Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0304 | 0.7433 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.0288 | 0.0215 |
Echinococcus granulosus | neuroligin | 0.0051 | 0.1171 | 0.1105 |
Echinococcus multilocularis | acetylcholinesterase | 0.0304 | 0.7433 | 0.7414 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0099 | 0.0121 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1171 | 0.1565 |
Echinococcus granulosus | smad | 0.0008 | 0.0099 | 0.0025 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0051 | 0.1171 | 0.5 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0051 | 0.1171 | 0.1105 |
Brugia malayi | Carboxylesterase family protein | 0.0051 | 0.1171 | 0.1565 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0288 | 0.0215 |
Brugia malayi | MH2 domain containing protein | 0.0119 | 0.2847 | 0.3822 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0288 | 0.0215 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.074 | 0.074 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0304 | 0.7433 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1171 | 0.1565 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0288 | 0.0375 |
Brugia malayi | Carboxylesterase family protein | 0.0304 | 0.7433 | 1 |
Echinococcus multilocularis | neuroligin | 0.0051 | 0.1171 | 0.1105 |
Loa Loa (eye worm) | carboxylesterase | 0.0051 | 0.1171 | 0.1565 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.1129 | 0.1509 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0051 | 0.1171 | 0.5 |
Schistosoma mansoni | smad | 0.0008 | 0.0099 | 0.0099 |
Onchocerca volvulus | 0.0051 | 0.1171 | 1 | |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0099 | 0.0121 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0407 | 1 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0288 | 0.0215 |
Loa Loa (eye worm) | hypothetical protein | 0.0304 | 0.7433 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.074 | 0.0984 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0008 | 0.0099 | 0.0025 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0051 | 0.1171 | 0.1171 |
Brugia malayi | Carboxylesterase family protein | 0.0051 | 0.1171 | 0.1565 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0051 | 0.1171 | 0.1171 |
Brugia malayi | Carboxylesterase family protein | 0.0051 | 0.1171 | 0.1565 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0051 | 0.1171 | 0.1171 |
Onchocerca volvulus | 0.0051 | 0.1171 | 1 | |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0118 | 0.0044 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0288 | 0.0215 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1171 | 0.1565 |
Loa Loa (eye worm) | hypothetical protein | 0.0304 | 0.7433 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0051 | 0.1171 | 0.1105 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.1129 | 0.1509 |
Loa Loa (eye worm) | carboxylesterase | 0.0304 | 0.7433 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0051 | 0.1171 | 0.1171 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0051 | 0.1171 | 0.5 |
Schistosoma mansoni | gliotactin | 0.0051 | 0.1171 | 0.1171 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0118 | 0.0146 |
Onchocerca volvulus | 0.0051 | 0.1171 | 1 | |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0051 | 0.1171 | 0.1105 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0061 | 0.1403 | 0.1403 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0074 | 0.0074 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.0288 | 0.0215 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0051 | 0.1171 | 0.1105 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0051 | 0.1171 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0051 | 0.1171 | 0.1171 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0288 | 0.0375 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0648 | 0.0648 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0008 | 0.0099 | 0.0025 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0051 | 0.1171 | 0.1171 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.0648 | 0.0578 |
Brugia malayi | hypothetical protein | 0.0051 | 0.1171 | 0.1565 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0099 | 0.0121 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0288 | 0.0288 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0029 | 0.0608 | 0.0806 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0288 | 0.0375 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0099 | 0.0099 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.1129 | 0.1509 |
Brugia malayi | Carboxylesterase family protein | 0.0051 | 0.1171 | 0.1565 |
Echinococcus granulosus | acetylcholinesterase | 0.0304 | 0.7433 | 0.7414 |
Onchocerca volvulus | 0.0051 | 0.1171 | 1 | |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.0115 | 0.0142 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1171 | 0.1565 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0118 | 0.0044 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0099 | 0.0099 |
Echinococcus granulosus | Smad4 | 0.0008 | 0.0099 | 0.0025 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0288 | 0.0288 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0304 | 0.7433 | 0.7414 |
Echinococcus multilocularis | acetylcholinesterase | 0.0304 | 0.7433 | 0.7414 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0304 | 0.7433 | 0.7433 |
Echinococcus granulosus | acetylcholinesterase | 0.0304 | 0.7433 | 0.7414 |
Echinococcus granulosus | carboxylesterase 5A | 0.0304 | 0.7433 | 0.7414 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0051 | 0.1171 | 0.5 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0099 | 0.0099 |
Brugia malayi | CXXC zinc finger family protein | 0.0029 | 0.0608 | 0.0806 |
Echinococcus multilocularis | smad | 0.0008 | 0.0099 | 0.0025 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1171 | 0.1565 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0054 | 0.1242 | 0.5 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0008 | 0.0099 | 0.0099 |
Loa Loa (eye worm) | Smad1 | 0.0008 | 0.0099 | 0.0121 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0288 | 0.0288 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0099 | 0.0121 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0008 | 0.0099 | 0.0025 |
Echinococcus multilocularis | Smad4 | 0.0008 | 0.0099 | 0.0025 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0288 | 0.0375 |
Schistosoma mansoni | Smad4 | 0.0008 | 0.0099 | 0.0099 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0008 | 0.0099 | 0.0025 |
Brugia malayi | Smad1 | 0.0008 | 0.0099 | 0.0121 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0648 | 0.0648 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0008 | 0.0099 | 0.0121 |
Loa Loa (eye worm) | carboxylesterase | 0.0051 | 0.1171 | 0.1565 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0051 | 0.1171 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0407 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0288 | 0.0288 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.0608 | 0.0608 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1171 | 0.1565 |
Onchocerca volvulus | 0.0051 | 0.1171 | 1 | |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0051 | 0.1171 | 0.1105 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0051 | 0.1171 | 0.1105 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1171 | 0.1565 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0119 | 0.2847 | 0.3822 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.074 | 0.0984 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.1129 | 0.1509 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0008 | 0.0099 | 0.0121 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0119 | 0.2847 | 0.3822 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.0648 | 0.0578 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.