Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0064 | 0.1756 | 0.1718 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0061 | 0.1637 | 0.5 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0305 | 0.01 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0029 | 0.0525 | 0.0482 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.004 | 0.0895 | 1 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0023 | 0.0305 | 1 |
Plasmodium vivax | importin-beta 2, putative | 0.0028 | 0.049 | 0.3282 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0126 | 0.3917 | 0.5176 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0028 | 0.049 | 0.0447 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0.0305 | 0.1108 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0669 | 0.0669 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0052 | 0.133 | 0.129 |
Schistosoma mansoni | intermediate filament proteins | 0.0026 | 0.0427 | 0.0383 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0427 | 0.0427 |
Onchocerca volvulus | 0.0231 | 0.7582 | 1 | |
Brugia malayi | RNA, U transporter 1 | 0.008 | 0.2303 | 0.3042 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0015 | 0.0045 | 0.0045 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.0427 | 0.0383 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.0525 | 0.372 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0669 | 0.0884 |
Brugia malayi | Importin beta-1 subunit | 0.0028 | 0.049 | 0.0648 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0029 | 0.0525 | 0.0482 |
Onchocerca volvulus | 0.0029 | 0.0525 | 0.0137 | |
Echinococcus granulosus | importin subunit beta 1 | 0.0028 | 0.049 | 0.0447 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.049 | 0.049 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0305 | 0.01 |
Echinococcus multilocularis | NMDA receptor | 0.0024 | 0.0338 | 0.0294 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0064 | 0.1756 | 0.1718 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0085 | 0.2467 | 0.2433 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0231 | 0.0305 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0043 | 0.1022 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.1152 | 0.1111 |
Echinococcus granulosus | glutamate receptor subunit protein glur | 0.0024 | 0.0338 | 0.0294 |
Echinococcus multilocularis | snurportin 1 | 0.03 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.1207 | 0.1207 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0147 | 0.4656 | 0.4632 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0052 | 0.133 | 0.1757 |
Loa Loa (eye worm) | acetyltransferase | 0.0147 | 0.4656 | 0.4656 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0064 | 0.1756 | 0.1718 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0525 | 0.0482 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0064 | 0.1756 | 0.1718 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0029 | 0.0525 | 0.0482 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.3917 | 0.3889 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.1152 | 0.1111 |
Echinococcus multilocularis | Ribosomal protein S1, RNA binding domain | 0.0024 | 0.0338 | 0.0294 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0043 | 0.1022 | 0.1076 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0525 | 0.0482 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.03 | 1 | 1 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0052 | 0.133 | 0.133 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0064 | 0.1756 | 0.1718 |
Plasmodium falciparum | importin beta, putative | 0.0028 | 0.049 | 0.3905 |
Echinococcus granulosus | lamin | 0.0026 | 0.0427 | 0.0383 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0028 | 0.049 | 1 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0052 | 0.133 | 0.1757 |
Echinococcus granulosus | glutamate receptor 2 | 0.0041 | 0.0925 | 0.0884 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0021 | 0.0231 | 0.0187 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.3917 | 0.3889 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.0427 | 0.0427 |
Echinococcus multilocularis | tar DNA binding protein | 0.0126 | 0.3917 | 0.3889 |
Trichomonas vaginalis | importin beta-1, putative | 0.0023 | 0.0305 | 0.01 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0085 | 0.2467 | 0.2433 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0231 | 0.0231 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0061 | 0.1637 | 0.5 |
Echinococcus multilocularis | musashi | 0.0026 | 0.0427 | 0.0383 |
Echinococcus granulosus | glutamate receptor ionotropic kainate 3 | 0.0024 | 0.0338 | 0.0294 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0338 | 0.0294 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0669 | 0.0627 |
Echinococcus multilocularis | glutamate receptor ionotropic kainate | 0.0024 | 0.0338 | 0.0294 |
Schistosoma mansoni | ATP-binding cassette transporter | 0.0052 | 0.133 | 0.129 |
Echinococcus granulosus | geminin | 0.0165 | 0.5283 | 0.5262 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.3917 | 0.3889 |
Schistosoma mansoni | lamin | 0.0026 | 0.0427 | 0.0383 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0.0525 | 0.372 |
Schistosoma mansoni | glutamate receptor kainate | 0.0052 | 0.133 | 0.129 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0061 | 0.1637 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0085 | 0.2467 | 0.2433 |
Brugia malayi | Pre-SET motif family protein | 0.0203 | 0.6602 | 0.8723 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0052 | 0.133 | 0.129 |
Schistosoma mansoni | ran | 0.0021 | 0.0231 | 0.0187 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0525 | 0.0482 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0043 | 0.1022 | 0.1076 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.1207 | 0.1595 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0043 | 0.1022 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.0525 | 0.0694 |
Trichomonas vaginalis | set domain proteins, putative | 0.0231 | 0.7582 | 1 |
Brugia malayi | hypothetical protein | 0.0231 | 0.7568 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0231 | 0.7568 | 0.7557 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.7568 | 0.7568 |
Echinococcus multilocularis | glutamate receptor subunit protein glur | 0.0024 | 0.0338 | 0.0294 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.0427 | 0.0383 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.0488 | 0.0444 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0143 | 0.4512 | 0.4487 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0525 | 0.0482 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0028 | 0.049 | 1 |
Onchocerca volvulus | 0.0047 | 0.1152 | 0.1013 | |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0028 | 0.049 | 0.3282 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0015 | 0.0045 | 0.006 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0043 | 0.1022 | 0.0981 |
Brugia malayi | TAR-binding protein | 0.0126 | 0.3917 | 0.5176 |
Echinococcus granulosus | glutamate receptor ionotropic kainate | 0.0024 | 0.0338 | 0.0294 |
Loa Loa (eye worm) | RNA binding protein | 0.0126 | 0.3917 | 0.3917 |
Schistosoma mansoni | glutamate receptor kainate | 0.0052 | 0.133 | 0.129 |
Schistosoma mansoni | lamin | 0.0026 | 0.0427 | 0.0383 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0064 | 0.1756 | 0.1718 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.3917 | 0.3889 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.0427 | 0.0383 |
Leishmania major | importin beta-1 subunit, putative | 0.0023 | 0.0305 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0045 | 0.0045 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0052 | 0.133 | 0.129 |
Schistosoma mansoni | importin beta-1 | 0.0028 | 0.049 | 0.0447 |
Echinococcus granulosus | tar DNA binding protein | 0.0126 | 0.3917 | 0.3889 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.004 | 0.0895 | 1 |
Brugia malayi | RNA binding protein | 0.0126 | 0.3917 | 0.5176 |
Schistosoma mansoni | glutamate receptor kainate | 0.0052 | 0.133 | 0.129 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0203 | 0.6602 | 0.6602 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0015 | 0.0045 | 0.006 |
Schistosoma mansoni | hypothetical protein | 0.03 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0126 | 0.3917 | 0.3917 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.004 | 0.0895 | 1 |
Echinococcus multilocularis | geminin | 0.0165 | 0.5283 | 0.5262 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.5283 | 0.5262 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.0427 | 0.0564 |
Echinococcus multilocularis | lamin | 0.0026 | 0.0427 | 0.0383 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0052 | 0.133 | 0.129 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.041 | 0.041 |
Schistosoma mansoni | ran | 0.0021 | 0.0231 | 0.0187 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0147 | 0.4656 | 0.4632 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0061 | 0.1637 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0064 | 0.1756 | 0.1718 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0052 | 0.133 | 0.133 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.0427 | 0.0564 |
Chlamydia trachomatis | glutamine binding protein | 0.0061 | 0.1637 | 0.5 |
Echinococcus granulosus | glutamate receptor 2 | 0.0064 | 0.1756 | 0.1718 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0231 | 0.7568 | 0.7557 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0061 | 0.1637 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.5283 | 0.5262 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.1152 | 0.1522 |
Echinococcus granulosus | Ribosomal protein S1 RNA binding domain | 0.0024 | 0.0338 | 0.0294 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0064 | 0.1756 | 0.1718 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0021 | 0.0231 | 0.0187 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0525 | 0.0525 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0064 | 0.1756 | 0.1718 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0126 | 0.3917 | 0.3917 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0052 | 0.133 | 0.129 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1207 | 0.1207 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0064 | 0.1756 | 0.1718 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0041 | 0.0925 | 0.0884 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.1207 | 0.1595 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.3917 | 0.3889 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.0427 | 0.0427 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0043 | 0.1022 | 1 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0147 | 0.4656 | 0.6152 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0052 | 0.133 | 0.129 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.