0.3916 | 0.3916 |
Schistosoma mansoni | tar DNA-binding protein | 0.0142 | 0.4963 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0142 | 0.4963 | 0.4963 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0268 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.142 | 0.2861 |
Brugia malayi | Probable ClpP-like protease | 0.0091 | 0.2904 | 0.2904 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.142 | 0.2861 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0142 | 0.4963 | 0.4963 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.017 | 0.6067 | 0.6067 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0054 | 0.142 | 0.142 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.017 | 0.6067 | 0.6067 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0054 | 0.142 | 0.2861 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0091 | 0.2904 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0054 | 0.142 | 0.2861 |
Schistosoma mansoni | tar DNA-binding protein | 0.0142 | 0.4963 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0054 | 0.142 | 0.2861 |
Echinococcus multilocularis | tar DNA binding protein | 0.0142 | 0.4963 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0142 | 0.4963 | 1 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0091 | 0.2904 | 0.5852 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.