TDR Targets

Basic information

Technical information

TDR Targets ID: 652585
Name: 4-(2-chloro-5-nitrophenyl)-3,4-dihydro-1H-ben zo[h]quinolin-2-one
MW: 352.771 | Formula: C19H13ClN2O3
H donors: 1 H acceptors: 3 LogP: 4.23 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: O=C1CC(c2cc(ccc2Cl)[N+](=O)[O-])c2c(N1)c1ccccc1cc2
InChi: 1S/C19H13ClN2O3/c20-17-8-6-12(22(24)25)9-16(17)15-10-18(23)21-19-13-4-2-1-3-11(13)5-7-14(15)19/h1-9,15H,10H2,(H,21,23)
InChiKey: CBYXPVWJTRRFKY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-(2-chloro-5-nitro-phenyl)-3,4-dihydro-1H-benzo[h]quinolin-2-one
ST017102
Oprea1_149545
EU-0070389

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	ataxin-2 like protein, putative	0.003	0.034	0.7217
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.034	0.7217
Loa Loa (eye worm)	hypothetical protein	0.0241	0.6306	0.6306
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0241	0.6306	0.6306
Brugia malayi	Nuclear hormone receptor-like 1	0.0236	0.6172	0.9787
Brugia malayi	steroid hormone receptor	0.0241	0.6306	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.034	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0241	0.6306	0.6306
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0241	0.6306	0.6306
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0058	0.1127	0.1127
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0241	0.6306	1
Schistosoma mansoni	thyroid hormone receptor	0.0241	0.6306	0.6306
Loa Loa (eye worm)	hypothetical protein	0.0236	0.6172	0.6172
Schistosoma mansoni	ran	0.0026	0.0204	0.0204
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0019	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0236	0.6172	0.6172
Loa Loa (eye worm)	hypothetical protein	0.003	0.034	0.034
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0236	0.6172	0.6172
Toxoplasma gondii	HEAT repeat-containing protein	0.0035	0.0464	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0241	0.6306	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.0241	0.6306	1
Loa Loa (eye worm)	hypothetical protein	0.0236	0.6172	0.6172
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0026	0.0204	0.416
Brugia malayi	Isocitrate dehydrogenase	0.0019	0.0019	0.0029
Brugia malayi	nuclear receptor NHR-88	0.0241	0.6306	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0241	0.6306	1
Loa Loa (eye worm)	hypothetical protein	0.0241	0.6306	0.6306
Brugia malayi	ecdysteroid receptor	0.0241	0.6306	1
Loa Loa (eye worm)	hypothetical protein	0.0241	0.6306	0.6306
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0028	0.0278	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0241	0.6306	0.6306
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0241	0.6306	1
Trypanosoma brucei	importin beta-1 subunit, putative	0.0035	0.0464	1
Brugia malayi	RNA, U transporter 1	0.0099	0.2281	0.3617
Schistosoma mansoni	coup transcription factor	0.0241	0.6306	0.6306
Schistosoma mansoni	retinoic acid receptor RXR	0.0241	0.6306	0.6306
Brugia malayi	Steroid receptor seven-up type 2	0.0241	0.6306	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0464	0.0464
Onchocerca volvulus	Bile acid receptor homolog	0.0241	0.6306	1
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0019	0.0019	0.0019
Echinococcus multilocularis	FTZ F1 alpha	0.0241	0.6306	0.6306
Echinococcus multilocularis	isocitrate dehydrogenase	0.0019	0.0019	0.0019
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0058	0.1127	0.1787
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0026	0.0204	0.416
Plasmodium falciparum	importin beta, putative	0.0035	0.0464	1
Schistosoma mansoni	nuclear hormone receptor	0.0241	0.6306	0.6306
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0026	0.0204	0.0204
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0241	0.6306	0.6306
Brugia malayi	nuclear receptor RXR	0.0236	0.6172	0.9787
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0019	0.0019	0.5
Loa Loa (eye worm)	hypothetical protein	0.0182	0.4643	0.4643
Trypanosoma brucei	importin beta-1 subunit, putative	0.0035	0.0464	1
Echinococcus multilocularis	snurportin 1	0.0372	1	1
Loa Loa (eye worm)	hypothetical protein	0.0241	0.6306	0.6306
Brugia malayi	MH2 domain containing protein	0.0144	0.3559	0.5644
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0241	0.6306	0.6306
Trypanosoma brucei	PAB1-binding protein , putative	0.003	0.034	0.7217
Schistosoma mansoni	hypothetical protein	0.0372	1	1
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0026	0.0204	0.416
Leishmania major	importin beta-1 subunit, putative	0.0028	0.0278	0.806
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0372	1	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.034	1
Loa Loa (eye worm)	hypothetical protein	0.0058	0.1127	0.1127
Loa Loa (eye worm)	steroid hormone receptor	0.0241	0.6306	0.6306
Schistosoma mansoni	importin beta-1	0.0035	0.0464	0.0464
Brugia malayi	hypothetical protein	0.002	0.0035	0.0055
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0241	0.6306	1
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0028	0.0278	1
Brugia malayi	hypothetical protein	0.0236	0.6172	0.9787
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0241	0.6306	1
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0026	0.0204	0.5764
Brugia malayi	Nuclear hormone receptor-like 1	0.0241	0.6306	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0241	0.6306	0.6306
Schistosoma mansoni	RAR-like nuclear receptor	0.0241	0.6306	0.6306
Brugia malayi	hypothetical protein	0.0236	0.6172	0.9787
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0058	0.1127	0.1787
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0241	0.6306	0.6306
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0241	0.6306	1
Schistosoma mansoni	hypothetical protein	0.004	0.0605	0.0605
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0241	0.6306	0.6306
Brugia malayi	hypothetical protein	0.0182	0.4643	0.7363
Loa Loa (eye worm)	hypothetical protein	0.0236	0.6172	0.6172
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0241	0.6306	1
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0019	0.0019	0.0019
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0241	0.6306	0.6306
Echinococcus multilocularis	importin subunit beta 1	0.0035	0.0464	0.0464
Trichomonas vaginalis	importin beta-1, putative	0.0028	0.0278	1
Entamoeba histolytica	hypothetical protein	0.0028	0.0278	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0241	0.6306	0.6306
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0236	0.6172	0.6172
Loa Loa (eye worm)	hypothetical protein	0.0241	0.6306	0.6306
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0026	0.0204	0.0204
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0241	0.6306	0.6306
Schistosoma mansoni	ran	0.0026	0.0204	0.0204
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0241	0.6306	0.6306
Brugia malayi	hypothetical protein	0.003	0.034	0.0539
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0019	0.0019	0.0019
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0241	0.6306	0.6306
Brugia malayi	photoreceptor-specific nuclear receptor	0.0241	0.6306	1
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0028	0.0278	0.806
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0241	0.6306	0.6306
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0241	0.6306	0.6306
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0241	0.6306	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0241	0.6306	0.6306
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0019	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0241	0.6306	0.6306
Loa Loa (eye worm)	hypothetical protein	0.0236	0.6172	0.6172
Brugia malayi	nuclear hormone receptor	0.0241	0.6306	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0241	0.6306	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0241	0.6306	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0241	0.6306	0.6306
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0019	0.0019	0.0019
Onchocerca volvulus		0.0241	0.6306	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0241	0.6306	0.6306
Loa Loa (eye worm)	hypothetical protein	0.004	0.0605	0.0605
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0026	0.0204	0.416
Loa Loa (eye worm)	hypothetical protein	0.0241	0.6306	0.6306
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0019	0.0019	0.0019
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0241	0.6306	0.6306
Leishmania major	hypothetical protein, conserved	0.003	0.034	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0241	0.6306	1
Brugia malayi	isocitrate dehydrogenase	0.0019	0.0019	0.0029
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0241	0.6306	0.6306
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0026	0.0204	0.0204
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0236	0.6172	0.6172
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0236	0.6172	0.6172
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0241	0.6306	0.6306
Brugia malayi	latrophilin 2 splice variant baaae	0.004	0.0605	0.096
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0241	0.6306	0.6306
Brugia malayi	Importin beta-1 subunit	0.0035	0.0464	0.0736
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0241	0.6306	1
Echinococcus granulosus	FTZ F1 alpha	0.0241	0.6306	0.6306
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0236	0.6172	0.6172
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0026	0.0204	0.5764
Loa Loa (eye worm)	hypothetical protein	0.0241	0.6306	0.6306
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0241	0.6306	0.6306
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0241	0.6306	0.6306
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0241	0.6306	0.6306
Schistosoma mansoni	thyroid hormone receptor	0.0241	0.6306	0.6306
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0241	0.6306	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.034	0.7217
Brugia malayi	Nuclear hormone receptor-like 1	0.0236	0.6172	0.9787
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0026	0.0204	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0241	0.6306	0.6306
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.3559	0.3559
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0241	0.6306	0.6306
Toxoplasma gondii	LsmAD domain-containing protein	0.003	0.034	0.7217
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0241	0.6306	0.6306
Leishmania major	GTP-binding protein, putative	0.0026	0.0204	0.5764
Echinococcus granulosus	importin subunit beta 1	0.0035	0.0464	0.0464
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.3559	0.3559
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0026	0.0204	0.0323
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0241	0.6306	0.6306
Plasmodium vivax	importin-beta 2, putative	0.0035	0.0464	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 652585