Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0119 | 0.2134 | 0.9706 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0044 | 0.0264 | 0.0264 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0119 | 0.2134 | 0.9706 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.004 | 0.0172 | 0.0785 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0896 | 0.4099 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0102 | 0.1708 | 0.1708 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0121 | 0.2185 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.004 | 0.0172 | 0.0785 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0102 | 0.1708 | 0.7245 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0121 | 0.2185 | 1 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0102 | 0.1708 | 0.7245 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0102 | 0.1708 | 1 |
Onchocerca volvulus | 0.0121 | 0.2185 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.2185 | 1 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0102 | 0.1708 | 0.7245 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0102 | 0.1708 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0347 | 0.782 | 0.5 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0102 | 0.1708 | 0.7816 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0102 | 0.1708 | 0.1708 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0347 | 0.782 | 1 |
Echinococcus granulosus | 6 phosphofructo 2 kinase:fructose 2 | 0.0121 | 0.2185 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0347 | 0.782 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0347 | 0.782 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.0119 | 0.2134 | 0.9706 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0102 | 0.1708 | 0.7816 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0102 | 0.1708 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0121 | 0.2185 | 1 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0102 | 0.1708 | 0.5 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0102 | 0.1708 | 0.7245 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0121 | 0.2185 | 0.2185 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0102 | 0.1708 | 0.1108 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0038 | 0.0105 | 0.0616 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0102 | 0.1708 | 0.7245 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.1708 | 0.7816 |
Mycobacterium ulcerans | hypothetical protein | 0.0347 | 0.782 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.004 | 0.0172 | 0.0785 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0102 | 0.1708 | 0.7816 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0102 | 0.1708 | 0.7816 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0102 | 0.1708 | 1 |
Brugia malayi | eukaryotic initiation factor 4A | 0.0102 | 0.1708 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0038 | 0.0176 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0119 | 0.2134 | 0.9706 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0044 | 0.0264 | 0.0264 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0038 | 0.0105 | 0.0616 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0102 | 0.1708 | 0.7816 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0121 | 0.2185 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0102 | 0.1708 | 1 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.0121 | 0.2185 | 1 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0102 | 0.1708 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0347 | 0.782 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.2134 | 0.9767 |
Plasmodium vivax | RNA helicase-1, putative | 0.0102 | 0.1708 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.004 | 0.0172 | 0.1004 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
I50 (functional) | 0 uM | Inhibition of dihydrosterculate synthesis in Crithidia fasciculata; No inhibition | ChEMBL. | 3398003 |
I50 (functional) | > 100 uM | The compound was tested for 50% growth inhibition against Crithidia fasciculata | ChEMBL. | 3398003 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.