Detailed information for compound 650265

Basic information

Technical information
  • TDR Targets ID: 650265
  • Name: 2-methoxy-5-pyrrolidin-1-ylsulfonylbenzoic ac id
  • MW: 285.316 | Formula: C12H15NO5S
  • H donors: 1 H acceptors: 4 LogP: 1.06 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1C(=O)O)S(=O)(=O)N1CCCC1
  • InChi: 1S/C12H15NO5S/c1-18-11-5-4-9(8-10(11)12(14)15)19(16,17)13-6-2-3-7-13/h4-5,8H,2-3,6-7H2,1H3,(H,14,15)
  • InChiKey: OMZGXILDEBYINK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-methoxy-5-pyrrolidin-1-ylsulfonyl-benzoic acid
  • 2-methoxy-5-1-pyrrolidinylsulfonylbenzoic acid
  • ST5271635
  • Oprea1_379221
  • IFLab1_003872
  • Oprea1_085851
  • IDI1_009979

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0043 0.0289 0.0627
Toxoplasma gondii hypothetical protein 0.0029 0.0126 0.0102
Trypanosoma brucei pyruvate dehydrogenase complex E3 binding protein, putative 0.003 0.0129 0.0135
Echinococcus granulosus snurportin 1 0.0304 0.3291 0.3422
Brugia malayi Pre-SET motif family protein 0.0211 0.2225 0.2388
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.0818 0.9226 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0381 0.0383
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0037 0.0217 0.0227
Loa Loa (eye worm) beta-lactamase 0.0043 0.0289 0.0283
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.0115 0.1112 0.1641
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.0073 0.0629 0.0832
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0028 0.0004
Plasmodium falciparum dihydrolipoamide acyltransferase component E2 0.003 0.0129 0.0148
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0165 0.0141
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.0323 0.3513 0.5632
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0289 0.0265
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0289 0.0265
Loa Loa (eye worm) hypothetical protein 0.0028 0.0111 0.009
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0174 0.0074
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0037 0.0217 0.0146
Brugia malayi Bromodomain containing protein 0.009 0.0825 0.0866
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0323 0.3513 0.6012
Loa Loa (eye worm) hypothetical protein 0.0071 0.0604 0.0626
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0037 0.0217 0.0146
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0219 0.0294
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0585 0.6537 1
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0165 0.0149
Toxoplasma gondii dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase 0.003 0.0129 0.0106
Schistosoma mansoni hypothetical protein 0.0071 0.0604 0.0631
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0289 0.0494
Plasmodium vivax dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative 0.003 0.0129 0.0148
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.0115 0.1112 0.1091
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0037 0.0217 0.0146
Brugia malayi jmjC domain containing protein 0.0028 0.0111 0.009
Mycobacterium tuberculosis Conserved protein 0.0043 0.0289 0.0265
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.003 0.0129 0.0222
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0053 0.0038
Trypanosoma brucei 2-oxoglutarate dehydrogenase E2 component, putative 0.003 0.0129 0.0135
Schistosoma mansoni peptidase Clp (S14 family) 0.0085 0.0772 0.0807
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0085 0.0772 0.1007
Brugia malayi jmjC domain containing protein 0.0028 0.0111 0.009
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.0115 0.1112 0.1636
Giardia lamblia Fructose-bisphosphate aldolase 0.0585 0.6537 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.0056 0.0432 0.0409
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0289 0.0265
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0037 0.0217 0.0227
Leishmania major carbamoyl-phosphate synthase, putative 0.0073 0.0629 0.0657
Chlamydia trachomatis oxoacy-ACP reductase 0.0037 0.0217 0.0146
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0323 0.3513 0.3671
Brugia malayi Probable ClpP-like protease 0.0085 0.0772 0.0808
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.0323 0.3513 0.5632
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0024 0.0026
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0101 0.0077
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0037 0.0217 0.0193
Trypanosoma brucei dihydrolipoamide acetyltransferase E2 subunit, putative 0.003 0.0129 0.0135
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0585 0.6537 1
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.0848 0.9568 1
Entamoeba histolytica hypothetical protein 0.0023 0.0053 0.0038
Echinococcus multilocularis jumonji domain containing 1A 0.0028 0.0111 0.0087
Mycobacterium tuberculosis Possible oxidoreductase 0.0037 0.0217 0.0146
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.0115 0.1112 0.1636
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.0115 0.1112 0.1162
Schistosoma mansoni aspartate carbamoyltransferase 0.0073 0.0629 0.0657
Mycobacterium leprae Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex SucB 0.003 0.0129 0.0005
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0024 0.0026
Echinococcus granulosus importin subunit beta 1 0.0028 0.0115 0.0095
Loa Loa (eye worm) hypothetical protein 0.0049 0.0354 0.0355
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0037 0.0217 0.0146
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0136 0.0112
Loa Loa (eye worm) hypothetical protein 0.0085 0.0772 0.0808
Schistosoma mansoni pyruvate carboxylase 0.0323 0.3513 0.3671
Mycobacterium ulcerans beta-lactamase 0.0043 0.0289 0.0265
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.055 0.6136 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0129 0.011
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0289 0.04
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.0115 0.1112 0.1641
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0033 0.0005
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0219 0.015
Mycobacterium ulcerans short chain dehydrogenase 0.0037 0.0217 0.0146
Loa Loa (eye worm) retinol dehydrogenase 12 0.0037 0.0217 0.0205
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0619 0.0596
Brugia malayi Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta 0.003 0.0129 0.011
Schistosoma mansoni hypothetical protein 0.0025 0.0074 0.0078
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0115 0.0127
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0028 0.0111 0.019
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0552 0.0576
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0037 0.0217 0.0371
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0286 0.3084 0.4919
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0552 0.0703
Loa Loa (eye worm) hypothetical protein 0.0149 0.151 0.1611
Loa Loa (eye worm) hypothetical protein 0.003 0.0129 0.011
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0085 0.0772 0.1087
Echinococcus multilocularis JmjC domain containing protein 4 0.0028 0.0111 0.0087
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0037 0.0217 0.0146
Plasmodium falciparum phd finger protein, putative 0.0087 0.0792 0.1117
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E2 0.003 0.0129 0.0106
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.055 0.6136 1
Mycobacterium tuberculosis Possible oxidoreductase 0.0037 0.0217 0.0146
Brugia malayi dihydrolipoamide S-acetyltransferase precursor, putative 0.003 0.0129 0.011
Schistosoma mansoni importin beta-1 0.0028 0.0115 0.012
Brugia malayi Inositol-1 0.0037 0.0219 0.0208
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.0323 0.3513 0.5632
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0219 0.0195
Echinococcus granulosus dihydrolipoyllysine residue succinyltransferase 0.003 0.0129 0.011
Echinococcus granulosus Biotin lipoyl attachment 0.003 0.0129 0.011
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0124 0.0104
Loa Loa (eye worm) hypothetical protein 0.0043 0.0289 0.0283
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0115 0.1112 0.1904
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0037 0.0217 0.0146
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.003 0.0129 0.0222
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0289 0.04
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.0848 0.9568 1
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0037 0.0217 0.0146
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.0115 0.1112 0.1636
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.0323 0.3513 0.5632
Echinococcus multilocularis Biotin lipoyl attachment 0.003 0.0129 0.0105
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0285 0.3079 0.3062
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.0115 0.1112 0.1641
Mycobacterium ulcerans short chain dehydrogenase 0.0037 0.0217 0.0146
Brugia malayi AF-10 protein 0.0028 0.0115 0.0095
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.0115 0.1112 0.1636
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0111 0.009
Plasmodium falciparum dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 0.003 0.0129 0.0148
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0028 0.0049
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0037 0.0217 0.0146
Plasmodium vivax hypothetical protein, conserved 0.0087 0.0792 0.1117
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0552 0.0703
Schistosoma mansoni acetyl-CoA carboxylase 0.0848 0.9568 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.2992 0.4766
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0552 0.0703
Leishmania major importin beta-1 subunit, putative 0.0023 0.0053 0.0055
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0136 0.0143
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0552 0.0576
Leishmania major GTP-binding protein, putative 0.0021 0.0028 0.003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0051 0.0374 0.0391
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.003 0.0129 0.0222
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0552 0.0552
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0056 0.0432 0.051
Mycobacterium ulcerans short chain dehydrogenase 0.0037 0.0217 0.0146
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0619 0.0623
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0286 0.3084 0.4919
Echinococcus multilocularis jumonji domain containing protein 0.0121 0.1186 0.1164
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0037 0.0217 0.0146
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.0115 0.1112 0.1636
Schistosoma mansoni hypothetical protein 0.0087 0.0792 0.0828
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0037 0.0217 0.0146
Giardia lamblia PHD finger protein 15 0.0087 0.0792 0.1173
Echinococcus multilocularis PHD finger protein rhinoceros 0.0087 0.0792 0.0769
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0174 0.008
Schistosoma mansoni inositol monophosphatase 0.0037 0.0219 0.0229
Trichomonas vaginalis hypothetical protein 0.055 0.6136 0.9384
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0288 0.0264
Schistosoma mansoni jumonji/arid domain-containing protein 0.0108 0.103 0.1077
Schistosoma mansoni mixed-lineage leukemia protein mll 0.003 0.0128 0.0134
Mycobacterium ulcerans hypothetical protein 0.0043 0.0289 0.0265
Trypanosoma cruzi acetyl-CoA carboxylase 0.0525 0.5842 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0087 0.0792 0.08
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.055 0.6136 1
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0037 0.0217 0.0146
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0165 0.0147
Echinococcus granulosus jumonji domain containing protein 0.0121 0.1186 0.1217
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0037 0.0217 0.029
Brugia malayi RNA, U transporter 1 0.0081 0.072 0.0752
Trypanosoma cruzi glutamine-dependent carbamoyl-phosphate synthetase, putative 0.0073 0.0629 0.1076
Loa Loa (eye worm) hypothetical protein 0.0028 0.0111 0.009
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0219 0.0294
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0037 0.0217 0.0205
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.0115 0.1112 0.1904
Loa Loa (eye worm) hypothetical protein 0.0104 0.0982 0.1037
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.0115 0.1112 0.1636
Echinococcus multilocularis lysine specific demethylase 6a 0.0028 0.0111 0.0087
Mycobacterium ulcerans short chain dehydrogenase 0.0037 0.0217 0.0146
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0028 0.0111 0.0116
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0028 0.0111 0.0087
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0051 0.0374 0.0391
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0219 0.02
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0136 0.0143
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0037 0.0217 0.0227
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.0613 0.6865 1
Toxoplasma gondii pyruvate carboxylase 0.0323 0.3513 0.3652
Brugia malayi Bromodomain containing protein 0.0046 0.032 0.0318
Leishmania major acetyl-CoA carboxylase, putative 0.0848 0.9568 1
Mycobacterium tuberculosis Conserved protein 0.0043 0.0289 0.0265
Trypanosoma brucei unspecified product 0.0212 0.2236 0.2337
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0085 0.0772 0.1074
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0363 0.0379
Leishmania major 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.003 0.0129 0.0135
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0053 0.0038
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0585 0.6537 1
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.0073 0.0629 0.0832
Trichomonas vaginalis esterase, putative 0.0043 0.0289 0.04
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0028 0.0004
Echinococcus granulosus jumonji domain containing 1A 0.0028 0.0111 0.0091
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.055 0.6136 0.6403
Schistosoma mansoni microtubule-associated protein tau 0.0681 0.7642 0.7987
Schistosoma mansoni phosphatidylserine receptor 0.0028 0.0111 0.0116
Plasmodium falciparum carbamoyl phosphate synthetase 0.0073 0.0629 0.0878
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0363 0.0364
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.2225 0.2388
Schistosoma mansoni dihydrolipoamide S-acetyltransferase 0.003 0.0129 0.0135
Treponema pallidum pyruvate carboxylase subunit B 0.003 0.0129 0.0005
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0289 0.0283
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0037 0.0217 0.0146
Trypanosoma brucei acetyl-CoA carboxylase 0.0848 0.9568 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0289 0.04
Echinococcus granulosus peregrin 0.009 0.0825 0.0839
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0289 0.0494
Loa Loa (eye worm) hypothetical protein 0.0043 0.0289 0.0283
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0037 0.0217 0.0198
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0585 0.6537 1
Mycobacterium ulcerans short chain dehydrogenase 0.0037 0.0217 0.0146
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0085 0.0772 0.1087
Loa Loa (eye worm) hypothetical protein 0.0028 0.0115 0.0094
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0037 0.0217 0.0198
Brugia malayi jmjC domain containing protein 0.0108 0.103 0.1089
Loa Loa (eye worm) hypothetical protein 0.0051 0.0374 0.0376
Mycobacterium ulcerans short chain dehydrogenase 0.0037 0.0217 0.0146
Loa Loa (eye worm) hypothetical protein 0.0043 0.0289 0.0283
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0028 0.0111 0.0116
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0085 0.0772 0.0749
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0028 0.003
Toxoplasma gondii ABC1 family protein 0.0043 0.0289 0.0273
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0289 0.0265
Loa Loa (eye worm) inositol-1 0.0037 0.0219 0.0208
Trypanosoma brucei pteridine reductase 1 0.0037 0.0217 0.0227
Plasmodium falciparum enoyl-acyl carrier reductase 0.055 0.6136 0.8934
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0087 0.0792 0.0828
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0101 0.0106
Brugia malayi jmjC domain containing protein 0.0028 0.0111 0.009
Loa Loa (eye worm) hypothetical protein 0.0087 0.0792 0.083
Loa Loa (eye worm) jmjC domain-containing protein 0.0108 0.103 0.1089
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0028 0.0049
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0363 0.0339
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0585 0.6537 1
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.003 0.0129 0.0222
Loa Loa (eye worm) hypothetical protein 0.003 0.0129 0.011
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0101 0.008
Brugia malayi jmjC domain containing protein 0.0028 0.0111 0.009
Mycobacterium ulcerans oxidoreductase 0.0037 0.0217 0.0146
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0085 0.0772 0.1069
Toxoplasma gondii dihydrolipoamide acyltransferase, putative 0.003 0.0129 0.0106
Schistosoma mansoni jumonji domain containing protein 0.0227 0.2402 0.2511
Mycobacterium ulcerans short chain dehydrogenase 0.0037 0.0217 0.0146
Mycobacterium leprae Probable biotinylated protein homolog TB7.3 0.003 0.0129 0.0005
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0286 0.3084 0.4922
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0037 0.0217 0.0146
Schistosoma mansoni hypothetical protein 0.0028 0.0115 0.0121
Echinococcus multilocularis lysine specific demethylase 5A 0.0105 0.1004 0.0981
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0552 0.0576
Schistosoma mansoni inositol monophosphatase 0.0037 0.0219 0.0229
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0111 0.009
Schistosoma mansoni protein phosphatase 2C 0.0028 0.0111 0.0116
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.0982 0.1037
Plasmodium vivax enoyl-acyl carrier protein reductase 0.055 0.6136 0.8934
Leishmania major hypothetical protein, conserved 0.0028 0.0111 0.0116
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0552 0.0703
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0289 0.0265
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0037 0.0217 0.0146
Schistosoma mansoni dihydropteridine reductase 0.0037 0.0217 0.0227
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0053 0.0038
Echinococcus granulosus zinc finger protein 0.0024 0.006 0.0037
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0219 0.0294
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.055 0.6136 1
Echinococcus multilocularis dihydrolipoyllysine residue succinyltransferase 0.003 0.0129 0.0105
Echinococcus granulosus histone lysine methyltransferase setb 0.0051 0.0374 0.0366
Plasmodium vivax importin-beta 2, putative 0.0028 0.0115 0.0127
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0056 0.0432 0.0504
Onchocerca volvulus 0.024 0.2561 1
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0037 0.0217 0.0146
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0028 0.0111 0.019
Leishmania major carboxylase, putative 0.0323 0.3513 0.3671
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0219 0.0376
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0037 0.0217 0.0276
Toxoplasma gondii biotin-requiring enzyme domain-containing protein 0.003 0.0129 0.0106
Echinococcus granulosus lysine specific demethylase 5A 0.0108 0.103 0.1054
Echinococcus multilocularis zinc finger protein 0.0024 0.006 0.0035
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0028 0.0115 0.0091
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0585 0.6537 1
Onchocerca volvulus Alhambra homolog 0.0087 0.0792 0.2703
Loa Loa (eye worm) hypothetical protein 0.0037 0.0217 0.0205
Loa Loa (eye worm) hypothetical protein 0.0046 0.0321 0.0319
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.0613 0.6865 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0085 0.0772 0.0779
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0029 0.0126 0.0143
Leishmania major dihydrolipoamide acetyltransferase precursorlike protein 0.003 0.0129 0.0135
Mycobacterium ulcerans short chain dehydrogenase 0.0037 0.0217 0.0146
Leishmania major dihydrolipoamide branched chain transacylase, putative 0.003 0.0129 0.0135
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0037 0.0217 0.0146
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.0073 0.0629 0.0878
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0289 0.027
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0037 0.0217 0.0146
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0219 0.0376
Onchocerca volvulus 0.0043 0.0289 0.0627
Trypanosoma brucei oxidoreductase-like protein 0.0037 0.0217 0.0227
Leishmania major dihydrolipoamide acetyltransferase precursor, putative 0.003 0.0129 0.0135
Plasmodium vivax lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative 0.003 0.0129 0.0148
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0585 0.6537 1
Schistosoma mansoni hypothetical protein 0.0033 0.0165 0.0172
Brugia malayi beta-lactamase 0.0043 0.0289 0.0283
Brugia malayi Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor 0.003 0.0129 0.011
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0585 0.6537 1
Mycobacterium leprae Probable lipase LipE 0.0043 0.0289 0.027
Echinococcus granulosus GPCR family 2 0.0033 0.0165 0.0147
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.0145 0.1455 0.2192
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0037 0.0217 0.0371
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0051 0.0374 0.0351
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0085 0.0772 0.1069
Schistosoma mansoni ran 0.0021 0.0028 0.003
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0289 0.0265
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.0323 0.3513 0.3671
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0136 0.0113
Trypanosoma cruzi dihydrolipoamide acetyltransferase, putative 0.003 0.0129 0.0222
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0285 0.3079 0.3201
Echinococcus granulosus acetyl coenzyme A carboxylase 1 0.0848 0.9568 1
Schistosoma mansoni hypothetical protein 0.0304 0.3291 0.3439
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0289 0.04
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0289 0.0265
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.0115 0.1112 0.114
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0053 0.0091
Schistosoma mansoni dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase 0.003 0.0129 0.0135
Plasmodium vivax SET domain protein, putative 0.003 0.0136 0.0158
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0115 0.0091
Brugia malayi Pre-SET motif family protein 0.003 0.0136 0.0118
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0115 0.012
Brugia malayi Importin beta-1 subunit 0.0028 0.0115 0.0094
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0028 0.0115 0.0121
Schistosoma mansoni zinc finger protein 0.0024 0.006 0.0062
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0304 0.3291 0.3547
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0028 0.0115 0.0127
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0552 0.0548
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.0323 0.3513 0.5634
Entamoeba histolytica acetyl-coA carboxylase, putative 0.0145 0.1455 0.2192
Loa Loa (eye worm) oxidoreductase 0.0037 0.0217 0.0205
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0111 0.009
Echinococcus granulosus PHD finger protein rhinoceros 0.0087 0.0792 0.0804
Echinococcus granulosus phd:f box containing protein 0.0028 0.0111 0.0091
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0289 0.0265
Plasmodium vivax JmjC domain containing protein 0.0028 0.0111 0.0121
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.0982 0.1037
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.0115 0.1112 0.1636
Brugia malayi F/Y-rich N-terminus family protein 0.0032 0.0155 0.0137
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0037 0.0217 0.0146
Plasmodium falciparum importin beta, putative 0.0028 0.0115 0.0127
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0289 0.0302
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.0115 0.1112 0.1136
Trypanosoma brucei dihydrolipoamide branched chain transacylase, putative 0.003 0.0129 0.0135
Loa Loa (eye worm) PHD-finger family protein 0.0087 0.0792 0.083
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0219 0.0229
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.0115 0.1112 0.1636
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0288 0.0276
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0085 0.0772 0.0783
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0037 0.0217 0.0146
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0219 0.0229
Echinococcus granulosus peptidase Clp S14 family 0.0056 0.0432 0.0427
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0126 0.0143
Echinococcus granulosus lysine specific demethylase 6a 0.0028 0.0111 0.0091
Loa Loa (eye worm) hypothetical protein 0.0085 0.0772 0.0809
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0037 0.0217 0.0205
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0363 0.0339
Toxoplasma gondii carbamoylphosphate synthetase 0.0073 0.0629 0.063
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0073 0.0629 0.0657
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0037 0.0217 0.0146
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.0115 0.1112 0.1636
Schistosoma mansoni hypothetical protein 0.0033 0.0165 0.0172
Brugia malayi Carboxyl transferase domain containing protein 0.0818 0.9226 1
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0037 0.0217 0.0198
Schistosoma mansoni jumonji domain containing protein 0.0028 0.0111 0.0116
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0115 0.0091
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0289 0.0265
Mycobacterium ulcerans short chain dehydrogenase 0.0037 0.0217 0.0146
Toxoplasma gondii 2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein 0.003 0.0129 0.0106
Mycobacterium ulcerans short chain dehydrogenase 0.0037 0.0217 0.0146
Echinococcus multilocularis microtubule associated protein 2 0.0681 0.7642 0.7636
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0323 0.3513 0.3671
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0289 0.0277
Brugia malayi jmjC domain containing protein 0.0285 0.3079 0.3317
Mycobacterium ulcerans pyruvate carboxylase 0.0323 0.3513 0.5632
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.003 0.0129 0.0222
Echinococcus multilocularis dihydrolipoyllysine residue acetyltransferase 0.003 0.0129 0.0105
Leishmania major propionyl-coa carboxylase beta chain, putative 0.0115 0.1112 0.1162
Loa Loa (eye worm) jmjC domain-containing protein 0.018 0.1862 0.1994
Loa Loa (eye worm) hypothetical protein 0.0043 0.0289 0.0283
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.003 0.0129 0.0222
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0289 0.0302
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0115 0.1112 0.1904
Echinococcus multilocularis phd:f box containing protein 0.0028 0.0111 0.0087
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.0124
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.0323 0.3513 0.3497
Giardia lamblia Deoxynucleoside kinase 0.0261 0.2793 0.4248
Trypanosoma brucei glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative 0.0073 0.0629 0.0657
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0289 0.0283
Mycobacterium ulcerans short chain dehydrogenase 0.0037 0.0217 0.0146
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0323 0.3513 0.3671
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.003 0.0129 0.0135
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0585 0.6537 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0552 0.0528
Mycobacterium ulcerans short chain dehydrogenase 0.0037 0.0217 0.0146
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0037 0.0217 0.0146
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0219 0.0294
Echinococcus multilocularis snurportin 1 0.0304 0.3291 0.3274
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0085 0.0772 0.1069
Toxoplasma gondii PHD-finger domain-containing protein 0.0087 0.0792 0.08
Schistosoma mansoni ran 0.0021 0.0028 0.003
Plasmodium falciparum JmjC domain-containing protein, putative 0.0028 0.0111 0.0121
Mycobacterium tuberculosis Conserved protein 0.0043 0.0289 0.0265
Treponema pallidum fructose-bisphosphate aldolase 0.0585 0.6537 1
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.0848 0.9568 0.9567
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0363 0.0355
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0073 0.0629 0.0657
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0323 0.3513 0.3671
Echinococcus granulosus microtubule associated protein 2 0.0681 0.7642 0.7982
Brugia malayi PHD-finger family protein 0.003 0.0134 0.0115
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0115 0.012
Leishmania major hypothetical protein, conserved 0.0043 0.0289 0.0302
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0037 0.0217 0.0371
Loa Loa (eye worm) hypothetical protein 0.0033 0.0165 0.0149
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0363 0.0379
Echinococcus multilocularis GPCR, family 2 0.0033 0.0165 0.0141
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0363 0.0379
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.055 0.6136 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0037 0.0217 0.0146
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0037 0.0217 0.0276
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0037 0.0217 0.0146
Onchocerca volvulus 0.0037 0.0217 0.0331
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0604 0.0626
Schistosoma mansoni phd/f-box containing protein 0.0028 0.0111 0.0116
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0037 0.0217 0.0227
Schistosoma mansoni hypothetical protein 0.0033 0.0165 0.0172
Schistosoma mansoni bromodomain containing protein 0.0076 0.0669 0.0699
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0289 0.0302
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.0323 0.3513 0.3655
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0165 0.0141
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0115 0.1112 0.1162
Plasmodium falciparum lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex 0.003 0.0129 0.0148
Loa Loa (eye worm) hypothetical protein 0.0043 0.0289 0.0283
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0585 0.6537 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0363 0.0355
Echinococcus granulosus JmjC domain containing protein 4 0.0028 0.0111 0.0091
Schistosoma mansoni hypothetical protein 0.0033 0.0165 0.0172
Schistosoma mansoni jumonji/arid domain-containing protein 0.0108 0.103 0.1077
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0289 0.0265
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0037 0.0217 0.0202
Leishmania major oxidoreductase-like protein 0.0037 0.0217 0.0227
Brugia malayi PHD-finger family protein 0.0087 0.0792 0.083
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.0323 0.3513 0.5632
Loa Loa (eye worm) hypothetical protein 0.0043 0.0289 0.0283
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0165 0.0149
Brugia malayi PHD-finger family protein 0.0031 0.0142 0.0124
Echinococcus multilocularis peregrin 0.009 0.0825 0.0803
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.0323 0.3513 0.5632
Mycobacterium ulcerans lipase LipD 0.0043 0.0289 0.0265
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.003 0.0138 0.0114
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.0982 0.1037
Mycobacterium tuberculosis Probable oxidoreductase 0.0037 0.0217 0.0146
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.003 0.0138 0.0119
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0037 0.0217 0.0146
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.0037 0.0217 0.0151
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0074 0.005
Trypanosoma cruzi glutamine dependent carbamoyl-phosphate synthase, putative 0.0073 0.0629 0.1076
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0323 0.3513 0.6012
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0056 0.0432 0.0504
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0289 0.04
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0037 0.0217 0.0205
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0028 0.0111 0.0087
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0085 0.0772 0.0779
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.003 0.0129 0.0135
Brugia malayi beta-lactamase family protein 0.0043 0.0289 0.0283
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0115 0.0091
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0085 0.0772 0.1069
Chlamydia trachomatis biotin carboxylase 0.0293 0.317 0.5062
Onchocerca volvulus 0.0043 0.0289 0.0627
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0165 0.0147
Brugia malayi beta-lactamase family protein 0.0043 0.0289 0.0283
Echinococcus granulosus dihydrolipoyllysine residue acetyltransferase 0.003 0.0129 0.011
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.0037 0.0217 0.0151
Brugia malayi Bromodomain containing protein 0.0091 0.0832 0.0874
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0085 0.0772 0.1069
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0363 0.0364
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0219 0.0204
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0028 0.0115 0.0121
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0165 0.0149
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0037 0.0217 0.0227
Trichomonas vaginalis set domain proteins, putative 0.024 0.2561 0.3892
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0219 0.015
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0115 0.1112 0.1162
Leishmania major pteridine reductase 1 0.0037 0.0217 0.0227
Onchocerca volvulus 0.0037 0.0217 0.0331
Chlamydia trachomatis acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 0.0115 0.1112 0.1636
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0289 0.038

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.7079 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 2.3323 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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