Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0131 | 0.0645 | 0.48 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0622 | 0.3788 | 1 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.1593 | 1 | 1 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative | 0.0248 | 0.1393 | 0.1393 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.1343 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0039 | 0.006 | 0.006 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0622 | 0.3788 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0622 | 0.3788 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0622 | 0.3788 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0622 | 0.3788 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0622 | 0.3788 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0622 | 0.3788 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0039 | 0.006 | 0.006 |
Echinococcus multilocularis | cAMP and cAMP inhibited cGMP 3',5' cyclic | 0.0248 | 0.1393 | 0.3677 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0622 | 0.3788 | 0.3788 |
Trypanosoma brucei | cytochrome P450, putative | 0.0039 | 0.006 | 0.006 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0039 | 0.006 | 0.0447 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0039 | 0.006 | 0.006 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0622 | 0.3788 | 0.5 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.1593 | 1 | 1 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0622 | 0.3788 | 0.5 |
Leishmania major | dihydroorotate dehydrogenase | 0.1593 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0622 | 0.3788 | 0.3788 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.1593 | 1 | 0.5 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0622 | 0.3788 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.022 | 0.1214 | 0.9041 |
Brugia malayi | Cytochrome P450 family protein | 0.0131 | 0.0645 | 0.0645 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0039 | 0.006 | 0.0447 |
Brugia malayi | Cytochrome P450 family protein | 0.0039 | 0.006 | 0.006 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.1593 | 1 | 1 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.1593 | 1 | 0.5 |
Echinococcus granulosus | cAMP and cAMP inhibited cGMP 3'5' cyclic | 0.0248 | 0.1393 | 0.3677 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.1593 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0039 | 0.006 | 0.0447 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0039 | 0.006 | 0.006 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0622 | 0.3788 | 0.5 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.1593 | 1 | 1 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.1593 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.1593 | 1 | 1 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.1593 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0039 | 0.006 | 0.006 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.1593 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.1593 | 1 | 0.5 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.1593 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | The compound was tested ex vivo at a dose of 0.15 mmol/kg for collagen induced platelet aggregation in guinea pig; ND=No data | ChEMBL. | 4067991 |
Activity (functional) | 0 | The compound was tested ex vivo at a dose of 0.15 mmol/kg for ADP induced platelet aggregation in guinea pig; ND=No data | ChEMBL. | 4067991 |
Activity (functional) | = 1 | The compound was tested ex vivo at a dose of 0.15 mmol/kg for collagen induced platelet aggregation in rat | ChEMBL. | 4067991 |
Activity (functional) | = 1 | The compound was tested ex vivo at a dose of 0.15 mmol/kg for ADP induced platelet aggregation in rat | ChEMBL. | 4067991 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.