Detailed information for compound 652845

Basic information

Technical information
  • TDR Targets ID: 652845
  • Name: 2-(4-methoxyphenyl)-6-methylchromen-4-one
  • MW: 266.291 | Formula: C17H14O3
  • H donors: 0 H acceptors: 1 LogP: 3.52 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1cc(=O)c2c(o1)ccc(c2)C
  • InChi: 1S/C17H14O3/c1-11-3-8-16-14(9-11)15(18)10-17(20-16)12-4-6-13(19-2)7-5-12/h3-10H,1-2H3
  • InChiKey: YTSXWTNKPYQBGN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(4-methoxyphenyl)-6-methyl-chromen-4-one
  • 2-(4-methoxyphenyl)-6-methyl-4-chromenone
  • 2-(4-methoxyphenyl)-6-methyl-chromone
  • ST056229
  • Oprea1_385050
  • ZINC00057693

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens potassium voltage-gated channel, shaker-related subfamily, member 5 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit Get druggable targets OG5_127659 All targets in OG5_127659
Schistosoma japonicum ko:K04876 potassium voltage-gated channel, Shaker-related subfamily A, member, putative Get druggable targets OG5_127659 All targets in OG5_127659
Schistosoma japonicum Potassium voltage-gated channel protein Shaker, putative Get druggable targets OG5_127659 All targets in OG5_127659
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127659 All targets in OG5_127659
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_127659 All targets in OG5_127659
Echinococcus multilocularis potassium voltage gated channel protein Get druggable targets OG5_127659 All targets in OG5_127659
Echinococcus granulosus potassium voltage gated channel protein Get druggable targets OG5_127659 All targets in OG5_127659
Echinococcus multilocularis potassium voltage gated channel subfamily A Get druggable targets OG5_127659 All targets in OG5_127659
Schistosoma japonicum Potassium voltage-gated channel subfamily A member 5, putative Get druggable targets OG5_127659 All targets in OG5_127659
Echinococcus granulosus potassium voltage gated channel subfamily A Get druggable targets OG5_127659 All targets in OG5_127659
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_127659 All targets in OG5_127659
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis voltage gated potassium channel potassium voltage-gated channel, shaker-related subfamily, member 5 613 aa 521 aa 34.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum thioredoxin reductase 0.005 0.0801 1
Toxoplasma gondii thioredoxin reductase 0.005 0.0801 0.3528
Trichomonas vaginalis esterase, putative 0.004 0.0595 0.0569
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0114 0.212 0.4178
Loa Loa (eye worm) bromodomain containing protein 0.0038 0.0562 0.0641
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0128 0.0101
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0428 0.0489
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0294 0.1132
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0294 0.1216
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0051 0.0818 0.0895
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0294 0.0305
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0294 0.0305
Brugia malayi PHD-finger family protein 0.0056 0.0924 0.1026
Trichomonas vaginalis inositol monophosphatase, putative 0.0119 0.2219 0.2197
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0595 0.1133
Echinococcus multilocularis cpg binding protein 0.0038 0.0551 0.0581
Entamoeba histolytica hypothetical protein 0.0075 0.1322 0.5909
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0595 0.0569
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0114 0.212 0.4178
Echinococcus granulosus potassium voltage gated channel protein 0.0104 0.1906 0.2069
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0119 0.2219 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0128 0.0458
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0128 0.0458
Mycobacterium tuberculosis Probable oxidoreductase 0.0127 0.2382 0.4702
Plasmodium falciparum glutathione reductase 0.005 0.0801 1
Plasmodium vivax SET domain protein, putative 0.0063 0.1073 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0595 0.0679
Echinococcus multilocularis lamin dm0 0.0029 0.0366 0.0378
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0595 0.0629
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0128 0.0458
Toxoplasma gondii ABC1 family protein 0.004 0.0595 0.2589
Echinococcus granulosus zinc finger protein 0.0044 0.0685 0.0728
Loa Loa (eye worm) hypothetical protein 0.0029 0.0366 0.0418
Mycobacterium tuberculosis Conserved protein 0.004 0.0595 0.1133
Echinococcus multilocularis survival motor neuron protein 1 0.0245 0.4819 0.5267
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0119 0.2219 0.2197
Loa Loa (eye worm) hypothetical protein 0.004 0.0595 0.0679
Brugia malayi Bromodomain containing protein 0.0083 0.1485 0.1669
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0595 0.1133
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0104 0.1906 0.2151
Entamoeba histolytica hypothetical protein 0.0075 0.1322 0.5909
Mycobacterium leprae Probable lipase LipE 0.004 0.0595 0.241
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.009 0.0071
Echinococcus granulosus intermediate filament protein 0.0029 0.0366 0.0378
Brugia malayi beta-lactamase family protein 0.004 0.0595 0.065
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.1322 0.1428
Schistosoma mansoni hypothetical protein 0.0455 0.9131 1
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0366 0.0418
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0595 0.1133
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0162 1
Schistosoma mansoni cpg binding protein 0.0032 0.0428 0.0469
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0119 0.2219 1
Onchocerca volvulus 0.004 0.0595 0.0569
Echinococcus multilocularis inositol monophosphatase 0.0012 0.0028 0.0006
Mycobacterium ulcerans lipase LipD 0.004 0.0595 0.2589
Echinococcus granulosus lamin 0.0029 0.0366 0.0378
Loa Loa (eye worm) hypothetical protein 0.0014 0.0058 0.0066
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0128 0.0458
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0128 0.0458
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0128 0.0458
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0106 0.1962 0.8219
Mycobacterium tuberculosis Conserved protein 0.004 0.0595 0.1133
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0114 0.212 0.4178
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.1073 0.1154
Brugia malayi glutathione reductase 0.005 0.0801 0.0885
Onchocerca volvulus 0.004 0.0595 0.0569
Schistosoma mansoni inositol monophosphatase 0.0119 0.2219 0.243
Schistosoma mansoni voltage-gated potassium channel 0.0104 0.1906 0.2087
Loa Loa (eye worm) hypothetical protein 0.0053 0.0862 0.0984
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0128 0.0458
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0256 0.5035 1
Loa Loa (eye worm) hypothetical protein 0.0154 0.2937 0.3352
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0595 0.0569
Loa Loa (eye worm) hypothetical protein 0.0095 0.1717 0.1961
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.01 0.1836 0.2011
Onchocerca volvulus 0.005 0.0801 0.0775
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0801 0.712
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0037 0.0534 0.0563
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0595 0.0652
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0595 0.0569
Echinococcus granulosus dnaJ subfamily B 0.0455 0.9131 1
Schistosoma mansoni intermediate filament proteins 0.0029 0.0366 0.0401
Schistosoma mansoni survival motor neuron protein 0.005 0.0801 0.0877
Trypanosoma brucei trypanothione reductase 0.005 0.0801 0.3528
Echinococcus granulosus fetal alzheimer antigen falz 0.0051 0.0818 0.0874
Echinococcus multilocularis dnaJ subfamily B 0.0455 0.9131 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0534 0.0585
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0127 0.2382 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0128 0.0116
Loa Loa (eye worm) hypothetical protein 0.004 0.0595 0.0679
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0294 0.1216
Mycobacterium ulcerans beta-lactamase 0.004 0.0595 0.2589
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0294 0.1216
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0294 0.0532
Plasmodium vivax glutathione reductase, putative 0.005 0.0801 0.712
Plasmodium vivax hypothetical protein, conserved 0.004 0.0595 0.4943
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0294 0.1216
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0294 0.1216
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0294 0.1216
Loa Loa (eye worm) hypothetical protein 0.0028 0.0355 0.0405
Loa Loa (eye worm) hypothetical protein 0.0245 0.4819 0.5502
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0119 0.2219 0.2197
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0801 0.3528
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0595 0.065
Brugia malayi intermediate filament protein 0.0029 0.0366 0.0388
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0595 0.1133
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0294 0.0532
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0128 0.0458
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0294 0.1216
Echinococcus granulosus survival motor neuron protein 1 0.0245 0.4819 0.5267
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0132 0.2481 0.27
Entamoeba histolytica hypothetical protein 0.0075 0.1322 0.5909
Onchocerca volvulus 0.0029 0.0366 0.0339
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0294 0.1216
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0595 0.2589
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0033 0.0006
Brugia malayi beta-lactamase family protein 0.004 0.0595 0.065
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.01 0.1836 0.2011
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0141 0.0226
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0801 0.0855
Schistosoma mansoni zinc finger protein 0.0044 0.0685 0.075
Brugia malayi CXXC zinc finger family protein 0.0032 0.0428 0.0459
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0128 0.7465
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0595 0.1133
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0141 0.0226
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0801 0.0855
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0119 0.2219 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0595 0.0652
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0128 0.014
Echinococcus granulosus inositol monophosphatase 0.0012 0.0028 0.0006
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0366 0.0388
Schistosoma mansoni zinc finger protein 0.0033 0.0456 0.0499
Brugia malayi Pre-SET motif family protein 0.0437 0.876 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0294 0.1216
Schistosoma mansoni cpg binding protein 0.0038 0.0551 0.0604
Loa Loa (eye worm) PHD-finger family protein 0.0045 0.0695 0.0793
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0162 0.0613
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.1073 0.1175
Loa Loa (eye worm) hypothetical protein 0.0019 0.0162 0.0185
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0128 0.0115
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0114 0.212 0.4178
Schistosoma mansoni pap-inositol-14-phosphatase 0.0012 0.0028 0.003
Mycobacterium tuberculosis Probable reductase 0.0114 0.212 0.4178
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0595 0.0569
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0051 0.0818 0.0874
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0119 0.2219 1
Onchocerca volvulus 0.004 0.0595 0.0569
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0294 0.1216
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0437 0.876 1
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0128 0.0458
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0595 0.2589
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0128 0.0458
Mycobacterium ulcerans hypothetical protein 0.0025 0.0294 0.1216
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0128 1
Schistosoma mansoni hypothetical protein 0.0012 0.0028 0.003
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0128 0.0458
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0128 0.0458
Mycobacterium leprae conserved hypothetical protein 0.004 0.0595 0.241
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0294 0.1216
Echinococcus multilocularis inositol monophosphatase 1 0.0119 0.2219 0.2412
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0141 0.0226
Echinococcus granulosus tumor protein p63 0.0362 0.7225 0.7908
Onchocerca volvulus 0.0053 0.0862 0.0837
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0801 0.0885
Loa Loa (eye worm) hypothetical protein 0.0083 0.1489 0.1699
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0162 0.0268
Treponema pallidum NADH oxidase 0.0017 0.0128 0.5
Brugia malayi F/Y-rich N-terminus family protein 0.0016 0.0105 0.0088
Trypanosoma cruzi ISWI complex protein 0.0033 0.0456 0.1954
Schistosoma mansoni voltage-gated potassium channel 0.0104 0.1906 0.2087
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0534 0.0585
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.1073 0.1175
Loa Loa (eye worm) hypothetical protein 0.0013 0.0047 0.0054
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0119 0.2219 1
Schistosoma mansoni bromodomain containing protein 0.0139 0.2641 0.2892
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0033 0.0006
Leishmania major hypothetical protein, conserved 0.004 0.0595 0.2589
Loa Loa (eye worm) glutathione reductase 0.005 0.0801 0.0914
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.01 0.1836 0.1992
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0294 0.0305
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0128 0.0116
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0058 0.004
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0114 0.212 0.8887
Schistosoma mansoni hypothetical protein 0.0075 0.1322 0.1448
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0595 0.2589
Echinococcus multilocularis tumor protein p63 0.0362 0.7225 0.7908
Onchocerca volvulus 0.0029 0.0366 0.0339
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0366 0.0418
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.1322 0.1428
Loa Loa (eye worm) inositol-1 0.0119 0.2219 0.2533
Echinococcus granulosus methyl CpG binding domain protein 2 0.0037 0.0534 0.0563
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0119 0.2219 1
Brugia malayi hypothetical protein 0.0075 0.1322 0.1483
Mycobacterium tuberculosis Conserved protein 0.004 0.0595 0.1133
Loa Loa (eye worm) hypothetical protein 0.0104 0.1906 0.2176
Schistosoma mansoni hypothetical protein 0.0045 0.0695 0.0761
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0128 0.0458
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0128 0.0458
Loa Loa (eye worm) hypothetical protein 0.0025 0.0294 0.0336
Brugia malayi Bromodomain containing protein 0.0165 0.3166 0.3593
Loa Loa (eye worm) beta-lactamase 0.004 0.0595 0.0679
Onchocerca volvulus 0.0025 0.0294 0.0267
Onchocerca volvulus 0.0063 0.1073 0.1048
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0595 0.0679
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0128 0.0458
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0078 0.1379 0.149
Echinococcus granulosus inositol monophosphatase 1 0.0119 0.2219 0.2412
Loa Loa (eye worm) hypothetical protein 0.0012 0.0028 0.0031
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0862 0.0944
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0058 0.004
Onchocerca volvulus 0.0032 0.0428 0.0402
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0128 0.0458
Brugia malayi Thioredoxin reductase 0.005 0.0801 0.0885
Loa Loa (eye worm) hypothetical protein 0.0089 0.1594 0.182
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0801 0.1544
Trypanosoma brucei ISWI complex protein 0.0033 0.0456 0.1954
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0119 0.2219 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0047 0.0054
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0022 0.0025
Echinococcus multilocularis musashi 0.0029 0.0366 0.0378
Loa Loa (eye worm) hypothetical protein 0.0025 0.0294 0.0336
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.1011 0.1086
Brugia malayi beta-lactamase 0.004 0.0595 0.065
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0294 0.1216
Schistosoma mansoni lamin 0.0029 0.0366 0.0401
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0595 0.2589
Mycobacterium ulcerans hypothetical protein 0.004 0.0595 0.2589
Echinococcus multilocularis 3'(2'),5' bisphosphate nucleotidase 1 0.0012 0.0028 0.0006
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0128 0.0101
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0127 0.2382 0.4702
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0128 0.0458
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0162 0.036
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0595 0.0629
Trichomonas vaginalis set domain proteins, putative 0.0497 1 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0128 0.0458
Loa Loa (eye worm) hypothetical protein 0.0019 0.0162 0.0185
Loa Loa (eye worm) hypothetical protein 0.004 0.0595 0.0679
Echinococcus multilocularis potassium voltage gated channel protein 0.0104 0.1906 0.2069
Echinococcus granulosus lamin dm0 0.0029 0.0366 0.0378
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0099 0.1813 0.1966
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0128 0.02
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.009 0.0102
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0595 0.0569
Brugia malayi Pre-SET motif family protein 0.0063 0.1073 0.1197
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0127 0.2382 0.4702
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0801 0.0914
Trypanosoma cruzi ISWI complex protein 0.0033 0.0456 0.1954
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0162 0.0506
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0595 0.1133
Loa Loa (eye worm) hypothetical protein 0.0019 0.0162 0.0185
Loa Loa (eye worm) hypothetical protein 0.01 0.1836 0.2096
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0294 0.1132
Echinococcus granulosus cpg binding protein 0.0038 0.0551 0.0581
Echinococcus multilocularis lamin 0.0029 0.0366 0.0378
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0595 0.2589
Mycobacterium tuberculosis Probable dehydrogenase 0.0114 0.212 0.4178
Leishmania major trypanothione reductase 0.005 0.0801 0.3528
Loa Loa (eye worm) hypothetical protein 0.0025 0.0294 0.0336
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0119 0.2219 1
Schistosoma mansoni hypothetical protein 0.0012 0.0028 0.003
Entamoeba histolytica hypothetical protein 0.0075 0.1322 0.5909
Schistosoma mansoni hypothetical protein 0.005 0.0801 0.0877
Schistosoma mansoni inositol monophosphatase 0.0119 0.2219 0.243
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0106 0.1962 0.3864
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0078 0.1379 0.149
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0128 0.0458
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0128 0.0458
Loa Loa (eye worm) hypothetical protein 0.004 0.0595 0.0679
Schistosoma mansoni hypothetical protein 0.0033 0.0456 0.0499
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0132 0.2481 0.27
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.1322 0.1448
Schistosoma mansoni lamin 0.0029 0.0366 0.0401
Schistosoma mansoni myo inositol monophosphatase 0.0012 0.0028 0.003
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0128 0.0458
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.1212 0.1328
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.1073 0.4769
Schistosoma mansoni cpg binding protein 0.0038 0.0551 0.0604
Toxoplasma gondii histone lysine methyltransferase SET1 0.0068 0.1169 0.5211
Loa Loa (eye worm) hypothetical protein 0.004 0.0595 0.0679
Echinococcus granulosus histone lysine methyltransferase setb 0.01 0.1836 0.1992
Brugia malayi Inositol-1 0.0119 0.2219 0.2509
Loa Loa (eye worm) hypothetical protein 0.0012 0.0028 0.0031
Echinococcus granulosus 3'2'5' bisphosphate nucleotidase 1 0.0012 0.0028 0.0006
Leishmania major hypothetical protein, conserved 0.0033 0.0456 0.1954
Loa Loa (eye worm) hypothetical protein 0.0019 0.0162 0.0185
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0141 0.0226
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0128 0.0458
Loa Loa (eye worm) hypothetical protein 0.0019 0.0162 0.0185
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0104 0.1906 0.2069
Brugia malayi hypothetical protein 0.0245 0.4819 0.5487
Echinococcus multilocularis zinc finger protein 0.0044 0.0685 0.0728
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0595 0.1133
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0294 0.1216

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 73 % Inhibition of recombinant human CK2 using RRRDDDSDDD as substrate assessed as residual activity at 10 uM after 20 mins by beta counting analysis in presence of [gamma-labeled 32P]ATP relative to control ChEMBL. 24011954
IC50 (binding) = 13.7 uM Inhibition of human Kv1 PATENT. No reference
IC50 (binding) > 30 uM Inhibition of recombinant human CK2 using RRRDDDSDDD as substrate after 20 mins by beta counting analysis in presence of [gamma-labeled 32P]ATP ChEMBL. 24011954

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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