Detailed information for compound 651087

Basic information

Technical information
  • TDR Targets ID: 651087
  • Name: (6Z)-5-imino-6-[[3-methoxy-4-[2-(2-methoxyphe noxy)ethoxy]phenyl]methylidene]-2-propyl-[1,3 ,4]thiadiazolo[3,2-a]pyrimidin-7-one
  • MW: 494.563 | Formula: C25H26N4O5S
  • H donors: 0 H acceptors: 1 LogP: 4.66 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCc1nn2c(=NC(=O)C(=Cc3ccc(c(c3)OC)OCCOc3ccccc3OC)C2=N)s1
  • InChi: 1S/C25H26N4O5S/c1-4-7-22-28-29-23(26)17(24(30)27-25(29)35-22)14-16-10-11-20(21(15-16)32-3)34-13-12-33-19-9-6-5-8-18(19)31-2/h5-6,8-11,14-15,26H,4,7,12-13H2,1-3H3/b17-14-,26-23?
  • InChiKey: YAHMXNZRBXBMAO-PLPOMQQBSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-imino-6-[[3-methoxy-4-[2-(2-methoxyphenoxy)ethoxy]phenyl]methylidene]-2-propyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one
  • (6Z)-5-imino-6-[[3-methoxy-4-[2-(2-methoxyphenoxy)ethoxy]phenyl]methylene]-2-propyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one
  • 5-imino-6-[[3-methoxy-4-[2-(2-methoxyphenoxy)ethoxy]phenyl]methylene]-2-propyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one
  • 5-imino-6-[3-methoxy-4-[2-(2-methoxyphenoxy)ethoxy]benzylidene]-2-propyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one
  • (6Z)-5-imino-6-[3-methoxy-4-[2-(2-methoxyphenoxy)ethoxy]benzylidene]-2-propyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one
  • STK066348
  • AO-299/15048361

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0049 0.0151
Echinococcus multilocularis excitatory amino acid transporter 2 0.1274 0.367 0.367
Echinococcus granulosus L aminoadipate semialdehyde 0.0085 0.0186 0.0186
Leishmania major glycosyl hydrolase-like protein 0.0055 0.01 0.1165
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0086 0.019 0.019
Echinococcus multilocularis L aminoadipate semialdehyde 0.0085 0.0186 0.0186
Trypanosoma brucei glucosidase, putative 0.0148 0.0373 0.4612
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0019 0.0051
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0096 0.022 0.0599
Loa Loa (eye worm) hypothetical protein 0.007 0.0143 0.0391
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0035 0.0035
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0019 0.0009
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0055 0.0478
Echinococcus granulosus neuropeptide receptor A26 0.0974 0.2791 0.2791
Chlamydia trachomatis neutral amino acid transporter 0.0565 0.1592 0.4326
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0056 0.0186
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0443 0.2128
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0056 0.0607
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0019 0.0534
Loa Loa (eye worm) hypothetical protein 0.0055 0.01 0.0272
Echinococcus granulosus CREB binding protein 0.0096 0.022 0.022
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.047 0.2264
Echinococcus granulosus sodium:dicarboxylate symporter 0.1274 0.367 0.367
Schistosoma mansoni kinase 0.0049 0.0081 0.0081
Onchocerca volvulus 0.0028 0.0019 0.0051
Loa Loa (eye worm) hypothetical protein 0.004 0.0056 0.0152
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 0.0799 1
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0565 0.1592 0.1592
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0019 0.0031
Loa Loa (eye worm) hypothetical protein 0.004 0.0056 0.0152
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0055 0.0055
Echinococcus granulosus Excitatory amino acid transporter 0.1274 0.367 0.367
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0055 0.0055
Trichomonas vaginalis alpha-glucosidase, putative 0.0148 0.0373 0.1774
Brugia malayi CXXC zinc finger family protein 0.0031 0.0029 0.008
Loa Loa (eye worm) hypothetical protein 0.0094 0.0213 0.058
Brugia malayi MH1 domain containing protein 0.0033 0.0035 0.0094
Echinococcus multilocularis Excitatory amino acid transporter 0.1274 0.367 0.367
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0028 0.0019 0.0009
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0028 0.0019 0.0031
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0019 0.0138
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0056 0.0658
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0035 0.0094
Brugia malayi Glycosyl hydrolases family 31 protein 0.0668 0.1895 0.5164
Schistosoma mansoni smad1 5 8 and 0.0033 0.0035 0.0035
Schistosoma mansoni Smad4 0.0033 0.0035 0.0035
Mycobacterium tuberculosis Conserved protein 0.004 0.0056 0.0132
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0056 0.0152
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0028 0.0019 0.03
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0443 0.2128
Echinococcus multilocularis Excitatory amino acid transporter 0.1274 0.367 0.367
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0018 0.0528
Echinococcus multilocularis sodium:dicarboxylate symporter 0.1274 0.367 0.367
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0076 0.0206
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0017 0.0112
Schistosoma mansoni smad 0.0033 0.0035 0.0035
Loa Loa (eye worm) excitatory amino acid transporter 0.1274 0.367 1
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.022 0.022
Echinococcus granulosus neuropeptide s receptor 0.0974 0.2791 0.2791
Leishmania major hypothetical protein, conserved 0.004 0.0056 0.0607
Brugia malayi beta-lactamase family protein 0.004 0.0056 0.0152
Onchocerca volvulus 0.0028 0.0019 0.0051
Mycobacterium ulcerans hypothetical protein 0.0094 0.0213 0.281
Loa Loa (eye worm) hypothetical protein 0.0028 0.0019 0.0051
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0076 0.0076
Mycobacterium tuberculosis Conserved protein 0.004 0.0056 0.0132
Loa Loa (eye worm) hypothetical protein 0.004 0.0057 0.0154
Mycobacterium tuberculosis Conserved protein 0.004 0.0056 0.0132
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.0708 0.3455
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0028 0.0019 0.015
Loa Loa (eye worm) hypothetical protein 0.0025 0.0013 0.0034
Echinococcus multilocularis neutral amino acid transporter A 0.1274 0.367 0.367
Loa Loa (eye worm) Smad1 0.0033 0.0035 0.0094
Trypanosoma brucei transcription factor BTF3, putative 0.0038 0.0049 0.052
Echinococcus multilocularis musashi 0.0055 0.0098 0.0098
Loa Loa (eye worm) oxidoreductase 0.0028 0.0019 0.0051
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0056 0.0056
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0028 0.0019 0.015
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0055 0.0055
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0052 0.0559
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.022 0.1007
Brugia malayi MH1 domain containing protein 0.0033 0.0035 0.0094
Loa Loa (eye worm) hypothetical protein 0.0101 0.0235 0.0641
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0201 0.0201
Onchocerca volvulus Excitatory amino acid transporter homolog 0.1274 0.367 1
Leishmania major DNA polymerase kappa, putative 0.0039 0.0052 0.0559
Leishmania major 4-coumarate:coa ligase-like protein 0.0094 0.0213 0.2592
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0148 0.0373 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0035 0.0035
Plasmodium vivax acyl-CoA synthetase, putative 0.007 0.0143 0.7001
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 0.0799 1
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0055 0.01 0.0272
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0096 0.022 0.022
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0055 0.0478
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0055 0.01 0.0407
Echinococcus multilocularis neuropeptide s receptor 0.0974 0.2791 0.2791
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0056 0.0658
Loa Loa (eye worm) hypothetical protein 0.0054 0.0096 0.026
Echinococcus granulosus neutral amino acid transporter A 0.1274 0.367 0.367
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0263 0.0708 0.1928
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0028 0.0019 0.0807
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0035 0.0035
Brugia malayi MH2 domain containing protein 0.0033 0.0035 0.0094
Loa Loa (eye worm) hypothetical protein 0.007 0.0143 0.0391
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.0052 0.0167
Loa Loa (eye worm) hypothetical protein 0.007 0.0143 0.0391
Echinococcus granulosus Excitatory amino acid transporter 0.1274 0.367 0.367
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0035 0.0035
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0073 0.0073
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.0391 0.1048
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0085 0.0186 0.0507
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0028 0.0019 0.0019
Echinococcus multilocularis neutral amino acid transporter A 0.1274 0.367 0.367
Echinococcus multilocularis lipoxygenase domain containing protein 0.004 0.0057 0.0057
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0141 0.0141
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0056 0.0056
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0056 0.0484
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0056 0.0186
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0052 0.0559
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0028 0.0019 0.0019
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0055 0.0601
Mycobacterium ulcerans hypothetical protein 0.0155 0.0391 0.5259
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0028 0.0019 0.015
Schistosoma mansoni cpg binding protein 0.0033 0.0034 0.0034
Trichomonas vaginalis sucrase-isomaltase, putative 0.0148 0.0373 0.1774
Loa Loa (eye worm) hypothetical protein 0.0025 0.0013 0.0034
Trichomonas vaginalis maltase-glucoamylase, putative 0.0148 0.0373 0.1774
Trypanosoma brucei unspecified product 0.0027 0.0017 0.0112
Entamoeba histolytica acyl-coA synthetase, putative 0.0094 0.0213 0.5619
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.1274 0.367 1
Echinococcus granulosus GPCR family 2 0.0047 0.0076 0.0076
Loa Loa (eye worm) glutaminase 2 0.0273 0.0737 0.2008
Echinococcus multilocularis lysosomal alpha glucosidase 0.0668 0.1895 0.1895
Onchocerca volvulus 0.004 0.0057 0.0154
Echinococcus multilocularis excitatory amino acid transporter 3 0.1274 0.367 0.367
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.0708 0.3455
Loa Loa (eye worm) MH2 domain-containing protein 0.0483 0.1353 0.3686
Onchocerca volvulus 0.0386 0.107 0.2916
Leishmania major 4-coumarate:coa ligase-like protein 0.0094 0.0213 0.2592
Echinococcus multilocularis cpg binding protein 0.0033 0.0034 0.0034
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0119 0.1526
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0055 0.0151
Brugia malayi hypothetical protein 0.004 0.0057 0.0154
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0028 0.0019 0.03
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.007 0.0143 0.037
Brugia malayi MH2 domain containing protein 0.0033 0.0035 0.0094
Echinococcus granulosus geminin 0.0173 0.0447 0.0447
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0076 0.0076
Schistosoma mansoni DNA polymerase eta 0.0065 0.0128 0.0128
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0055 0.0601
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0028 0.0019 0.0534
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0055 0.01 0.0407
Toxoplasma gondii ABC1 family protein 0.004 0.0056 0.1317
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0052 0.0121
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0076 0.0206
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0066 0.0132 0.034
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0565 0.1592 0.1592
Trichomonas vaginalis maltase-glucoamylase, putative 0.0055 0.01 0.0407
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0017 0.0112
Mycobacterium ulcerans beta-lactamase 0.004 0.0056 0.0658
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.022 0.2583
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0086 0.0865
Schistosoma mansoni smad1 5 8 and 0.0033 0.0035 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0052 0.0559
Echinococcus multilocularis microtubule associated protein 2 0.3434 1 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.0052 0.0142
Loa Loa (eye worm) ICD-1 protein 0.0038 0.0049 0.0134
Entamoeba histolytica acyl-CoA synthetase, putative 0.0094 0.0213 0.5619
Schistosoma mansoni lamin 0.0055 0.0098 0.0098
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0017 0.0112
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0019 0.015
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0052 0.0436
Echinococcus multilocularis Smad4 0.0033 0.0035 0.0035
Echinococcus multilocularis lipoxygenase domain containing protein 0.004 0.0057 0.0057
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0056 0.0484
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0028 0.0019 0.0031
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.022 0.2583
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0019 0.0138
Schistosoma mansoni hypothetical protein 0.0047 0.0076 0.0076
Brugia malayi Glycosyl hydrolases family 31 protein 0.0148 0.0373 0.1015
Leishmania major DNA polymerase eta, putative 0.0065 0.0128 0.1519
Trichomonas vaginalis alpha-glucosidase, putative 0.0055 0.01 0.0407
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0073 0.0073
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0029 0.008
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0028 0.0019 0.0031
Onchocerca volvulus 0.0028 0.0019 0.0051
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0028 0.0019 0.03
Echinococcus multilocularis tumor protein p63 0.0681 0.1932 0.1932
Loa Loa (eye worm) hypothetical protein 0.004 0.0056 0.0152
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0094 0.0213 1
Brugia malayi beta-NAC-like protein 0.0038 0.0049 0.0134
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0066 0.0132 0.034
Echinococcus granulosus cpg binding protein 0.0033 0.0034 0.0034
Onchocerca volvulus 0.004 0.0056 0.0152
Echinococcus multilocularis GPCR, family 2 0.0047 0.0076 0.0076
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0035 0.0035
Leishmania major acetyl-CoA synthetase, putative 0.0028 0.0019 0.0138
Brugia malayi AMP-binding enzyme family protein 0.0094 0.0213 0.058
Trichomonas vaginalis esterase, putative 0.004 0.0056 0.0186
Echinococcus granulosus histone lysine methyltransferase setb 0.009 0.0201 0.0201
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0094 0.0213 1
Toxoplasma gondii propionate-CoA ligase 0.0028 0.0019 0.03
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0148 0.0373 0.1774
Echinococcus multilocularis dna polymerase eta 0.0065 0.0128 0.0128
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0052 0.0559
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0668 0.1895 0.5164
Brugia malayi AMP-binding enzyme family protein 0.0094 0.0213 0.058
Echinococcus granulosus smad 0.0033 0.0035 0.0035
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0098 0.0268
Loa Loa (eye worm) hypothetical protein 0.004 0.0056 0.0152
Echinococcus granulosus Polycystic kidney disease protein 0.004 0.0057 0.0057
Schistosoma mansoni loxhd1 0.004 0.0057 0.0057
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0019 0.015
Brugia malayi Smad1 0.0033 0.0035 0.0094
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.0019 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0052 0.0559
Brugia malayi glutaminase DH11.1 0.0273 0.0737 0.2008
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0119 0.0119
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.0708 0.3455
Brugia malayi Pre-SET motif family protein 0.0622 0.1761 0.4799
Onchocerca volvulus 0.0708 0.2013 0.5484
Loa Loa (eye worm) hypothetical protein 0.0055 0.0098 0.0268
Echinococcus multilocularis neutral amino acid transporter A 0.1274 0.367 0.367
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0055 0.0184
Mycobacterium ulcerans lipase LipD 0.004 0.0056 0.0658
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0028 0.0019 0.0031
Schistosoma mansoni cellular tumor antigen P53 0.01 0.023 0.023
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0019 0.015
Brugia malayi Glycosyl hydrolases family 31 protein 0.0055 0.01 0.0272
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0055 0.0055
Treponema pallidum glutamate transporter 0.0565 0.1592 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.0052 0.1213
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0059 0.0526
Loa Loa (eye worm) transcription factor SMAD2 0.0483 0.1353 0.3686
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.022 0.1007
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0055 0.0055
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.0052 0.0167
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0028 0.0019 0.0051
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0049 0.0396
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0055 0.01 0.2525
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0052 0.0559
Trichomonas vaginalis set domain proteins, putative 0.0708 0.2013 1
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.022 0.1007
Schistosoma mansoni hypothetical protein 0.0173 0.0447 0.0447
Onchocerca volvulus 0.0028 0.0019 0.0051
Echinococcus multilocularis dnaJ subfamily B 0.0442 0.1235 0.1235
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0119 0.1526
Plasmodium vivax SET domain protein, putative 0.009 0.0201 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0148 0.0373 0.1774
Loa Loa (eye worm) hypothetical protein 0.0085 0.0186 0.0507
Entamoeba histolytica hypothetical protein 0.0038 0.0049 0.1129
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0565 0.1592 0.1592
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0028 0.0019 0.0138
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0052 0.0606
Entamoeba histolytica acyl-CoA synthetase, putative 0.0094 0.0213 0.5619
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.009 0.0201 0.5308
Echinococcus granulosus lamin 0.0055 0.0098 0.0098
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.0708 0.3455
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0056 0.0056
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0066 0.0132 0.034
Loa Loa (eye worm) hypothetical protein 0.009 0.0201 0.0549
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0019 0.015
Brugia malayi Pre-SET motif family protein 0.009 0.0201 0.0549
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.004 0.0055 0.0151
Brugia malayi serine/threonine-protein kinase plk-2 0.0096 0.022 0.0599
Echinococcus granulosus excitatory amino acid transporter 2 0.1274 0.367 0.367
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0076 0.0076
Schistosoma mansoni hypothetical protein 0.004 0.0057 0.0057
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0345 0.4268
Loa Loa (eye worm) hypothetical protein 0.01 0.023 0.0627
Schistosoma mansoni rab6-interacting 0.004 0.0057 0.0057
Schistosoma mansoni hypothetical protein 0.0442 0.1235 0.1235
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0056 0.0186
Trypanosoma cruzi hypothetical protein, conserved 0.0148 0.0373 0.4541
Echinococcus granulosus dna polymerase kappa 0.0039 0.0052 0.0052
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0098 0.0268
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.022 0.1007
Echinococcus multilocularis RUN 0.004 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.007 0.0143 0.0391
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0018 0.0754
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0056 0.0132
Mycobacterium ulcerans acyl-CoA synthetase 0.0094 0.0213 0.281
Mycobacterium leprae Probable lipase LipE 0.004 0.0056 0.2343
Schistosoma mansoni hypothetical protein 0.0101 0.0235 0.0235
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0094 0.0213 0.281
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0028 0.0019 0.0031
Loa Loa (eye worm) hypothetical protein 0.004 0.0057 0.0154
Onchocerca volvulus 0.004 0.0057 0.0154
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0019 0.0051
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0119 0.3051
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0096 0.022 0.2679
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0565 0.1592 0.1592
Schistosoma mansoni polycystin 1-related 0.004 0.0057 0.0057
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0263 0.0708 0.1928
Brugia malayi beta-lactamase family protein 0.004 0.0056 0.0152
Treponema pallidum glutamate/aspartate transporter 0.0565 0.1592 1
Leishmania major mitochondrial DNA polymerase beta 0.0294 0.0799 1
Echinococcus multilocularis lamin dm0 0.0055 0.0098 0.0098
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0055 0.01 0.1049
Echinococcus multilocularis Polycystic kidney disease protein 0.004 0.0057 0.0057
Chlamydia trachomatis glutamate symporter 0.1274 0.367 1
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0049 0.0151
Schistosoma mansoni cpg binding protein 0.0033 0.0034 0.0034
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0052 0.0559
Leishmania major alpha glucosidase II subunit, putative 0.0148 0.0373 0.4612
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0076 0.0076
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.009 0.0201 0.0201
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0019 0.0051
Onchocerca volvulus 0.0031 0.0029 0.008
Toxoplasma gondii hypothetical protein 0.0047 0.0077 0.1895
Loa Loa (eye worm) hypothetical protein 0.0094 0.0213 0.058
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0119 0.0119
Echinococcus granulosus neutral alpha glucosidase AB 0.0148 0.0373 0.0373
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0028 0.0019 0.015
Loa Loa (eye worm) hypothetical protein 0.0026 0.0016 0.0042
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0019 0.0051
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0028 0.0019 0.015
Echinococcus multilocularis dna polymerase kappa 0.0039 0.0052 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0049 0.0151
Mycobacterium ulcerans fatty-acid-CoA ligase 0.007 0.0143 0.1858
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0119 0.0119
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0056 0.0152
Plasmodium vivax basic transcription factor 3b, putative 0.0038 0.0049 0.2126
Echinococcus granulosus neutral amino acid transporter 0.1274 0.367 0.367
Loa Loa (eye worm) hypothetical protein 0.004 0.0056 0.0152
Leishmania major basic transcription factor 3a, putative 0.0038 0.0049 0.052
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0073 0.0198
Plasmodium vivax hypothetical protein, conserved 0.004 0.0056 0.2481
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0052 0.0559
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0019 0.0009
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0056 0.0132
Onchocerca volvulus 0.0055 0.0098 0.0268
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0024 0.0066
Entamoeba histolytica transcription factor BTF3, putative 0.0038 0.0049 0.1129
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0094 0.0213 0.056
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0119 0.0304
Echinococcus multilocularis neuropeptide receptor A26 0.0974 0.2791 0.2791
Plasmodium falciparum LCCL domain-containing protein 0.004 0.0057 0.3587
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0257 0.069 0.1863
Echinococcus granulosus dnaJ subfamily B 0.0442 0.1235 0.1235
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0035 0.0094
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0055 0.1304
Trichomonas vaginalis alpha-glucosidase, putative 0.0055 0.01 0.0407
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0066 0.0132 0.034
Loa Loa (eye worm) hypothetical protein 0.007 0.0143 0.0391
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0028 0.0019 0.0009
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0056 0.0132
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0055 0.01 0.1049
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0148 0.0373 1
Loa Loa (eye worm) CBP-B 0.0096 0.022 0.06
Schistosoma mansoni microtubule-associated protein tau 0.3434 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0052 0.0559
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0443 0.2128
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0443 0.2128
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.0708 0.3455
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0052 0.0559
Schistosoma mansoni glutaminase 0.0273 0.0737 0.0737
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0028 0.0019 0.015
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0443 0.2128
Brugia malayi Doublecortin family protein 0.004 0.0057 0.0154
Trypanosoma cruzi hypothetical protein, conserved 0.0148 0.0373 0.4541
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0018 0.028
Echinococcus granulosus lamin dm0 0.0055 0.0098 0.0098
Onchocerca volvulus 0.004 0.0056 0.0152
Loa Loa (eye worm) hypothetical protein 0.004 0.0056 0.0152
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0052 0.0142
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.0055 0.0198
Echinococcus multilocularis transcription factor btf3 0.0038 0.0049 0.0049
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0019 0.015
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.007 0.0143 0.0371
Echinococcus granulosus excitatory amino acid transporter 2 0.1274 0.367 0.367
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0055 0.0055
Leishmania major hypothetical protein, conserved 0.0027 0.0018 0.0129
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.022 0.1007
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0059 0.0526
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0052 0.0436
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0052 0.0436
Trichomonas vaginalis alpha-glucosidase, putative 0.0148 0.0373 0.1774
Loa Loa (eye worm) hypothetical protein 0.0148 0.0373 0.1015
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0059 0.0526
Schistosoma mansoni CREB-binding protein 2 0.0096 0.022 0.022
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0052 0.0436
Trichomonas vaginalis alpha-glucosidase, putative 0.0148 0.0373 0.1774
Leishmania major DNA polymerase eta, putative 0.0038 0.0049 0.0526
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0148 0.0373 0.1015
Echinococcus multilocularis neutral alpha glucosidase AB 0.0148 0.0373 0.0373
Schistosoma mansoni acetyl-CoA synthetase 0.0028 0.0019 0.0019
Echinococcus granulosus lipoxygenase domain containing protein 0.004 0.0057 0.0057
Trichomonas vaginalis alpha-glucosidase, putative 0.0148 0.0373 0.1774
Onchocerca volvulus 0.009 0.0201 0.0549
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0094 0.0213 0.281
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0073 0.0073
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0201 0.0201
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0056 0.0186
Plasmodium falciparum acyl-CoA synthetase 0.007 0.0143 1
Trypanosoma brucei DNA polymerase eta, putative 0.0065 0.0128 0.1519
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0113 0.0269 0.0269
Loa Loa (eye worm) doublecortin family protein 0.004 0.0057 0.0154
Schistosoma mansoni lipoxygenase 0.0113 0.0269 0.0269
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.0052 0.0052
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0028 0.0019 0.0051
Onchocerca volvulus Glucosylceramidase homolog 0.0172 0.0443 0.1207
Echinococcus multilocularis CREB binding protein 0.0096 0.022 0.022
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0076 0.0206
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0016 0.0016
Trichomonas vaginalis alpha-glucosidase, putative 0.0055 0.01 0.0407
Brugia malayi ImpB/MucB/SamB family protein 0.0065 0.0128 0.0349
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.1274 0.367 0.367
Schistosoma mansoni rab6-interacting 0.004 0.0057 0.0057
Schistosoma mansoni hypothetical protein 0.0047 0.0076 0.0076
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0028 0.0019 0.0031
Brugia malayi Excitatory amino acid transporter 0.1274 0.367 1
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0028 0.0019 0.0534
Leishmania major 4-coumarate:coa ligase-like protein 0.0094 0.0213 0.2592
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.009 0.0201 0.0201
Echinococcus granulosus lysosomal alpha glucosidase 0.0668 0.1895 0.1895
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0119 0.0119
Loa Loa (eye worm) glutaminase 0.0273 0.0737 0.2008
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0055 0.0184
Loa Loa (eye worm) hypothetical protein 0.0094 0.0213 0.058
Schistosoma mansoni lipoxygenase 0.004 0.0057 0.0057
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.012 0.3083
Brugia malayi AMP-binding enzyme family protein 0.0094 0.0213 0.058
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0056 0.0132
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.0019 0.0051
Echinococcus multilocularis excitatory amino acid transporter 2 0.1274 0.367 0.367
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0119 0.1526
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0056 0.0132
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0052 0.0121
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0148 0.0373 0.1015
Echinococcus multilocularis geminin 0.0173 0.0447 0.0447
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.0708 0.3455
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0055 0.0184
Echinococcus granulosus tumor protein p63 0.0681 0.1932 0.1932
Echinococcus granulosus intermediate filament protein 0.0055 0.0098 0.0098
Echinococcus granulosus transcription factor btf3 0.0038 0.0049 0.0049
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0073 0.0073
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0049 0.114
Leishmania major acetyl-CoA synthetase, putative 0.0028 0.0019 0.0138
Mycobacterium leprae conserved hypothetical protein 0.004 0.0056 0.2343
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0055 0.0055
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0019 0.015
Plasmodium falciparum basic transcription factor 3b, putative 0.0038 0.0049 0.3037
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.047 0.2264
Onchocerca volvulus 0.004 0.0056 0.0152
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.0345 0.4268
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0094 0.0213 0.281
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0113 0.0269 0.0269
Onchocerca volvulus Serine\/threonine kinase homolog 0.0096 0.022 0.0599
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.009 0.0201 0.0201
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0019 0.015
Loa Loa (eye worm) hypothetical protein 0.0047 0.0076 0.0206
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.1274 0.367 1
Loa Loa (eye worm) beta-lactamase 0.004 0.0056 0.0152
Trichomonas vaginalis alpha-glucosidase, putative 0.0055 0.01 0.0407
Echinococcus granulosus lipoxygenase domain containing protein 0.004 0.0057 0.0057
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0052 0.0559
Onchocerca volvulus 0.0094 0.0213 0.058
Trichomonas vaginalis alpha-glucosidase, putative 0.0055 0.01 0.0407
Schistosoma mansoni alpha-glucosidase 0.0575 0.1623 0.1623
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0148 0.0373 0.1015
Brugia malayi intermediate filament protein 0.0055 0.0098 0.0268
Schistosoma mansoni intermediate filament proteins 0.0055 0.0098 0.0098
Echinococcus granulosus Smad4 0.0033 0.0035 0.0035
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0019 0.0031
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0094 0.0213 0.281
Toxoplasma gondii NAC domain-containing protein 0.0038 0.0049 0.1129
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0018 0.0129
Onchocerca volvulus 0.0085 0.0186 0.0507
Brugia malayi hypothetical protein 0.004 0.0057 0.0154
Mycobacterium ulcerans acyl-CoA synthetase 0.0094 0.0213 0.281
Brugia malayi TAZ zinc finger family protein 0.0096 0.022 0.06
Entamoeba histolytica serine/threonine protein kinase, putative 0.0096 0.022 0.5809
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0052 0.0606
Trypanosoma brucei unspecified product 0.0027 0.0017 0.0112
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0056 0.0056
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0056 0.0186
Mycobacterium ulcerans glutaminase 0.0273 0.0737 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0018 0.0754
Echinococcus granulosus RUN 0.004 0.0057 0.0057
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0622 0.1761 0.4799
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0008 0.0001
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.022 0.1007
Plasmodium vivax acetyl-CoA synthetase, putative 0.0028 0.0019 0.0565
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0056 0.0132
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.1274 0.367 0.367
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0094 0.0213 0.056
Echinococcus granulosus neutral amino acid transporter A 0.1274 0.367 0.367
Brugia malayi Calcitonin receptor-like protein seb-1 0.0148 0.0373 0.1015
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0119 0.1407
Brugia malayi MH2 domain containing protein 0.0483 0.1353 0.3686
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0096 0.022 0.022
Echinococcus multilocularis smad 0.0033 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0065 0.0128 0.0349
Echinococcus granulosus dna polymerase eta 0.0065 0.0128 0.0128
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0028 0.0019 0.015
Trypanosoma brucei unspecified product 0.0039 0.0052 0.0559
Schistosoma mansoni lamin 0.0055 0.0098 0.0098
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0024 0.0066
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0028 0.0019 0.0031
Schistosoma mansoni hypothetical protein 0.0047 0.0076 0.0076
Brugia malayi beta-lactamase 0.004 0.0056 0.0152
Trichomonas vaginalis alpha-glucosidase, putative 0.0148 0.0373 0.1774
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.0235 0.0641
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.0052 0.0052
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0443 0.2128
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0443 0.2128
Schistosoma mansoni hypothetical protein 0.0173 0.0447 0.0447
Mycobacterium ulcerans acyl-CoA synthetase 0.0094 0.0213 0.281
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0085 0.0186 0.0186
Mycobacterium ulcerans acetyl-CoA synthetase 0.0028 0.0019 0.015
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0073 0.0198
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0078 0.0294
Onchocerca volvulus 0.0055 0.0098 0.0268
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0059 0.0649
Echinococcus multilocularis lamin 0.0055 0.0098 0.0098
Schistosoma mansoni alpha glucosidase 0.0148 0.0373 0.0373
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.022 0.1007
Plasmodium vivax multidomain scavenger receptor, putative 0.004 0.0057 0.2511
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0049 0.0396
Trypanosoma brucei polo-like protein kinase 0.0096 0.022 0.2679
Schistosoma mansoni smad1 5 8 and 0.0033 0.0035 0.0035
Mycobacterium ulcerans hypothetical protein 0.004 0.0056 0.0658
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0073 0.0073
Giardia lamblia Kinase, PLK 0.0096 0.022 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.0052 0.0052
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0345 0.4193
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0096 0.022 0.022
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0019 0.015
Schistosoma mansoni hypothetical protein 0.0047 0.0076 0.0076
Schistosoma mansoni cpg binding protein 0.0031 0.0029 0.0029
Echinococcus multilocularis lysosomal alpha glucosidase 0.0668 0.1895 0.1895
Trypanosoma brucei glycosyl hydrolase-like protein 0.0055 0.01 0.1165
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0049 0.0402
Schistosoma mansoni transcription factor btf3 0.0038 0.0049 0.0049
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0148 0.0373 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0098 0.0268
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0078 0.0294
Echinococcus granulosus CREB binding protein 0.0096 0.022 0.022
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0052 0.0559
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0201 0.0201
Trichomonas vaginalis glutaminase, putative 0.0273 0.0737 0.3601
Echinococcus granulosus excitatory amino acid transporter 3 0.1274 0.367 0.367
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0019 0.0031
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.0052 0.0052
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0294 0.0799 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0065 0.0128 0.1408
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0056 0.0132
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0052 0.0559
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0019 0.0051
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0027 0.0018 0.0049
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0019 0.015
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0019 0.0031
Schistosoma mansoni alpha-glucosidase 0.0575 0.1623 0.1623
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0052 0.0559
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0073 0.0073
Onchocerca volvulus 0.01 0.023 0.0627
Brugia malayi hypothetical protein 0.0027 0.0018 0.0049

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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