Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0034 | 0.0058 | 0.0187 |
Giardia lamblia | Hypothetical protein | 0.0416 | 0.2757 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0034 | 0.0058 | 0.0187 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0058 | 0.0121 |
Schistosoma mansoni | hypothetical protein | 0.0349 | 0.2283 | 0.2238 |
Loa Loa (eye worm) | ACC-1 protein | 0.0034 | 0.0058 | 0.0121 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0034 | 0.0058 | 0.0187 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0058 | 0.0121 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0112 | 0.061 | 0.0555 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0705 | 0.4799 | 1 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0034 | 0.0058 | 0.0121 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0058 | 0.0121 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0039 | 0.0089 | 0.0185 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0034 | 0.0058 | 0.0187 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0705 | 0.4799 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0464 | 0.3099 | 0.3059 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0112 | 0.061 | 0.1271 |
Echinococcus granulosus | muscleblind protein | 0.0464 | 0.3099 | 0.3059 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0075 | 0.0017 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.0075 | 0.0017 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0039 | 0.0089 | 0.0185 |
Onchocerca volvulus | 0.0705 | 0.4799 | 1 | |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0039 | 0.0089 | 0.0185 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0039 | 0.0089 | 0.0185 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.0075 | 0.0017 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0039 | 0.0089 | 0.0031 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0301 | 0.1942 | 0.4046 |
Brugia malayi | Cation transporter family protein | 0.0034 | 0.0058 | 0.0187 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.0075 | 0.0017 |
Echinococcus granulosus | 6 phosphofructo 2 kinase:fructose 2 | 0.0705 | 0.4799 | 0.4769 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0034 | 0.0058 | 0.0121 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0034 | 0.0058 | 0.0187 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein | 0.0301 | 0.1942 | 0.4046 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0039 | 0.0089 | 0.5 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0112 | 0.061 | 0.0555 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0039 | 0.0089 | 0.0052 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0034 | 0.0058 | 0.0187 |
Giardia lamblia | Hypothetical protein | 0.0416 | 0.2757 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0693 | 0.4715 | 0.9825 |
Brugia malayi | Cation transporter family protein | 0.0034 | 0.0058 | 0.0187 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0039 | 0.0089 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0058 | 0.0121 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0034 | 0.0058 | 0.0187 |
Loa Loa (eye worm) | hypothetical protein | 0.0404 | 0.2672 | 0.5568 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0075 | 0.0241 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0058 | 0.0121 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0034 | 0.0058 | 0.0121 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0034 | 0.0058 | 0.0121 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0705 | 0.4799 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0034 | 0.0058 | 0.0187 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0112 | 0.061 | 0.0555 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0039 | 0.0089 | 1 |
Echinococcus multilocularis | geminin | 0.0349 | 0.2283 | 0.2238 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0034 | 0.0058 | 0.0187 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.0693 | 0.4715 | 0.9825 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0034 | 0.0058 | 0.0187 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0301 | 0.1942 | 0.4046 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0039 | 0.0089 | 0.0287 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0034 | 0.0058 | 0.0121 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0039 | 0.0089 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0705 | 0.4799 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0058 | 0.0121 |
Schistosoma mansoni | ap endonuclease | 0.0039 | 0.0089 | 0.0031 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0058 | 0.0121 |
Schistosoma mansoni | microtubule-associated protein tau | 0.1441 | 1 | 1 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.0705 | 0.4799 | 0.4769 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0034 | 0.0058 | 0.0187 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0058 | 0.0121 |
Loa Loa (eye worm) | LGC-31 protein | 0.0034 | 0.0058 | 0.0121 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0464 | 0.3099 | 0.3059 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0112 | 0.061 | 0.0555 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0112 | 0.061 | 0.0555 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0039 | 0.0089 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0058 | 0.0121 |
Schistosoma mansoni | ap endonuclease | 0.0039 | 0.0089 | 0.0031 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0058 | 0.0121 |
Onchocerca volvulus | Putative nachr subunit | 0.0112 | 0.061 | 0.1164 |
Brugia malayi | Cation transporter family protein | 0.0034 | 0.0058 | 0.0187 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0034 | 0.0058 | 0.0187 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.061 | 0.1271 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0705 | 0.4799 | 0.4769 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0693 | 0.4715 | 0.9825 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0058 | 0.0121 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0301 | 0.1942 | 0.4046 |
Schistosoma mansoni | hypothetical protein | 0.0349 | 0.2283 | 0.2238 |
Mycobacterium ulcerans | hypothetical protein | 0.0416 | 0.2757 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0693 | 0.4715 | 0.9825 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0112 | 0.061 | 0.1968 |
Loa Loa (eye worm) | hypothetical protein | 0.0693 | 0.4715 | 0.9825 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0058 | 0.0121 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0039 | 0.0089 | 0.0031 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0058 | 0.0121 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0034 | 0.0058 | 0.0187 |
Loa Loa (eye worm) | hypothetical protein | 0.0464 | 0.3099 | 0.6457 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0039 | 0.0089 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0058 | 0.0121 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0039 | 0.0089 | 0.0185 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0034 | 0.0058 | 0.0187 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0058 | 0.0121 |
Brugia malayi | Muscleblind-like protein | 0.0464 | 0.3099 | 1 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.0416 | 0.2757 | 1 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0034 | 0.0058 | 0.0187 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0034 | 0.0058 | 0.0187 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0039 | 0.0089 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0464 | 0.3099 | 0.6457 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0112 | 0.061 | 0.0555 |
Loa Loa (eye worm) | hypothetical protein | 0.0705 | 0.4799 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0058 | 0.0121 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0058 | 0.0121 |
Toxoplasma gondii | exonuclease III APE | 0.0039 | 0.0089 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.1441 | 1 | 1 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0416 | 0.2757 | 1 |
Loa Loa (eye worm) | ACC-1 protein | 0.0034 | 0.0058 | 0.0121 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0058 | 0.0121 |
Echinococcus granulosus | geminin | 0.0349 | 0.2283 | 0.2238 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.00003 M | In vitro cytotoxic activity against mouse mammary tumor FM3A cells | ChEMBL. | 10937718 |
EC50 (functional) | > 0.000038 M | In vitro antimalarial activity against chloroquine sensitive (FCR-3 strain) Plasmodium falciparum | ChEMBL. | 10937718 |
Growth (functional) | = 92 % | In vitro antimalarial activity against Plasmodium falciparum expressed as growth percent at the concentration of >3.8 * 10 e-5 | ChEMBL. | 10937718 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.