Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0015 | 0.0006 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0017 | 0.052 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0015 | 0.0006 | 0.0122 |
Trypanosoma brucei | cytochrome P450, putative | 0.0026 | 0.2696 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.8374 | 0.8374 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0017 | 0.052 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0017 | 0.052 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0026 | 0.2696 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0026 | 0.2696 | 0.2696 |
Brugia malayi | Isocitrate dehydrogenase | 0.0015 | 0.0006 | 0.0006 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0017 | 0.052 | 0.1909 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0015 | 0.0006 | 0.0122 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0017 | 0.052 | 1 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0017 | 0.052 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0017 | 0.052 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0017 | 0.052 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0026 | 0.2696 | 1 |
Trypanosoma brucei | Lanosterol 14-alpha demethylase | 0.0017 | 0.052 | 0.1909 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.8374 | 0.8374 |
Brugia malayi | Cytochrome P450 family protein | 0.0026 | 0.2696 | 0.2696 |
Echinococcus multilocularis | 0.0017 | 0.052 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.052 | 0.1156 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0026 | 0.2696 | 1 |
Schistosoma mansoni | cytochrome P450 | 0.0017 | 0.052 | 0.1156 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0015 | 0.0006 | 0.0122 |
Brugia malayi | cytochrome P450 | 0.0017 | 0.052 | 0.052 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0026 | 0.2696 | 0.2696 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0015 | 0.0006 | 0.0122 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.8374 | 0.8374 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0026 | 0.2696 | 0.2696 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.4498 | 1 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0017 | 0.052 | 0.1909 |
Leishmania major | cytochrome p450-like protein | 0.0017 | 0.052 | 0.1909 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0017 | 0.052 | 1 |
Mycobacterium leprae | putative cytochrome p450 | 0.0017 | 0.052 | 0.5 |
Leishmania major | lanosterol 14-alpha-demethylase, putative | 0.0017 | 0.052 | 0.1909 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0017 | 0.052 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.4498 | 0.4498 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0017 | 0.052 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0026 | 0.2696 | 0.2696 |
Loa Loa (eye worm) | cytochrome P450 | 0.0017 | 0.052 | 0.052 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0055 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0017 | 0.052 | 1 |
Trypanosoma cruzi | cytochrome p450-like protein, putative | 0.0017 | 0.052 | 0.1909 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0017 | 0.052 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0015 | 0.0006 | 0.0122 |
Brugia malayi | Cytochrome P450 family protein | 0.0017 | 0.052 | 0.052 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0017 | 0.052 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0017 | 0.052 | 1 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0015 | 0.0006 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0017 | 0.052 | 1 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0017 | 0.052 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0017 | 0.052 | 0.5 |
Brugia malayi | isocitrate dehydrogenase | 0.0015 | 0.0006 | 0.0006 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0015 | 0.0006 | 0.0014 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.4498 | 0.4498 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0017 | 0.052 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0017 | 0.052 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0017 | 0.052 | 0.1909 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.8374 | 0.8374 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0026 | 0.2696 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0017 | 0.052 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0017 | 0.052 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0015 | 0.0006 | 0.0122 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0015 | 0.0006 | 0.0006 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0017 | 0.052 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0017 | 0.052 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.