Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cavia porcellus | Platelet activating factor receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0266 | 0.3739 | 1 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.0681 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0266 | 0.3739 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0033 | 0.0228 | 0.0147 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0082 | 0.0082 |
Brugia malayi | Cytochrome P450 family protein | 0.0033 | 0.0228 | 0.0228 |
Echinococcus multilocularis | 0.0023 | 0.0082 | 0.0219 | |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0266 | 0.3739 | 0.3687 |
Brugia malayi | Cytochrome P450 family protein | 0.0087 | 0.1036 | 0.1036 |
Trypanosoma brucei | cytochrome P450, putative | 0.0033 | 0.0228 | 0.0147 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0266 | 0.3739 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0266 | 0.3739 | 0.5 |
Onchocerca volvulus | 0.0018 | 0 | 0.5 | |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0266 | 0.3739 | 0.5 |
Onchocerca volvulus | 0.0018 | 0 | 0.5 | |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0266 | 0.3739 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0266 | 0.3739 | 1 |
Onchocerca volvulus | 0.0018 | 0 | 0.5 | |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0266 | 0.3739 | 1 |
Onchocerca volvulus | 0.0018 | 0 | 0.5 | |
Loa Loa (eye worm) | cytochrome P450 | 0.0023 | 0.0082 | 0.079 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0033 | 0.0228 | 0.22 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0033 | 0.0228 | 0.22 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.0681 | 1 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0266 | 0.3739 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0033 | 0.0228 | 0.0147 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.0681 | 1 | 1 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0681 | 1 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0681 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0681 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0033 | 0.0228 | 0.22 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.0681 | 1 | 0.5 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0681 | 1 | 1 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0023 | 0.0082 | 0.0219 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.0681 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0266 | 0.3739 | 0.5 |
Onchocerca volvulus | 0.0018 | 0 | 0.5 | |
Brugia malayi | Cytochrome P450 family protein | 0.0033 | 0.0228 | 0.0228 |
Schistosoma mansoni | cytochrome P450 | 0.0023 | 0.0082 | 0.0082 |
Leishmania major | dihydroorotate dehydrogenase | 0.0681 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0087 | 0.1036 | 1 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.0681 | 1 | 1 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.0681 | 1 | 1 |
Onchocerca volvulus | 0.0018 | 0 | 0.5 | |
Brugia malayi | Cytochrome P450 family protein | 0.0023 | 0.0082 | 0.0082 |
Brugia malayi | cytochrome P450 | 0.0023 | 0.0082 | 0.0082 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0033 | 0.0228 | 0.0147 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0266 | 0.3739 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0033 | 0.0228 | 0.0147 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.0681 | 1 | 1 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.0681 | 1 | 1 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0266 | 0.3739 | 0.3739 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.61 uM | Inhibition of PAF induced platelet aggregation in rabbit | ChEMBL. | 1578493 |
IC50 (functional) | = 0.61 uM | Inhibition of PAF induced platelet aggregation in rabbit | ChEMBL. | 1578493 |
Lethality (functional) | = 0 dead/total | Compound was tested for protecting PAF-induced lethality in mouse at a dose of 2.5 mg/kg (Out of 10) | ChEMBL. | 1578493 |
Lethality (functional) | = 0 dead/total | Compound was tested for protecting PAF-induced lethality in mouse at a dose of 2.5 mg/kg (Out of 10) | ChEMBL. | 1578493 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.