Detailed information for compound 649861

Basic information

Technical information
  • TDR Targets ID: 649861
  • Name: 4-chloro-N-[(4-methoxyphenyl)methylideneamino ]benzenesulfonamide
  • MW: 324.783 | Formula: C14H13ClN2O3S
  • H donors: 1 H acceptors: 2 LogP: 3.12 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C=NNS(=O)(=O)c1ccc(cc1)Cl
  • InChi: 1S/C14H13ClN2O3S/c1-20-13-6-2-11(3-7-13)10-16-17-21(18,19)14-8-4-12(15)5-9-14/h2-10,17H,1H3/b16-10+
  • InChiKey: XXQDFXQVFCAUKO-MHWRWJLKSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-chloro-N-[(4-methoxyphenyl)methyleneamino]benzenesulfonamide
  • 4-chloro-N-[(4-methoxybenzylidene)amino]benzenesulfonamide
  • CBMicro_034498
  • IVK/8050667
  • BIM-0034381.P001

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.2656 0.2655
Loa Loa (eye worm) hypothetical protein 0.0049 0.2648 0.3024
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0049 0.2656 1
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.2648 0.997
Brugia malayi MAP kinase sur-1 0.0049 0.2656 0.3033
Loa Loa (eye worm) hypothetical protein 0.0145 0.8756 1
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.2656 0.5
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0049 0.2656 1
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.2648 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.2648 0.997
Schistosoma mansoni hypothetical protein 0.0022 0.091 0.091
Loa Loa (eye worm) type III restriction enzyme 0.0008 0 0.0001
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0049 0.2656 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0049 0.2656 1
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.2656 0.5
Echinococcus granulosus mitogen activated protein kinase 0.0049 0.2656 0.2656
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.091 0.091
Brugia malayi hypothetical protein 0.0032 0.1531 0.1748
Entamoeba histolytica DNA repair protein, putative 0.0008 0 0.5
Echinococcus multilocularis mitogen activated protein kinase 3 0.0049 0.2656 0.2656
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.2648 1
Echinococcus multilocularis geminin 0.0164 1 1
Loa Loa (eye worm) hypothetical protein 0.0145 0.8756 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0049 0.2656 0.3033
Brugia malayi hypothetical protein 0.0049 0.2648 0.3024
Schistosoma mansoni hypothetical protein 0.0164 1 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0049 0.2656 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.091 0.091
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.2656 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0049 0.2656 0.2656
Leishmania major hypothetical protein, conserved 0.0049 0.2648 0.997
Echinococcus multilocularis muscleblind protein 0.0145 0.8756 0.8756
Loa Loa (eye worm) hypothetical protein 0.0008 0 0.0001
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.2648 0.997
Echinococcus multilocularis mitogen activated protein kinase 0.0049 0.2656 0.2656
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.2656 1
Brugia malayi Muscleblind-like protein 0.0145 0.8756 1
Giardia lamblia Kinase, CMGC MAPK 0.0049 0.2656 0.5
Entamoeba histolytica DNA repair protein, putative 0.0008 0 0.5
Echinococcus granulosus muscleblind protein 0.0145 0.8756 0.8756
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.2648 1
Schistosoma mansoni hypothetical protein 0.0164 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.2656 0.5
Trypanosoma brucei protein kinase, putative 0.0049 0.2656 1
Loa Loa (eye worm) hypothetical protein 0.0008 0 0.0001
Echinococcus multilocularis muscleblind protein 1 0.0145 0.8756 0.8756
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0049 0.2656 1
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.2656 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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