TDR Targets

Basic information

Technical information

TDR Targets ID: 650867
Name: 5-(4-propoxyphenyl)-N-(pyridin-4-ylmethyliden eamino)-2H-pyrazole-3-carboxamide
MW: 349.386 | Formula: C19H19N5O2
H donors: 2 H acceptors: 3 LogP: 2.22 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCCOc1ccc(cc1)c1n[nH]c(c1)C(=O)N/N=C/c1ccncc1
InChi: 1S/C19H19N5O2/c1-2-11-26-16-5-3-15(4-6-16)17-12-18(23-22-17)19(25)24-21-13-14-7-9-20-10-8-14/h3-10,12-13H,2,11H2,1H3,(H,22,23)(H,24,25)/b21-13+
InChiKey: BMTLVPIYWYTCLY-FYJGNVAPSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-(4-propoxyphenyl)-N-(4-pyridylmethyleneamino)-2H-pyrazole-3-carboxamide
BAS 01859809
ST021417

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	glutathione reductase, putative	0.0039	0.0827	1
Mycobacterium tuberculosis	Probable reductase	0.0088	0.2247	0.8837
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0013	0.0102	0.5
Brugia malayi	RNA recognition motif domain containing protein	0.0128	0.338	0.5235
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0268	0.234
Giardia lamblia	DINP protein human, muc B family	0.0019	0.0268	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0268	0.234
Plasmodium falciparum	thioredoxin reductase	0.0039	0.0827	1
Echinococcus granulosus	thioredoxin glutathione reductase	0.0039	0.0841	0.0747
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0268	0.234
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0013	0.0102	0.0068
Schistosoma mansoni	hypothetical protein	0.0048	0.1092	0.1
Schistosoma mansoni	hypothetical protein	0.0359	1	1
Schistosoma mansoni	DNA polymerase eta	0.0019	0.0268	0.0167
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0013	0.0102	0.0068
Brugia malayi	TAR-binding protein	0.0128	0.338	0.5235
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0268	0.234
Plasmodium vivax	thioredoxin reductase, putative	0.0039	0.0827	1
Echinococcus multilocularis	dna polymerase eta	0.0019	0.0268	0.0167
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.0268	0.0167
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0268	0.234
Treponema pallidum	NADH oxidase	0.0013	0.0102	0.5
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0268	0.0415
Brugia malayi	glutathione reductase	0.0039	0.0827	0.128
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0268	0.0167
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0268	0.234
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0013	0.0102	0.5
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0013	0.0102	0.0158
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0098	0.2529	1
Trichomonas vaginalis	DNA polymerase eta, putative	0.0019	0.0268	1
Leishmania major	trypanothione reductase	0.0039	0.0827	1
Brugia malayi	hypothetical protein	0.0235	0.6456	1
Plasmodium falciparum	glutathione reductase	0.0039	0.0827	1
Brugia malayi	N-terminal motif family protein	0.0175	0.4723	0.7316
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0268	0.0415
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.1092	0.1692
Loa Loa (eye worm)	hypothetical protein	0.0175	0.4723	0.7199
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0268	0.2287
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0088	0.2247	0.8837
Brugia malayi	Thioredoxin reductase	0.0039	0.0827	0.128
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0019	0.0268	0.5
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0268	0.234
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0268	1
Echinococcus granulosus	tar DNA binding protein	0.0128	0.338	0.3311
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0088	0.2247	0.8837
Loa Loa (eye worm)	glutathione reductase	0.0039	0.0827	0.0903
Schistosoma mansoni	survival motor neuron protein	0.0048	0.1092	0.1
Loa Loa (eye worm)	TAR-binding protein	0.0128	0.338	0.5028
Loa Loa (eye worm)	hypothetical protein	0.0235	0.6456	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0268	0.234
Mycobacterium tuberculosis	Probable oxidoreductase	0.0098	0.2529	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0098	0.2529	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0019	0.0268	0.0683
Echinococcus granulosus	dna polymerase eta	0.0019	0.0268	0.0167
Trypanosoma cruzi	DNA polymerase eta, putative	0.0019	0.0268	0.2287
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0268	0.234
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0019	0.0268	1
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0088	0.2247	0.8837
Loa Loa (eye worm)	thioredoxin reductase	0.0039	0.0827	0.0903
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0268	0.2287
Echinococcus multilocularis	tar DNA binding protein	0.0128	0.338	0.3311
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0039	0.0841	0.0747
Schistosoma mansoni	tar DNA-binding protein	0.0128	0.338	0.3311
Loa Loa (eye worm)	RNA binding protein	0.0128	0.338	0.5028
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0268	0.234
Toxoplasma gondii	thioredoxin reductase	0.0039	0.0827	1
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0268	1
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0019	0.0268	0.2287
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0013	0.0102	0.0068
Leishmania major	DNA polymerase kappa, putative	0.0019	0.0268	0.2287
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0175	0.4723	1
Schistosoma mansoni	hypothetical protein	0.0359	1	1
Leishmania major	DNA polymerase eta, putative	0.0019	0.0268	0.2287
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0268	0.234
Schistosoma mansoni	tar DNA-binding protein	0.0128	0.338	0.3311
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0268	0.0167
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0098	0.2529	1
Echinococcus multilocularis	survival motor neuron protein 1	0.0235	0.6456	0.642
Trypanosoma brucei	DNA polymerase eta, putative	0.0019	0.0268	0.234
Schistosoma mansoni	tar DNA-binding protein	0.0128	0.338	0.3311
Brugia malayi	RNA binding protein	0.0128	0.338	0.5235
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0088	0.2247	0.8837
Echinococcus multilocularis	geminin	0.0359	1	1
Trypanosoma brucei	unspecified product	0.0019	0.0268	0.234
Schistosoma mansoni	tar DNA-binding protein	0.0128	0.338	0.3311
Trypanosoma brucei	trypanothione reductase	0.0039	0.0827	1
Echinococcus granulosus	survival motor neuron protein 1	0.0235	0.6456	0.642
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0268	0.234
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.0268	0.0167
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0019	0.0268	0.0683
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0268	0.0167
Trypanosoma cruzi	trypanothione reductase, putative	0.0039	0.0827	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0268	0.2287
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0268	0.0167
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0039	0.0827	0.2985
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0013	0.0102	0.0068
Schistosoma mansoni	tar DNA-binding protein	0.0128	0.338	0.3311
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0013	0.0102	0.5
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0128	0.338	0.5028
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0268	0.2287
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0268	0.234
Mycobacterium tuberculosis	Probable dehydrogenase	0.0088	0.2247	0.8837

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 650867