Detailed information for compound 651304

Basic information

Technical information
  • TDR Targets ID: 651304
  • Name: 2-(4-acetylphenyl)-4-nitroisoindole-1,3-dione
  • MW: 310.261 | Formula: C16H10N2O5
  • H donors: 0 H acceptors: 5 LogP: 1.97 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)c1ccc(cc1)N1C(=O)c2c(C1=O)cccc2[N+](=O)[O-]
  • InChi: 1S/C16H10N2O5/c1-9(19)10-5-7-11(8-6-10)17-15(20)12-3-2-4-13(18(22)23)14(12)16(17)21/h2-8H,1H3
  • InChiKey: KXPUVYNCPXMIGF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(4-acetylphenyl)-4-nitro-isoindoline-1,3-dione
  • 2-(4-acetylphenyl)-4-nitroisoindoline-1,3-dione
  • 2-(4-acetylphenyl)-4-nitro-isoindoline-1,3-quinone
  • 2-(4-ethanoylphenyl)-4-nitro-isoindole-1,3-dione
  • BAS 00135783
  • EU-0000963
  • ST5217896
  • ZINC00242737
  • 2-(4-Acetyl-phenyl)-4-nitro-isoindole-1,3-dione

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0084 0.1023 0.1023
Brugia malayi RNA recognition motif domain containing protein 0.0283 0.3665 0.3665
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0049 0.0049
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0049 0.0049
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0204 0.1223
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0204 0.0204
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0204 0.0204
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0204 0.0204
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0049 0.0049
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0204 0.0204
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0058 0.0677 0.0677
Loa Loa (eye worm) hypothetical protein 0.0012 0.0065 0.0065
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0049 0.0049
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0104 0.0104
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0022 0.0204 0.0204
Onchocerca volvulus 0.001 0.0049 0.0292
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.019 1
Brugia malayi hypothetical protein 0.0012 0.0065 0.0065
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0204 0.0204
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0204 0.0204
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0204 0.0204
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0204 0.0204
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0204 0.0204
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0055 0.2902
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.0065 0.0065
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0049 0.0049
Brugia malayi RNA binding protein 0.0283 0.3665 0.3665
Schistosoma mansoni nuclear receptor 0.001 0.0049 0.0049
Brugia malayi nuclear receptor NHR-67 0.001 0.0049 0.0049
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.019 0.5
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0271 0.265
Brugia malayi nuclear hormone receptor 0.0022 0.0204 0.0204
Schistosoma mansoni ap endonuclease 0.0021 0.019 0.019
Brugia malayi hypothetical protein 0.001 0.0049 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0204 0.0204
Loa Loa (eye worm) hypothetical protein 0.0014 0.0096 0.0096
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0204 0.0204
Brugia malayi Sodium:solute symporter family protein 0.0084 0.1023 0.1023
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0049 0.0049
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0204 0.0204
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0311 0.0311
Loa Loa (eye worm) hypothetical protein 0.0022 0.0204 0.0204
Echinococcus multilocularis lamin 0.003 0.0311 0.0311
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0049 0.0049
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0011 0.0055 0.0055
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0204 0.0204
Leishmania major hypothetical protein, conserved 0.0027 0.0271 1
Brugia malayi hypothetical protein 0.001 0.0049 0.0049
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0204 0.0204
Loa Loa (eye worm) hypothetical protein 0.0022 0.0204 0.0204
Echinococcus granulosus sodium:myo inositol cotransporter 0.0084 0.1023 0.1023
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0271 1
Schistosoma mansoni tankyrase 0.0077 0.0926 0.0926
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.019 0.5
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0204 0.0204
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.019 0.019
Brugia malayi WGR domain containing protein 0.0011 0.0055 0.0055
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0084 0.1023 0.1023
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0022 0.0204 0.0204
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0049 0.0292
Brugia malayi WGR domain containing protein 0.0011 0.0055 0.0055
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.019 0.019
Brugia malayi intermediate filament protein 0.003 0.0311 0.0311
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0049 0.0049
Echinococcus multilocularis microtubule associated protein 2 0.0745 0.9791 0.9791
Schistosoma mansoni sodium/solute symporter 0.0084 0.1023 0.1023
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0055 0.2902
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0204 0.0204
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.019 0.5
Onchocerca volvulus 0.0007 0.0000000097135 0.000000058362
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.0011 0.0055 0.0055
Brugia malayi steroid hormone receptor 0.0022 0.0204 0.0204
Loa Loa (eye worm) tnks protein 0.007 0.0836 0.0836
Echinococcus granulosus tar DNA binding protein 0.0283 0.3665 0.3665
Schistosoma mansoni lamin 0.003 0.0311 0.0311
Loa Loa (eye worm) hypothetical protein 0.0022 0.0204 0.0204
Schistosoma mansoni nuclear receptor 0.001 0.0049 0.0049
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0049 0.0292
Brugia malayi nuclear hormone receptor 0.001 0.0049 0.0049
Onchocerca volvulus 0.0084 0.1023 0.6147
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0055 0.2902
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0049 0.0049
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.019 0.624
Loa Loa (eye worm) hypothetical protein 0.0014 0.0096 0.0096
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0204 0.0204
Schistosoma mansoni tar DNA-binding protein 0.0283 0.3665 0.3665
Loa Loa (eye worm) RNA binding protein 0.0283 0.3665 0.3665
Echinococcus granulosus tankyrase 0.0076 0.0925 0.0925
Echinococcus granulosus Sterile alpha motif SAM 0.0007 0.0000000097135 0.0000000097135
Echinococcus multilocularis poly (ADP ribose) polymerase 0.0011 0.0055 0.0055
Echinococcus multilocularis high affinity choline transporter 1 0.076 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0055 0.0055
Onchocerca volvulus Huntingtin homolog 0.0132 0.1664 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0204 0.0204
Echinococcus multilocularis tar DNA binding protein 0.0283 0.3665 0.3665
Schistosoma mansoni nuclear hormone receptor 0.001 0.0049 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0204 0.0204
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0204 0.0204
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0049
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0204 0.0204
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0204 0.0204
Brugia malayi hypothetical protein 0.0132 0.1664 0.1664
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0204 0.1223
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0055 0.2902
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0204 0.0204
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0271 1
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.019 1
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0011 0.0055 0.0055
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.019 0.624
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.0011 0.0055 0.0055
Brugia malayi ecdysone receptor 0.001 0.0049 0.0049
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0049 0.0049
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.019 0.019
Loa Loa (eye worm) hypothetical protein 0.076 1 1
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0204 0.0204
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0204 0.0204
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.0065 0.0065
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0204 0.0204
Schistosoma mansoni microtubule-associated protein tau 0.0745 0.9791 0.9791
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0311 0.0311
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0084 0.1023 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.1664 0.1664
Brugia malayi nuclear receptor NHR-88 0.0022 0.0204 0.0204
Loa Loa (eye worm) hypothetical protein 0.003 0.0304 0.0304
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0204 0.0204
Loa Loa (eye worm) hypothetical protein 0.0022 0.0204 0.0204
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.019 0.5
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0049
Schistosoma mansoni coup transcription factor 0.0022 0.0204 0.0204
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0049
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.0049 0.0049
Echinococcus granulosus solute carrier family 5 0.0084 0.1023 0.1023
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0049
Brugia malayi hypothetical protein 0.0027 0.0271 0.0271
Echinococcus granulosus high affinity choline transporter 1 0.076 1 1
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0084 0.1023 0.1023
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.019 0.019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0204 0.0204
Brugia malayi nuclear receptor NHR-88 0.001 0.0049 0.0049
Echinococcus multilocularis solute carrier family 5 0.0084 0.1023 0.1023
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0204 0.0204
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0204 0.0204
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0049
Brugia malayi tailless protein 0.001 0.0049 0.0049
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.019 0.5
Brugia malayi ecdysteroid receptor 0.0022 0.0204 0.0204
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0065 0.0065
Loa Loa (eye worm) DR-78 0.001 0.0049 0.0049
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0049 0.0049
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0065 0.0065
Brugia malayi nuclear receptor RXR 0.0012 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0049
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0049 0.0049
Echinococcus granulosus sodium:glucose cotransporter 2 0.0084 0.1023 0.1023
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0204 0.0204
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0065 0.0065
Brugia malayi Nuclear hormone receptor E75 0.001 0.0049 0.0049
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0049 0.0049
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0204 0.0204
Loa Loa (eye worm) hypothetical protein 0.0084 0.1023 0.1023
Echinococcus granulosus microtubule associated protein 2 0.0745 0.9791 0.9791
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.0049 0.0049
Brugia malayi Nuclear hormone receptor E75 0.001 0.0049 0.0049
Schistosoma mansoni hypothetical protein 0.0012 0.0072 0.0072
Brugia malayi Tnks protein 0.0076 0.0912 0.0912
Toxoplasma gondii exonuclease III APE 0.0021 0.019 0.1856
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.0065 0.0065
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0049 0.0049
Echinococcus multilocularis lamin dm0 0.003 0.0311 0.0311
Echinococcus granulosus poly ADP ribose polymerase 1 0.0011 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0132 0.1664 0.1664
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0204 0.0204
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0204 0.0204
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0204 0.0204
Schistosoma mansoni inositol transporter 0.0084 0.1023 0.1023
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0055 0.2902
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0204 0.0204
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0204 0.0204
Loa Loa (eye worm) hypothetical protein 0.003 0.0311 0.0311
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0204 0.0204
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0204 0.0204
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0204 0.1223
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0204 0.0204
Echinococcus granulosus poly adp ribose polymerase 2 0.0011 0.0055 0.0055
Loa Loa (eye worm) TAR-binding protein 0.0283 0.3665 0.3665
Loa Loa (eye worm) hypothetical protein 0.0022 0.0204 0.0204
Schistosoma mansoni lamin 0.003 0.0311 0.0311
Loa Loa (eye worm) hypothetical protein 0.0015 0.0104 0.0104
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0049 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0204 0.0204
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0055 0.2902
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0049
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.019 0.7005
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0204 0.0204
Echinococcus multilocularis tankyrase 0.0076 0.0925 0.0925
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0012 0.0065 0.0065
Echinococcus granulosus sodium:glucose cotransporter 0.0084 0.1023 0.1023
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0271 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0065 0.0065
Schistosoma mansoni high-affinity choline transporter 0.076 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0204 0.0204
Loa Loa (eye worm) hypothetical protein 0.0022 0.0204 0.0204
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0049
Schistosoma mansoni inositol transporter 0.0084 0.1023 0.1023
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0012 0.0065 0.0065
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0072 0.0072
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0204 0.0204
Echinococcus granulosus lamin dm0 0.003 0.0311 0.0311
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.019 1
Loa Loa (eye worm) intermediate filament protein 0.003 0.0311 0.0311
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0049
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0049
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.0065 0.0065
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0011 0.0055 0.0539
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0204 0.0204
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0049 0.0049
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.019 0.624
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0204 0.0204
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0271 1
Schistosoma mansoni intermediate filament proteins 0.003 0.0311 0.0311
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0011 0.0055 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0055 0.2902
Onchocerca volvulus Huntingtin homolog 0.0132 0.1664 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.019 0.7005
Schistosoma mansoni tar DNA-binding protein 0.0283 0.3665 0.3665
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0204 0.0204
Echinococcus granulosus lamin 0.003 0.0311 0.0311
Echinococcus multilocularis musashi 0.003 0.0311 0.0311
Brugia malayi TAR-binding protein 0.0283 0.3665 0.3665
Onchocerca volvulus Tankyrase homolog 0.0069 0.0821 0.4933
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0084 0.1023 0.1023
Onchocerca volvulus 0.003 0.0311 0.187
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0049
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0125 0.0125
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0204 0.0204
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0204 0.0204
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0204 0.0204
Schistosoma mansoni tar DNA-binding protein 0.0283 0.3665 0.3665
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0204 0.0204
Loa Loa (eye worm) hypothetical protein 0.0027 0.0271 0.0271
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0204 0.0204
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0283 0.3665 0.3665
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0271 1
Schistosoma mansoni tar DNA-binding protein 0.0283 0.3665 0.3665
Onchocerca volvulus 0.001 0.0049 0.0292
Loa Loa (eye worm) hypothetical protein 0.0012 0.0065 0.0065
Schistosoma mansoni ap endonuclease 0.0021 0.019 0.019
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0204 0.0204
Brugia malayi hypothetical protein 0.0012 0.0065 0.0065
Brugia malayi conserved hypotetical protein 0.001 0.0049 0.0049
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0271 1
Schistosoma mansoni tar DNA-binding protein 0.0283 0.3665 0.3665
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0072 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0055 0.2902
Onchocerca volvulus 0.0022 0.0204 0.1223
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0055 0.2902
Brugia malayi nuclear receptor RXR 0.001 0.0049 0.0049
Schistosoma mansoni nuclear hormone receptor 0.001 0.0049 0.0049
Onchocerca volvulus 0.003 0.0311 0.187
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0204 0.0204
Schistosoma mansoni zinc finger protein 0.001 0.0049 0.0049
Echinococcus granulosus intermediate filament protein 0.003 0.0311 0.0311
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0049 0.0049
Brugia malayi hypothetical protein 0.0018 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0049

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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