Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.0218 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0218 | 0.156 |
Echinococcus multilocularis | geminin | 0.0149 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.005 | 0.2612 | 0.3513 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0034 | 0.1387 | 0.1387 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.3738 | 0.3738 |
Schistosoma mansoni | tar DNA-binding protein | 0.005 | 0.2612 | 0.2612 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.1315 | 0.1315 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0076 | 0.4536 | 0.8776 |
Entamoeba histolytica | hypothetical protein | 0.0065 | 0.3738 | 1 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0031 | 0.1177 | 0.2724 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0076 | 0.4536 | 0.8776 |
Trypanosoma brucei | trypanothione reductase | 0.0033 | 0.1352 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.0218 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.0218 | 0.5 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0015 | 0.0002 | 0.0002 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0015 | 0.0002 | 0.0002 |
Plasmodium vivax | glutathione reductase, putative | 0.0033 | 0.1352 | 0.9749 |
Echinococcus multilocularis | tar DNA binding protein | 0.005 | 0.2612 | 0.2612 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0065 | 0.3738 | 0.3738 |
Loa Loa (eye worm) | acetyltransferase | 0.0115 | 0.7437 | 1 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0115 | 0.7437 | 0.7437 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0111 | 0.7196 | 0.7196 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0115 | 0.7437 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0084 | 0.5169 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0033 | 0.1352 | 0.9749 |
Brugia malayi | isocitrate dehydrogenase | 0.0015 | 0.0002 | 0.0002 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.0218 | 0.0218 |
Entamoeba histolytica | hypothetical protein | 0.0065 | 0.3738 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.005 | 0.2612 | 0.3513 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0218 | 0.16 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0218 | 0.16 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0015 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.0218 | 0.0293 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0034 | 0.1385 | 0.1385 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0084 | 0.5169 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0033 | 0.1352 | 0.1818 |
Toxoplasma gondii | thioredoxin reductase | 0.0033 | 0.1352 | 0.9749 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0015 | 0.0002 | 0.0002 |
Schistosoma mansoni | tar DNA-binding protein | 0.005 | 0.2612 | 0.2612 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0015 | 0.0002 | 0.0002 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0218 | 0.0218 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0076 | 0.4536 | 0.8776 |
Plasmodium falciparum | glutathione reductase | 0.0033 | 0.1352 | 1 |
Brugia malayi | Isocitrate dehydrogenase | 0.0015 | 0.0002 | 0.0002 |
Brugia malayi | glutathione reductase | 0.0033 | 0.1352 | 0.1818 |
Brugia malayi | TAR-binding protein | 0.005 | 0.2612 | 0.3513 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0065 | 0.3738 | 0.3738 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.1315 | 0.1768 |
Schistosoma mansoni | tar DNA-binding protein | 0.005 | 0.2612 | 0.2612 |
Entamoeba histolytica | hypothetical protein | 0.0065 | 0.3738 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0218 | 0.16 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0034 | 0.1385 | 0.1385 |
Echinococcus granulosus | tar DNA binding protein | 0.005 | 0.2612 | 0.2612 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0033 | 0.1352 | 1 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0034 | 0.1387 | 1 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0031 | 0.1177 | 1 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0031 | 0.1177 | 0.8703 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0065 | 0.3738 | 0.3738 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0015 | 0.0002 | 0.0002 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0218 | 0.0218 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0034 | 0.1387 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0065 | 0.3738 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.0218 | 0.0418 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0015 | 0.0002 | 0.0002 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0034 | 0.1387 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2448 | 0.3292 |
Schistosoma mansoni | tar DNA-binding protein | 0.005 | 0.2612 | 0.2612 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0076 | 0.4536 | 0.8776 |
Loa Loa (eye worm) | TAR-binding protein | 0.005 | 0.2612 | 0.3513 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.005 | 0.2612 | 0.3513 |
Loa Loa (eye worm) | glutathione reductase | 0.0033 | 0.1352 | 0.1818 |
Schistosoma mansoni | hypothetical protein | 0.0149 | 1 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0015 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1315 | 0.1768 |
Leishmania major | trypanothione reductase | 0.0033 | 0.1352 | 1 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0034 | 0.1387 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0033 | 0.1352 | 0.2613 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0115 | 0.7437 | 0.7437 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.0218 | 0.0218 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0034 | 0.1387 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.2448 | 0.3292 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0084 | 0.5169 | 1 |
Brugia malayi | RNA binding protein | 0.005 | 0.2612 | 0.3513 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.0218 | 0.0293 |
Schistosoma mansoni | hypothetical protein | 0.0149 | 1 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.0218 | 0.156 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.2448 | 0.3292 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.2448 | 0.3292 |
Brugia malayi | Thioredoxin reductase | 0.0033 | 0.1352 | 0.1818 |
Schistosoma mansoni | tar DNA-binding protein | 0.005 | 0.2612 | 0.2612 |
Plasmodium falciparum | thioredoxin reductase | 0.0033 | 0.1352 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.0218 | 0.16 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0076 | 0.4536 | 0.8776 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0084 | 0.5169 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.0218 | 0.16 |
Brugia malayi | hypothetical protein | 0.0065 | 0.3738 | 0.5027 |
Mycobacterium tuberculosis | Probable reductase | 0.0076 | 0.4536 | 0.8776 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.