Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0289 | 1 | 1 |
Leishmania major | rac serine-threonine kinase, putative,protein kinase, putative | 0.0248 | 0.8227 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0133 | 0.3289 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.3289 | 0.2672 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0131 | 0.3192 | 0.9706 |
Brugia malayi | ribosomal protein S6 kinase alpha 3 | 0.0248 | 0.8227 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0133 | 0.3289 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0289 | 1 | 1 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.0079 | 0.0938 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.0131 | 0.3192 | 0.9706 |
Giardia lamblia | Kinase, AGC AKT | 0.0248 | 0.8227 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0079 | 0.0938 | 0.5 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0079 | 0.0938 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0133 | 0.3289 | 0.3997 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0133 | 0.3289 | 1 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0289 | 1 | 1 |
Onchocerca volvulus | 0.0133 | 0.3289 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.3192 | 0.2567 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0131 | 0.3192 | 0.9706 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0131 | 0.3192 | 0.3879 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 490 nM | Inhibitry activity against TNF-alpha production using lipopolysaccharide stimulated human monocytic cells | ChEMBL. | 12729637 |
IC50 (functional) | = 490 nM | Inhibitry activity against TNF-alpha production using lipopolysaccharide stimulated human monocytic cells | ChEMBL. | 12729637 |
IC50 (functional) | = 1069 nM | Inhibitry activity against TNF-alpha production using lipopolysaccharide stimulated human monocytic cells | ChEMBL. | 12729637 |
IC50 (functional) | = 1069 nM | Inhibitry activity against TNF-alpha production using lipopolysaccharide stimulated human monocytic cells | ChEMBL. | 12729637 |
IC50 (functional) | = 1070 nM | Inhibitory activity of the compound against lipopolysaccharide stimulated TNF-alpha production in THP-1 cells (human monocytic cells) | ChEMBL. | 15837310 |
IC50 (functional) | = 1070 nM | Inhibitory activity of the compound against lipopolysaccharide stimulated TNF-alpha production in THP-1 cells (human monocytic cells) | ChEMBL. | 15837310 |
IC50 (binding) | = 2430 nM | Inhibition of Mitogen-activated protein kinase p38 alpha | ChEMBL. | 15837310 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 12729637 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.