Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0033 | 0.4331 | 0.4425 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.7328 | 0.8289 |
Echinococcus granulosus | JmjC domain containing protein 4 | 0.0016 | 0.172 | 0.145 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.227 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0062 | 0.8731 | 1 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.006 | 0.8443 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0062 | 0.8731 | 0.8731 |
Brugia malayi | jmjC domain containing protein | 0.006 | 0.8443 | 0.9636 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.006 | 0.8443 | 0.9648 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0016 | 0.172 | 0.1116 |
Echinococcus granulosus | cpg binding protein | 0.0035 | 0.4619 | 0.4986 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.006 | 0.8443 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.227 | 1 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.227 | 0.227 |
Brugia malayi | jmjC domain containing protein | 0.0016 | 0.172 | 0.1138 |
Schistosoma mansoni | ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related | 0.0016 | 0.172 | 0.172 |
Schistosoma mansoni | jumonji domain containing protein | 0.0016 | 0.172 | 0.172 |
Echinococcus granulosus | lysine specific demethylase 6a | 0.0016 | 0.172 | 0.145 |
Brugia malayi | jmjC domain containing protein | 0.0016 | 0.172 | 0.1138 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.7328 | 0.8289 |
Echinococcus multilocularis | lysine specific demethylase 6a | 0.0016 | 0.172 | 0.1502 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.7328 | 0.8591 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.5005 | 0.5005 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.227 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.227 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.5005 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0033 | 0.4331 | 0.4439 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0016 | 0.172 | 0.1116 |
Schistosoma mansoni | phd/f-box containing protein | 0.0016 | 0.172 | 0.172 |
Brugia malayi | jmjC domain containing protein | 0.0062 | 0.8731 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.4619 | 0.4619 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.5005 | 0.5005 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.172 | 0.1116 |
Brugia malayi | jmjC domain containing protein | 0.0016 | 0.172 | 0.1138 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0.227 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.227 | 0.1813 |
Echinococcus multilocularis | jumonji domain containing 1A | 0.0016 | 0.172 | 0.1502 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0062 | 0.8731 | 0.8731 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.001 | 0.0839 | 0.0376 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0062 | 0.8854 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0.227 | 0.0771 |
Echinococcus multilocularis | JmjC domain containing protein 4 | 0.0016 | 0.172 | 0.1502 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.227 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0.227 | 0.5 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.227 | 0.2121 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.7328 | 0.7328 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.5005 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.7328 | 0.8591 |
Schistosoma mansoni | phosphatidylserine receptor | 0.0016 | 0.172 | 0.172 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.172 | 0.1116 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0016 | 0.172 | 0.1116 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.7328 | 0.7328 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.227 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0008 | 0.0531 | 0.0531 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.4619 | 0.4619 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.227 | 0.5 |
Brugia malayi | jmjC domain containing protein | 0.0016 | 0.172 | 0.1138 |
Schistosoma mansoni | jumonji domain containing protein | 0.006 | 0.8443 | 0.8443 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0062 | 0.8731 | 1 |
Brugia malayi | hypothetical protein | 0.0037 | 0.5005 | 0.529 |
Echinococcus granulosus | phd:f box containing protein | 0.0016 | 0.172 | 0.145 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.227 | 0.227 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.001 | 0.0839 | 0.039 |
Echinococcus granulosus | jumonji domain containing 1A | 0.0016 | 0.172 | 0.145 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.5005 | 1 |
Echinococcus multilocularis | Jumonji, AT rich interactive domain 1B | 0.0018 | 0.2008 | 0.1867 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.5005 | 1 |
Onchocerca volvulus | 0.0033 | 0.4331 | 0.5 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.7328 | 0.7328 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.172 | 0.1116 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.227 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.227 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.227 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.5005 | 0.5654 |
Echinococcus granulosus | Jumonji AT rich interactive domain 1B | 0.0018 | 0.2008 | 0.1801 |
Echinococcus multilocularis | phd:f box containing protein | 0.0016 | 0.172 | 0.1502 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.7328 | 0.8227 |
Echinococcus multilocularis | cpg binding protein | 0.0035 | 0.4619 | 0.5167 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.4331 | 0.4331 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.7328 | 0.8222 |
Schistosoma mansoni | protein phosphatase 2C | 0.0016 | 0.172 | 0.172 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.227 | 0.2198 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.227 | 0.1834 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.5005 | 0.5456 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.227 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.