Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.0442 | 0.0685 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.0122 | 0.1315 |
Brugia malayi | Cathepsin L-like precursor | 0.0018 | 0.0018 | 0.0028 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0067 | 0.0644 | 1 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0028 | 0.0145 | 0.1599 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0089 | 0.0921 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0122 | 0.1315 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0487 | 0.597 | 0.597 |
Brugia malayi | hypothetical protein | 0.0089 | 0.0921 | 0.1426 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0389 | 0.0602 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0067 | 0.0644 | 1 |
Onchocerca volvulus | 0.0089 | 0.0921 | 1 | |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0089 | 0.0921 | 0.0921 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0089 | 0.0921 | 0.1426 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0018 | 0.0018 | 0.0018 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0089 | 0.0921 | 0.1426 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0018 | 0.0018 | 0.0028 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0389 | 0.0389 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0122 | 0.1661 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0089 | 0.0921 | 0.1426 |
Brugia malayi | Carboxylesterase family protein | 0.0089 | 0.0921 | 0.1426 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0018 | 0.0018 | 0.0018 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0089 | 0.0921 | 1 |
Leishmania major | cathepsin L-like protease | 0.0067 | 0.0644 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0526 | 0.6454 | 1 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.008 | 0.081 | 1 |
Onchocerca volvulus | 0.0089 | 0.0921 | 1 | |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0064 | 0.0604 | 0.0935 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.0389 | 0.0602 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0064 | 0.0604 | 0.7397 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0073 | 0.0715 | 0.1107 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.008 | 0.081 | 0.6497 |
Echinococcus multilocularis | neuroligin | 0.0089 | 0.0921 | 0.0921 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0067 | 0.0644 | 1 |
Onchocerca volvulus | 0.0089 | 0.0921 | 1 | |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0067 | 0.0644 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0089 | 0.0921 | 0.1426 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0122 | 0.019 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.0715 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.0715 | 1 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0028 | 0.0145 | 0.1599 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0089 | 0.0921 | 1 |
Echinococcus granulosus | neuroligin | 0.0089 | 0.0921 | 0.1426 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0018 | 0.0018 | 0.0028 |
Brugia malayi | hypothetical protein | 0.0073 | 0.0715 | 0.1107 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.008 | 0.081 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0237 | 0.0368 |
Loa Loa (eye worm) | hypothetical protein | 0.0526 | 0.6454 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.008 | 0.081 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0018 | 0.0028 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0487 | 0.597 | 0.9249 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.008 | 0.081 | 0.1254 |
Brugia malayi | follicle stimulating hormone receptor | 0.0233 | 0.2742 | 0.4248 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0052 | 0.046 | 0.046 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0067 | 0.0644 | 1 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0053 | 0.0463 | 0.7098 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0067 | 0.0644 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0067 | 0.0644 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0067 | 0.0644 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0064 | 0.0604 | 0.0935 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0064 | 0.0604 | 0.3115 |
Brugia malayi | Cathepsin L-like precursor | 0.0018 | 0.0018 | 0.0028 |
Loa Loa (eye worm) | cysteine protease | 0.0018 | 0.0018 | 0.0028 |
Brugia malayi | Carboxylesterase family protein | 0.0089 | 0.0921 | 0.1426 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0237 | 0.0368 |
Echinococcus multilocularis | cysteine protease | 0.0018 | 0.0018 | 0.0018 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.0442 | 0.0685 |
Echinococcus multilocularis | acetylcholinesterase | 0.0526 | 0.6454 | 0.6454 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0089 | 0.0921 | 0.1426 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0018 | 0.0018 | 0.0028 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0921 | 0.1426 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0921 | 0.1426 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0122 | 0.1661 |
Leishmania major | cathepsin L-like protease | 0.0067 | 0.0644 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0067 | 0.0644 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0122 | 0.1315 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0064 | 0.0604 | 0.9347 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0089 | 0.0921 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0052 | 0.046 | 0.4744 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0122 | 0.019 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0067 | 0.0644 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0089 | 0.0921 | 0.1426 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0089 | 0.0921 | 1 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.008 | 0.081 | 0.1254 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0018 | 0.0018 | 0.0018 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.081 | 0.1254 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0089 | 0.0921 | 0.0921 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.0715 | 0.1107 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.008 | 0.081 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0089 | 0.0921 | 0.1426 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0233 | 0.2742 | 0.4248 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0921 | 0.1426 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.0442 | 0.0685 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.0715 | 1 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0006 | 0.001 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0089 | 0.0921 | 0.0921 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0018 | 0.0018 | 0.0018 |
Echinococcus granulosus | acetylcholinesterase | 0.0526 | 0.6454 | 1 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.008 | 0.081 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0237 | 0.0368 |
Echinococcus multilocularis | cysteine protease | 0.0018 | 0.0018 | 0.0018 |
Onchocerca volvulus | 0.0089 | 0.0921 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0018 | 0.0018 | 0.0028 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0067 | 0.0644 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0018 | 0.0018 | 0.0028 |
Brugia malayi | Carboxylesterase family protein | 0.0089 | 0.0921 | 0.1426 |
Brugia malayi | Cathepsin L-like precursor | 0.0018 | 0.0018 | 0.0028 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0921 | 0.1426 |
Loa Loa (eye worm) | carboxylesterase | 0.0089 | 0.0921 | 0.1426 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0389 | 0.0602 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0921 | 0.1426 |
Onchocerca volvulus | 0.0089 | 0.0921 | 1 | |
Echinococcus granulosus | carboxylesterase 5A | 0.0526 | 0.6454 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0067 | 0.0644 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0089 | 0.0921 | 1 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.008 | 0.081 | 0.081 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0526 | 0.6454 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0018 | 0.0018 | 0.0028 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0526 | 0.6454 | 0.6454 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0089 | 0.0921 | 0.1426 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0067 | 0.0644 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0526 | 0.6454 | 1 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0487 | 0.597 | 0.597 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0442 | 0.0685 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0389 | 0.0389 |
Brugia malayi | Probable ClpP-like protease | 0.008 | 0.081 | 0.1254 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0389 | 0.0602 |
Loa Loa (eye worm) | ctsf protein | 0.0018 | 0.0018 | 0.0028 |
Echinococcus granulosus | neuropeptide s receptor | 0.0487 | 0.597 | 0.9249 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0389 | 0.0602 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0921 | 0.1426 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0389 | 0.0602 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0089 | 0.0921 | 0.1426 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0122 | 0.1661 |
Echinococcus granulosus | cathepsin l1 | 0.0018 | 0.0018 | 0.0028 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.008 | 0.081 | 0.5 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0052 | 0.046 | 0.0713 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0921 | 0.1426 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0064 | 0.0604 | 0.0935 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0018 | 0.0018 | 0.0028 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0073 | 0.0715 | 0.1107 |
Schistosoma mansoni | gliotactin | 0.0089 | 0.0921 | 0.1426 |
Loa Loa (eye worm) | fibroinase | 0.0018 | 0.0018 | 0.0028 |
Schistosoma mansoni | acetylcholinesterase | 0.0089 | 0.0921 | 0.1426 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.0122 | 0.1315 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0018 | 0.0018 | 0.0028 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.008 | 0.081 | 0.6497 |
Echinococcus multilocularis | acetylcholinesterase | 0.0526 | 0.6454 | 0.6454 |
Brugia malayi | Carboxylesterase family protein | 0.0526 | 0.6454 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0526 | 0.6454 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0526 | 0.6454 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.0389 | 0.0602 |
Toxoplasma gondii | hypothetical protein | 0.0028 | 0.0145 | 0.1599 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0064 | 0.0604 | 0.0604 |
Brugia malayi | Carboxylesterase family protein | 0.0089 | 0.0921 | 0.1426 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0067 | 0.0644 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0061 | 0.0571 | 0.8824 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.008 | 0.081 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0526 | 0.6454 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.008 | 0.081 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0018 | 0.0018 | 0.0028 |
Leishmania major | cathepsin L-like protease | 0.0067 | 0.0644 | 1 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.008 | 0.081 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0073 | 0.0715 | 0.0715 |
Brugia malayi | Cathepsin L-like precursor | 0.0018 | 0.0018 | 0.0028 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.0715 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0067 | 0.0644 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.