Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | glutaminase | 0.0267 | 0.5176 | 1 |
Toxoplasma gondii | integral membrane protein, GNS1/SUR4 family protein, putative | 0.0328 | 0.6783 | 1 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0328 | 0.6783 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0071 | 0.0098 | 0.019 |
Plasmodium falciparum | fatty acid elongation protein, GNS1/SUR4 family, putative | 0.0328 | 0.6783 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0098 | 0.0145 |
Leishmania major | fatty acid elongase, putative | 0.0328 | 0.6783 | 1 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0328 | 0.6783 | 1 |
Onchocerca volvulus | 0.0071 | 0.0098 | 0.5 | |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0071 | 0.0098 | 0.5 |
Onchocerca volvulus | 0.0071 | 0.0098 | 0.5 | |
Mycobacterium ulcerans | glutaminase | 0.0267 | 0.5176 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0071 | 0.0098 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0098 | 0.0145 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0098 | 0.0145 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0098 | 0.0805 | 0.1187 |
Trichomonas vaginalis | glutaminase, putative | 0.0267 | 0.5176 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0098 | 0.0805 | 0.1187 |
Brugia malayi | beta-lactamase | 0.0071 | 0.0098 | 0.0145 |
Mycobacterium leprae | conserved hypothetical protein | 0.0071 | 0.0098 | 0.5 |
Trypanosoma brucei | Fatty acid elongase | 0.0328 | 0.6783 | 1 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.0328 | 0.6783 | 1 |
Loa Loa (eye worm) | glutaminase 2 | 0.0267 | 0.5176 | 0.763 |
Onchocerca volvulus | 0.0071 | 0.0098 | 0.5 | |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0071 | 0.0098 | 0.019 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0071 | 0.0098 | 0.0145 |
Brugia malayi | beta-lactamase family protein | 0.0071 | 0.0098 | 0.0145 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0328 | 0.6783 | 1 |
Leishmania major | fatty acid elongase, putative | 0.0328 | 0.6783 | 1 |
Plasmodium vivax | GNS1/SUR4 domain containing protein | 0.0328 | 0.6783 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0098 | 0.0145 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0098 | 0.0145 |
Loa Loa (eye worm) | GNS1/SUR4 family protein | 0.0328 | 0.6783 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0071 | 0.0098 | 0.0145 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0328 | 0.6783 | 1 |
Brugia malayi | GNS1/SUR4 family protein | 0.0328 | 0.6783 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0071 | 0.0098 | 0.5 |
Toxoplasma gondii | GNS1/SUR4 family protein | 0.0328 | 0.6783 | 1 |
Leishmania major | fatty acid elongase, putative | 0.0328 | 0.6783 | 1 |
Brugia malayi | Fatty acid elongation protein 3 | 0.0328 | 0.6783 | 1 |
Brugia malayi | glutaminase DH11.1 | 0.0267 | 0.5176 | 0.763 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0098 | 0.0805 | 0.1187 |
Plasmodium falciparum | long chain fatty acid elongation enzyme, putative | 0.0328 | 0.6783 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0071 | 0.0098 | 0.0145 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0098 | 0.0145 |
Loa Loa (eye worm) | glutaminase | 0.0267 | 0.5176 | 0.763 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0805 | 0.1187 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0071 | 0.0098 | 0.0145 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.