Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0085 | 0.5908 | 0.8342 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0095 | 0.7038 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0085 | 0.5908 | 0.8342 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0085 | 0.5908 | 0.8342 |
Mycobacterium tuberculosis | Probable reductase | 0.0085 | 0.5908 | 0.8342 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0095 | 0.7038 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0085 | 0.5908 | 0.8342 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3214 | 0.3214 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0095 | 0.7038 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0037 | 0.0217 | 0.5 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0085 | 0.5908 | 0.8342 |
Brugia malayi | Thioredoxin reductase | 0.0037 | 0.0217 | 0.0676 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3214 | 0.3214 |
Plasmodium falciparum | glutathione reductase | 0.0037 | 0.0217 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.3214 | 1 |
Leishmania major | trypanothione reductase | 0.0037 | 0.0217 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.3214 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3214 | 0.3214 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0095 | 0.7038 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.3214 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0037 | 0.0217 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.3214 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.3214 | 1 |
Brugia malayi | RNA binding protein | 0.0063 | 0.3214 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3214 | 0.3214 |
Plasmodium vivax | glutathione reductase, putative | 0.0037 | 0.0217 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0037 | 0.0217 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.3214 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0038 | 0.0277 | 0.0861 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.3214 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0037 | 0.0217 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0038 | 0.0277 | 0.0861 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3214 | 0.3214 |
Brugia malayi | glutathione reductase | 0.0037 | 0.0217 | 0.0676 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0037 | 0.0217 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.