Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | intermediate filament protein | 0.0027 | 0.0879 | 0.2811 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0051 | 0.2364 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0206 | 0.0663 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0206 | 0.0634 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.2044 | 0.1877 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.3103 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.1328 | 0.4264 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0037 | 0.1504 | 0.5 |
Loa Loa (eye worm) | glutamate receptor | 0.0013 | 0.001 | 0.0031 |
Loa Loa (eye worm) | glutamate receptor | 0.0019 | 0.0422 | 0.1361 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0206 | 0.0176 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0879 | 0.2833 |
Schistosoma mansoni | lamin | 0.0027 | 0.0879 | 0.0688 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0051 | 0.2364 | 0.2341 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0051 | 0.2364 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.0206 | 0.0176 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0879 | 0.2833 |
Brugia malayi | Inositol-1 | 0.0037 | 0.1504 | 0.4831 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.016 | 0.9089 | 0.907 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3103 | 0.2958 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.3103 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3103 | 0.2958 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3103 | 0.2958 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0051 | 0.2364 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0051 | 0.2364 | 0.2341 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0013 | 0.001 | 0.0031 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0879 | 0.2833 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0206 | 0.0176 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0206 | 0.0176 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0019 | 0.0422 | 0.0221 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0014 | 0.0117 | 0.0348 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.001 | 0.0031 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0879 | 0.0852 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0879 | 0.0852 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1328 | 0.4282 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3103 | 0.2958 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0033 | 0.1266 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0051 | 0.2364 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0051 | 0.2364 | 0.2203 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.2296 | 0.74 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0051 | 0.2364 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.2044 | 0.1877 |
Trypanosoma brucei | protein kinase, putative | 0.0051 | 0.2364 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0849 | 0.2737 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0879 | 0.0852 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.3103 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0051 | 0.2364 | 1 |
Brugia malayi | RNA binding protein | 0.0063 | 0.3103 | 1 |
Schistosoma mansoni | lamin | 0.0027 | 0.0879 | 0.0688 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0879 | 0.2811 |
Onchocerca volvulus | 0.0027 | 0.0879 | 0.5 | |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.3103 | 0.3082 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.2044 | 0.202 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0024 | 0.0705 | 0.2249 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0051 | 0.2364 | 1 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0013 | 0.001 | 0.0031 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.2044 | 0.202 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0037 | 0.1504 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.3103 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0117 | 0.0378 |
Echinococcus multilocularis | geminin | 0.0175 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0051 | 0.2364 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0705 | 0.2273 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0037 | 0.1504 | 0.1478 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.2296 | 0.7392 |
Onchocerca volvulus | 0.0027 | 0.0879 | 0.5 | |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.3103 | 0.3082 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0024 | 0.0705 | 0.0677 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0206 | 0.0176 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.1328 | 0.1146 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.2044 | 0.202 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0037 | 0.1504 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.003 | 0.0097 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0051 | 0.2364 | 1 |
Loa Loa (eye worm) | inositol-1 | 0.0037 | 0.1504 | 0.4847 |
Brugia malayi | MAP kinase sur-1 | 0.0051 | 0.2364 | 0.7611 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0051 | 0.2364 | 0.7618 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3103 | 0.2958 |
Echinococcus granulosus | lamin | 0.0027 | 0.0879 | 0.0852 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.2296 | 0.74 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0206 | 0.0634 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.2044 | 0.6577 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0051 | 0.2364 | 0.2341 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.2044 | 0.6588 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0879 | 0.0852 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.2044 | 0.202 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0024 | 0.0705 | 0.0677 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0206 | 0.0663 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0051 | 0.2364 | 1 |
Echinococcus multilocularis | musashi | 0.0027 | 0.0879 | 0.0852 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0051 | 0.2364 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.1504 | 0.1325 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0037 | 0.1504 | 0.1478 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0051 | 0.2364 | 0.2341 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.2044 | 0.1877 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0051 | 0.2364 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.0879 | 0.0688 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.0206 | 0.0176 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0051 | 0.2364 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.2296 | 0.7392 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.1504 | 0.1325 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0033 | 0.1266 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.3103 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.