Detailed information for compound 649784

Basic information

Technical information
  • TDR Targets ID: 649784
  • Name: 2-cyano-N-cyclohexyl-3-[5-(4-methyl-2-nitroph enyl)furan-2-yl]prop-2-enamide
  • MW: 379.409 | Formula: C21H21N3O4
  • H donors: 1 H acceptors: 4 LogP: 4.87 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC(=Cc1ccc(o1)c1ccc(cc1[N+](=O)[O-])C)C(=O)NC1CCCCC1
  • InChi: 1S/C21H21N3O4/c1-14-7-9-18(19(11-14)24(26)27)20-10-8-17(28-20)12-15(13-22)21(25)23-16-5-3-2-4-6-16/h7-12,16H,2-6H2,1H3,(H,23,25)/b15-12+
  • InChiKey: BSMNEVKEIAWSJD-NTCAYCPXSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (E)-2-cyano-N-cyclohexyl-3-[5-(4-methyl-2-nitrophenyl)furan-2-yl]prop-2-enamide
  • (E)-2-cyano-N-cyclohexyl-3-[5-(4-methyl-2-nitro-phenyl)-2-furyl]prop-2-enamide
  • 2-cyano-N-cyclohexyl-3-[5-(4-methyl-2-nitro-phenyl)-2-furyl]prop-2-enamide
  • (E)-2-cyano-N-cyclohexyl-3-[5-(4-methyl-2-nitrophenyl)-2-furyl]prop-2-enamide
  • 2-cyano-N-cyclohexyl-3-[5-(4-methyl-2-nitrophenyl)-2-furyl]prop-2-enamide
  • (E)-2-cyano-N-cyclohexyl-3-[5-(4-methyl-2-nitro-phenyl)-2-furyl]acrylamide
  • 2-cyano-N-cyclohexyl-3-[5-(4-methyl-2-nitro-phenyl)-2-furyl]acrylamide
  • (E)-2-cyano-N-cyclohexyl-3-[5-(4-methyl-2-nitro-phenyl)furan-2-yl]prop-2-enamide
  • 2-cyano-N-cyclohexyl-3-[5-(4-methyl-2-nitro-phenyl)furan-2-yl]prop-2-enamide
  • ZINC01209234

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.1882 0.1908
Loa Loa (eye worm) beta-lactamase 0.0036 0.0891 0.0891
Mycobacterium leprae Probable lipase LipE 0.0036 0.0891 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0891 0.0891
Onchocerca volvulus 0.0036 0.0891 0.0891
Loa Loa (eye worm) hypothetical protein 0.0036 0.0891 0.0891
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.1277 0.1295
Brugia malayi mbt repeat family protein 0.0047 0.1277 0.1277
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0977 0.101
Trichomonas vaginalis DNA polymerase eta, putative 0.0038 0.0977 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0977 0.101
Plasmodium falciparum DNA repair protein REV1, putative 0.0012 0.0098 0.1503
Schistosoma mansoni hypothetical protein 0.0304 0.9863 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.1882 0.1946
Mycobacterium ulcerans hypothetical protein 0.0157 0.4954 1
Brugia malayi ImpB/MucB/SamB family protein 0.0063 0.1818 0.1818
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0403 0.6162
Mycobacterium ulcerans hypothetical protein 0.0036 0.0891 0.1799
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0891 0.1222
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.7295 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.1882 0.1882
Trypanosoma brucei chrX additional, unordered contigs 0.0012 0.0098 0.0102
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0977 0.101
Schistosoma mansoni ran 0.0021 0.0403 0.0409
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.001 0.003 0.046
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0582 0.0601
Onchocerca volvulus 0.0047 0.1277 0.1277
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0891 0.1222
Schistosoma mansoni DNA helicase recq1 0.001 0.003 0.0031
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0655 0.0677
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.1105 0.1142
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0582 0.0601
Loa Loa (eye worm) hypothetical protein 0.0036 0.0891 0.0891
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0304 0.9863 0.9863
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0977 0.101
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0964 0.0978
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.1277 0.1295
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0495 0.507
Schistosoma mansoni importin beta-1 0.0029 0.0655 0.0664
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0186 0.5907 0.5989
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0655 0.4995
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0495 0.0502
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0475 0.4859
Leishmania major DNA polymerase eta, putative 0.0063 0.1818 0.188
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0038 0.0977 0.1339
Echinococcus multilocularis snurportin 1 0.0304 0.9863 1
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0098 0.0102
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.003 0.003
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0977 0.101
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0403 0.0417
Loa Loa (eye worm) hypothetical protein 0.0036 0.0891 0.0891
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0098 0.0102
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.1495 0.1495
Entamoeba histolytica Ran family GTPase 0.0021 0.0403 0.2144
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.1411 0.1459
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0891 0.0904
Brugia malayi follicle stimulating hormone receptor 0.0225 0.7229 0.7229
Entamoeba histolytica hypothetical protein 0.0023 0.0475 0.2523
Mycobacterium tuberculosis Conserved protein 0.0036 0.0891 0.1222
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0977 0.101
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0098 0.0102
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0977 0.101
Leishmania major GTP-binding protein, putative 0.0021 0.0403 0.0417
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.1882 0.1946
Schistosoma mansoni hypothetical protein 0.0287 0.9274 0.9403
Plasmodium vivax DNA repair protein REV1, putative 0.0012 0.0098 0.1104
Schistosoma mansoni eyes absent homolog 0.0093 0.2799 0.2838
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0891 0.1222
Loa Loa (eye worm) hypothetical protein 0.0093 0.2799 0.2799
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0403 0.0403
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.1882 0.1946
Toxoplasma gondii ABC1 family protein 0.0036 0.0891 0.68
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0891 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0403 0.0409
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0399 0.6096
Loa Loa (eye worm) hypothetical protein 0.0029 0.0655 0.0655
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0964 0.0978
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0037 0.0939 0.7165
Schistosoma mansoni terminal deoxycytidyl transferase 0.0038 0.0977 0.0991
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.003 0.0031
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0126 0.0671
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0403 0.0403
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.4421 0.4571
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0891 0.1799
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0012 0.0098 0.0751
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0977 0.101
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.1882 0.1908
Trichomonas vaginalis esterase, putative 0.0036 0.0891 0.9124
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0891 0.0904
Loa Loa (eye worm) RecQ helicase 0.0024 0.0495 0.0495
Echinococcus multilocularis dna polymerase eta 0.0063 0.1818 0.1843
Trypanosoma cruzi DNA damage repair protein, putative 0.0012 0.0098 0.0102
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.4421 0.4571
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.1882 0.1882
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.003
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.003 0.003
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0891 0.9124
Onchocerca volvulus 0.0036 0.0891 0.0891
Chlamydia trachomatis metal transport ATPase 0.0009 0 0.5
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0403 0.413
Loa Loa (eye worm) hypothetical protein 0.0309 1 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0891 0.0891
Leishmania major DNA polymerase eta, putative 0.0037 0.0939 0.0971
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.003 0.003
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0977 0.101
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.1495 0.1516
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0098 0.0102
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0475 0.4859
Mycobacterium ulcerans lipase LipD 0.0036 0.0891 0.1799
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0891 0.1799
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.1882 0.1946
Trypanosoma brucei unspecified product 0.0026 0.0582 0.0601
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0891 0.1222
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0977 0.101
Echinococcus granulosus bloom syndrome protein 0.0024 0.0495 0.0502
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0098 0.0102
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0475 0.0491
Brugia malayi RNA, U transporter 1 0.0081 0.2409 0.2409
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.1105 0.1142
Giardia lamblia DNA damage repair protein 0.0012 0.0098 0.1007
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0038 0.0977 0.0991
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0239 0.2679
Brugia malayi mbt repeat family protein 0.0047 0.1277 0.1277
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.1277 0.1277
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.1105 0.1142
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0891 0.1222
Schistosoma mansoni DNA helicase recq5 0.001 0.003 0.0031
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0891 0.9124
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0891 0.0904
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0403 0.0417
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0655 0.0664
Loa Loa (eye worm) hypothetical protein 0.0036 0.0891 0.0891
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0891 0.0904
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0977 0.0977
Treponema pallidum cation-transporting ATPase, P-type 0.0009 0 0.5
Mycobacterium ulcerans hypothetical protein 0.0012 0.0098 0.0199
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0126 0.0131
Mycobacterium ulcerans beta-lactamase 0.0036 0.0891 0.1799
Loa Loa (eye worm) MBCTL1 0.0054 0.1495 0.1495
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0232 0.1773
Brugia malayi beta-lactamase family protein 0.0036 0.0891 0.0891
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0012 0.0098 0.0751
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.1495 0.1516
Leishmania major DNA damage repair protein, putative 0.0012 0.0098 0.0102
Loa Loa (eye worm) hypothetical protein 0.0093 0.2799 0.2799
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0098 0.0102
Brugia malayi hypothetical protein 0.0093 0.2799 0.2799
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0655 0.0677
Leishmania major importin beta-1 subunit, putative 0.0023 0.0475 0.0491
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0977 0.101
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0299 0.9671 1
Echinococcus granulosus dna polymerase eta 0.0063 0.1818 0.1843
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.1277 0.1295
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.1105 0.1142
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0126 0.0131
Schistosoma mansoni ran 0.0021 0.0403 0.0409
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0225 0.7229 0.7229
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0891 0.9124
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0891 0.1222
Loa Loa (eye worm) hypothetical protein 0.0119 0.3691 0.3691
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0977 0.101
Onchocerca volvulus 0.0036 0.0891 0.0891
Trypanosoma brucei unspecified product 0.0038 0.0977 0.101
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.003 0.023
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0403 0.4526
Loa Loa (eye worm) hypothetical protein 0.0054 0.1495 0.1495
Giardia lamblia DINP protein human, muc B family 0.0038 0.0977 1
Leishmania major hypothetical protein, conserved 0.0036 0.0891 0.0922
Plasmodium vivax importin-beta 2, putative 0.0029 0.0655 0.7345
Onchocerca volvulus 0.0309 1 1
Leishmania major DNA polymerase kappa, putative 0.0012 0.0098 0.0102
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.1277 0.1295
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0329 0.0333
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.4421 0.4571
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0299 0.9671 1
Toxoplasma gondii hypothetical protein 0.0048 0.1311 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0977 0.101
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0977 0.101
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.003 0.0031
Echinococcus granulosus importin subunit beta 1 0.0029 0.0655 0.0664
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.4954 0.679
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0126 0.0131
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0977 0.1972
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0495 0.507
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0186 0.5907 0.5989
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0891 0.1222
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.1495 0.1516
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.1277 0.1295
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0891 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0475 0.4859
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0403 0.3078
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0891 0.0891
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.003 0.023
Loa Loa (eye worm) hypothetical protein 0.0047 0.1277 0.1277
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.0977 0.1339
Brugia malayi Importin beta-1 subunit 0.0029 0.0655 0.0655
Plasmodium falciparum importin beta, putative 0.0029 0.0655 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.0939 0.0971
Giardia lamblia Sgs1 DNA helicase, putative 0.001 0.003 0.0308
Mycobacterium tuberculosis Conserved protein 0.0036 0.0891 0.1222
Brugia malayi beta-lactamase 0.0036 0.0891 0.0891
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0977 0.1972
Schistosoma mansoni DNA polymerase IV / kappa 0.0012 0.0098 0.01
Leishmania major DNA polymerase kappa, putative 0.0038 0.0977 0.101
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0891 0.9124
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0582 0.0601
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0126 0.1293
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0038 0.0977 0.0991
Trichomonas vaginalis ran, putative 0.0021 0.0403 0.413
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.1495 0.1516
Treponema pallidum hypothetical protein 0.0009 0 0.5
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.1277 0.1295
Trypanosoma brucei unspecified product 0.0026 0.0582 0.0601
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0891 0.0922
Echinococcus granulosus dna polymerase kappa 0.0038 0.0977 0.0991
Echinococcus multilocularis dna polymerase kappa 0.0038 0.0977 0.0991
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0977 0.101
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.1882 1
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.0098 0.0102
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.003 0.0031
Schistosoma mansoni DNA polymerase eta 0.0063 0.1818 0.1843
Loa Loa (eye worm) hypothetical protein 0.0036 0.0891 0.0891
Mycobacterium tuberculosis Conserved protein 0.0036 0.0891 0.1222
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0038 0.0977 0.0977
Brugia malayi polk-prov protein 0.0012 0.0098 0.0098
Leishmania major mitochondrial DNA polymerase beta 0.0299 0.9671 1
Echinococcus granulosus snurportin 1 0.0304 0.9863 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0063 0.1818 0.188
Trypanosoma cruzi DNA damage repair protein, putative 0.0012 0.0098 0.0102
Entamoeba histolytica deoxycytidyl transferase, putative 0.0038 0.0977 0.5192
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0977 0.101
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.003 0.0031
Loa Loa (eye worm) hypothetical protein 0.0063 0.1818 0.1818
Loa Loa (eye worm) hypothetical protein 0.0012 0.0098 0.0098
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.1277 0.1295
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0038 0.0977 0.101
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0038 0.0977 0.0991
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0977 0.101
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.0098 0.0102
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.1277 0.1277
Trypanosoma brucei DNA polymerase eta, putative 0.0063 0.1818 0.188
Brugia malayi beta-lactamase family protein 0.0036 0.0891 0.0891
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0403 0.0417
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0495 0.0495
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0403 0.0409
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.1495 0.1516
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0038 0.0977 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0299 0.9671 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0891 0.9124
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0891 0.0922
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0891 0.0922
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.1882 0.1908

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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