Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Oryctolagus cuniculus | Acyl-CoA:cholesterol acyltransferase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Schistosoma japonicum | ko:K00637 sterol O-acyltransferase [EC2.3.1.26], putative | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Echinococcus multilocularis | sterol O acyltransferase 1 | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Schistosoma mansoni | sterol O-acyltransferase 1 | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Echinococcus granulosus | sterol O acyltransferase 1 | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Dictyostelium discoideum | diacylglycerol O-acyltransferase 1 | Acyl-CoA:cholesterol acyltransferase | 305 aa | 278 aa | 21.9 % |
Neospora caninum | sterol O-acyltransferase, putative | Acyl-CoA:cholesterol acyltransferase | 305 aa | 258 aa | 20.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0119 | 0.3408 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0119 | 0.3408 | 1 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.007 | 0.1176 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0117 | 0.3316 | 0.9706 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.3316 | 0.3316 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0119 | 0.3408 | 1 |
Onchocerca volvulus | 0.0119 | 0.3408 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.3408 | 0.3408 |
Schistosoma mansoni | sterol O-acyltransferase 1 | 0.0264 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.007 | 0.1176 | 0.5 |
Echinococcus granulosus | 6 phosphofructo 2 kinase:fructose 2 | 0.0119 | 0.3408 | 0.3408 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0117 | 0.3316 | 0.9706 |
Echinococcus multilocularis | geminin | 0.0164 | 0.543 | 0.543 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.0119 | 0.3408 | 0.3408 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0119 | 0.3408 | 0.3408 |
Mycobacterium ulcerans | hypothetical protein | 0.007 | 0.1176 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0119 | 0.3408 | 1 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.007 | 0.1176 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.007 | 0.1176 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.0117 | 0.3316 | 0.9706 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 0.8824 | 0.8824 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0117 | 0.3316 | 0.9706 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.543 | 0.543 |
Echinococcus granulosus | geminin | 0.0164 | 0.543 | 0.543 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.543 | 0.543 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.1084 | 0.1084 |
Echinococcus multilocularis | sterol O acyltransferase 1 | 0.0264 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Delta TC (functional) | = -53 % | Percent change in total cholesterol in peanut oil (5.5%)-, cholic acid (0.3%)-, Cholesterol (1.5%)-fed rats after a single dose. | ChEMBL. | 8201599 |
IC50 (binding) | = 0.023 uM | Tested for in vitro inhibition against Acyl coenzyme A:cholesterol acyltransferase of intestinal microsomes in cholesterol-fed rabbits | ChEMBL. | 8201599 |
IC50 (binding) | = 0.023 uM | Tested for in vitro inhibition against Acyl coenzyme A:cholesterol acyltransferase of intestinal microsomes in cholesterol-fed rabbits | ChEMBL. | 8201599 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.