Detailed information for compound 652549

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 459.598 | Formula: C25H33NO5S
  • H donors: 1 H acceptors: 2 LogP: 3.69 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCSCCOC(=C1C(=NC2=C(C1c1ccc(cc1OC)OC)C(=O)CC(C2)(C)C)C)O
  • InChi: 1S/C25H33NO5S/c1-7-32-11-10-31-24(28)21-15(2)26-18-13-25(3,4)14-19(27)23(18)22(21)17-9-8-16(29-5)12-20(17)30-6/h8-9,12,22,28H,7,10-11,13-14H2,1-6H3
  • InChiKey: IGPKRSKEYOYYNN-UHFFFAOYSA-N  


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Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0052 0.0364 0.1775
Loa Loa (eye worm) hypothetical protein 0.0039 0.0242 0.1178
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0044 0.0081
Loa Loa (eye worm) MH2 domain-containing protein 0.0128 0.1084 0.5277
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0015 0.0023 0.0004
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0044 0.0081
Entamoeba histolytica hypothetical protein 0.0388 0.3516 1
Plasmodium vivax glutathione reductase, putative 0.0051 0.0353 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0115 0.096 0.6983
Trichomonas vaginalis set domain proteins, putative 0.0264 0.2353 1
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0044 0.066
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0015 0.0023 0.0148
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0052 0.0364 0.3233
Loa Loa (eye worm) hypothetical protein 0.0027 0.0134 0.065
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0015 0.0023 0.0002
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.0109
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0015 0.0023 0.0004
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0138 0.0673
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0015 0.0023 0.0004
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.0353 0.256
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0038 0.0234 0.114
Mycobacterium tuberculosis Probable dehydrogenase 0.0115 0.096 0.6983
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0015 0.0023 0.0004
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.006 0.0141
Loa Loa (eye worm) oxidoreductase 0.0015 0.0022 0.0109
Loa Loa (eye worm) hypothetical protein 0.0106 0.0875 0.4262
Schistosoma mansoni hypothetical protein 0.0034 0.0195 0.0494
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0306 0.0813
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0015 0.0022 0.0018
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0015 0.0023 0.0148
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0015 0.0023 0.0148
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0015 0.0022 0.0144
Plasmodium vivax SET domain protein, putative 0.0033 0.0192 0.5119
Entamoeba histolytica hypothetical protein 0.0388 0.3516 1
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0015 0.0023 0.0004
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.0044 0.0162
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0195 0.0553
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0015 0.0022 0.0018
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0303 0.2715 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0195 0.019
Loa Loa (eye worm) hypothetical protein 0.0039 0.0242 0.1178
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0015 0.0023 0.0002
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0364 0.1035
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0044 0.0081
Leishmania major cytochrome p450-like protein 0.0015 0.0023 0.0002
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0015 0.0023 0.0004
Brugia malayi Cytochrome P450 family protein 0.0025 0.0111 0.0314
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0015 0.0022 0.0144
Mycobacterium leprae Conserved hypothetical protein 0.0015 0.0023 0.0005
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0279 0.0952
Loa Loa (eye worm) hypothetical protein 0.0052 0.0364 0.1775
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0111 0.033
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0306 0.0302
Schistosoma mansoni hypothetical protein 0.0034 0.0195 0.0494
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0044 0.0304
Mycobacterium tuberculosis Probable oxidoreductase 0.0128 0.108 0.7862
Entamoeba histolytica acyl-CoA synthetase, putative 0.0052 0.0364 0.0979
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0192 0.0485
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0015 0.0023 0.0148
Leishmania major trypanothione reductase 0.0051 0.0353 0.123
Brugia malayi Cytochrome P450 family protein 0.0015 0.0023 0.0063
Plasmodium falciparum thioredoxin reductase 0.0051 0.0353 1
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0015 0.0023 0.0004
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.056 0.1592
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0044 0.066
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0015 0.0022 0.0062
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0015 0.0023 0.0148
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0306 0.0302
Echinococcus granulosus lamin 0.0028 0.0138 0.0134
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0044 0.0081
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0364 0.2531
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.0364 0.127
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0111 0.0541
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0015 0.0023 0.0004
Schistosoma mansoni cellular tumor antigen P53 0.0158 0.1361 0.3833
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0364 0.2639
Schistosoma mansoni lamin 0.0028 0.0138 0.0332
Loa Loa (eye worm) transcription factor SMAD2 0.0128 0.1084 0.5277
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0052 0.0364 0.2639
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0192 0.0187
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.006 1
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0015 0.0023 0.0148
Entamoeba histolytica hypothetical protein 0.0388 0.3516 1
Onchocerca volvulus 0.0158 0.1361 0.5744
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0022 0.0062
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0279 0.0952
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0111 0.0541
Echinococcus multilocularis musashi 0.0028 0.0138 0.0134
Plasmodium falciparum glutathione reductase 0.0018 0.0044 0.066
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0052 0.0364 0.2531
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.006 0.1143
Echinococcus granulosus cytochrome P450 2K1 0.0015 0.0023 0.0018
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0195 0.019
Plasmodium falciparum glutathione reductase 0.0051 0.0353 1
Toxoplasma gondii cytochrome p450 superfamily protein 0.0015 0.0023 0.0016
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.0875 0.4262
Loa Loa (eye worm) hypothetical protein 0.0033 0.0192 0.0934
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0111 0.033
Schistosoma mansoni ap endonuclease 0.0019 0.006 0.0108
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0015 0.0023 0.0148
Plasmodium falciparum acyl-CoA synthetase 0.0039 0.0242 0.6632
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0128 0.108 0.7862
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0022 0.0062
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0044 0.0081
Mycobacterium ulcerans hypothetical protein 0.0052 0.0364 0.2531
Loa Loa (eye worm) hypothetical protein 0.0028 0.0138 0.0673
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0044 0.0081
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0015 0.0023 0.0004
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0015 0.0023 0.0004
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0222 0.1602
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.006 0.0141
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.006 0.0108
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0044 0.0094
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0195 0.095
Leishmania major cytochrome p450-like protein 0.0015 0.0023 0.0002
Mycobacterium tuberculosis Conserved hypothetical protein 0.0159 0.1373 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0115 0.096 0.6983
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0022 0.0062
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0022 0.0062
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0044 0.0081
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.006 0.028
Echinococcus multilocularis lamin 0.0028 0.0138 0.0134
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0353 0.123
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0044 0.0094
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0195 0.019
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0015 0.0022 0.0144
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0364 0.2531
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0015 0.0023 0.0004
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0018 0.009
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0015 0.0022 0.0144
Schistosoma mansoni rotamase 0.0038 0.0234 0.0606
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0044 0.066
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0015 0.0023 0.0002
Echinococcus multilocularis tumor protein p63 0.108 1 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0025 0.0111 0.0657
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0022 0.0144
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0044 0.0081
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0015 0.0023 0.0148
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0022 0.0109
Loa Loa (eye worm) hypothetical protein 0.0034 0.0195 0.095
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0353 0.1722
Brugia malayi intermediate filament protein 0.0028 0.0138 0.0392
Mycobacterium tuberculosis Probable reductase 0.0115 0.096 0.6983
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0022 0.0144
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0052 0.0364 0.2531
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0303 0.2715 1
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0364 0.1035
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.0044 0.0162
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0234 0.0908
Echinococcus multilocularis expressed protein 0.0038 0.0234 0.0229
Brugia malayi cytochrome P450 0.0015 0.0023 0.0063
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0044 0.0081
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0018 0.0051
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0044 0.0039
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0015 0.0023 0.0004
Schistosoma mansoni cytochrome P450 0.0015 0.0023 0.0001
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0015 0.0023 0.0004
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0015 0.0022 0.0144
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0306 0.0813
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0364 0.1035
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0128 0.108 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0052 0.0364 0.2531
Schistosoma mansoni hypothetical protein 0.0073 0.056 0.154
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0023 0.0002
Brugia malayi glutathione reductase 0.0051 0.0353 0.1004
Brugia malayi Thioredoxin reductase 0.0051 0.0353 0.1004
Schistosoma mansoni hypothetical protein 0.0034 0.0195 0.0494
Toxoplasma gondii thioredoxin reductase 0.0051 0.0353 1
Loa Loa (eye worm) CYP4Cod1 0.0025 0.0111 0.0541
Brugia malayi Pre-SET motif family protein 0.0232 0.2053 0.5839
Schistosoma mansoni ap endonuclease 0.0019 0.006 0.0108
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.0109
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0015 0.0023 0.0004
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.1222 0.4455
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0015 0.0022 0.0144
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.0364 0.127
Echinococcus multilocularis lamin dm0 0.0028 0.0138 0.0134
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0222 0.1602
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0128 0.108 0.7862
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0052 0.0364 0.3233
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0222 0.1602
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0115 0.096 0.6983
Toxoplasma gondii exonuclease III APE 0.0019 0.006 0.1143
Echinococcus granulosus intermediate filament protein 0.0028 0.0138 0.0134
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0195 0.019
Mycobacterium leprae putative cytochrome p450 0.0015 0.0023 0.0005
Echinococcus granulosus expressed protein 0.0038 0.0234 0.0229
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0279 0.0952
Mycobacterium ulcerans hypothetical protein 0.0159 0.1373 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0353 0.0349
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0195 0.0553
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0138 0.0673
Echinococcus multilocularis 0.0015 0.0023 0.0018
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.0875 0.2488
Trypanosoma brucei cytochrome P450, putative 0.0025 0.0111 0.033
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0044 0.0081
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0044 0.0081
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0306 0.0869
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0039 0.0242 0.1625
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0023
Loa Loa (eye worm) hypothetical protein 0.0039 0.0242 0.1178
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0037 0.0226 0.0755
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.0353 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0044 0.0081
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0044 0.0081
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0015 0.0023 0.0148
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0015 0.0023 0.0148
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0023 0.0002
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0022 0.0109
Echinococcus multilocularis GPCR, family 2 0.0034 0.0195 0.019
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.006 0.0141
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0015 0.0023 0.0148
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.1222 0.4455
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0366 0.1276
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0015 0.0023 0.0004
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0015 0.0023 0.0004
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.0875 0.2488
Loa Loa (eye worm) cytochrome P450 family protein 0.0056 0.0407 0.1985
Trypanosoma brucei trypanothione reductase 0.0051 0.0353 0.123
Toxoplasma gondii peptidylprolyl isomerase 0.0037 0.0226 0.6141
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0279 0.0952
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0037 0.0226 0.0755
Brugia malayi Cytochrome P450 family protein 0.0056 0.0407 0.1157
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.006 0.0293
Entamoeba histolytica acyl-CoA synthetase, putative 0.0052 0.0364 0.0979
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0138 0.0392
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0015 0.0023 0.0148
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0115 0.096 0.6983
Onchocerca volvulus 0.0033 0.0192 0.0727
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.006 0.0162
Leishmania major mitochondrial DNA polymerase beta 0.0303 0.2715 1
Trichomonas vaginalis rotamase, putative 0.0037 0.0226 0.0872
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0015 0.0023 0.0148
Entamoeba histolytica acyl-coA synthetase, putative 0.0052 0.0364 0.0979
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0192 0.0187
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0015 0.0023 0.0004
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0115 0.096 0.8861
Loa Loa (eye worm) cytochrome P450 0.0015 0.0023 0.0111
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0037 0.0226 0.0755
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.0364 0.127
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0192 0.5119
Schistosoma mansoni transcription factor LCR-F1 0.0388 0.3516 1
Plasmodium falciparum thioredoxin reductase 0.0018 0.0044 0.066
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0192 0.0485
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.006 0.042
Leishmania major cytochrome p450-like protein 0.0025 0.0111 0.033
Schistosoma mansoni hypothetical protein 0.0034 0.0195 0.0494
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0044 0.0124
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.0044 0.0162
Echinococcus granulosus GPCR family 2 0.0034 0.0195 0.019
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0044 0.0081
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0306 0.0302
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0388 0.3516 0.3513
Toxoplasma gondii hypothetical protein 0.0049 0.0337 0.9515
Loa Loa (eye worm) hypothetical protein 0.0039 0.0242 0.1178
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0015 0.0023 0.0148
Loa Loa (eye worm) hypothetical protein 0.0158 0.1361 0.663
Onchocerca volvulus 0.0028 0.0138 0.0497
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0303 0.2715 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.006 0.0055
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.1222 0.4455
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0192 0.0485
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0044 0.066
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.006 0.0141
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.006 0.0162
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0052 0.0364 0.2531
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0022 0.0144
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0039 0.0242 0.1746
Loa Loa (eye worm) glutathione reductase 0.0051 0.0353 0.1722
Onchocerca volvulus 0.0264 0.2353 1
Entamoeba histolytica hypothetical protein 0.0388 0.3516 1
Schistosoma mansoni hypothetical protein 0.0015 0.0023 0.0001
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0037 0.0226 0.0582
Loa Loa (eye worm) hypothetical protein 0.0052 0.0364 0.1775
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0037 0.0226 0.0755
Brugia malayi hypothetical protein 0.0388 0.3516 1
Trichomonas vaginalis rotamase, putative 0.0038 0.0234 0.0908
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.006 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0306 0.0302
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0306 0.1492
Onchocerca volvulus 0.0028 0.0138 0.0497
Brugia malayi MH2 domain containing protein 0.0128 0.1084 0.3081
Brugia malayi Pre-SET motif family protein 0.0033 0.0192 0.0544
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0306 0.0813
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0015 0.0023 0.0148
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.006 0.0055
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0015 0.0023 0.0148
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0015 0.0023 0.0148
Brugia malayi Cytochrome P450 family protein 0.0025 0.0111 0.0314
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0015 0.0023 0.0004
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0192 0.0187
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0044 0.066
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0353 0.0349
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0044 0.0081
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0022 0.0144
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0015 0.0023 0.0148
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0015 0.0023 0.0004
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0044 0.0063
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0015 0.0023 0.0148
Loa Loa (eye worm) hypothetical protein 0.0073 0.056 0.2729
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0388 0.3516 0.3513
Echinococcus granulosus lamin dm0 0.0028 0.0138 0.0134
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.006 0.0169
Loa Loa (eye worm) hypothetical protein 0.0039 0.0242 0.1178
Schistosoma mansoni intermediate filament proteins 0.0028 0.0138 0.0332
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0022 0.0062
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0044 0.066
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0044 0.0039
Schistosoma mansoni hypothetical protein 0.0388 0.3516 1
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0015 0.0023 0.0148
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0232 0.2053 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.006 0.1143
Onchocerca volvulus 0.0052 0.0364 0.1467
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0044 0.0081
Plasmodium vivax acyl-CoA synthetase, putative 0.0039 0.0242 0.6632
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.006 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0222 0.1602
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.018 0.0176
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0039 0.0242 1
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0038 0.0234 0.0664
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0015 0.0023 0.0004
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0015 0.0022 0.0144
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0192 0.0485
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0364 0.2531
Schistosoma mansoni lamin 0.0028 0.0138 0.0332
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0044 0.0081

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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