Detailed information for compound 649767

Basic information

Technical information
  • TDR Targets ID: 649767
  • Name: (5Z)-5-[(4-hydroxy-3,5-dimethoxyphenyl)methyl idene]-1-(3-methoxyphenyl)-1,3-diazinane-2,4, 6-trione
  • MW: 398.366 | Formula: C20H18N2O7
  • H donors: 2 H acceptors: 4 LogP: 2.26 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)N1C(=O)NC(=O)C(=Cc2cc(OC)c(c(c2)OC)O)C1=O
  • InChi: 1S/C20H18N2O7/c1-27-13-6-4-5-12(10-13)22-19(25)14(18(24)21-20(22)26)7-11-8-15(28-2)17(23)16(9-11)29-3/h4-10,23H,1-3H3,(H,21,24,26)/b14-7-
  • InChiKey: MNZLBHNRJDGKIG-AUWJEWJLSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (5Z)-5-[(4-hydroxy-3,5-dimethoxy-phenyl)methylene]-1-(3-methoxyphenyl)hexahydropyrimidine-2,4,6-trione
  • (5Z)-5-[(4-hydroxy-3,5-dimethoxyphenyl)methylene]-1-(3-methoxyphenyl)hexahydropyrimidine-2,4,6-trione
  • (5Z)-5-(4-hydroxy-3,5-dimethoxy-benzylidene)-1-(3-methoxyphenyl)barbituric acid
  • (5Z)-5-[(4-hydroxy-3,5-dimethoxy-phenyl)methylidene]-1-(3-methoxyphenyl)-1,3-diazinane-2,4,6-trione
  • STOCK1S-89451
  • ZINC04833561

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0079 0.4291 0.5
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.1373 0.5
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0079 0.4291 0.3582
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0079 0.4291 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1104 0.1104
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1104 0.1104
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.4291 0.5
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0133 1 1
Schistosoma mansoni tar DNA-binding protein 0.0133 1 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.1104 0.1104
Loa Loa (eye worm) TAR-binding protein 0.0133 1 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.1104 0.1104
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0079 0.4291 0.5
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0079 0.4291 0.3582
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0079 0.4291 0.5
Schistosoma mansoni tar DNA-binding protein 0.0133 1 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.1373 0.0301
Brugia malayi TAR-binding protein 0.0133 1 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.4291 0.5
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.1373 0.0301
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1104 0.1104
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.1935 0.1935
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.1935 0.1935
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.4291 0.5
Schistosoma mansoni tar DNA-binding protein 0.0133 1 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.1935 0.1935
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.1935 0.1935
Loa Loa (eye worm) hypothetical protein 0.0079 0.4291 0.4291
Schistosoma mansoni tar DNA-binding protein 0.0133 1 1
Brugia malayi Probable ClpP-like protease 0.0079 0.4291 0.4291
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.4291 0.5
Echinococcus multilocularis tar DNA binding protein 0.0133 1 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.4291 0.5
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0079 0.4291 0.5
Schistosoma mansoni peptidase Clp (S14 family) 0.0079 0.4291 0.4291
Echinococcus granulosus tar DNA binding protein 0.0133 1 1
Loa Loa (eye worm) RNA binding protein 0.0133 1 1
Brugia malayi RNA recognition motif domain containing protein 0.0133 1 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.1373 0.5
Schistosoma mansoni tar DNA-binding protein 0.0133 1 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.4291 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.