Detailed information for compound 649501

Basic information

Technical information
  • TDR Targets ID: 649501
  • Name: 2-[2-(4-methoxy-3-methylphenyl)-2-oxoethyl]su lfanyl-5,7-dimethyl-1H-pyrido[3,2-e]pyrimidin -4-one
  • MW: 369.437 | Formula: C19H19N3O3S
  • H donors: 1 H acceptors: 5 LogP: 4.14 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1C)C(=O)CSc1nc(O)c2c(n1)nc(cc2C)C
  • InChi: 1S/C19H19N3O3S/c1-10-8-13(5-6-15(10)25-4)14(23)9-26-19-21-17-16(18(24)22-19)11(2)7-12(3)20-17/h5-8H,9H2,1-4H3,(H,20,21,22,24)
  • InChiKey: SKJWYNHOGZBUAB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[2-(4-methoxy-3-methyl-phenyl)-2-oxo-ethyl]sulfanyl-5,7-dimethyl-1H-pyrido[3,2-e]pyrimidin-4-one
  • 2-[[2-(4-methoxy-3-methylphenyl)-2-oxoethyl]thio]-5,7-dimethyl-1H-pyrido[3,2-e]pyrimidin-4-one
  • 2-[[2-keto-2-(4-methoxy-3-methyl-phenyl)ethyl]thio]-5,7-dimethyl-1H-pyrido[3,2-e]pyrimidin-4-one
  • Oprea1_289251
  • 2-(4-Hydroxy-5,7-dimethyl-pyrido[2,3-d]pyrimidin-2-ylsulfanyl)-1-(4-methoxy-3-methyl-phenyl)-ethanone
  • MLS000123886
  • BAS 03014646
  • SMR000124377

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) aldehyde dehydrogenase 0.0013 0.0011 0.0014
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0081 0.0372
Trichomonas vaginalis heat shock protein, putative 0.0142 0.0957 0.1364
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0203 0.0953
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0131 0.0334
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0004
Leishmania major aldehyde dehydrogenase, putative 0.0013 0.0011 0.0042
Loa Loa (eye worm) hypothetical protein 0.003 0.0133 0.0214
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0029 0.0029
Trypanosoma brucei delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0013 0.0011 0.0042
Brugia malayi nuclear hormone receptor 0.0014 0.0016 0.0023
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, GabD1 0.0013 0.0011 0.0051
Onchocerca volvulus DNA topoisomerase 2 homolog 0.002 0.0063 0.0078
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0013 0.0011 0.0011
Plasmodium vivax heat shock protein, putative 0.0537 0.3871 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.0023
Entamoeba histolytica hypothetical protein 0.0036 0.0177 0.1751
Echinococcus multilocularis histone deacetylase 1 0.0096 0.0624 0.0624
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0254 0.0254
Leishmania major GTP-binding protein, putative 0.0023 0.0081 0.0372
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0016 0.0011
Echinococcus granulosus snurportin 1 0.0332 0.236 0.236
Loa Loa (eye worm) hypothetical protein 0.0083 0.0524 0.0855
Entamoeba histolytica hypothetical protein 0.0036 0.0177 0.1751
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0041 0.0215 0.101
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0523 0.3773 0.6181
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0072 0.0442 0.0442
Brugia malayi glutathione reductase 0.0119 0.0787 0.1287
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0133 0.0892 1
Toxoplasma gondii histone deacetylase HDAC3 0.0096 0.0624 0.1605
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.0645 0.1053
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0041 0.0215 0.0215
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0133 0.0133
Brugia malayi beta-lactamase family protein 0.0075 0.0467 0.0762
Trypanosoma brucei heat shock protein 90, putative 0.0142 0.0957 0.4525
Brugia malayi Cytochrome P450 family protein 0.0081 0.051 0.0832
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0133 0.0892 0.4221
Trypanosoma cruzi histone deacetylase, putative 0.0028 0.0115 0.0534
Loa Loa (eye worm) heat shock protein 90 0.0142 0.0957 0.1564
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0133 0.0214
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0108 0.0707 0.0707
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.0013 0.0011 0.0014
Schistosoma mansoni nuclear receptor 0.0014 0.0016 0.0016
Schistosoma mansoni 6-phosphofructokinase 0.011 0.0724 0.0724
Schistosoma mansoni Smad4 0.0017 0.0035 0.0035
Leishmania major heat shock protein 83-1 0.0142 0.0957 0.4525
Brugia malayi MH1 domain containing protein 0.0017 0.0035 0.0053
Loa Loa (eye worm) hypothetical protein 0.0075 0.0467 0.0762
Brugia malayi hypothetical protein 0.0036 0.0177 0.0286
Echinococcus granulosus DNA topoisomerase 2 alpha 0.002 0.0063 0.0063
Brugia malayi histone deacetylase 3 (HD3) 0.0096 0.0624 0.1018
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.0016 0.0016
Trypanosoma brucei DNA topoisomerase ii 0.002 0.0063 0.0287
Loa Loa (eye worm) hypothetical protein 0.0031 0.0141 0.0228
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0081 0.0203
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.002 0.0063 0.0099
Loa Loa (eye worm) hypothetical protein 0.0052 0.0297 0.0483
Brugia malayi follicle stimulating hormone receptor 0.0254 0.1783 0.2919
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0039 0.0196 0.0548
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0221 0.1038
Echinococcus granulosus histone deacetylase 6 0.0028 0.0115 0.0115
Plasmodium vivax histone deacetylase, putative 0.0028 0.0115 0.0291
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0184 0.086
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0083 0.0524 0.0524
Onchocerca volvulus 0.0075 0.0467 0.066
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0133 0.0133
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0039 0.0196 0.0919
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0039 0.0196 0.1132
Loa Loa (eye worm) beta-lactamase 0.0075 0.0467 0.0762
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0108 0.0707 0.0707
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0043 0.0227 0.0579
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0125 0.0834 0.3943
Trypanosoma cruzi histone deacetylase 1, putative 0.0096 0.0624 0.2945
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.011 0.011
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0039 0.0196 0.1132
Schistosoma mansoni hypothetical protein 0.043 0.3086 0.3086
Onchocerca volvulus 0.0014 0.0016 0.0011
Brugia malayi hypothetical protein 0.0038 0.0196 0.0317
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0121 0.0804 0.0804
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0121 0.0804 0.0804
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.002 0.0063 0.0587
Leishmania major heat shock protein 83-1 0.0142 0.0957 0.4525
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0035 0.0053
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0016 0.0016
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0467 0.066
Mycobacterium tuberculosis Probable reductase 0.0271 0.1909 0.5508
Leishmania major DNA polymerase kappa, putative 0.0039 0.0203 0.0953
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0016 0.0016
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0096 0.0624 0.0885
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.0203 0.0203
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0013 0.0009 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0203 0.0953
Brugia malayi Hsp90 protein 0.0094 0.0606 0.0989
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0131 0.0176
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.0013 0.0011 0.0011
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0133 0.0133
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0133 0.0214
Trichomonas vaginalis heat shock protein, putative 0.0121 0.0806 0.1147
Trichomonas vaginalis heat shock protein, putative 0.0133 0.0892 0.1272
Schistosoma mansoni hypothetical protein 0.0041 0.0215 0.0215
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0013 0.0011 0.0042
Trypanosoma brucei heat shock protein 90, putative 0.0142 0.0957 0.4525
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.0023
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0013 0.0011 0.0011
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0081 0.0128
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0244 0.1714 0.4945
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.002 0.0063 0.0353
Entamoeba histolytica hypothetical protein 0.0023 0.0084 0.0771
Toxoplasma gondii cell division protein CDC48AP 0.0013 0.0007 0.0012
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0084 0.0211
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.0188 0.0188
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0094 0.0606 0.0859
Onchocerca volvulus 0.0075 0.0467 0.066
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0724 0.7543
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0467 0.066
Mycobacterium ulcerans aldehyde dehydrogenase 0.0013 0.0011 0.0051
Echinococcus granulosus Niemann Pick C1 protein 0.0142 0.0959 0.0959
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0039 0.0196 0.1132
Leishmania major heat shock protein 83-1 0.0142 0.0957 0.4525
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0016 0.0064
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0133 0.0214
Loa Loa (eye worm) hypothetical protein 0.0094 0.0602 0.0983
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0098 0.0128
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.002 0.0063 0.0063
Mycobacterium tuberculosis Conserved protein 0.0075 0.0467 0.1333
Trypanosoma brucei DNA topoisomerase II beta, putative 0.002 0.0063 0.0287
Trypanosoma cruzi heat shock protein 90, putative 0.0142 0.0957 0.4525
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.2111 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0113 0.0524
Onchocerca volvulus 0.0014 0.0016 0.0011
Schistosoma mansoni histone deacetylase 1 2 3 0.0028 0.0115 0.0115
Schistosoma mansoni heat shock protein 0.0142 0.0957 0.0957
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.0203 0.0203
Echinococcus granulosus dna polymerase eta 0.0039 0.0203 0.0203
Echinococcus granulosus expressed conserved protein 0.0093 0.06 0.06
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0133 0.0214
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0131 0.0334
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0043
Giardia lamblia Grp94/Hsp90 0.0133 0.0892 0.9327
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0039 0.0196 0.1132
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0203 0.0569
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0113 0.0524
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0203 0.1174
Onchocerca volvulus 0.0037 0.0188 0.0258
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0141 0.0359
Toxoplasma gondii histone deacetylase HDAC5 0.0028 0.0115 0.0291
Echinococcus multilocularis heat shock protein 90 0.0142 0.0957 0.0957
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0084 0.0211
Treponema pallidum NADH oxidase 0.0041 0.0215 0.2316
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0203 0.0329
Leishmania major protein kinase, putative 0.0125 0.0834 0.3943
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0041 0.0215 0.055
Schistosoma mansoni tar DNA-binding protein 0.0523 0.3773 0.3773
Leishmania major cytochrome p450-like protein 0.0067 0.0404 0.1904
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0039 0.0196 0.0548
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0043 0.0227 0.0227
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0041 0.0215 0.101
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0035 0.0035
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.0467 0.1333
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0108 0.0707 0.0707
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0133 0.0133
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 0.0013 0.0011 0.0012
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.0023
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.003 0.0135 0.0217
Echinococcus granulosus geminin 0.0678 0.4912 0.4912
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0244 0.1714 0.8118
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0302 0.0302
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0016 0.0011
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.0467 0.0467
Plasmodium vivax importin-beta 2, putative 0.0031 0.0141 0.0359
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0041 0.0215 0.1244
Trichomonas vaginalis ran, putative 0.0023 0.0081 0.0103
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0081 0.0372
Schistosoma mansoni hypothetical protein 0.0039 0.0196 0.0196
Brugia malayi steroid hormone receptor 0.003 0.0133 0.0214
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0271 0.1909 0.5508
Schistosoma mansoni coup transcription factor 0.003 0.0133 0.0133
Trichomonas vaginalis esterase, putative 0.0075 0.0467 0.066
Trichomonas vaginalis histone deacetylase, putative 0.0096 0.0624 0.0885
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0131 0.0334
Toxoplasma gondii DNA topoisomerase 2, putative 0.002 0.0063 0.0156
Brugia malayi CHE-14 protein 0.0043 0.0226 0.0367
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0133 0.0214
Echinococcus granulosus aryl hydrocarbon receptor 0.0013 0.0009 0.0009
Echinococcus multilocularis neuropeptide receptor A26 0.0503 0.362 0.362
Brugia malayi Cytochrome P450 family protein 0.0067 0.0404 0.0658
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0029 0.0029
Brugia malayi valosin containing protein 0.0013 0.0005 0.0004
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0039 0.0196 0.0548
Schistosoma mansoni hypothetical protein 0.0041 0.0215 0.0215
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0039 0.0196 0.1132
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0039 0.0196 0.1132
Echinococcus granulosus tumor protein p63 0.0355 0.2534 0.2534
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.0013 0.0011 0.0014
Mycobacterium ulcerans beta-lactamase 0.0075 0.0467 0.2716
Plasmodium falciparum endoplasmin, putative 0.0103 0.067 0.1726
Loa Loa (eye worm) hypothetical protein 0.003 0.0133 0.0214
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0041 0.0215 0.101
Leishmania major heat shock protein 83-1 0.0142 0.0957 0.4525
Loa Loa (eye worm) cytochrome P450 family protein 0.0081 0.051 0.0832
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0184 0.0252
Schistosoma mansoni thyroid hormone receptor 0.003 0.0133 0.0133
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.002 0.0063 0.0156
Brugia malayi Protein kinase domain containing protein 0.0125 0.0834 0.1363
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0043 0.0227 0.0367
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0125 0.0834 0.3943
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0226 0.0226
Echinococcus multilocularis histone deacetylase 6 0.0028 0.0115 0.0115
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.0656 0.0656
Onchocerca volvulus 0.0046 0.0254 0.0353
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0039 0.0196 0.1132
Mycobacterium leprae Probable two-component sensor kinase 0.002 0.0063 0.0254
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.005 0.0283 0.0724
Brugia malayi F/Y-rich N-terminus family protein 0.0014 0.0013 0.0017
Plasmodium falciparum histone deacetylase 1 0.0096 0.0624 0.1605
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0043
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0131 0.1352
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0121 0.0806 0.0806
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.0203 0.0329
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0133 0.0214
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0302 0.0302
Schistosoma mansoni delta 1-pyrroline-5-carboxylate synthetase 0.0013 0.0011 0.0011
Leishmania major DNA topoisomerase ii 0.002 0.0063 0.0287
Brugia malayi 6-phosphofructokinase 0.011 0.0724 0.1183
Mycobacterium tuberculosis Probable pyrroline-5-carboxylate dehydrogenase RocA 0.0013 0.0011 0.0012
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0367 0.0942
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0133 0.0133
Brugia malayi phosphofructokinase 0.011 0.0724 0.1183
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.0016 0.0016
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0131 0.0176
Trichomonas vaginalis receptor histidine kinase, putative 0.002 0.0063 0.0078
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0203 0.0953
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0094 0.0606 0.0606
Loa Loa (eye worm) cytochrome P450 family protein 0.0067 0.0404 0.0658
Leishmania major protein kinase, putative 0.0014 0.0016 0.0064
Leishmania major pyrroline-5-carboxylate synthetase-like protein 0.0013 0.0011 0.0042
Leishmania major mitochondrial DNA topoisomerase II 0.002 0.0063 0.0287
Mycobacterium ulcerans lipase LipD 0.0075 0.0467 0.2716
Echinococcus granulosus dual specificity protein kinase clk2 0.0125 0.0834 0.0834
Mycobacterium ulcerans aldehyde dehydrogenase 0.0244 0.1714 1
Trypanosoma brucei heat shock protein, putative 0.0142 0.0957 0.4525
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0254 0.0353
Echinococcus multilocularis protein dispatched 1 0.0049 0.0271 0.0271
Echinococcus granulosus histone deacetylase 1 0.0096 0.0624 0.0624
Schistosoma mansoni endoplasmin 0.0142 0.0957 0.0957
Echinococcus granulosus dnaJ subfamily B 0.043 0.3086 0.3086
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0724 0.103
Leishmania major heat shock protein 83-1 0.0142 0.0957 0.4525
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.002 0.0063 0.0287
Echinococcus multilocularis neuropeptide s receptor 0.0503 0.362 0.362
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0133 0.0214
Brugia malayi Smad1 0.0017 0.0035 0.0053
Brugia malayi beta-lactamase family protein 0.0075 0.0467 0.0762
Mycobacterium leprae Conserved hypothetical protein 0.0039 0.0196 0.0883
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0177 0.0177
Trypanosoma brucei heat shock protein, putative 0.0142 0.0957 0.4525
Echinococcus granulosus histone deacetylase 3 0.0096 0.0624 0.0624
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0094 0.0602 0.0602
Plasmodium falciparum thioredoxin reductase 0.0041 0.0215 0.055
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0133 0.0133
Echinococcus multilocularis histone deacetylase 8 0.0028 0.0115 0.0115
Brugia malayi mbt repeat family protein 0.0046 0.0254 0.0413
Schistosoma mansoni aldehyde dehydrogenase 0.0244 0.1714 0.1714
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0133 0.0214
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0098 0.0128
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0254 0.0254
Schistosoma mansoni pyruvate dehydrogenase 0.002 0.0063 0.0063
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0041 0.0215 0.0349
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0094 0.0606 0.6291
Brugia malayi Aldehyde dehydrogenase protein 4 0.0013 0.0011 0.0014
Leishmania major importin beta-1 subunit, putative 0.0025 0.0098 0.0453
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0041 0.0215 0.101
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0254 0.0413
Schistosoma mansoni tar DNA-binding protein 0.0523 0.3773 0.3773
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.0023
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0133 0.0179
Loa Loa (eye worm) cytochrome P450 family protein 0.0067 0.0404 0.0658
Schistosoma mansoni tar DNA-binding protein 0.0523 0.3773 0.3773
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.002 0.0063 0.0353
Echinococcus granulosus cpg binding protein 0.0032 0.0148 0.0148
Echinococcus multilocularis 0.0039 0.0196 0.0196
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0133 0.0214
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0133 0.0133
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.0016 0.0016
Leishmania major cytochrome p450-like protein 0.0039 0.0196 0.0919
Trypanosoma brucei heat shock protein, putative 0.0142 0.0957 0.4525
Leishmania major histone deacetylase, putative 0.0028 0.0115 0.0534
Trichomonas vaginalis histone deacetylase, putative 0.0096 0.0624 0.0885
Mycobacterium ulcerans methylmalonate semialdehyde dehydrogenase, MmsA 0.0013 0.0011 0.0051
Mycobacterium leprae putative cytochrome p450 0.0039 0.0196 0.0883
Echinococcus multilocularis histone deacetylase 7 0.0028 0.0115 0.0115
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.0016 0.0023
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0197 0.1367 0.1367
Plasmodium vivax DNA gyrase subunit B, putative 0.002 0.0063 0.0156
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.0467 0.0762
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0133 0.0133
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0296 0.0296
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0039 0.0196 0.0548
Mycobacterium leprae PROBABLE GAMMA-GLUTAMYL PHOSPHATE REDUCTASE PROTEIN PROA (GPR) (GLUTAMATE-5-SEMIALDEHYDE DEHYDROGENASE) (GLUTAMYL-GAMMA-SEMIALDE 0.0013 0.0011 0.0011
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0039 0.0196 0.1132
Echinococcus multilocularis microtubule associated protein 2 0.1367 1 1
Plasmodium vivax histone deacetylase 2, putative 0.0028 0.0115 0.0291
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0121 0.0804 0.0804
Giardia lamblia AAA family ATPase 0.0013 0.0007 0.0047
Toxoplasma gondii heat shock protein 90, putative 0.0142 0.0957 0.2466
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0133 0.0214
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0041 0.0215 0.0215
Mycobacterium ulcerans DNA gyrase subunit B 0.002 0.0063 0.0353
Echinococcus multilocularis musashi 0.0056 0.0323 0.0323
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0094 0.0602 0.0983
Mycobacterium ulcerans putative regultory protein 0.002 0.0063 0.0353
Mycobacterium ulcerans aldehyde dehydrogenase 0.0244 0.1714 1
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0133 0.0133
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0467 0.0467
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0041 0.0215 1
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.002 0.0063 0.0078
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0203 0.0953
Loa Loa (eye worm) hypothetical protein 0.003 0.0133 0.0214
Schistosoma mansoni hypothetical protein 0.0094 0.0602 0.0602
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0016 0.0016
Schistosoma mansoni 6-phosphofructokinase 0.011 0.0724 0.0724
Schistosoma mansoni lamin 0.0056 0.0323 0.0323
Onchocerca volvulus 0.0121 0.0804 0.1144
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0184 0.0184
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0096 0.0624 0.0885
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0121 0.0804 0.0804
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0177 0.0177
Loa Loa (eye worm) histone deacetylase 1 0.0096 0.0624 0.1018
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.0023
Leishmania major histone deacetylase, putative 0.0028 0.0115 0.0534
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0132 0.0213
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.002 0.0063 0.0162
Echinococcus multilocularis histone deacetylase 6 0.0028 0.0115 0.0115
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0203 0.0953
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0203 0.0953
Echinococcus multilocularis geminin 0.0678 0.4912 0.4912
Loa Loa (eye worm) intermediate filament protein 0.0056 0.0323 0.0525
Loa Loa (eye worm) hypothetical protein 0.003 0.0133 0.0214
Schistosoma mansoni endoplasmin 0.0142 0.0957 0.0957
Leishmania major aldehyde dehydrogenase, putative 0.0013 0.0011 0.0042
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.005 0.0283 0.0459
Trichomonas vaginalis histone deacetylase, putative 0.0096 0.0624 0.0885
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0197 0.1367 0.2237
Schistosoma mansoni hypothetical protein 0.0041 0.0215 0.0215
Plasmodium vivax serine/threonine kinase-1, putative 0.0125 0.0834 0.2149
Echinococcus granulosus cytochrome P450 2K1 0.0039 0.0196 0.0196
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0081 0.0081
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0116 0.0767 0.0767
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.002 0.0063 0.0287
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0203 0.1174
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0203 0.0953
Leishmania major heat shock protein 83-1 0.0142 0.0957 0.4525
Brugia malayi Thioredoxin reductase 0.0119 0.0787 0.1287
Giardia lamblia Histone deacetylase 0.0096 0.0624 0.6509
Onchocerca volvulus 0.0052 0.0296 0.0413
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0133 0.0133
Trichomonas vaginalis conserved hypothetical protein 0.0168 0.115 0.1643
Plasmodium falciparum DNA topoisomerase 2 0.002 0.0063 0.0156
Leishmania major DNA polymerase eta, putative 0.0039 0.0203 0.0953
Trypanosoma brucei histone deacetylase 1 0.0096 0.0624 0.2945
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0133 0.0214
Schistosoma mansoni nuclear receptor 0.0014 0.0016 0.0016
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0013 0.0011 0.0042
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0724 0.103
Echinococcus granulosus histone deacetylase 6 0.0028 0.0115 0.0115
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0084 0.0223
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0093 0.0234
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0184 0.086
Schistosoma mansoni lamin 0.0056 0.0323 0.0323
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0108 0.0707 0.0707
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0184 0.1825
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0467 0.1202
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0133 0.0133
Schistosoma mansoni hypothetical protein 0.0094 0.0602 0.0602
Brugia malayi Inositol-1 0.0037 0.0184 0.0297
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0133 0.0133
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0125 0.0834 0.3943
Schistosoma mansoni smad 0.0017 0.0035 0.0035
Schistosoma mansoni intermediate filament proteins 0.0056 0.0323 0.0323
Mycobacterium tuberculosis Probable oxidoreductase 0.0301 0.2131 0.6153
Brugia malayi nuclear receptor RXR 0.0014 0.0016 0.0023
Treponema pallidum heat shock protein 90 0.0133 0.0892 1
Entamoeba histolytica hypothetical protein 0.0036 0.0177 0.1751
Trypanosoma brucei histone deacetylase, putative 0.0028 0.0115 0.0534
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0041 0.0215 0.055
Loa Loa (eye worm) MBCTL1 0.0053 0.0302 0.0491
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0016 0.0023
Leishmania major heat shock protein 83-1 0.0142 0.0957 0.4525
Onchocerca volvulus Transitional endoplasmic reticulum ATPase homolog 0.0022 0.0071 0.0089
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0081 0.0203
Toxoplasma gondii TIM10 family protein, putative 0.005 0.0283 0.0724
Schistosoma mansoni tar DNA-binding protein 0.0523 0.3773 0.3773
Echinococcus multilocularis thioredoxin glutathione reductase 0.012 0.0799 0.0799
Brugia malayi mbt repeat family protein 0.0046 0.0254 0.0413
Echinococcus multilocularis Niemann Pick C1 protein 0.0142 0.0959 0.0959
Onchocerca volvulus DNA topoisomerase 2 homolog 0.002 0.0063 0.0078
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0133 0.0133
Brugia malayi Probable DNA topoisomerase II 0.002 0.0063 0.0099
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0131 0.0176
Entamoeba histolytica hypothetical protein 0.0036 0.0177 0.1751
Trypanosoma brucei unspecified product 0.0027 0.0113 0.0524
Trypanosoma brucei trypanothione reductase 0.0119 0.0787 0.3722
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0203 0.0329
Schistosoma mansoni DNA topoisomerase II 0.002 0.0063 0.0063
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0203 0.0953
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0467 0.2204
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0016 0.0023
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0244 0.1714 0.1714
Trichomonas vaginalis mercuric reductase, putative 0.0041 0.0215 0.0297
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.002 0.0063 0.0156
Toxoplasma gondii heat shock protein 75, putative 0.0094 0.0606 0.156
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.0467 0.1333
Loa Loa (eye worm) hypothetical protein 0.002 0.0063 0.0099
Loa Loa (eye worm) hypothetical protein 0.003 0.0133 0.0214
Leishmania major cytochrome p450-like protein 0.0039 0.0196 0.0919
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0084 0.0827
Brugia malayi heat shock protein 90 0.0142 0.0957 0.1564
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0041 0.0215 0.101
Schistosoma mansoni zinc finger protein 0.0014 0.0016 0.0016
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.0013 0.0011 0.0011
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.011 0.0724 0.3371
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0332 0.236 0.3865
Mycobacterium ulcerans aldehyde dehydrogenase (NAD+) dependent 0.0013 0.0011 0.0051
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.0023
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0133 0.0133
Echinococcus multilocularis protein patched 0.0043 0.0226 0.0226
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.0016 0.0016
Brugia malayi RNA recognition motif domain containing protein 0.0523 0.3773 0.6181
Brugia malayi tailless protein 0.0014 0.0016 0.0023
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0043 0.0227 0.0367
Echinococcus granulosus heat shock protein 90 0.0142 0.0957 0.0957
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0184 0.086
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0039 0.0196 0.0548
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.0467 0.0467
Schistosoma mansoni histone deacetylase 0.0096 0.0624 0.0624
Mycobacterium ulcerans two component sensor kinase MprB 0.002 0.0063 0.0353
Schistosoma mansoni aldehyde dehydrogenase 0.0013 0.0011 0.0011
Loa Loa (eye worm) vesicle-fusing ATPase 0.0013 0.0005 0.0004
Brugia malayi histone deacetylase 1 (HD1) 0.0096 0.0624 0.1018
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0039 0.0196 0.0548
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0039 0.0196 0.0548
Leishmania major protein kinase, putative 0.0014 0.0016 0.0064
Schistosoma mansoni hypothetical protein 0.0282 0.1993 0.1993
Trichomonas vaginalis histone deacetylase, putative 0.0096 0.0624 0.0885
Plasmodium falciparum thioredoxin reductase 0.0119 0.0787 0.2029
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0081 0.0081
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0039 0.0196 0.0919
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0039 0.0196 0.0548
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0093 0.0234
Echinococcus multilocularis 0.0124 0.0827 0.0827
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0203 0.0953
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0039 0.0196 0.0548
Schistosoma mansoni histone deacetylase hda2 0.0028 0.0115 0.0115
Trypanosoma cruzi cytochrome P450, putative 0.0067 0.0404 0.1904
Loa Loa (eye worm) hypothetical protein 0.0039 0.0203 0.0329
Trypanosoma cruzi trypanothione reductase, putative 0.0119 0.0787 0.3722
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0133 0.0214
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0467 0.2204
Brugia malayi CXXC zinc finger family protein 0.003 0.0135 0.0217
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.0013 0.0011 0.0014
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0013 0.0011 0.0042
Brugia malayi Endoplasmin precursor 0.0142 0.0957 0.1564
Plasmodium vivax cell division cycle protein 48 homologue, putative 0.002 0.0062 0.0155
Brugia malayi hypothetical protein 0.0014 0.0016 0.0023
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0043 0.0227 0.0579
Loa Loa (eye worm) hypothetical protein 0.002 0.0063 0.0099
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0013 0.0011 0.0042
Leishmania major delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0013 0.0011 0.0042
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0013 0.0011 0.0042
Brugia malayi RNA, U transporter 1 0.0088 0.0564 0.0921
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.002 0.0063 0.0287
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0016 0.0023
Onchocerca volvulus 0.0083 0.0524 0.0741
Loa Loa (eye worm) hypothetical protein 0.0075 0.0467 0.0762
Echinococcus multilocularis dna polymerase kappa 0.0039 0.0203 0.0203
Plasmodium falciparum glutathione reductase 0.0041 0.0215 0.055
Echinococcus granulosus dna polymerase kappa 0.0039 0.0203 0.0203
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.0645 0.6699
Leishmania major histone deacetylase, putative 0.0096 0.0624 0.2945
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0244 0.1714 0.1714
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0301 0.2131 0.6153
Brugia malayi Histone deacetylase family protein 0.0028 0.0115 0.0185
Loa Loa (eye worm) hypothetical protein 0.0173 0.1185 0.1939
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0131 0.0176
Loa Loa (eye worm) hypothetical protein 0.0099 0.0645 0.1053
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0093 0.0429
Trypanosoma brucei Valosin-containing protein 0.002 0.0062 0.0285
Mycobacterium tuberculosis Probable methylmalonate-semialdehyde dehydrogenase MmsA (methylmalonic acid semialdehyde dehydrogenase) (MMSDH) 0.0013 0.0011 0.0012
Plasmodium vivax glutathione reductase, putative 0.0119 0.0787 0.2029
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0133 0.0133
Mycobacterium ulcerans hypothetical protein 0.0157 0.107 0.6239
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0094 0.0606 0.0606
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0724 0.103
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0039 0.0196 0.1132
Onchocerca volvulus 0.0056 0.0323 0.0452
Mycobacterium ulcerans two component regulator - sensor kinase 0.002 0.0063 0.0353
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0009 0.0031
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.0203 0.0203
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0084 0.0827
Mycobacterium ulcerans pyrroline-5-carboxylate dehydrogenase, RocA 0.0013 0.0011 0.0051
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0133 0.0892 0.2565
Schistosoma mansoni cpg binding protein 0.0032 0.0148 0.0148
Brugia malayi Melibiase family protein 0.0072 0.0442 0.0721
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0197 0.1367 0.1367
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0013 0.0011 0.0051
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0016 0.0016
Mycobacterium ulcerans bifunctional acetaldehyde-CoA/alcohol dehydrogenase 0.0013 0.0011 0.0051
Echinococcus granulosus L aminoadipate semialdehyde 0.0083 0.0524 0.0524
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0041 0.0215 0.2316
Trichomonas vaginalis histone deacetylase, putative 0.0096 0.0624 0.0885
Schistosoma mansoni single-minded 0.0051 0.0285 0.0285
Leishmania major heat shock protein 83-1 0.0142 0.0957 0.4525
Trypanosoma cruzi DNA topoisomerase II, putative 0.002 0.0063 0.0287
Echinococcus multilocularis endoplasmin 0.0133 0.0892 0.0892
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0197 0.1367 0.1367
Mycobacterium ulcerans heat shock protein 90 0.0133 0.0892 0.52
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0133 0.0133
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.002 0.0063 0.0587
Plasmodium falciparum heat shock protein 90, putative 0.0537 0.3871 1
Toxoplasma gondii histone deacetylase HDAC4 0.0028 0.0115 0.0291
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0254 0.0254
Loa Loa (eye worm) histone deacetylase 0.0028 0.0115 0.0185
Trichomonas vaginalis heat shock protein, putative 0.0133 0.0892 0.1272
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0009 0.0031
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0041 0.0215 0.055
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0121 0.0804 0.0804
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0839 0.6103 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0197 0.1367 0.1367
Brugia malayi Histone deacetylase family protein 0.0028 0.0115 0.0185
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0271 0.1909 0.5508
Brugia malayi RNA binding protein 0.0523 0.3773 0.6181
Schistosoma mansoni thyroid hormone receptor 0.003 0.0133 0.0133
Plasmodium vivax SET domain protein, putative 0.0121 0.0804 0.2072
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0096 0.0624 0.0885
Trichomonas vaginalis CMGC family protein kinase 0.0125 0.0834 0.1187
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0016 0.0023
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.0013 0.0011 0.0011
Treponema pallidum chemotaxis histidine kinase (cheA) 0.002 0.0063 0.0587
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0041 0.0215 0.101
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0125 0.0834 0.3943
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0125 0.0834 0.2149
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0041 0.0215 0.101
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0039 0.0196 0.1132
Loa Loa (eye worm) hypothetical protein 0.0055 0.0315 0.0513
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.011 0.0724 0.2078
Entamoeba histolytica hypothetical protein 0.0025 0.0098 0.0918
Trypanosoma brucei heat shock protein, putative 0.0142 0.0957 0.4525
Brugia malayi nuclear receptor NHR-88 0.003 0.0133 0.0214
Toxoplasma gondii aldehyde dehydrogenase 0.0244 0.1714 0.4425
Toxoplasma gondii hypothetical protein 0.0048 0.0267 0.0683
Schistosoma mansoni smad1 5 8 and 0.0017 0.0035 0.0035
Mycobacterium tuberculosis Conserved protein 0.002 0.0063 0.0162
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0197 0.1367 0.2237
Trypanosoma cruzi cytochrome P450, putative 0.0067 0.0404 0.1904
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0184 0.0184
Trypanosoma brucei heat shock protein, putative 0.0142 0.0957 0.4525
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0125 0.0834 0.1363
Echinococcus granulosus neuropeptide s receptor 0.0503 0.362 0.362
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0041 0.0215 0.0603
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0221 0.1038
Mycobacterium leprae PROBABLE ALDEHYDE DEHYDROGENASE (NAD+) DEPENDENT 0.0013 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.0023
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0043
Echinococcus multilocularis dnaJ subfamily B 0.043 0.3086 0.3086
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0226 0.0226
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0203 0.0953
Schistosoma mansoni hypothetical protein 0.0036 0.0177 0.0177
Entamoeba histolytica heat shock protein 90, putative 0.0142 0.0957 1
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0131 0.0334
Echinococcus multilocularis histone deacetylase 3 0.0096 0.0624 0.0624
Loa Loa (eye worm) heat shock protein 75 0.0094 0.0606 0.0989
Schistosoma mansoni nuclear hormone receptor 0.003 0.0133 0.0133
Schistosoma mansoni DNA polymerase eta 0.0039 0.0203 0.0203
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.002 0.0063 0.0078
Echinococcus multilocularis expressed conserved protein 0.0093 0.06 0.06
Toxoplasma gondii melibiase subfamily protein 0.0108 0.0707 0.1821
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0133 0.0214
Brugia malayi hypothetical protein 0.0016 0.0029 0.0043
Schistosoma mansoni microtubule-associated protein tau 0.1367 1 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0121 0.0804 0.0804
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.0724 0.1183
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0203 0.0953
Echinococcus granulosus lamin 0.0056 0.0323 0.0323
Leishmania major heat shock protein, putative 0.0094 0.0606 0.2862
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0184 0.1958
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0203 0.0569
Leishmania major heat shock protein 83-1 0.0142 0.0957 0.4525
Toxoplasma gondii heat shock protein HSP90 0.0142 0.0957 0.2466
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0164
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0467 0.2204
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0081 0.0821
Entamoeba histolytica transitional endoplasmic reticulum ATPase, putative 0.002 0.0062 0.0543
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.002 0.0063 0.0162
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.002 0.0063 0.0587
Echinococcus multilocularis histone deacetylase 0.0028 0.0115 0.0115
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0014 0.0014
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.0323 0.0525
Schistosoma mansoni cell division control protein 48 aaa family protein 0.002 0.0062 0.0062
Echinococcus granulosus thioredoxin glutathione reductase 0.012 0.0799 0.0799
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0041 0.0215 0.101
Brugia malayi Pre-SET motif family protein 0.0121 0.0804 0.1314
Schistosoma mansoni apoptosis regulator bax 0.0094 0.0602 0.0602
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0724 0.103
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0133 0.0214
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0098 0.0128
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.002 0.0063 0.0063
Mycobacterium tuberculosis Probable aldehyde dehydrogenase NAD dependent AldA (aldehyde dehydrogenase [NAD+]) 0.0013 0.0011 0.0012
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0226 0.0226
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.0467 0.2716
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0022 0.0071 0.0071
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.0203 0.0203
Echinococcus granulosus histone deacetylase 8 0.0028 0.0115 0.0115
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0254 0.1783 0.2919
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0013 0.0011 0.0051
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.0724 0.3423
Toxoplasma gondii NADP-dependent succinate-semialdehyde dehydrogenase 0.0013 0.0011 0.0023
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.011 0.011
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0302 0.0302
Trypanosoma brucei heat shock protein, putative 0.0142 0.0957 0.4525
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0016 0.0023
Echinococcus granulosus Smad4 0.0017 0.0035 0.0035
Brugia malayi MH1 domain containing protein 0.0017 0.0035 0.0053
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0039 0.0196 0.0919
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0039 0.0196 0.1132
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0221 0.1038
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0016 0.0016
Leishmania major heat shock protein 83-1 0.0142 0.0957 0.4525
Plasmodium vivax heat shock protein 90, putative 0.0094 0.0606 0.156
Giardia lamblia DINP protein human, muc B family 0.0039 0.0203 0.2105
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0131 0.4498
Schistosoma mansoni patched 1 0.0043 0.0226 0.0226
Echinococcus granulosus importin subunit beta 1 0.0031 0.0141 0.0141
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0724 0.7543
Leishmania major hypothetical protein, conserved 0.0075 0.0467 0.2204
Trypanosoma cruzi histone deacetylase, putative 0.0028 0.0115 0.0534
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0093 0.0429
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.0467 0.1333
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0013 0.0011 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0226 0.0313
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0094 0.0602 0.0602
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0039 0.0196 0.0548
Schistosoma mansoni hypothetical protein 0.0678 0.4912 0.4912
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0184 0.0252
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.0013 0.0011 0.0011
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0133 0.0892 0.4163
Trichomonas vaginalis receptor histidine kinase, putative 0.002 0.0063 0.0078
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0302 0.0302
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0016 0.0023
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0094 0.0602 0.0602
Loa Loa (eye worm) hypothetical protein 0.0124 0.0827 0.1352
Plasmodium falciparum DNA gyrase subunit B 0.002 0.0063 0.0156
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0013 0.0011 0.0051
Schistosoma mansoni ran 0.0023 0.0081 0.0081
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0197 0.1367 0.1367
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0301 0.2131 0.6153
Echinococcus granulosus histone deacetylase 6 0.0028 0.0115 0.0115
Brugia malayi 6-phosphofructokinase 0.011 0.0724 0.1183
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0298 0.2111 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.011 0.0177
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0035 0.0035
Schistosoma mansoni smad1 5 8 and 0.0017 0.0035 0.0035
Schistosoma mansoni histone deacetylase 0.0096 0.0624 0.0624
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0093 0.0234
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0035 0.0035
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.002 0.0063 0.0287
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.002 0.0063 0.0078
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0043
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0041 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.0023
Echinococcus granulosus heat shock protein 0.0142 0.0957 0.0957
Leishmania major heat shock protein 83-1 0.0142 0.0957 0.4525
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.0016 0.0016
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.002 0.0063 0.0156
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0015 0.0025 0.0025
Schistosoma mansoni ran 0.0023 0.0081 0.0081
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0081 0.0203
Entamoeba histolytica cdc48-like protein, putative 0.002 0.0062 0.0543
Loa Loa (eye worm) hypothetical protein 0.0052 0.0296 0.0481
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0035 0.0053
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0043
Brugia malayi beta-lactamase 0.0075 0.0467 0.0762
Echinococcus multilocularis aryl hydrocarbon receptor 0.0013 0.0009 0.0009
Echinococcus granulosus histone deacetylase 7 0.0028 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0028 0.0115 0.0185
Plasmodium falciparum histone deacetylase 2 0.0028 0.0115 0.0291
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0039 0.0196 0.0919
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0467 0.066
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0084 0.0211
Schistosoma mansoni aryl hydrocarbon receptor 0.0051 0.0285 0.0285
Giardia lamblia Heat shock protein HSP 90-alpha 0.0121 0.0806 0.8418
Loa Loa (eye worm) RNA binding protein 0.0523 0.3773 0.6181
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, PutA_2 0.0013 0.0011 0.0051
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0141 0.0659
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.002 0.0063 0.0162
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0039 0.0196 0.0548
Plasmodium vivax thioredoxin reductase, putative 0.0119 0.0787 0.2029
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0953 0.4507
Loa Loa (eye worm) inositol-1 0.0037 0.0184 0.0297
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0039 0.0196 0.0548
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0039 0.0196 0.1132
Entamoeba histolytica histone deacetylase, putative 0.0096 0.0624 0.6477
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0035 0.0035
Brugia malayi cytochrome P450 0.0039 0.0196 0.0318
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0131 0.0334
Schistosoma mansoni inositol monophosphatase 0.0037 0.0184 0.0184
Mycobacterium tuberculosis Probable dehydrogenase 0.0271 0.1909 0.5508
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0013 0.0011 0.0042
Loa Loa (eye worm) hypothetical protein 0.0075 0.0467 0.0762
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0203 0.0953
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0016 0.0023
Schistosoma mansoni hypothetical protein 0.0094 0.0602 0.0602
Loa Loa (eye worm) glutathione reductase 0.0119 0.0787 0.1287
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0098 0.0453
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0417 0.0417
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0301 0.2131 1
Echinococcus multilocularis dna polymerase eta 0.0039 0.0203 0.0203
Brugia malayi Pre-SET motif family protein 0.0839 0.6103 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0041 0.0215 0.101
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.0203 0.028
Brugia malayi histone deacetylase 11 0.0028 0.0115 0.0185
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.0023
Leishmania major histone deacetylase, putative 0.0096 0.0624 0.2945
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0131 0.0334
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.002 0.0063 0.0162
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0133 0.0179
Schistosoma mansoni cytochrome P450 0.0039 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0164
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0016 0.0016
Toxoplasma gondii Alpha-galactosidase 0.0015 0.0025 0.0057
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0013 0.0011 0.0042
Echinococcus multilocularis Smad4 0.0017 0.0035 0.0035
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.002 0.0063 0.0587
Trypanosoma brucei heat shock protein, putative 0.0142 0.0957 0.4525
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.005 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0025 0.0093 0.0148
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0724 0.7543
Brugia malayi bHLH-PAS transcription factor 0.0037 0.0188 0.0304
Loa Loa (eye worm) hypothetical protein 0.0096 0.0624 0.1018
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0081 0.0372
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.0013 0.0011 0.0011
Onchocerca volvulus 0.0056 0.0323 0.0452
Echinococcus granulosus 6 phosphofructokinase 0.011 0.0724 0.0724
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0039 0.0196 0.1132
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.011 0.0724 0.8092
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0133 0.0133
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0133 0.0133
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0133 0.0133
Brugia malayi nuclear receptor NHR-88 0.0014 0.0016 0.0023
Brugia malayi Histone deacetylase 1 0.0096 0.0624 0.1018
Echinococcus granulosus hypothetical protein 0.0124 0.0827 0.0827
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0131 0.4498
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0039 0.0196 0.1132
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0016 0.0064
Trichomonas vaginalis spermatogenesis associated factor, putative 0.0022 0.0071 0.0089
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.0467 0.1333
Loa Loa (eye worm) phosphofructokinase 0.011 0.0724 0.1183
Plasmodium falciparum histone deacetylase, putative 0.0028 0.0115 0.0291
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0039 0.0196 0.0548
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0013 0.0011 0.0042
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.002 0.0063 0.0254
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.002 0.0063 0.0287
Brugia malayi Cytochrome P450 family protein 0.0067 0.0404 0.0658
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0084 0.0387
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.0013 0.0011 0.0011
Giardia lamblia Pms1-like protein 0.002 0.0063 0.0634
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0041 0.0215 0.055
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0271 0.1909 0.895
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0039 0.0196 0.0919
Brugia malayi kinase, mitochondrial precursor 0.002 0.0063 0.0099
Onchocerca volvulus Aldehyde dehydrogenase homolog 0.0013 0.0011 0.0003
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.0323 0.0525
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0041 0.0215 0.101
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.003 0.0135 0.0217
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0022 0.0071 0.0071
Plasmodium vivax histone deacetylase 1, putative 0.0096 0.0624 0.1605
Entamoeba histolytica DNA topoisomerase II, putative 0.002 0.0063 0.0547
Leishmania major protein kinase, putative 0.0125 0.0834 0.3943
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0041 0.0215 0.1244
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.0467 0.0762
Echinococcus multilocularis smad 0.0017 0.0035 0.0035
Trypanosoma brucei unspecified product 0.0039 0.0203 0.0953
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0271 0.1909 0.5508
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0131 0.1365
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0041 0.0215 0.1244
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0084 0.0477
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.002 0.0063 0.0353
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0155 0.043
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0029 0.0043
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.002 0.0063 0.0353
Schistosoma mansoni DNA polymerase IV / kappa 0.0012 0.0002 0.0002
Mycobacterium leprae PROBABLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP+] DEPENDENT (SSDH) GABD 0.0013 0.0011 0.0011
Brugia malayi nuclear receptor RXR 0.0016 0.0029 0.0043
Onchocerca volvulus 0.0955 0.6957 1
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.0467 0.1333
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0039 0.0196 0.0548
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0132 0.0213
Mycobacterium tuberculosis Probable gamma-glutamyl phosphate reductase protein ProA (GPR) (glutamate-5-semialdehyde dehydrogenase) (glutamyl-gamma-semialde 0.0013 0.0011 0.0012
Echinococcus multilocularis snurportin 1 0.0332 0.236 0.236
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0108 0.0707 0.0707
Giardia lamblia Heat shock protein HSP 90-alpha 0.0142 0.0957 1
Leishmania major hypothetical protein, conserved 0.0025 0.0093 0.0429
Mycobacterium ulcerans gamma-glutamyl phosphate reductase 0.0013 0.0011 0.0051
Brugia malayi PAS domain containing protein 0.0051 0.0285 0.0463
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0302 0.0491
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0013 0.0011 0.0042
Trypanosoma cruzi DNA topoisomerase II, putative 0.002 0.0063 0.0287
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0041 0.0215 0.2316
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0155 0.069
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0009 0.0031
Loa Loa (eye worm) endoplasmin 0.0142 0.0957 0.1564
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0041 0.0215 0.101
Schistosoma mansoni serine/threonine protein kinase 0.0125 0.0834 0.0834
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0254 0.0254
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0072 0.0442 0.0442
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0034 0.016 0.6359
Schistosoma mansoni cpg binding protein 0.0032 0.0148 0.0148
Trichomonas vaginalis histone deacetylase, putative 0.0096 0.0624 0.0885
Schistosoma mansoni aldehyde dehydrogenase 0.0013 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.0023
Leishmania major heat shock protein 83-1 0.0142 0.0957 0.4525
Plasmodium falciparum heat shock protein 90 0.0142 0.0957 0.2466
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0083 0.0524 0.0855
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0133 0.0214
Trypanosoma brucei histone deacetylase 2 0.0028 0.0115 0.0534
Plasmodium falciparum cell division cycle protein 48 homologue, putative 0.002 0.0062 0.0155
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.002 0.0063 0.0162
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0953 0.4507
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0016 0.0064
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0039 0.0196 0.1132
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.0016 0.0016
Echinococcus granulosus neuropeptide receptor A26 0.0503 0.362 0.362
Leishmania major Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog 0.002 0.0062 0.0285
Entamoeba histolytica heat shock protein 90, putative 0.0142 0.0957 1
Loa Loa (eye worm) histone deacetylase 11 0.0028 0.0115 0.0185
Echinococcus multilocularis heat shock protein 90 0.0121 0.0806 0.0806
Loa Loa (eye worm) apoptosis regulator protein 0.0094 0.0602 0.0983
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0081 0.0128
Brugia malayi vesicle-fusing ATPase 0.0013 0.0005 0.0004
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0125 0.0834 0.3943
Giardia lamblia Kinase, CMGC CLK 0.0125 0.0834 0.8713
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0121 0.0804 0.2072
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0013 0.0011 0.0042
Schistosoma mansoni cpg binding protein 0.003 0.0135 0.0135
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0014 0.0014
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.002 0.0063 0.0078
Brugia malayi nuclear hormone receptor 0.003 0.0133 0.0214
Mycobacterium ulcerans gamma-aminobutyraldehyde dehydrogenase 0.0013 0.0011 0.0051
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.002 0.0063 0.0254
Mycobacterium tuberculosis Conserved protein 0.0075 0.0467 0.1333
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0197 0.1367 0.1367
Mycobacterium leprae conserved hypothetical protein 0.0075 0.0467 0.216
Echinococcus multilocularis tumor protein p63 0.0355 0.2534 0.2534
Schistosoma mansoni heat shock protein 0.0094 0.0606 0.0606
Plasmodium vivax endoplasmin, putative 0.0142 0.0957 0.2466
Brugia malayi conserved hypotetical protein 0.0014 0.0016 0.0023
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0013 0.0011 0.0042
Trypanosoma cruzi histone deacetylase, putative 0.0028 0.0115 0.0534
Loa Loa (eye worm) DR-78 0.0014 0.0016 0.0023
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0254 0.0254
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0125 0.0834 0.3943
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.002 0.0063 0.0353
Trichomonas vaginalis heat shock protein, putative 0.0103 0.067 0.0952
Trypanosoma brucei heat shock protein 84, putative 0.0094 0.0606 0.2862
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0141 0.0659
Loa Loa (eye worm) hypothetical protein 0.003 0.0133 0.0214
Mycobacterium tuberculosis Probable sensor protein KdpD 0.002 0.0063 0.0162
Trichomonas vaginalis succinate semialdehyde dehydrogenase, putative 0.0013 0.0011 0.0003
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0039 0.0196 0.0548
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0041 0.0215 0.055
Loa Loa (eye worm) Smad1 0.0017 0.0035 0.0053
Trypanosoma cruzi heat shock protein 85, putative 0.0121 0.0806 0.381
Echinococcus granulosus smad 0.0017 0.0035 0.0035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0133 0.0214
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0113 0.0524
Leishmania major heat shock protein 83-1 0.0142 0.0957 0.4525
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0013 0.0011 0.0042
Trypanosoma brucei heat shock protein, putative 0.0142 0.0957 0.4525
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0043 0.0227 0.0579
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.002 0.0063 0.0162
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0133 0.0214
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0039 0.0196 0.0548
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0133 0.0214
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0108 0.0707 0.0707
Trypanosoma cruzi DNA polymerase eta, putative 0.0039 0.0203 0.0953
Mycobacterium ulcerans hypothetical protein 0.0075 0.0467 0.2716
Loa Loa (eye worm) cytochrome P450 0.0039 0.0196 0.0318
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.0023
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0254 0.0254
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0226 0.0367
Echinococcus multilocularis lamin dm0 0.0056 0.0323 0.0323
Echinococcus granulosus heat shock protein 90 0.0121 0.0806 0.0806
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0029 0.0043
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0041 0.0215 0.101
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0203 0.0953
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.0016 0.0016
Entamoeba histolytica Ran family GTPase 0.0023 0.0081 0.0736
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0133 0.0133
Toxoplasma gondii thioredoxin reductase 0.0119 0.0787 0.2029
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0184 0.1059
Mycobacterium tuberculosis Conserved protein 0.0075 0.0467 0.1333
Loa Loa (eye worm) MH2 domain-containing protein 0.0244 0.1714 0.2807
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.2111 1
Toxoplasma gondii methylmalonate-semialdehyde dehydrogenase [acylating], putative 0.0013 0.0011 0.0023
Loa Loa (eye worm) hypothetical protein 0.0028 0.012 0.0192
Mycobacterium ulcerans putative regulatory protein 0.0037 0.0188 0.1084
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0467 0.0467
Onchocerca volvulus Histone deacetylase 10 homolog 0.0028 0.0115 0.0153
Schistosoma mansoni tar DNA-binding protein 0.0523 0.3773 0.3773
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0289 0.1358
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0016 0.0016
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0043 0.0227 0.0367
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0013 0.0011 0.0042
Loa Loa (eye worm) hypothetical protein 0.0075 0.0467 0.0762
Trypanosoma cruzi heat shock protein 90, putative 0.0059 0.0349 0.1645
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0039 0.0196 0.0548
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0221 0.1038
Leishmania major developmentally regulated phosphoprotein-like protein 0.002 0.0063 0.0287
Plasmodium falciparum glutathione reductase 0.0119 0.0787 0.2029
Brugia malayi hypoxia-induced factor 1 0.0156 0.1066 0.1744
Brugia malayi nuclear receptor NHR-67 0.0014 0.0016 0.0023
Trypanosoma cruzi histone deacetylase, putative 0.0028 0.0115 0.0534
Mycobacterium tuberculosis Probable aldehyde dehydrogenase AldC 0.0013 0.0011 0.0012
Echinococcus granulosus tar DNA binding protein 0.0523 0.3773 0.3773
Schistosoma mansoni importin beta-1 0.0031 0.0141 0.0141
Mycobacterium tuberculosis Probable aldehyde dehydrogenase (NAD+) dependent 0.0013 0.0011 0.0012
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0016 0.0023
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0093 0.0429
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0084 0.0387
Loa Loa (eye worm) CYP4Cod1 0.0067 0.0404 0.0658
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0203 0.0953
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0131 0.1272
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0203 0.0953
Schistosoma mansoni histone deacetylase hda2 0.0028 0.0115 0.0115
Loa Loa (eye worm) histone deacetylase 7A 0.0028 0.0115 0.0185
Echinococcus granulosus histone deacetylase 0.0028 0.0115 0.0115
Echinococcus granulosus intermediate filament protein 0.0056 0.0323 0.0323
Echinococcus granulosus betaine aldehyde dehydrogenase 0.0013 0.0011 0.0011
Trypanosoma brucei histone deacetylase 3 0.0028 0.0115 0.0534
Echinococcus multilocularis cpg binding protein 0.0032 0.0148 0.0148
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0133 0.0214
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0039 0.0196 0.0548
Loa Loa (eye worm) hypothetical protein 0.0046 0.0254 0.0413
Brugia malayi hypothetical protein 0.0025 0.0093 0.0148
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0013 0.0011 0.0042
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0133 0.0133
Echinococcus granulosus expressed protein 0.005 0.0283 0.0283
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0131 0.0334
Mycobacterium tuberculosis Probable two component sensor kinase 0.002 0.0063 0.0162
Brugia malayi aldehyde dehydrogenase 0.0013 0.0011 0.0014
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0072 0.0442 0.0623
Toxoplasma gondii aldehyde dehydrogenase (NAD) family protein 0.0013 0.0011 0.0023
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.002 0.0063 0.0078
Loa Loa (eye worm) hypothetical protein 0.0075 0.0467 0.0762
Loa Loa (eye worm) transcription factor SMAD2 0.0244 0.1714 0.2807
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.002 0.0063 0.0353
Loa Loa (eye worm) histone methyltransferase 0.0014 0.0014 0.0018
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.002 0.0063 0.0078
Onchocerca volvulus 0.003 0.0135 0.0181
Trichomonas vaginalis glutathione reductase, putative 0.0041 0.0215 0.0297
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0271 0.1909 0.5508
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0184 0.0252
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0016 0.0064
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.002 0.0063 0.0063
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.0016 0.0016
Mycobacterium ulcerans ATPase 0.0013 0.0007 0.0026
Plasmodium vivax heat shock protein 86, putative 0.0142 0.0957 0.2466
Brugia malayi Importin beta-1 subunit 0.0031 0.0141 0.0228
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0133 0.0214
Trypanosoma cruzi Heat shock protein 83, putative 0.0142 0.0957 0.4525
Leishmania major hypothetical protein, conserved 0.002 0.0063 0.0287
Trichomonas vaginalis endoplasmin, putative 0.0103 0.067 0.0952
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0467 0.066
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0203 0.0953
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0039 0.0196 0.0548
Echinococcus multilocularis L aminoadipate semialdehyde 0.0083 0.0524 0.0524
Plasmodium falciparum importin beta, putative 0.0031 0.0141 0.0359
Brugia malayi hypothetical protein 0.0016 0.0029 0.0043
Loa Loa (eye worm) hypothetical protein 0.017 0.1163 0.1903
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0133 0.0133
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0029 0.0029
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0133 0.0214
Plasmodium vivax DNA topoisomerase II, putative 0.002 0.0063 0.0156
Brugia malayi TAR-binding protein 0.0523 0.3773 0.6181
Brugia malayi Cytochrome P450 family protein 0.0039 0.0196 0.0318
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.002 0.0063 0.0162
Trypanosoma brucei developmentally regulated phosphoprotein 0.002 0.0063 0.0287
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0039 0.0196 0.1132
Echinococcus multilocularis 6 phosphofructokinase 0.011 0.0724 0.0724
Trypanosoma cruzi Valosin-containing protein, putative 0.002 0.0062 0.0285
Mycobacterium ulcerans aldehyde dehydrogenase 0.0244 0.1714 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0013 0.0011 0.0012
Schistosoma mansoni smad1 5 8 and 0.0017 0.0035 0.0035
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0039 0.0196 0.1132
Mycobacterium leprae Probable lipase LipE 0.0075 0.0467 0.216
Brugia malayi MH2 domain containing protein 0.0017 0.0035 0.0053
Toxoplasma gondii Hsp90 domain-containing protein 0.0537 0.3871 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0203 0.0953
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.002 0.0063 0.0353
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0184 0.0469
Echinococcus granulosus histone lysine methyltransferase setb 0.0121 0.0804 0.0804
Echinococcus multilocularis heat shock protein 0.0142 0.0957 0.0957
Leishmania major aldehyde dehydrogenase, putative 0.0013 0.0011 0.0042
Trypanosoma cruzi heat shock protein 85, putative 0.0142 0.0957 0.4525
Giardia lamblia NADH oxidase lateral transfer candidate 0.0041 0.0215 0.2231
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.002 0.0063 0.0162
Giardia lamblia Alcohol dehydrogenase 0.0013 0.0011 0.0092
Brugia malayi MH2 domain containing protein 0.0244 0.1714 0.2807
Onchocerca volvulus 0.0075 0.0467 0.066
Mycobacterium ulcerans 6-phosphofructokinase 0.011 0.0724 0.4217
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0135 0.0217
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0043 0.0227 0.0367
Schistosoma mansoni hypothetical protein 0.0041 0.0215 0.0215
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.107 0.308
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0035 0.0035
Mycobacterium tuberculosis Possible two component sensor kinase 0.002 0.0063 0.0162
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0467 0.066
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0133 0.0214
Schistosoma mansoni hypothetical protein 0.0043 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0072 0.0442 0.0721
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0133 0.0214
Loa Loa (eye worm) hypothetical protein 0.0075 0.0467 0.0762
Toxoplasma gondii ABC1 family protein 0.0075 0.0467 0.1202
Schistosoma mansoni hypothetical protein 0.0332 0.236 0.236
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0094 0.0602 0.0602
Mycobacterium ulcerans piperideine-6-carboxilic acid dehydrogenase Pcd 0.0013 0.0011 0.0051
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0013 0.0009 0.0011
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.0203 0.2032
Echinococcus granulosus transitional endoplasmic reticulum atpase 0.0022 0.0071 0.0071
Echinococcus multilocularis dual specificity protein kinase clk2 0.0125 0.0834 0.0834
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0084 0.1386
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0039 0.0196 0.1132
Trypanosoma cruzi trypanothione reductase, putative 0.0041 0.0215 0.101
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0133 0.0179
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.0016 0.0016
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0094 0.0602 0.0602
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0014
Leishmania major heat shock protein 83-1 0.0142 0.0957 0.4525
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0041 0.0215 0.101
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.0013 0.0011 0.0011
Echinococcus multilocularis expressed protein 0.005 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0056 0.0323 0.0525
Loa Loa (eye worm) hypoxia-induced factor 1 0.0156 0.1066 0.1744
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.002 0.0063 0.0287
Loa Loa (eye worm) TOPoisomerase family member 0.002 0.0063 0.0099
Trypanosoma brucei unspecified product 0.0027 0.0113 0.0524
Leishmania major trypanothione reductase 0.0119 0.0787 0.3722
Schistosoma mansoni hypothetical protein 0.0678 0.4912 0.4912
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.005 0.0283 0.0459
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0013 0.0011 0.0042
Brugia malayi hypothetical protein 0.0016 0.0029 0.0043
Toxoplasma gondii transitional endoplasmic reticulum ATPase, putative 0.0013 0.0007 0.0012
Trypanosoma brucei histone deacetylase 4 0.0028 0.0115 0.0534
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.0953 0.4507
Schistosoma mansoni aldehyde dehydrogenase 0.0013 0.0011 0.0011
Plasmodium falciparum protein serine/threonine kinase-1 0.0125 0.0834 0.2149
Echinococcus granulosus single minded 2 0.0037 0.0188 0.0188
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.002 0.0063 0.0353
Echinococcus granulosus endoplasmin 0.0133 0.0892 0.0892
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0173 0.1185 0.1939
Schistosoma mansoni aldehyde dehydrogenase 0.0013 0.0011 0.0011
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.0467 0.1333
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0197 0.1367 0.1367
Echinococcus multilocularis tar DNA binding protein 0.0523 0.3773 0.3773
Mycobacterium tuberculosis Two component sensor kinase MprB 0.002 0.0063 0.0162
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0177 0.0177
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0016 0.0016
Schistosoma mansoni histone deacetylase 4 5 0.0028 0.0115 0.0115
Trichomonas vaginalis DNA topoisomerase II, putative 0.002 0.0063 0.0078
Leishmania major mitochondrial DNA polymerase beta 0.0298 0.2111 1
Trypanosoma cruzi histone deacetylase, putative 0.0028 0.0115 0.0534
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.0645 0.0645
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0119 0.0787 0.226
Brugia malayi DNA topoisomerase II, alpha isozyme 0.002 0.0063 0.0099
Loa Loa (eye worm) thioredoxin reductase 0.0119 0.0787 0.1287
Toxoplasma gondii cytochrome p450 superfamily protein 0.0039 0.0196 0.0501
Echinococcus granulosus lamin dm0 0.0056 0.0323 0.0323
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0039 0.0196 0.1132
Schistosoma mansoni heat shock protein 0.0142 0.0957 0.0957
Schistosoma mansoni hypothetical protein 0.0013 0.0011 0.0011
Toxoplasma gondii histone deacetylase HDAC1 0.0028 0.0115 0.0291
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0014
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.0023
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.005 0.0283 0.0724
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0084 0.0211
Leishmania major heat shock protein 83-1 0.0142 0.0957 0.4525
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0013 0.0011 0.0042
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.0467 0.1333
Brugia malayi ecdysteroid receptor 0.003 0.0133 0.0214
Mycobacterium tuberculosis Possible succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD2 0.0013 0.0011 0.0012
Mycobacterium leprae Probable two component sensor kinase MprB 0.002 0.0063 0.0254
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0013 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0053 0.0302 0.0491
Leishmania major heat shock protein 83-1 0.0142 0.0957 0.4525
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0041 0.0215 0.101
Trypanosoma cruzi heat shock protein, putative 0.0094 0.0606 0.2862
Leishmania major ATP-dependent phosphofructokinase 0.011 0.0724 0.3423
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0131 0.0176
Echinococcus multilocularis lamin 0.0056 0.0323 0.0323
Toxoplasma gondii NADPH-glutathione reductase 0.0041 0.0215 0.055
Loa Loa (eye worm) hypothetical protein 0.0121 0.0804 0.1314
Brugia malayi hypothetical protein 0.017 0.1163 0.1903
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0203 0.0953
Toxoplasma gondii cell division protein CDC48CY 0.0022 0.0071 0.0176
Brugia malayi MH2 domain containing protein 0.0017 0.0035 0.0053
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.0023
Schistosoma mansoni aldehyde dehydrogenase 0.0244 0.1714 0.1714
Brugia malayi hypothetical protein 0.0014 0.0016 0.0023
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0084 0.0477
Plasmodium vivax hypothetical protein, conserved 0.002 0.0063 0.0156
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0133 0.0214
Loa Loa (eye worm) hypothetical protein 0.003 0.0133 0.0214
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0184 0.086
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0133 0.0133
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0029 0.0043
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0011
Brugia malayi ecdysone receptor 0.0014 0.0016 0.0023
Echinococcus granulosus FTZ F1 alpha 0.003 0.0133 0.0133
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0254 0.0254
Schistosoma mansoni inositol monophosphatase 0.0037 0.0184 0.0184
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0141 0.0141
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0041 0.0215 0.101
Loa Loa (eye worm) TAR-binding protein 0.0523 0.3773 0.6181
Schistosoma mansoni aldehyde dehydrogenase 0.0013 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.003 0.0133 0.0214
Onchocerca volvulus 0.003 0.0133 0.0179
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0039 0.0196 0.0548
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0067 0.0404 0.2345
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.002 0.0063 0.0063
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0029 0.0029
Trichomonas vaginalis sensor histidine kinase, putative 0.002 0.0063 0.0078
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0133 0.0133
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0041 0.0215 0.101
Trichomonas vaginalis set domain proteins, putative 0.0955 0.6957 1
Trichomonas vaginalis heat shock protein, putative 0.0082 0.0519 0.0735
Brugia malayi intermediate filament protein 0.0056 0.0323 0.0525
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0039 0.0196 0.1132
Trypanosoma brucei Heat shock protein 83, putative 0.0142 0.0957 0.4525
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0084 0.0354
Trypanosoma brucei DNA polymerase eta, putative 0.0039 0.0203 0.0953
Echinococcus multilocularis histone deacetylase 6 0.0028 0.0115 0.0115
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0093 0.0234
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.002 0.0063 0.0156
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.002 0.0063 0.0099
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0183 0.1261 0.1261
Toxoplasma gondii histone deacetylase HDAC2 0.0096 0.0624 0.1605
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0183 0.1261 0.1261
Leishmania major heat shock protein 83-1 0.0142 0.0957 0.4525
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.0203 0.028
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.0467 0.2716
Toxoplasma gondii gamma-glutamyl phosphate reductase, putative 0.0013 0.0011 0.0023
Trypanosoma brucei cytochrome P450, putative 0.0067 0.0404 0.1904
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.0645 0.0645
Trypanosoma cruzi histone deacetylase 1, putative 0.0096 0.0624 0.2945
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.0724 0.3423
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.002 0.0063 0.0162
Schistosoma mansoni serine/threonine protein kinase 0.0125 0.0834 0.0834
Brugia malayi Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor 0.0013 0.0011 0.0014
Trypanosoma cruzi heat shock protein 85, putative 0.0142 0.0957 0.4525
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0131 0.0176
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0108 0.0707 0.0707
Trypanosoma cruzi heat shock protein 90, putative 0.0121 0.0806 0.381
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0131 0.0176
Loa Loa (eye worm) histone deacetylase 3 0.0096 0.0624 0.1018
Trypanosoma cruzi heat shock protein 85, putative 0.0142 0.0957 0.4525
Plasmodium falciparum heat shock protein 90, putative 0.0082 0.0519 0.1336
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0043 0.0226 0.0367
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.005 0.0283 0.0724
Plasmodium vivax histone deacetylase, putative 0.0028 0.0115 0.0291
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0481 0.346 1
Brugia malayi hypothetical protein 0.0038 0.0196 0.0317
Schistosoma mansoni histone deacetylase 4 5 0.0028 0.0115 0.0115
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.0724 0.1183

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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