Detailed information for compound 652335

Basic information

Technical information
  • TDR Targets ID: 652335
  • Name: methyl 4-[(4-methyl-6-nitro-1,3-benzothiazol- 2-yl)carbamoyl]benzoate
  • MW: 371.367 | Formula: C17H13N3O5S
  • H donors: 1 H acceptors: 5 LogP: 3.59 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1ccc(cc1)C(=O)Nc1sc2c(n1)c(C)cc(c2)[N+](=O)[O-]
  • InChi: 1S/C17H13N3O5S/c1-9-7-12(20(23)24)8-13-14(9)18-17(26-13)19-15(21)10-3-5-11(6-4-10)16(22)25-2/h3-8H,1-2H3,(H,18,19,21)
  • InChiKey: PJIXSBCNXXUWIR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[[(4-methyl-6-nitro-1,3-benzothiazol-2-yl)amino]-oxomethyl]benzoic acid methyl ester
  • 4-[(4-methyl-6-nitro-1,3-benzothiazol-2-yl)carbamoyl]benzoic acid methyl ester
  • N-(4-Methyl-6-nitro-benzothiazol-2-yl)-terephthalamic acid methyl ester
  • ZINC00822258
  • Oprea1_367221
  • EU-0067786
  • Oprea1_866266
  • BAS 00355923
  • AG-690/36466002

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0017 0.0114 0.0114
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0163 0.2127 0.2076
Schistosoma mansoni steroid hormone receptor ad4bp 0.0017 0.0114 0.0114
Echinococcus granulosus tar DNA binding protein 0.0067 0.0795 0.0795
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0381 0.1542
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0357 0.0296
Trichomonas vaginalis esterase, putative 0.0038 0.0398 0.4858
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0139 0.0083
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0114 0.0114
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0064 0.0753 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0331 0.0921
Trypanosoma cruzi hexokinase, putative 0.0735 1 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0017 0.0114 0.0114
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0087 0.0087
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0063 0.0063
Echinococcus granulosus nmda type glutamate receptor 0.0009 0.0001 0.0001
Echinococcus multilocularis thyroid hormone receptor alpha 0.0017 0.0114 0.0114
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0017 0.0114 0.0114
Brugia malayi Steroid receptor seven-up type 2 0.0017 0.0114 0.0114
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0061 0.0712 0.0712
Loa Loa (eye worm) hypothetical protein 0.0034 0.0336 0.0336
Schistosoma mansoni hexokinase 0.0735 1 1
Entamoeba histolytica hypothetical protein 0.0033 0.033 0.0268
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.0163 0.2127 1
Toxoplasma gondii hexokinase 0.0735 1 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0357 0.0357
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0087 0.0087
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0398 0.1132
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0063 0.0083
Onchocerca volvulus 0.0735 1 1
Leishmania major DNA polymerase kappa, putative 0.0019 0.0139 0.0076
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0521 0.1518
Loa Loa (eye worm) hypothetical protein 0.0047 0.0521 0.0521
Schistosoma mansoni hypothetical protein 0.0016 0.0087 0.0087
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0139 0.0076
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0139 0.0139
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0349 0.4681 0.4681
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0795 0.0795
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0139 0.0083
Schistosoma mansoni retinoic acid receptor RXR 0.0017 0.0114 0.0114
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0332 0.0923
Loa Loa (eye worm) hypothetical protein 0.0017 0.0114 0.0114
Loa Loa (eye worm) hexokinase 0.0735 1 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0017 0.0114 0.0114
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0017 0.0114 0.0114
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0332 0.0332
Echinococcus multilocularis dna polymerase eta 0.0019 0.0139 0.0139
Echinococcus granulosus ecdysone induced protein 78C 0.0017 0.0114 0.0114
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0398 0.0398
Loa Loa (eye worm) glutamate receptor 1 0.0025 0.0219 0.0219
Echinococcus granulosus glutamate receptor 2 0.003 0.0285 0.0285
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0332 0.027
Echinococcus multilocularis pyruvate kinase 0.0017 0.0108 0.0108
Brugia malayi steroid hormone receptor 0.0017 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0035 0.0357 0.0357
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0139 0.0365
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0063 0.0007
Schistosoma mansoni glutamate receptor kainate 0.0056 0.0646 0.0646
Brugia malayi nuclear hormone receptor 0.0017 0.0114 0.0114
Trypanosoma brucei hexokinase 0.0735 1 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0398 0.0398
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0398 0.1624
Echinococcus multilocularis pyruvate kinase 0.0017 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0038 0.0398 0.0398
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0193 0.0193
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0381 0.0381
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0139 0.0319
Schistosoma mansoni inositol monophosphatase 0.0037 0.0381 0.0381
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0087 0.0087
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0063 0.0063
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0139 0.0319
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0332 0.0277
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0332 0.027
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0114 0.0114
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0551 0.0551
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0064 0.0753 0.0753
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0795 0.0795
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0332 0.1301
Brugia malayi Hexokinase family protein 0.0227 0.3006 0.3006
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0114 0.0114
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0017 0.0114 0.0114
Loa Loa (eye worm) hexokinase 0.0735 1 1
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.0163 0.2127 0.6545
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0114 0.0114
Brugia malayi Glutamate receptor 1 precursor 0.0025 0.0219 0.0219
Echinococcus granulosus glutamate NMDA receptor subunit 0.0025 0.0219 0.0219
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.004 0.0428 0.0428
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0087 0.0087
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0064 0.0753 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0139 0.0083
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0063 0.0007
Schistosoma mansoni dihydroorotate dehydrogenase 0.0163 0.2127 0.2127
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.0163 0.2127 1
Echinococcus granulosus GPCR family 2 0.0016 0.0087 0.0087
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0398 0.1132
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0398 0.0398
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0139 0.1092
Entamoeba histolytica hypothetical protein 0.0033 0.033 0.0268
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0521 0.0461
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0521 0.0461
Entamoeba histolytica hypothetical protein 0.0033 0.033 0.0268
Echinococcus granulosus pyruvate kinase 0.0017 0.0108 0.0108
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0521 0.0461
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0063 0.0083
Schistosoma mansoni ATP-binding cassette transporter 0.0025 0.0219 0.0219
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0061 0.0712 0.0712
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0017 0.0114 0.0051
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0521 0.0521
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0328 0.0913
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0063 0.0083
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0398 0.1624
Echinococcus multilocularis pyruvate kinase 0.0026 0.0235 0.0235
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0268 0.0268
Schistosoma mansoni cpg binding protein 0.003 0.029 0.029
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0114 0.0114
Onchocerca volvulus Hexokinase homolog 0.0461 0.6226 0.6202
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0381 0.032
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0017 0.0114 0.0114
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0381 0.0327
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0521 0.0521
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0331 0.0921
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0139 0.0083
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0114 0.0114
Plasmodium vivax hexokinase, putative 0.0735 1 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0357 0.0357
Loa Loa (eye worm) oxidoreductase 0.0014 0.0063 0.0063
Echinococcus multilocularis pyruvate kinase 0.0033 0.0332 0.0332
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0061 0.0712 0.0712
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0114 0.0114
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0017 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0033 0.0332 0.0332
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0163 0.2127 0.2127
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0398 0.4858
Echinococcus multilocularis pyruvate kinase 0.0017 0.0108 0.0108
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0139 0.0083
Loa Loa (eye worm) hypothetical protein 0.0023 0.0193 0.0193
Entamoeba histolytica hexokinase 1 0.0735 1 1
Schistosoma mansoni glutamate receptor kainate 0.0025 0.0219 0.0219
Brugia malayi beta-lactamase family protein 0.0038 0.0398 0.0398
Loa Loa (eye worm) hypothetical protein 0.0017 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0234 0.3093 0.3093
Onchocerca volvulus 0.0038 0.0398 0.0337
Schistosoma mansoni DNA polymerase eta 0.0019 0.0139 0.0139
Schistosoma mansoni hypothetical protein 0.0033 0.033 0.033
Brugia malayi TAR-binding protein 0.0067 0.0795 0.0795
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0521 0.222
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0163 0.2127 0.2076
Schistosoma mansoni hypothetical protein 0.0016 0.0087 0.0087
Onchocerca volvulus Protein ultraspiracle homolog 0.0017 0.0114 0.0051
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0139 0.0076
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0017 0.0114 0.0114
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0017 0.0114 0.0114
Entamoeba histolytica hypothetical protein 0.0033 0.033 0.0268
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0063 0.0083
Echinococcus multilocularis hexokinase 0.0735 1 1
Trypanosoma cruzi hexokinase, putative 0.0735 1 1
Loa Loa (eye worm) hypothetical protein 0.0234 0.3093 0.3093
Echinococcus multilocularis hexokinase type 2 0.0735 1 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0357 0.0296
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0398 0.4858
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0336 0.0336
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0063 0.0063
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0398 0.4858
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.004 0.0428 0.0428
Brugia malayi CXXC zinc finger family protein 0.0029 0.0268 0.0268
Leishmania major dihydroorotate dehydrogenase 0.0163 0.2127 0.2076
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0357 0.1426
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0521 0.222
Loa Loa (eye worm) hypothetical protein 0.0038 0.0398 0.0398
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0139 0.0083
Onchocerca volvulus 0.0017 0.0114 0.0051
Loa Loa (eye worm) steroid hormone receptor 0.0017 0.0114 0.0114
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0331 0.0921
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0332 0.027
Loa Loa (eye worm) RNA binding protein 0.0067 0.0795 0.0795
Mycobacterium ulcerans hypothetical protein 0.0038 0.0398 0.1624
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0017 0.0114 0.0114
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0398 0.1132
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0332 0.027
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0063 0.0063
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0009 0.0001 0.0001
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0521 0.222
Schistosoma mansoni pyruvate kinase 0.0033 0.0332 0.0332
Leishmania major DNA polymerase eta, putative 0.0019 0.0139 0.0076
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0017 0.0114 0.0114
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0795 0.0795
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0139 0.0083
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0061 0.0712 0.0712
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0139 0.0076
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0017 0.0114 0.0114
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0017 0.0114 0.0114
Schistosoma mansoni hypothetical protein 0.0016 0.0087 0.0087
Schistosoma mansoni thyroid hormone receptor 0.0017 0.0114 0.0114
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0521 0.222
Loa Loa (eye worm) hypothetical protein 0.0017 0.0114 0.0114
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.0163 0.2127 0.2082
Schistosoma mansoni transcription factor LCR-F1 0.0033 0.033 0.033
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0521 0.1518
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0332 0.1301
Echinococcus multilocularis ecdysone induced protein 78C 0.0017 0.0114 0.0114
Onchocerca volvulus Bile acid receptor homolog 0.0017 0.0114 0.0051
Echinococcus multilocularis dnaJ subfamily B 0.0408 0.5498 0.5498
Onchocerca volvulus 0.0047 0.0521 0.0461
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0139 0.0083
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0033 0.033 0.033
Loa Loa (eye worm) hypothetical protein 0.0019 0.0139 0.0139
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0398 0.0398
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0243 0.323 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0381 0.032
Loa Loa (eye worm) glutamate receptor 2 0.0025 0.0219 0.0219
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0139 0.0083
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0551 0.0551
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0381 0.4614
Echinococcus multilocularis nmda type glutamate receptor 0.0009 0.0001 0.0001
Treponema pallidum hexokinase (hxk) 0.0735 1 0.5
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0398 0.1132
Schistosoma mansoni thyroid hormone receptor 0.0017 0.0114 0.0114
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0398 0.4858
Plasmodium falciparum pyruvate kinase 0.0033 0.0332 0.027
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0017 0.0114 0.0114
Echinococcus granulosus pyruvate kinase 0.0017 0.0108 0.0108
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0711 0.0711
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0063 0.0063
Schistosoma mansoni glutamate receptor NMDA 0.0025 0.0219 0.0219
Brugia malayi ecdysteroid receptor 0.0017 0.0114 0.0114
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0398 0.0344
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0332 0.3891
Onchocerca volvulus 0.0735 1 1
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0063 0.0063
Trypanosoma brucei hexokinase 0.0735 1 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0017 0.0114 0.0114
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0025 0.0219 0.0219
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0163 0.2127 0.2127
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.0163 0.2127 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0398 0.0398
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0398 0.0337
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0139 0.0139
Schistosoma mansoni coup transcription factor 0.0017 0.0114 0.0114
Schistosoma mansoni hypothetical protein 0.0034 0.0336 0.0336
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0017 0.0114 0.0114
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0398 0.4858
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0064 0.0753 0.0753
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0017 0.0114 0.0114
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0033 0.033 0.033
Schistosoma mansoni inositol monophosphatase 0.0037 0.0381 0.0381
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0064 0.0753 0.0753
Echinococcus multilocularis hexokinase 0.0735 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0114 0.0114
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0795 0.0795
Giardia lamblia Pyruvate kinase 0.0033 0.0332 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0087 0.0087
Brugia malayi Glutamate receptor 2 precursor 0.0025 0.0219 0.0219
Onchocerca volvulus 0.0735 1 1
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0114 0.0114
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0017 0.0114 0.0114
Mycobacterium tuberculosis Conserved protein 0.0038 0.0398 0.1132
Schistosoma mansoni cpg binding protein 0.003 0.029 0.029
Loa Loa (eye worm) hypothetical protein 0.0017 0.0114 0.0114
Plasmodium falciparum dihydroorotate dehydrogenase 0.0163 0.2127 0.2076
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0521 0.0461
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0332 0.0332
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.0163 0.2127 0.2076
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0332 0.0277
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0114 0.0114
Echinococcus multilocularis glutamate receptor 2 0.0021 0.0157 0.0157
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0017 0.0114 0.0114
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0009 0.0001 0.0001
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0139 0.1092
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.0163 0.2127 0.2076
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0114 0.0114
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0047 0.0521 0.0521
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0501 0.678 0.678
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0063 0.0083
Echinococcus multilocularis glutamate receptor 2 0.003 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.0049 0.0551 0.0551
Onchocerca volvulus 0.0029 0.0268 0.0206
Loa Loa (eye worm) hexokinase 0.0227 0.3006 0.3006
Schistosoma mansoni RAR-like nuclear receptor 0.0017 0.0114 0.0114
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0795 0.0795
Echinococcus multilocularis cpg binding protein 0.003 0.029 0.029
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0064 0.0753 0.0694
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0332 0.3891
Leishmania major hexokinase, putative 0.0735 1 1
Schistosoma mansoni pyruvate kinase 0.0033 0.0332 0.0332
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0139 0.0139
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0017 0.0114 0.0114
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0061 0.0712 0.0712
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0087 0.0087
Echinococcus multilocularis GPCR, family 2 0.0016 0.0087 0.0087
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0139 0.0139
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0621 0.0561
Echinococcus granulosus dnaJ subfamily B 0.0408 0.5498 0.5498
Loa Loa (eye worm) hypothetical protein 0.0017 0.0114 0.0114
Brugia malayi hypothetical protein 0.0033 0.033 0.033
Onchocerca volvulus 0.0038 0.0398 0.0337
Brugia malayi hexokinase type II 0.0234 0.3093 0.3093
Echinococcus multilocularis pyruvate kinase 0.0033 0.0332 0.0332
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0017 0.0114 0.0114
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0063 0.0063
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0357 0.1004
Echinococcus granulosus pyruvate kinase 0.0033 0.0332 0.0332
Loa Loa (eye worm) hypothetical protein 0.0038 0.0398 0.0398
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0087 0.0087
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0108 0.0045
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0521 0.222
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0064 0.0753 1
Loa Loa (eye worm) beta-lactamase 0.0038 0.0398 0.0398
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0114 0.0114
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0064 0.0753 1
Leishmania major hypothetical protein, conserved 0.0038 0.0398 0.0337
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0139 0.0139
Brugia malayi RNA binding protein 0.0067 0.0795 0.0795
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0063 0.0083
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0398 0.1132
Brugia malayi beta-lactamase 0.0038 0.0398 0.0398
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0017 0.0114 0.0114
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0193 0.013
Echinococcus granulosus cpg binding protein 0.003 0.029 0.029
Echinococcus granulosus glutamate receptor subunit protein glur 0.0009 0.0001 0.0001
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0063 0.0083
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0063 0.0083
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0139 0.0083
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0551 0.0551
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0521 0.0461
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0061 0.0712 0.0712
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0139 0.0139
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0038 0.0398 0.0398
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0398 0.1132
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.003 0.0285 0.0285
Toxoplasma gondii ABC1 family protein 0.0038 0.0398 0.0337
Loa Loa (eye worm) hypothetical protein 0.0035 0.0357 0.0357
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0064 0.0753 0.0694
Trypanosoma brucei hexokinase, putative 0.0735 1 1
Echinococcus granulosus hexokinase 0.0735 1 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0063 0.0063
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0328 0.1284
Entamoeba histolytica hexokinase 2 0.0735 1 1
Mycobacterium ulcerans lipase LipD 0.0038 0.0398 0.1624
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0087 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0017 0.0114 0.0114
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0064 0.0753 1
Echinococcus granulosus hexokinase type 2 0.0735 1 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0332 0.027
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0398 0.1624
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0381 0.032
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0163 0.2127 0.2076
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0357 1
Loa Loa (eye worm) hexokinase type II 0.0735 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0139 0.0083
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0381 0.032
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0139 0.0139
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0017 0.0114 0.0114
Loa Loa (eye worm) inositol-1 0.0037 0.0381 0.0381
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0398 0.0337
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0139 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0017 0.0114 0.0114
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0398 0.0398
Brugia malayi Inositol-1 0.0037 0.0381 0.0381
Brugia malayi beta-lactamase family protein 0.0038 0.0398 0.0398
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0795 0.0795
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0398 0.0337
Echinococcus multilocularis FTZ F1 alpha 0.0017 0.0114 0.0114
Trypanosoma brucei unspecified product 0.0019 0.0139 0.0083
Echinococcus granulosus hexokinase 0.0735 1 1
Onchocerca volvulus 0.0038 0.0398 0.0337
Mycobacterium tuberculosis Conserved protein 0.0038 0.0398 0.1132
Schistosoma mansoni hypothetical protein 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0017 0.0114 0.0114
Schistosoma mansoni glutamate receptor kainate 0.0056 0.0646 0.0646
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0063 0.0083
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0017 0.0114 0.0114
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0064 0.0753 1
Schistosoma mansoni glutamate receptor AMPA 0.0025 0.0219 0.0219
Brugia malayi nuclear receptor NHR-88 0.0017 0.0114 0.0114
Schistosoma mansoni hypothetical protein 0.0408 0.5498 0.5498
Onchocerca volvulus 0.0461 0.6226 0.6202
Echinococcus granulosus glutamate receptor ionotropic kainate 0.004 0.0428 0.0428
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0521 0.222
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0332 0.0332
Schistosoma mansoni hypothetical protein 0.0016 0.0087 0.0087
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0331 0.0921
Brugia malayi photoreceptor-specific nuclear receptor 0.0017 0.0114 0.0114
Echinococcus granulosus dna polymerase eta 0.0019 0.0139 0.0139
Leishmania major hexokinase, putative 0.0735 1 1
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.004 0.0428 0.0428
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0521 0.0461
Echinococcus multilocularis NMDA receptor 0.004 0.0428 0.0428
Schistosoma mansoni glutamate receptor AMPA 0.0025 0.0219 0.0219
Brugia malayi Zinc finger, C2H2 type family protein 0.0064 0.0753 0.0753
Echinococcus multilocularis glutamate receptor 2 0.0025 0.0219 0.0219
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0795 0.0795
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0064 0.0753 0.0753
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0063 0.0063
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0063 0.0063
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0398 0.1132
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0139 0.0083
Mycobacterium ulcerans hypothetical protein 0.0047 0.0521 0.222
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0063 0.0063
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.003 0.0285 0.0285
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0139 0.0076
Schistosoma mansoni pyruvate kinase 0.0017 0.0108 0.0108
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0795 0.0795
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0017 0.0114 0.0114
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0795 0.0795
Mycobacterium tuberculosis Conserved protein 0.0038 0.0398 0.1132
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.0012 0.0012
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0381 0.4614
Echinococcus granulosus pyruvate kinase 0.0017 0.0108 0.0108
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0381 0.4614
Schistosoma mansoni glutamate receptor NMDA 0.003 0.0285 0.0285
Echinococcus granulosus hexokinase 0.0735 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0139 0.0083
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0332 0.0332
Schistosoma mansoni cpg binding protein 0.0029 0.0268 0.0268
Brugia malayi Hexokinase family protein 0.0461 0.6226 0.6226
Mycobacterium leprae Probable lipase LipE 0.0038 0.0398 0.1624
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0521 0.222
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0398 0.0398
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0139 0.0076
Loa Loa (eye worm) hypothetical protein 0.0014 0.0063 0.0063
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0332 0.027
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0139 0.0365
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0521 0.222
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0381 0.0381
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0139 0.0076
Mycobacterium ulcerans beta-lactamase 0.0038 0.0398 0.1624
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0009 0.0001 0.0001
Brugia malayi Hexokinase family protein 0.0735 1 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0139 0.0076
Leishmania major pyruvate kinase 0.0033 0.0332 0.027
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0332 0.0332
Giardia lamblia DINP protein human, muc B family 0.0019 0.0139 0.1356
Echinococcus granulosus pyruvate kinase 0.0033 0.0332 0.0332
Loa Loa (eye worm) hypothetical protein 0.0047 0.0521 0.0521
Echinococcus multilocularis hexokinase 0.0735 1 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0357 0.0357
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0108 0.0045
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0108 0.0045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0017 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0017 0.0114 0.0114
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0063 0.0083
Echinococcus granulosus dna polymerase kappa 0.0019 0.0139 0.0139
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0381 0.032
Plasmodium falciparum hexokinase 0.0735 1 1
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0521 0.0521
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0521 0.222
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0398 0.0398
Loa Loa (eye worm) hexokinase 0.0461 0.6226 0.6226
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0063 0.0083
Echinococcus granulosus glutamate receptor 2 0.0021 0.0157 0.0157
Echinococcus granulosus FTZ F1 alpha 0.0017 0.0114 0.0114
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0332 0.027
Leishmania major pyruvate kinase 0.0033 0.0332 0.027

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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