Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0724 | 0.1827 |
Loa Loa (eye worm) | RNA binding protein | 0.0201 | 0.5486 | 0.8296 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0201 | 0.5486 | 0.8296 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0199 | 0.543 | 0.8211 |
Loa Loa (eye worm) | acetyltransferase | 0.0143 | 0.3543 | 0.5326 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0303 | 0.8947 | 1 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0148 | 0.3702 | 0.5695 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0303 | 0.8947 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0219 | 0.6085 | 0.9213 |
Schistosoma mansoni | hypothetical protein | 0.0136 | 0.3298 | 0.5969 |
Brugia malayi | TAR-binding protein | 0.0201 | 0.5486 | 0.8296 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0093 | 0.1841 | 0.3284 |
Schistosoma mansoni | hypothetical protein | 0.0063 | 0.0824 | 0.141 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.0724 | 0.0669 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0063 | 0.0824 | 0.117 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.0724 | 0.0669 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0303 | 0.8947 | 1 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0234 | 0.66 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.0724 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0201 | 0.5486 | 1 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0143 | 0.3543 | 0.3504 |
Schistosoma mansoni | hypothetical protein | 0.0063 | 0.0824 | 0.141 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0303 | 0.8947 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0303 | 0.8947 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0063 | 0.0824 | 0.077 |
Brugia malayi | jmjC domain containing protein | 0.0061 | 0.0756 | 0.1065 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0063 | 0.0824 | 0.117 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0148 | 0.3702 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0063 | 0.0824 | 0.141 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0061 | 0.0756 | 0.1065 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.004 | 0.0059 | 0.0066 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0042 | 0.0119 | 0.0067 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0303 | 0.8947 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0061 | 0.0756 | 0.1284 |
Schistosoma mansoni | tar DNA-binding protein | 0.0201 | 0.5486 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0303 | 0.8947 | 1 |
Brugia malayi | RNA binding protein | 0.0201 | 0.5486 | 0.8296 |
Schistosoma mansoni | tar DNA-binding protein | 0.0201 | 0.5486 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0093 | 0.1841 | 0.1793 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0201 | 0.5486 | 0.8296 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0724 | 0.1827 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0093 | 0.1841 | 0.1793 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0049 | 0.0348 | 0.0532 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0303 | 0.8947 | 1 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0061 | 0.0756 | 0.0701 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0093 | 0.1841 | 0.1793 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0093 | 0.1841 | 0.3284 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0824 | 0.117 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0303 | 0.8947 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0251 | 0.7177 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.004 | 0.0059 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0234 | 0.66 | 1 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0042 | 0.0119 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0063 | 0.0824 | 0.077 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0042 | 0.0119 | 0.006 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0093 | 0.1841 | 0.3284 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0348 | 0.0441 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0061 | 0.0756 | 0.0701 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0199 | 0.543 | 0.8211 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0229 | 0.6455 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.004 | 0.0059 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0201 | 0.5486 | 0.5459 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0061 | 0.0756 | 0.1284 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.004 | 0.0059 | 0.0066 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0143 | 0.3543 | 0.642 |
Schistosoma mansoni | tar DNA-binding protein | 0.0201 | 0.5486 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0063 | 0.0824 | 0.077 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0724 | 0.1827 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0042 | 0.0119 | 0.0067 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0199 | 0.543 | 0.8211 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0143 | 0.3543 | 0.5326 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0093 | 0.1841 | 0.2724 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0061 | 0.0756 | 0.0701 |
Schistosoma mansoni | tar DNA-binding protein | 0.0201 | 0.5486 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0093 | 0.1841 | 0.2724 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0063 | 0.0824 | 0.117 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0148 | 0.3702 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0334 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.0724 | 0.1226 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.004 | 0.0059 | 0.5 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0042 | 0.0119 | 0.0899 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.004 | 0.0059 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0063 | 0.0824 | 0.077 |
Loa Loa (eye worm) | TAR-binding protein | 0.0201 | 0.5486 | 0.8296 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0139 | 0.3407 | 0.3368 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0061 | 0.0756 | 0.1284 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0.0724 | 0.104 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.004 | 0.0059 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.0724 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.3298 | 0.4952 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0063 | 0.0824 | 0.077 |
Brugia malayi | jmjC domain containing protein | 0.0061 | 0.0756 | 0.1065 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0303 | 0.8947 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0136 | 0.3298 | 0.4952 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0303 | 0.8947 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.0724 | 0.1226 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.543 | 0.8211 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0093 | 0.1841 | 0.1793 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0303 | 0.8947 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0042 | 0.0119 | 0.0899 |
Echinococcus multilocularis | tar DNA binding protein | 0.0201 | 0.5486 | 0.5459 |
Echinococcus multilocularis | GPCR, family 2 | 0.0063 | 0.0824 | 0.077 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0061 | 0.0756 | 0.0701 |
Schistosoma mansoni | hypothetical protein | 0.0063 | 0.0824 | 0.141 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.