TDR Targets

Basic information

Technical information

TDR Targets ID: 65140
Name: 1-[4,7-bis(7-chloroquinolin-4-yl)-1,4,7-triaz onan-1-yl]-4-phenylmethoxybutan-1-one
MW: 628.591 | Formula: C35H35Cl2N5O2
H donors: 0 H acceptors: 3 LogP: 6.56 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: Clc1ccc2c(c1)nccc2N1CCN(CCN(CC1)c1ccnc2c1ccc(c2)Cl)C(=O)CCCOCc1ccccc1
InChi: 1S/C35H35Cl2N5O2/c36-27-8-10-29-31(23-27)38-14-12-33(29)40-16-17-41(34-13-15-39-32-24-28(37)9-11-30(32)34)19-21-42(20-18-40)35(43)7-4-22-44-25-26-5-2-1-3-6-26/h1-3,5-6,8-15,23-24H,4,7,16-22,25H2
InChiKey: SFKBJBVNYNJFSK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-benzyloxy-1-[4,7-bis(7-chloro-4-quinolyl)-1,4,7-triazonan-1-yl]butan-1-one
4-benzyloxy-1-[4,7-bis(7-chloro-4-quinolyl)-1,4,7-triazonan-1-yl]-1-butanone
1-[4,7-bis(7-chloroquinolin-4-yl)-1,4,7-triazonan-1-yl]-4-phenylmethoxy-butan-1-one
4-benzoxy-1-[4,7-bis(7-chloro-4-quinolyl)-1,4,7-triazonan-1-yl]butan-1-one
1-[4,7-bis(7-chloroquinolin-4-yl)-1,4,7-triazonan-1-yl]-4-(phenylmethoxy)butan-1-one
1-[4,7-bis(7-chloro-4-quinolyl)-1,4,7-triazonan-1-yl]-4-(phenylmethoxy)butan-1-one
4-(benzyloxy)-1-[4,7-bis(7-chloro-4-quinolyl)-1,4,7-triazonan-1-yl]butan-1-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	heat shock protein, putative	0.00218079	0.00915172	0.313527
Brugia malayi	Cyclin, N-terminal domain containing protein	0.00423633	0.0272986	0.043659
Trypanosoma brucei	heat shock protein, putative	0.00285949	0.0151435	0.524646
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.00171757	0.00506235	0.169439
Trichomonas vaginalis	cyclin B, putative	0.00187211	0.00642668	0.217511
Leishmania major	heat shock protein 83-1	0.00285949	0.0151435	0.524646
Echinococcus multilocularis	nervana 2	0.0552867	0.477986	1
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.00423633	0.0272986	0.952927
Trypanosoma brucei	heat shock protein 90, putative	0.00285949	0.0151435	0.524646
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.00171757	0.00506235	0.010591
Brugia malayi	Cyclin, N-terminal domain containing protein	0.00187211	0.00642668	0.0099654
Trypanosoma cruzi	cdc2-related kinase 1	0.00438766	0.0286346	1
Leishmania major	heat shock protein 83-1	0.00285949	0.0151435	0.524646
Echinococcus granulosus	endoplasmin	0.00218079	0.00915172	0.018626
Echinococcus granulosus	sodium:potassium transporting ATPase subunit	0.0552867	0.477986	1
Trichomonas vaginalis	cyclins, putative	0.00423633	0.0272986	0.952927
Loa Loa (eye worm)	hypothetical protein	0.00423633	0.0272986	0.043659
Echinococcus multilocularis	cyclins	0.00187211	0.00642668	0.0129219
Mycobacterium ulcerans	proteasome PrcA	0.114417	1	1
Echinococcus multilocularis	cyclin dependent kinase 1	0.00438766	0.0286346	0.059408
Echinococcus multilocularis	nervana 2	0.0275688	0.233284	0.487786
Schistosoma mansoni	sodium / potassium ATPase beta chain	0.0275688	0.233284	0.488057
Plasmodium falciparum	cyclin	0.00187211	0.00642668	0.217511
Trypanosoma brucei	heat shock protein, putative	0.00285949	0.0151435	0.524646
Echinococcus granulosus	Galectin carbohydrate recognition domain	0.0133482	0.107741	0.224995
Echinococcus granulosus	cyclins	0.00187211	0.00642668	0.0129219
Echinococcus multilocularis	cyclin B	0.00423633	0.0272986	0.0566115
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	0.0552867	0.477986	1
Giardia lamblia	Hypothetical protein	0.00187211	0.00642668	0.0229789
Giardia lamblia	Cyclin A	0.00187211	0.00642668	0.0229789
Echinococcus granulosus	cyclin b3	0.00187211	0.00642668	0.0129219
Echinococcus granulosus	cyclins	0.00187211	0.00642668	0.0129219
Trypanosoma brucei	heat shock protein, putative	0.00285949	0.0151435	0.524646
Plasmodium falciparum	eukaryotic initiation factor 4A	0.00171757	0.00506235	0.169439
Treponema pallidum	heat shock protein 90	0.00218079	0.00915172	1
Echinococcus granulosus	cyclins	0.00187211	0.00642668	0.0129219
Giardia lamblia	Kinase, CMGC CDK	0.00438766	0.0286346	0.397017
Entamoeba histolytica	cyclin, putative	0.00423633	0.0272986	0.952927
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0552867	0.477986	1
Entamoeba histolytica	cyclin family protein	0.00187211	0.00642668	0.217511
Leishmania major	heat shock protein 83-1	0.00285949	0.0151435	0.524646
Echinococcus multilocularis	G2:mitotic specific cyclin B3	0.00187211	0.00642668	0.0129219
Brugia malayi	heat shock protein 90	0.00285949	0.0151435	0.024037
Echinococcus granulosus	eukaryotic initiation factor 4A	0.00171757	0.00506235	0.010066
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.00438766	0.0286346	0.0458156
Loa Loa (eye worm)	hypothetical protein	0.00171757	0.00506235	0.00776296
Echinococcus multilocularis	cyclins	0.00187211	0.00642668	0.0129219
Leishmania major	heat shock protein 83-1	0.00285949	0.0151435	0.524646
Trypanosoma cruzi	cdc2-related kinase 3	0.00438766	0.0286346	1
Schistosoma mansoni	serine/threonine protein kinase	0.00438766	0.0286346	0.0599068
Toxoplasma gondii	heat shock protein 90, putative	0.00285949	0.0151435	0.524646
Trichomonas vaginalis	cyclins, putative	0.00423633	0.0272986	0.952927
Schistosoma mansoni	galectin	0.0133482	0.107741	0.225406
Loa Loa (eye worm)	hypothetical protein	0.0552867	0.477986	0.771203
Echinococcus multilocularis	nervana 2	0.0552867	0.477986	1
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.00438766	0.0286346	0.0458156
Mycobacterium tuberculosis	Proteasome alpha subunit PrcA; assembles with beta subunit PrcB.	0.114417	1	1
Entamoeba histolytica	heat shock protein 90, putative	0.00285949	0.0151435	0.524646
Trypanosoma brucei	mitotic cyclin 6	0.00423633	0.0272986	0.952927
Trichomonas vaginalis	cyclin B3, putative	0.00187211	0.00642668	0.217511
Onchocerca volvulus	Eukaryotic initiation factor 4A homolog	0.00171757	0.00506235	0.00776296
Leishmania major	heat shock protein 83-1	0.00285949	0.0151435	0.524646
Leishmania major	heat shock protein 83-1	0.00285949	0.0151435	0.524646
Mycobacterium leprae	probable proteasome (alpha subunit) PrcA	0.114417	1	1
Trichomonas vaginalis	heat shock protein, putative	0.00218079	0.00915172	0.313527
Trichomonas vaginalis	cyclin B, putative	0.00423633	0.0272986	0.952927
Echinococcus multilocularis	eukaryotic initiation factor 4A III	0.00171757	0.00506235	0.010066
Schistosoma mansoni	endoplasmin	0.00285949	0.0151435	0.031682
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.00171757	0.00506235	0.169439
Echinococcus granulosus	G2:mitotic specific cyclin B3	0.00187211	0.00642668	0.0129219
Trypanosoma cruzi	heat shock protein 90, putative	0.00218079	0.00915172	0.313527
Loa Loa (eye worm)	hypothetical protein	0.00423633	0.0272986	0.043659
Echinococcus granulosus	nervana 2	0.0275688	0.233284	0.487786
Echinococcus granulosus	heat shock protein	0.00285949	0.0151435	0.0311682
Trichomonas vaginalis	cyclins, putative	0.0028426	0.0149944	0.519393
Brugia malayi	cell division control protein 2 homolog	0.00438766	0.0286346	0.0458156
Leishmania major	heat shock protein 83-1	0.00285949	0.0151435	0.524646
Echinococcus multilocularis	cyclin dependent kinase 5	0.00438766	0.0286346	0.059408
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.00171757	0.00506235	0.169439
Loa Loa (eye worm)	hypothetical protein	0.0174284	0.143762	0.231666
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.00218079	0.00915172	0.018626
Schistosoma mansoni	heat shock protein	0.00285949	0.0151435	0.031682
Giardia lamblia	Heat shock protein HSP 90-alpha	0.00285949	0.0151435	0.169793
Loa Loa (eye worm)	galactoside-binding lectin family protein	0.0133482	0.107741	0.173517
Leishmania major	eukaryotic initiation factor 4a, putative	0.00171757	0.00506235	0.169439
Trypanosoma cruzi	heat shock protein 85, putative	0.00285949	0.0151435	0.524646
Loa Loa (eye worm)	hypothetical protein	0.00844293	0.0644357	0.103609
Trypanosoma cruzi	cdc2-related kinase 1	0.00438766	0.0286346	1
Toxoplasma gondii	eukaryotic initiation factor-4A, putative	0.00171757	0.00506235	0.169439
Loa Loa (eye worm)	hypothetical protein	0.0552867	0.477986	0.771203
Plasmodium vivax	RNA helicase-1, putative	0.00171757	0.00506235	0.169439
Echinococcus granulosus	cyclins	0.00187211	0.00642668	0.0129219
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	0.00218079	0.00915172	0.00411018
Entamoeba histolytica	DEAD/DEAH box helicase, putative	0.00171757	0.00506235	0.169439
Entamoeba histolytica	heat shock protein 90, putative	0.00285949	0.0151435	0.524646
Giardia lamblia	Grp94/Hsp90	0.00218079	0.00915172	0.0688756
Loa Loa (eye worm)	hypothetical protein	0.0713409	0.619717	1
Trypanosoma brucei	Eukaryotic initiation factor 4A-1	0.00171757	0.00506235	0.169439
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0552867	0.477986	1
Entamoeba histolytica	cell division protein kinase 2, putative	0.00438766	0.0286346	1
Schistosoma mansoni	cyclin B3	0.00187211	0.00642668	0.0134454
Trichomonas vaginalis	cyclins, putative	0.00187211	0.00642668	0.217511
Trichomonas vaginalis	heat shock protein, putative	0.00185157	0.00624528	0.211119
Echinococcus granulosus	cyclins	0.00187211	0.00642668	0.0129219
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	0.0552867	0.477986	1
Plasmodium vivax	endoplasmin, putative	0.00285949	0.0151435	0.524646
Leishmania major	heat shock protein 83-1	0.00285949	0.0151435	0.524646
Echinococcus multilocularis	cyclin b3	0.00187211	0.00642668	0.0129219
Brugia malayi	Galactoside-binding lectin family protein	0.0133482	0.107741	0.173517
Echinococcus granulosus	cyclin dependent kinase 1	0.00438766	0.0286346	0.059408
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.00438766	0.0286346	0.059408
Brugia malayi	Cyclin, N-terminal domain containing protein	0.00423633	0.0272986	0.043659
Trypanosoma cruzi	CYC2-like cyclin, putative	0.00423633	0.0272986	0.952927
Echinococcus multilocularis	nervana 2	0.0275688	0.233284	0.487786
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.00438766	0.0286346	1
Leishmania major	heat shock protein 83-1	0.00285949	0.0151435	0.524646
Echinococcus granulosus	cyclin B	0.00423633	0.0272986	0.0566115
Plasmodium falciparum	protein kinase 5	0.00438766	0.0286346	1
Echinococcus multilocularis	cyclins	0.00187211	0.00642668	0.0129219
Echinococcus multilocularis	eukaryotic initiation factor 4A	0.00171757	0.00506235	0.010066
Trypanosoma cruzi	heat shock protein 90, putative	0.00285949	0.0151435	0.524646
Trypanosoma brucei	heat shock protein, putative	0.00285949	0.0151435	0.524646
Schistosoma mansoni	heat shock protein	0.00285949	0.0151435	0.031682
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0552867	0.477986	1
Echinococcus multilocularis	endoplasmin	0.00218079	0.00915172	0.018626
Plasmodium vivax	protein kinase Crk2	0.00438766	0.0286346	1
Echinococcus multilocularis	cyclin dependent kinase	0.00438766	0.0286346	0.059408
Schistosoma mansoni	cyclin B	0.00423633	0.0272986	0.0571118
Echinococcus granulosus	cyclin dependent kinase	0.00438766	0.0286346	0.059408
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0275688	0.233284	0.487786
Echinococcus granulosus	eukaryotic initiation factor 4A III	0.00171757	0.00506235	0.010066
Giardia lamblia	G2/mitotic-specific cyclin B	0.00423633	0.0272986	0.374516
Leishmania major	heat shock protein 83-1	0.00285949	0.0151435	0.524646
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0552867	0.477986	1
Loa Loa (eye worm)	hypothetical protein	0.0133482	0.107741	0.173517
Brugia malayi	Fibroblast growth factor family protein	0.00844293	0.0644357	0.103609
Echinococcus granulosus	nervana 2	0.0275688	0.233284	0.487786
Schistosoma mansoni	cyclins	0.00187211	0.00642668	0.0134454
Loa Loa (eye worm)	hypothetical protein	0.00236421	0.0107711	0.0169785
Leishmania major	heat shock protein 83-1	0.00285949	0.0151435	0.524646
Entamoeba histolytica	cell division protein kinase 2, putative	0.00438766	0.0286346	1
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	0.0275688	0.233284	0.488057
Trypanosoma brucei	heat shock protein, putative	0.00285949	0.0151435	0.524646
Plasmodium falciparum	heat shock protein 90	0.00285949	0.0151435	0.524646
Brugia malayi	Protein kinase domain containing protein	0.0174753	0.144176	0.232334
Echinococcus multilocularis	sodium:potassium transporting ATPase subunit	0.0552867	0.477986	1
Loa Loa (eye worm)	endoplasmin	0.00285949	0.0151435	0.024037
Echinococcus multilocularis	cyclins	0.00187211	0.00642668	0.0129219
Trypanosoma brucei	cdc2-related kinase 1	0.00438766	0.0286346	1
Echinococcus multilocularis	heat shock protein 90	0.00218079	0.00915172	0.018626
Giardia lamblia	Hypothetical protein	0.00844293	0.0644357	1
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.00218079	0.00915172	0.313527
Trypanosoma cruzi	cdc2-related kinase 3	0.00438766	0.0286346	1
Trypanosoma brucei	Heat shock protein 83, putative	0.00285949	0.0151435	0.524646
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.00171757	0.00506235	0.169439
Echinococcus granulosus	nervana 2	0.0552867	0.477986	1
Leishmania major	cyclin	0.00423633	0.0272986	0.952927
Echinococcus granulosus	cyclin B3 1	0.00187211	0.00642668	0.0129219
Trichomonas vaginalis	cyclin D, putative	0.00187211	0.00642668	0.217511
Trichomonas vaginalis	cyclins, putative	0.00423633	0.0272986	0.952927
Entamoeba histolytica	cyclin family protein	0.00187211	0.00642668	0.217511
Brugia malayi	Galactoside-binding lectin family protein	0.0133482	0.107741	0.173517
Onchocerca volvulus	Galectin homolog	0.0133482	0.107741	0.173517
Trypanosoma cruzi	heat shock protein 90, putative	0.00168663	0.00478916	0.159813
Toxoplasma gondii	heat shock protein HSP90	0.00285949	0.0151435	0.524646
Trypanosoma cruzi	Heat shock protein 83, putative	0.00285949	0.0151435	0.524646
Echinococcus granulosus	heat shock protein 90	0.00218079	0.00915172	0.018626
Trichomonas vaginalis	cyclin B, putative	0.00423633	0.0272986	0.952927
Trichomonas vaginalis	heat shock protein, putative	0.00285949	0.0151435	0.524646
Loa Loa (eye worm)	galactoside-binding lectin family protein	0.0133482	0.107741	0.173517
Trichomonas vaginalis	cyclins, putative	0.00423633	0.0272986	0.952927
Trypanosoma cruzi	cyclin, putative	0.00423633	0.0272986	0.952927
Schistosoma mansoni	endoplasmin	0.00285949	0.0151435	0.031682
Trypanosoma cruzi	cyclin 6, putative	0.00423633	0.0272986	0.952927
Trypanosoma cruzi	heat shock protein 85, putative	0.00285949	0.0151435	0.524646
Toxoplasma gondii	hypothetical protein	0.00139372	0.00220331	0.0687016
Trichomonas vaginalis	endoplasmin, putative	0.00185157	0.00624528	0.211119
Loa Loa (eye worm)	cyclin domain-containing protein	0.00187211	0.00642668	0.0099654
Trypanosoma brucei	heat shock protein, putative	0.00285949	0.0151435	0.524646
Onchocerca volvulus	Galectin homolog	0.0713409	0.619717	1
Plasmodium falciparum	endoplasmin, putative	0.00185157	0.00624528	0.211119
Schistosoma mansoni	heat shock protein	0.00117286	0.000253482	0.000530314
Onchocerca volvulus		0.0552867	0.477986	0.771203
Leishmania major	heat shock protein 83-1	0.00285949	0.0151435	0.524646
Trichomonas vaginalis	conserved hypothetical protein	0.00187211	0.00642668	0.217511
Trichomonas vaginalis	cyclin D, putative	0.00187211	0.00642668	0.217511
Trypanosoma brucei	heat shock protein 90, putative	0.00285949	0.0151435	0.524646
Brugia malayi	Fibroblast growth factor family protein	0.00844293	0.0644357	0.103609
Leishmania major	heat shock protein 83-1	0.00285949	0.0151435	0.524646
Echinococcus multilocularis	cyclin dependent kinase 1	0.00438766	0.0286346	0.059408
Trichomonas vaginalis	cyclin B, putative	0.00423633	0.0272986	0.952927
Loa Loa (eye worm)	hypothetical protein	0.00844293	0.0644357	0.103609
Trypanosoma cruzi	heat shock protein 85, putative	0.00218079	0.00915172	0.313527
Giardia lamblia	Heat shock protein HSP 90-alpha	0.00218079	0.00915172	0.0688756
Brugia malayi	galectin	0.0519685	0.448692	0.723914
Onchocerca volvulus		0.00423633	0.0272986	0.043659
Trypanosoma cruzi	heat shock protein 85, putative	0.00285949	0.0151435	0.524646
Trypanosoma brucei	cdc2-related kinase 3	0.00438766	0.0286346	1
Echinococcus granulosus	cyclin dependent kinase 5	0.00438766	0.0286346	0.059408
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0275688	0.233284	0.487786
Trypanosoma cruzi	cyclin, putative	0.00423633	0.0272986	0.952927
Leishmania major	heat shock protein 83-1	0.00285949	0.0151435	0.524646
Trichomonas vaginalis	cyclin A, putative	0.00423633	0.0272986	0.952927
Leishmania major	heat shock protein 83-1	0.00285949	0.0151435	0.524646
Loa Loa (eye worm)	hypothetical protein	0.0133482	0.107741	0.173517
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.00171757	0.00506235	0.169439
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.00438766	0.0286346	1
Leishmania major	heat shock protein 83-1	0.00285949	0.0151435	0.524646
Brugia malayi	Galactoside-binding lectin family protein	0.0133482	0.107741	0.173517
Leishmania major	eukaryotic initiation factor 4a, putative	0.00171757	0.00506235	0.169439
Loa Loa (eye worm)	galectin	0.0133482	0.107741	0.173517
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.00438766	0.0286346	1
Plasmodium vivax	heat shock protein 86, putative	0.00285949	0.0151435	0.524646
Entamoeba histolytica	cyclin, putative	0.00187211	0.00642668	0.217511
Brugia malayi	galectin	0.0133482	0.107741	0.173517
Brugia malayi	eukaryotic initiation factor 4A	0.00171757	0.00506235	0.00776296
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.00438766	0.0286346	0.0458156
Trichomonas vaginalis	CMGC family protein kinase	0.00438766	0.0286346	1
Trypanosoma brucei	heat shock protein, putative	0.00285949	0.0151435	0.524646
Trypanosoma brucei	heat shock protein, putative	0.00285949	0.0151435	0.524646
Schistosoma mansoni	transmemberane protein	0.0552867	0.477986	1
Echinococcus multilocularis	cyclins	0.00187211	0.00642668	0.0129219
Echinococcus multilocularis	Galectin, carbohydrate recognition domain	0.0133482	0.107741	0.224995
Echinococcus granulosus	heat shock protein 90	0.00285949	0.0151435	0.0311682
Leishmania major	heat shock protein 83-1	0.00285949	0.0151435	0.524646
Trichomonas vaginalis	cyclin B, putative	0.00423633	0.0272986	0.952927
Loa Loa (eye worm)	heat shock protein 90	0.00285949	0.0151435	0.024037
Loa Loa (eye worm)	galectin	0.0519685	0.448692	0.723914
Trichomonas vaginalis	heat shock protein, putative	0.00218079	0.00915172	0.313527
Onchocerca volvulus		0.0275688	0.233284	0.376182
Schistosoma mansoni	serine/threonine protein kinase	0.00438766	0.0286346	0.0599068
Echinococcus multilocularis	cyclins	0.00187211	0.00642668	0.0129219
Giardia lamblia	Kinase, CMGC CDK	0.00438766	0.0286346	0.397017
Loa Loa (eye worm)	galactoside-binding lectin family protein	0.0133482	0.107741	0.173517
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.00171757	0.00506235	0.010591
Echinococcus multilocularis	cyclins	0.00187211	0.00642668	0.0129219
Echinococcus multilocularis	heat shock protein 90	0.00285949	0.0151435	0.0311682
Brugia malayi	Endoplasmin precursor	0.00285949	0.0151435	0.024037
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.00218079	0.00915172	0.5
Echinococcus granulosus	nervana 2	0.0552867	0.477986	1
Echinococcus multilocularis	cyclin B3 1	0.00187211	0.00642668	0.0129219
Echinococcus multilocularis	heat shock protein	0.00285949	0.0151435	0.0311682
Trichomonas vaginalis	CMGC family protein kinase	0.00438766	0.0286346	1
Trichomonas vaginalis	CMGC family protein kinase	0.00438766	0.0286346	1
Brugia malayi	Galactoside-binding lectin family protein	0.0713409	0.619717	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Cytotoxicity (functional)	= 0 %	Cytotoxicity against MRC-5 cells at concentration 8 microM	ChEMBL.	11356101
Cytotoxicity (functional)	= 0 %	Cytotoxicity against MRC-5 cells at concentration 1 microM	ChEMBL.	11356101
Cytotoxicity (functional)	= 0 %	Cytotoxicity against MRC-5 cells at concentration 0.5 microM	ChEMBL.	11356101
Cytotoxicity (ADMET)	0 %	In vitro cytotoxicity against mouse peritoneal macrophages at concentration 32 microM; Toxic	ChEMBL.	11356101
Cytotoxicity (functional)	0 %	In vitro cytotoxic activity against mouse peritoneal macrophages at a concentration 8 microM; Non-toxic	ChEMBL.	11356101
Cytotoxicity (functional)	0 %	In vitro cytotoxic activity against mouse peritoneal macrophages at a concentration 2 microM; Non-toxic	ChEMBL.	11356101
Cytotoxicity (functional)	= 0 %	Cytotoxicity against MRC-5 cells at concentration 8 microM	ChEMBL.	11356101
Cytotoxicity (functional)	= 0 %	Cytotoxicity against MRC-5 cells at concentration 1 microM	ChEMBL.	11356101
Cytotoxicity (functional)	= 0 %	Cytotoxicity against MRC-5 cells at concentration 0.5 microM	ChEMBL.	11356101
Cytotoxicity (functional)	= 14 %	Cytotoxicity against MRC-5 cells at concentration 32 microM	ChEMBL.	11356101
Cytotoxicity (functional)	= 14 %	Cytotoxicity against MRC-5 cells at concentration 32 microM	ChEMBL.	11356101
IC50 (functional)	= 1000 nM	In vitro growth inhibition of P. falciparum FcB1R strain.	ChEMBL.	11356101
IC50 (functional)	= 1000 nM	In vitro growth inhibition of P. falciparum FcB1R strain.	ChEMBL.	11356101

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23	11356101

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL44905
PubChem: 10627771

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 65140