Detailed information for compound 652904

Basic information

Technical information
  • TDR Targets ID: 652904
  • Name: 4-(2,2-dimethylpropanoylamino)-N-(oxolan-2-yl methyl)benzamide
  • MW: 304.384 | Formula: C17H24N2O3
  • H donors: 2 H acceptors: 2 LogP: 2.18 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(C)(C)C)Nc1ccc(cc1)C(=O)NCC1CCCO1
  • InChi: 1S/C17H24N2O3/c1-17(2,3)16(21)19-13-8-6-12(7-9-13)15(20)18-11-14-5-4-10-22-14/h6-9,14H,4-5,10-11H2,1-3H3,(H,18,20)(H,19,21)
  • InChiKey: JNOVBOHSWIHFKC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(2,2-dimethylpropanoylamino)-N-(tetrahydrofuran-2-ylmethyl)benzamide
  • 4-[(2,2-dimethyl-1-oxopropyl)amino]-N-(2-tetrahydrofuranylmethyl)benzamide
  • 4-(pivaloylamino)-N-(tetrahydrofurfuryl)benzamide
  • Oprea1_751945

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0419 0.4289
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.033 0.3311
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.01 0.0779
Mycobacterium ulcerans leucyl aminopeptidase 0.0115 0.1198 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0037 0.0111
Plasmodium vivax glutathione reductase, putative 0.0051 0.048 0.3856
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0126 0.0253
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0664 0.6977
Loa Loa (eye worm) glutathione reductase 0.0051 0.048 0.1466
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.033 0.3311
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0126 0.0836
Loa Loa (eye worm) hypothetical protein 0.0012 0.0037 0.0111
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0126 0.0207
Onchocerca volvulus 0.0012 0.0036 0.0135
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.048 0.0478
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0156 0.1331
Loa Loa (eye worm) hypothetical protein 0.0011 0.0029 0.0084
Schistosoma mansoni coup transcription factor 0.0022 0.0156 0.041
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0464 0.0463
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0112 0.1173 0.1172
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0362 0.3666
Loa Loa (eye worm) hypothetical protein 0.0112 0.1173 0.3591
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0023 0.0162 0.0326
Brugia malayi chromobox protein homolog 3 0.0038 0.033 0.2813
Echinococcus granulosus snurportin 1 0.0298 0.3264 0.6602
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0047 0.0045
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.0029 0.0244
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.016 0.1439
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.0162 0.0535
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0643 0.4283
Trypanosoma brucei trypanothione reductase 0.0051 0.048 0.3435
Echinococcus granulosus Nuclear hormone receptor HR96 0.0011 0.0023 0.0044
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0023 0.0044
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0023 0.0162 0.0429
Schistosoma mansoni leucine aminopeptidase 0.0023 0.0162 0.0429
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0104 0.0249
Brugia malayi cytosol aminopeptidase 0.0023 0.0162 0.1383
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0156 0.0155
Onchocerca volvulus 0.0022 0.0156 0.1452
Trypanosoma brucei polo-like protein kinase 0.0092 0.0939 0.763
Plasmodium falciparum importin beta, putative 0.0028 0.0219 0.1629
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0156 0.0313
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0156 0.041
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0129 0.1363 1
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0643 0.1913
Loa Loa (eye worm) hypothetical protein 0.0016 0.008 0.0242
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.0029 0.0056
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0156 0.041
Schistosoma mansoni hypothetical protein 0.0016 0.008 0.0176
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0116 0.1217 0.112
Mycobacterium tuberculosis Probable reductase 0.0116 0.1217 0.8837
Echinococcus granulosus leucine aminopeptidase protein 0.0115 0.1198 0.2421
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0643 0.0642
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0156 0.0155
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0023 0.0162 0.0535
Echinococcus granulosus nuclear receptor nhr 48 0.0011 0.0023 0.0044
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0067
Trichomonas vaginalis importin beta-1, putative 0.0023 0.016 0.1439
Echinococcus multilocularis leucine aminopeptidase protein 0.0115 0.1198 0.1197
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0156 0.041
Entamoeba histolytica Ran family GTPase 0.0021 0.0136 0.118
Schistosoma mansoni importin beta-1 0.0028 0.0219 0.0605
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.0162 0.0161
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0126 0.0272
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.008 0.0159
Brugia malayi MAP kinase sur-1 0.005 0.0464 0.3955
Plasmodium falciparum thioredoxin reductase 0.0051 0.048 0.3856
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0464 0.4314
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.0037 0.0111
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0126 0.018
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0156 0.1452
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0156 0.1331
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0115 0.1198 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0156 0.0475
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0104 0.0825
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0011 0.0023 0.0044
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0011 0.0023 0.0022
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0112 0.1173 0.3547
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0284 0.242
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0464 0.3291
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0459 0.3917
Echinococcus granulosus GPCR family 2 0.0016 0.008 0.0159
Brugia malayi nuclear hormone receptor 0.0022 0.0156 0.1331
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0115 0.1198 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0067
Brugia malayi conserved hypotetical protein 0.0011 0.0023 0.0197
Echinococcus granulosus FTZ F1 alpha 0.0447 0.4944 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0459 0.1404
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0136 0.0135
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0156 0.1331
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0051 0.0433
Loa Loa (eye worm) hypothetical protein 0.0022 0.0156 0.0475
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0156 0.0313
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0104 0.0642
Echinococcus multilocularis cpg binding protein 0.0029 0.0235 0.0234
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0104 0.0885
Loa Loa (eye worm) hypothetical protein 0.0034 0.0284 0.0866
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0156 0.1331
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.008 0.0242
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0464 0.4783
Trypanosoma brucei aminopeptidase, putative 0.0023 0.0162 0.0535
Echinococcus multilocularis FTZ F1 alpha 0.0112 0.1173 0.1172
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0464 0.3291
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0136 0.116
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0156 0.0155
Toxoplasma gondii leucyl aminopeptidase LAP 0.0115 0.1198 1
Schistosoma mansoni chromobox protein 0.0011 0.0029 0.0017
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0023 0.0162 0.1383
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0126 0.1074
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0156 0.041
Brugia malayi Latrophilin receptor protein 2 0.0016 0.008 0.0682
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0643 0.1913
Loa Loa (eye worm) nuclear receptor NHR-67 0.0011 0.0023 0.0067
Echinococcus multilocularis Chromobox protein 3 0.0011 0.0029 0.0027
Echinococcus granulosus chromobox protein 1 0.0067 0.0664 0.134
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0104 0.0207
Onchocerca volvulus 0.003 0.0238 0.2347
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.01 0.0779
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0023 0.0162 0.0535
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0136 0.0918
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0464 0.0936
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0156 0.1452
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0459 0.1404
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0939 1
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0037 0.0319
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0136 0.0295
Onchocerca volvulus 0.0011 0.0029 0.0061
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0939 0.2825
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0156 0.0475
Brugia malayi M-phase phosphoprotein, mpp8 0.0011 0.0029 0.0244
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0115 0.1198 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0126 0.0207
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0023 0.0162 0.0535
Loa Loa (eye worm) hypothetical protein 0.0012 0.0037 0.0111
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0129 0.1363 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0643 0.4928
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0023 0.0162 0.0493
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0156 0.1331
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0067
Loa Loa (eye worm) heterochromatin protein 1 0.0067 0.0664 0.203
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0206 0.1945
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0067
Brugia malayi nuclear receptor NHR-88 0.0022 0.0156 0.1331
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0037 0.0319
Toxoplasma gondii thioredoxin reductase 0.0051 0.048 0.3856
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0104 0.0642
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.016 0.1439
Schistosoma mansoni cpg binding protein 0.0028 0.0217 0.0599
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.0939 0.0938
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0156 0.041
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0012 0.0036 0.0038
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0029 0.0017
Mycobacterium tuberculosis Probable oxidoreductase 0.0129 0.1363 1
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0115 0.1198 1
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0939 1
Schistosoma mansoni ap endonuclease 0.002 0.0126 0.0319
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0126 0.0207
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.048 0.2985
Brugia malayi tailless protein 0.0011 0.0023 0.0197
Loa Loa (eye worm) hypothetical protein 0.0022 0.0156 0.0475
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.0162 0.0535
Echinococcus granulosus thyroid hormone receptor alpha 0.0011 0.0023 0.0044
Schistosoma mansoni cpg binding protein 0.0029 0.0235 0.0654
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.0162 0.0161
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0464 0.136
Mycobacterium tuberculosis Probable dehydrogenase 0.0116 0.1217 0.8837
Brugia malayi nuclear hormone receptor family member nhr-6 0.0011 0.0023 0.0197
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0156 0.1331
Brugia malayi nuclear receptor RXR 0.0011 0.0023 0.0197
Echinococcus granulosus importin subunit beta 1 0.0028 0.0219 0.0441
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0023 0.0162 0.0535
Echinococcus multilocularis chromobox protein 1 0.0067 0.0664 0.0662
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0062 0.0361
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0136 0.0295
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0023 0.0162 0.1383
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.0029 0.0017
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0126 0.1074
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0643 0.4928
Echinococcus granulosus Chromo domain 0.0011 0.0029 0.0056
Brugia malayi Importin beta-1 subunit 0.0028 0.0219 0.1868
Echinococcus granulosus leucyl aminopeptidase 0.0023 0.0162 0.0326
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0136 0.0918
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0156 0.0313
Brugia malayi Thioredoxin reductase 0.0051 0.048 0.4089
Trypanosoma brucei protein kinase, putative 0.005 0.0464 0.3291
Brugia malayi CHD4 protein 0.0013 0.0047 0.0397
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0219 0.1629
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0067
Echinococcus multilocularis nuclear receptor nhr 48 0.0011 0.0023 0.0022
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0156 0.041
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0112 0.1173 0.237
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0104 0.0825
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0464 0.4783
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.0029 0.0027
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0219 0.1055
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0939 0.763
Leishmania major GTP-binding protein, putative 0.0021 0.0136 0.0295
Brugia malayi orphan nuclear receptor NR2E1 0.0011 0.0023 0.0197
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.048 0.3435
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.008 0.0079
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0156 0.0155
Schistosoma mansoni hypothetical protein 0.0298 0.3264 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0156 0.0313
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0067
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0067
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0664 0.6977
Brugia malayi nuclear hormone receptor 0.0011 0.0023 0.0197
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0939 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0136 0.0295
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0464 0.3291
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.048 0.1466
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0136 0.0413
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0136 0.0273
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.008 0.0159
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.0939 0.763
Loa Loa (eye worm) DR-78 0.0011 0.0023 0.0067
Toxoplasma gondii exonuclease III APE 0.002 0.0126 0.0836
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0112 0.1173 1
Echinococcus granulosus Chromobox protein 3 0.0011 0.0029 0.0056
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0362 0.3704
Brugia malayi Valyl-tRNA synthetase 0.0011 0.0029 0.0244
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0047 0.0092
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.033 0.3351
Loa Loa (eye worm) hypothetical protein 0.0028 0.0219 0.0668
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0126 0.0207
Echinococcus multilocularis chromobox protein 1 0.0067 0.0664 0.0662
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0156 0.0475
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0067
Loa Loa (eye worm) hypothetical protein 0.0012 0.0037 0.0111
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.01 0.0779
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0156 0.1331
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0939 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0116 0.1217 0.8837
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0156 0.0313
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0023 0.0162 0.1383
Echinococcus multilocularis snurportin 1 0.0298 0.3264 0.3263
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0115 0.1198 1
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0643 0.5254
Plasmodium falciparum glutathione reductase 0.0018 0.0104 0.0642
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0156 0.1331
Entamoeba histolytica hypothetical protein 0.0023 0.016 0.1439
Brugia malayi nuclear hormone receptor family member odr-7 0.0011 0.0023 0.0197
Schistosoma mansoni chromobox protein 0.0011 0.0029 0.0017
Schistosoma mansoni hypothetical protein 0.009 0.0921 0.2771
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0464 0.4783
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0126 0.0207
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.016 0.0511
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0116 0.1217 0.8837
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0126 0.1074
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.0939 1
Loa Loa (eye worm) nuclear hormone receptor 0.0011 0.0023 0.0067
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0939 0.763
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0156 0.0475
Loa Loa (eye worm) hypothetical protein 0.0011 0.0029 0.0084
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0136 0.0918
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.048 0.3856
Brugia malayi Nuclear hormone receptor E75 0.0011 0.0023 0.0197
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.01 0.0779
Brugia malayi nuclear receptor RXR 0.0012 0.0037 0.0319
Plasmodium vivax importin-beta 2, putative 0.0028 0.0219 0.1629
Echinococcus multilocularis chromobox protein 2 0.0011 0.0029 0.0027
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0047 0.0139
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0464 0.3722
Loa Loa (eye worm) hypothetical protein 0.0022 0.0156 0.0475
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0156 0.0155
Plasmodium falciparum M17 leucyl aminopeptidase 0.0115 0.1198 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0112 0.1173 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0156 0.1331
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0156 0.0475
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0011 0.0023 0.0197
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0126 0.0125
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0136 0.0387
Leishmania major importin beta-1 subunit, putative 0.0023 0.016 0.0511
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.0037 0.0073
Schistosoma mansoni ran 0.0021 0.0136 0.0348
Echinococcus multilocularis GPCR, family 2 0.0016 0.008 0.0079
Schistosoma mansoni ap endonuclease 0.002 0.0126 0.0319
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.0162 0.0161
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.0939 1
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0023 0.0162 0.0493
Schistosoma mansoni hypothetical protein 0.0016 0.008 0.0176
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0156 0.0475
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.0939 0.8003
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0011 0.0023 0.0022
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.0037 0.0044
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0156 0.041
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.01 0.0779
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0362 0.3666
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0464 0.0463
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0067
Brugia malayi hypothetical protein 0.0012 0.0037 0.0319
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0011 0.0023 0.0067
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0459 0.3917
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0156 0.0475
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.0939 0.2873
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0023 0.0022
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0037 0.0044
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0104 0.0642
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0104 0.0642
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0156 0.1331
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0464 0.3291
Leishmania major trypanothione reductase 0.0051 0.048 0.3435
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.008 0.0079
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0643 0.1299
Brugia malayi hypothetical protein 0.0012 0.0037 0.0319
Echinococcus granulosus chromobox protein 1 0.0067 0.0664 0.134
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0156 0.1331
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0156 0.0155
Schistosoma mansoni hypothetical protein 0.0034 0.0284 0.0804
Echinococcus granulosus Nuclear hormone receptor HR96 0.0011 0.0023 0.0044
Echinococcus granulosus cpg binding protein 0.0029 0.0235 0.0473
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0219 0.1055
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0464 0.1418
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0156 0.0313
Loa Loa (eye worm) helicase 0.0011 0.0029 0.0084
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0156 0.0155
Brugia malayi hypothetical protein 0.0011 0.0029 0.0244
Schistosoma mansoni hypothetical protein 0.0016 0.008 0.0176
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.01 0.0779
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0156 0.0313
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0029 0.0017
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0156 0.041
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0051 0.0433
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.0029 0.0244
Trichomonas vaginalis ran, putative 0.0021 0.0136 0.118
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0217 0.0662
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0126 0.0384
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0067
Chlamydia trachomatis cytosol aminopeptidase 0.0115 0.1198 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0156 0.1331
Brugia malayi Protein cec-1. 0.0011 0.0029 0.0244
Loa Loa (eye worm) hypothetical protein 0.0011 0.0029 0.0084
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.0037 0.0036
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.01 0.0779
Brugia malayi hypothetical protein 0.0011 0.0023 0.0197
Plasmodium falciparum thioredoxin reductase 0.0018 0.0104 0.0642
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0067 0.0418
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0643 0.4928
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0939 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0238 0.0726
Loa Loa (eye worm) hypothetical protein 0.0011 0.0029 0.0084
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0116 0.1217 0.8837
Brugia malayi steroid hormone receptor 0.0022 0.0156 0.1331
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0464 0.3291
Schistosoma mansoni kinase 0.0047 0.0433 0.1263
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0104 0.0642
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0115 0.1198 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0156 0.0475
Brugia malayi glutathione reductase 0.0051 0.048 0.4089
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0156 0.041
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0298 0.3264 1
Schistosoma mansoni chromobox protein 0.0067 0.0664 0.1976
Loa Loa (eye worm) hypothetical protein 0.0011 0.0029 0.0084
Brugia malayi ecdysone receptor 0.0011 0.0023 0.0197
Echinococcus granulosus chromobox protein 2 0.0011 0.0029 0.0056
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0011 0.0023 0.0022
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0497 0.4007
Loa Loa (eye worm) hypothetical protein 0.0012 0.0037 0.0111
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.01 0.0779
Brugia malayi nuclear receptor NHR-67 0.0011 0.0023 0.0197
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0115 0.1198 0.8691
Loa Loa (eye worm) hypothetical protein 0.0022 0.0156 0.0475
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0219 0.0218
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0156 0.0475
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0156 0.041
Schistosoma mansoni chromobox protein 0.0067 0.0664 0.1976
Onchocerca volvulus 0.0011 0.0029 0.0061
Brugia malayi hypothetical protein 0.0011 0.0023 0.0197
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0939 1
Brugia malayi Nuclear hormone receptor E75 0.0011 0.0023 0.0197
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.048 0.0968
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0126 0.0836
Schistosoma mansoni ran 0.0021 0.0136 0.0348
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0464 0.0936
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0156 0.1331
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0464 0.3291
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0067 0.0418
Schistosoma mansoni cpg binding protein 0.0029 0.0235 0.0654
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0067
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0464 0.4783
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0156 0.1452
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0419 0.4289
Echinococcus multilocularis Chromo domain 0.0011 0.0029 0.0027
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.0162 0.0535
Brugia malayi RNA, U transporter 1 0.0079 0.0799 0.6816
Giardia lamblia Kinase, PLK 0.0092 0.0939 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0104 0.0642
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0568 0.1682
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0067
Loa Loa (eye worm) hypothetical protein 0.0038 0.033 0.1007
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0939 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0116 0.1217 0.8837
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0126 0.0207
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0126 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0029 0.0084
Loa Loa (eye worm) hypothetical protein 0.0011 0.0029 0.0084
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0156 0.041
Loa Loa (eye worm) hypothetical protein 0.0022 0.0156 0.0475
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0011 0.0023 0.0022
Brugia malayi nuclear receptor NHR-88 0.0011 0.0023 0.0197
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0156 0.0475
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.0939 0.1897
Brugia malayi Heterochromatin protein 1 0.0067 0.0664 0.5658
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0643 0.4928
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0464 0.3291
Brugia malayi ecdysteroid receptor 0.0022 0.0156 0.1331
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0126 0.1078
Brugia malayi CXXC zinc finger family protein 0.0028 0.0217 0.1853
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0104 0.0103
Schistosoma mansoni hypothetical protein 0.0011 0.0029 0.0017
Echinococcus granulosus leucyl aminopeptidase 0.0023 0.0162 0.0326
Schistosoma mansoni hypothetical protein 0.0016 0.008 0.0176
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.008 0.0682
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0156 0.1331
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0047 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0206 0.1945
Onchocerca volvulus 0.0028 0.0217 0.2121
Brugia malayi SET domain containing protein 0.0012 0.0036 0.0303
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0129 0.1363 1
Plasmodium falciparum glutathione reductase 0.0051 0.048 0.3856

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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