Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.0492 | 0.0747 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.1436 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0109 | 0.1746 | 0.3106 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0492 | 0.0444 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0094 | 0.1436 | 0.2259 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0176 | 0.31 | 0.5 |
Schistosoma mansoni | alkaline phosphatase | 0.0319 | 0.6027 | 0.6027 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0109 | 0.1746 | 0.1746 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.1746 | 0.2868 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0047 | 0.0478 | 0.0683 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.003 | 0.0127 | 0.0121 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0094 | 0.1436 | 0.1436 |
Trypanosoma brucei | polo-like protein kinase | 0.0094 | 0.1436 | 0.2212 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0294 | 0.5509 | 0.8723 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.1436 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0333 | 0.6314 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0333 | 0.6314 | 1 |
Plasmodium vivax | importin-beta 2, putative | 0.003 | 0.0127 | 1 |
Echinococcus granulosus | intestinal type alkaline phosphatase | 0.0319 | 0.6027 | 0.6007 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0333 | 0.6314 | 1 |
Echinococcus multilocularis | alkaline phosphatase, intestinal, gene 2 | 0.0319 | 0.6027 | 0.6007 |
Echinococcus granulosus | carbonic anhydrase | 0.0109 | 0.1746 | 0.1704 |
Brugia malayi | RNA, U transporter 1 | 0.0084 | 0.1239 | 0.2176 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0109 | 0.1746 | 0.1746 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0047 | 0.0478 | 0.0739 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0047 | 0.0478 | 0.0739 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0316 | 0.5962 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0268 | 0.4981 | 0.4955 |
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.0026 | 0.0051 | 0.0061 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.0492 | 0.0809 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.1436 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0492 | 0.0492 |
Echinococcus multilocularis | importin subunit beta 1 | 0.003 | 0.0127 | 0.0076 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0047 | 0.0478 | 0.0739 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0046 | 0.047 | 0.3215 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0094 | 0.1436 | 1 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0094 | 0.1436 | 0.2538 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0057 | 0.0687 | 0.1071 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0492 | 0.0492 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0109 | 0.1746 | 0.3106 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0294 | 0.5509 | 0.5509 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0294 | 0.5509 | 0.9233 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0109 | 0.1746 | 0.2868 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.1436 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0514 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0268 | 0.4981 | 0.9032 |
Brugia malayi | Importin beta-1 subunit | 0.003 | 0.0127 | 0.0139 |
Echinococcus granulosus | snurportin 1 | 0.0316 | 0.5962 | 0.5942 |
Schistosoma mansoni | tar DNA-binding protein | 0.0268 | 0.4981 | 0.4981 |
Plasmodium falciparum | importin beta, putative | 0.003 | 0.0127 | 0.0448 |
Schistosoma mansoni | tar DNA-binding protein | 0.0268 | 0.4981 | 0.4981 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0109 | 0.1746 | 0.3106 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0294 | 0.5509 | 0.5509 |
Echinococcus multilocularis | snurportin 1 | 0.0316 | 0.5962 | 0.5942 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0109 | 0.1746 | 0.3106 |
Echinococcus multilocularis | intestinal type alkaline phosphatase 1 | 0.0319 | 0.6027 | 0.6007 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0046 | 0.047 | 0.3215 |
Toxoplasma gondii | hypothetical protein | 0.0109 | 0.1746 | 1 |
Echinococcus multilocularis | alkaline phosphatase | 0.0319 | 0.6027 | 0.6007 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0492 | 0.0444 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0094 | 0.1436 | 0.2259 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0294 | 0.5509 | 0.5486 |
Echinococcus multilocularis | geminin | 0.0514 | 1 | 1 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0094 | 0.1436 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0268 | 0.4981 | 0.9032 |
Brugia malayi | RNA binding protein | 0.0268 | 0.4981 | 0.9032 |
Echinococcus granulosus | carbonic anhydrase | 0.0109 | 0.1746 | 0.1704 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0294 | 0.5509 | 0.8723 |
Schistosoma mansoni | kinase | 0.0048 | 0.0495 | 0.0495 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0109 | 0.1746 | 0.3106 |
Entamoeba histolytica | Flap nuclease, putative | 0.0026 | 0.0051 | 0.0268 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0094 | 0.1436 | 0.1392 |
Echinococcus granulosus | alkaline phosphatase intestinal gene 2 | 0.0319 | 0.6027 | 0.6007 |
Schistosoma mansoni | alkaline phosphatase | 0.0319 | 0.6027 | 0.6027 |
Leishmania major | flap endonuclease-1 (FEN-1), putative | 0.0026 | 0.0051 | 0.0061 |
Schistosoma mansoni | importin beta-1 | 0.003 | 0.0127 | 0.0127 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.1436 | 1 |
Echinococcus multilocularis | intestinal type alkaline phosphatase | 0.0319 | 0.6027 | 0.6007 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0294 | 0.5509 | 0.9233 |
Schistosoma mansoni | tar DNA-binding protein | 0.0268 | 0.4981 | 0.4981 |
Echinococcus multilocularis | carbonic anhydrase | 0.0109 | 0.1746 | 0.1704 |
Schistosoma mansoni | hypothetical protein | 0.0514 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0492 | 0.0444 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0492 | 0.0492 |
Echinococcus multilocularis | carbonic anhydrase | 0.0109 | 0.1746 | 0.1704 |
Plasmodium falciparum | carbonic anhydrase | 0.0109 | 0.1746 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0268 | 0.4981 | 0.4955 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0333 | 0.6314 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0109 | 0.1746 | 0.1746 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.1436 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0158 | 0.2737 | 0.4324 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.003 | 0.0127 | 0.0448 |
Schistosoma mansoni | tar DNA-binding protein | 0.0268 | 0.4981 | 0.4981 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0492 | 0.0444 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0026 | 0.0051 | 0.0268 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.2903 | 0.2903 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0294 | 0.5509 | 1 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0094 | 0.1436 | 0.2343 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0094 | 0.1436 | 0.1392 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0158 | 0.2737 | 0.4324 |
Loa Loa (eye worm) | RNA binding protein | 0.0268 | 0.4981 | 0.834 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0294 | 0.5509 | 0.8716 |
Echinococcus granulosus | alkaline phosphatase | 0.0319 | 0.6027 | 0.6007 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0268 | 0.4981 | 0.834 |
Echinococcus granulosus | intestinal type alkaline phosphatase 1 | 0.0319 | 0.6027 | 0.6007 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.1746 | 0.2868 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0094 | 0.1436 | 0.2259 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0127 | 0.0128 |
Echinococcus granulosus | carbonic anhydrase | 0.0109 | 0.1746 | 0.1704 |
Schistosoma mansoni | tar DNA-binding protein | 0.0268 | 0.4981 | 0.4981 |
Leishmania major | carbonic anhydrase-like protein | 0.0294 | 0.5509 | 0.8723 |
Echinococcus multilocularis | carbonic anhydrase | 0.0109 | 0.1746 | 0.1704 |
Echinococcus granulosus | carbonic anhydrase II | 0.0294 | 0.5509 | 0.5486 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0158 | 0.2737 | 0.4289 |
Schistosoma mansoni | hypothetical protein | 0.0316 | 0.5962 | 0.5962 |
Schistosoma mansoni | carbonic anhydrase | 0.0109 | 0.1746 | 0.1746 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.1436 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0268 | 0.4981 | 0.834 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.003 | 0.0127 | 0.0121 |
Mycobacterium ulcerans | hypothetical protein | 0.0176 | 0.31 | 0.5 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0109 | 0.1746 | 0.1746 |
Toxoplasma gondii | hypothetical protein | 0.0054 | 0.0619 | 0.335 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0294 | 0.5509 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.1746 | 0.2868 |
Echinococcus granulosus | importin subunit beta 1 | 0.003 | 0.0127 | 0.0076 |
Giardia lamblia | Kinase, PLK | 0.0094 | 0.1436 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.