Detailed information for compound 650847

Basic information

Technical information
  • TDR Targets ID: 650847
  • Name: N-[4-[(2,4-dimethylphenyl)methyl]piperazin-1- yl]-1-(3-methylphenyl)methanimine
  • MW: 321.459 | Formula: C21H27N3
  • H donors: 0 H acceptors: 0 LogP: 4.52 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(c(c1)C)CN1CCN(CC1)N=Cc1cccc(c1)C
  • InChi: 1S/C21H27N3/c1-17-5-4-6-20(14-17)15-22-24-11-9-23(10-12-24)16-21-8-7-18(2)13-19(21)3/h4-8,13-15H,9-12,16H2,1-3H3/b22-15+
  • InChiKey: GMNGPZOFHMDVDL-PXLXIMEGSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[4-[(2,4-dimethylphenyl)methyl]-1-piperazinyl]-1-(3-methylphenyl)methanimine
  • (E)-[4-(2,4-dimethylbenzyl)piperazin-1-yl]-(3-methylbenzylidene)amine
  • [4-(2,4-dimethylbenzyl)piperazin-1-yl]-(3-methylbenzylidene)amine
  • T0505-0418
  • ST5177382
  • Oprea1_309967

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.009 0.009
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0024 0.009 0.0152
Brugia malayi hypothetical protein 0.021 0.4237 0.756
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0197 0.0202
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0182 0.0186
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0197 0.0197
Brugia malayi hypothetical protein 0.0024 0.009 0.016
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.5904 1
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0024 0.009 0.0152
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.1008 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.1008 0.1799
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0542 0.0556
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0315 0.0323
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0458 0.9748 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0024 0.009 0.0888
Schistosoma mansoni glutaminase 0.0272 0.5605 0.575
Brugia malayi glutaminase DH11.1 0.0272 0.5605 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.009 0.009
Echinococcus granulosus survival motor neuron protein 1 0.0239 0.4866 0.4866
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.5904 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.009 0.009
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0182 0.0186
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0542 0.0556
Loa Loa (eye worm) hypothetical protein 0.0029 0.0197 0.0202
Brugia malayi Bromodomain containing protein 0.0028 0.0182 0.0324
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0983 0.0983
Loa Loa (eye worm) hypothetical protein 0.0049 0.0635 0.0651
Trypanosoma brucei aminopeptidase, putative 0.0024 0.009 0.0911
Loa Loa (eye worm) hypothetical protein 0.0024 0.009 0.0092
Echinococcus multilocularis neuropeptide receptor A26 0.0469 1 1
Schistosoma mansoni hypothetical protein 0.0049 0.0632 0.0649
Entamoeba histolytica aminopeptidase, putative 0.0024 0.009 0.0152
Loa Loa (eye worm) hypothetical protein 0.0024 0.009 0.0092
Brugia malayi Peptidase family M1 containing protein 0.0024 0.009 0.016
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.2653 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.5904 1
Brugia malayi hypothetical protein 0.0024 0.009 0.016
Loa Loa (eye worm) aminopeptidase N 0.0024 0.009 0.0092
Loa Loa (eye worm) TATA binding protein associated factor 0.0024 0.009 0.0092
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.009 0.009
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0983 0.1009
Echinococcus multilocularis jumonji domain containing protein 0.004 0.043 0.043
Echinococcus granulosus jumonji domain containing protein 0.004 0.043 0.043
Loa Loa (eye worm) hypothetical protein 0.0024 0.009 0.0092
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0983 1
Brugia malayi Peptidase family M1 containing protein 0.0024 0.009 0.016
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0024 0.009 0.0911
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0024 0.009 0.009
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0024 0.009 0.0911
Brugia malayi hypothetical protein 0.0239 0.4866 0.8681
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0182 0.1802
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0458 0.9748 0.9748
Schistosoma mansoni hypothetical protein 0.0169 0.3303 0.3388
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0285 0.5904 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.5904 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.1624 0.1624
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0024 0.009 0.009
Brugia malayi Pre-SET motif family protein 0.0203 0.4074 0.7268
Echinococcus granulosus aminopeptidase N 0.0024 0.009 0.009
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0542 0.0542
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0024 0.009 0.009
Trypanosoma brucei Aminopeptidase M1, putative 0.0024 0.009 0.0911
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0024 0.009 0.0911
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0983 0.1009
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0542 0.0542
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0983 0.9752
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0182 0.1802
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0024 0.009 0.4931
Echinococcus granulosus peregrin 0.0028 0.0182 0.0182
Mycobacterium ulcerans aminopeptidase N PepN 0.0024 0.009 0.016
Plasmodium falciparum phd finger protein, putative 0.0028 0.0182 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.4074 0.4179
Loa Loa (eye worm) peptidase family M1 containing protein 0.0024 0.009 0.0092
Onchocerca volvulus 0.0049 0.0632 0.1178
Brugia malayi jmjC domain containing protein 0.0034 0.0315 0.0562
Loa Loa (eye worm) hypothetical protein 0.0239 0.4866 0.4991
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0197 0.0197
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0 0.5
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0024 0.009 0.0911
Echinococcus granulosus neuropeptide receptor A26 0.0469 1 1
Onchocerca volvulus Alhambra homolog 0.0028 0.0182 0.02
Schistosoma mansoni hypothetical protein 0.0169 0.3303 0.3388
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0285 0.5904 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0182 0.0182
Trypanosoma cruzi aminopeptidase, putative 0.0024 0.009 0.0911
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.1008 0.1034
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0182 0.9229
Schistosoma mansoni hypothetical protein 0.0028 0.0182 0.0186
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0024 0.009 0.0888
Onchocerca volvulus 0.0231 0.4699 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0024 0.009 0.009
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.009 0.009
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.2653 0.4732
Giardia lamblia PHD finger protein 15 0.0028 0.0182 0.0308
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0182 0.0182
Trichomonas vaginalis glutaminase, putative 0.0272 0.5605 0.9494
Giardia lamblia Fructose-bisphosphate aldolase 0.0285 0.5904 1
Brugia malayi Peptidase family M1 containing protein 0.0024 0.009 0.016
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0542 0.0556
Onchocerca volvulus 0.0029 0.0197 0.0233
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0024 0.009 0.0888
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.1008 0.1034
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0857 0.0879
Brugia malayi TATA binding protein associated factor 0.0024 0.009 0.016
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0024 0.009 0.009
Plasmodium vivax SET domain protein, putative 0.0029 0.0197 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.5904 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0983 1
Echinococcus multilocularis neuropeptide s receptor 0.0469 1 1
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0024 0.009 0.4551
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.0315 0.0315
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.1008 1
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0024 0.009 0.4551
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.1008 0.3801
Loa Loa (eye worm) glutaminase 2 0.0272 0.5605 0.575
Echinococcus granulosus leukotriene A 4 hydrolase 0.0458 0.9748 0.9748
Schistosoma mansoni survival motor neuron protein 0.0049 0.0632 0.0649
Echinococcus multilocularis geminin 0.0169 0.3303 0.3303
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0983 0.1665
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0542 0.0542
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.5904 1
Echinococcus multilocularis peregrin 0.0028 0.0182 0.0182
Loa Loa (eye worm) glutaminase 0.0272 0.5605 0.575
Trypanosoma cruzi aminopeptidase, putative 0.0024 0.009 0.0911
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0379 0.0379
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0024 0.009 0.0092
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.5904 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0024 0.009 0.0888
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0024 0.009 0.0092
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.1008 0.1799
Brugia malayi PHD-finger family protein 0.0028 0.0182 0.0324
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.1008 0.1008
Mycobacterium ulcerans aminopeptidase N PepN 0.0024 0.009 0.016
Mycobacterium ulcerans glutaminase 0.0272 0.5605 1
Echinococcus multilocularis survival motor neuron protein 1 0.0239 0.4866 0.4866
Echinococcus multilocularis aminopeptidase N 0.0024 0.009 0.009
Trypanosoma cruzi Aminopeptidase M1, putative 0.0024 0.009 0.0911
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0024 0.009 0.0092
Schistosoma mansoni aminopeptidase A (M01 family) 0.0024 0.009 0.0092
Trichomonas vaginalis set domain proteins, putative 0.0231 0.4699 0.7959
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0197 0.0197
Treponema pallidum fructose-bisphosphate aldolase 0.0285 0.5904 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.1008 0.1799
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0315 0.0315
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.5904 1
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0458 0.9748 1
Schistosoma mansoni jumonji domain containing protein 0.0074 0.1197 0.1228
Brugia malayi jmjC domain containing protein 0.0093 0.1624 0.2898
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0632 0.1128
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0197 0.0202
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0379 0.0379
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0542 0.0556
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.1624 0.1624
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0983 0.1754
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0197 0.1952
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0315 0.0323
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0197 0.0202
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.009 0.009
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0983 1
Toxoplasma gondii aminopeptidase N protein 0.0024 0.009 0.0888
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.1008 0.1008
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0542 0.0968
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0024 0.009 0.4931
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0024 0.009 0.0911
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.2653 0.5
Echinococcus granulosus geminin 0.0169 0.3303 0.3303
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0197 0.0202
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0173 0.0173
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0024 0.009 0.0152
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0315 0.0323
Toxoplasma gondii aminopeptidase n, putative 0.0024 0.009 0.0888
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0983 0.0983
Loa Loa (eye worm) hypothetical protein 0.0028 0.0182 0.0186
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0024 0.009 0.0911
Toxoplasma gondii aminopeptidase N, putative 0.0024 0.009 0.0888
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0542 0.0542
Brugia malayi Pre-SET motif family protein 0.0029 0.0197 0.0351
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0024 0.009 0.009
Trypanosoma brucei Aminopeptidase M1, putative 0.0024 0.009 0.0911

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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