Detailed information for compound 653152

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 444.565 | Formula: C28H32N2O3
  • H donors: 1 H acceptors: 2 LogP: 4.52 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(c1ccc(cc1)C1C(=C(C)N=C2C1=C(O)CCC2)C(=O)OCc1ccccc1)CC
  • InChi: 1S/C28H32N2O3/c1-4-30(5-2)22-16-14-21(15-17-22)26-25(28(32)33-18-20-10-7-6-8-11-20)19(3)29-23-12-9-13-24(31)27(23)26/h6-8,10-11,14-17,26,31H,4-5,9,12-13,18H2,1-3H3
  • InChiKey: NBSDNZDODOEPQF-UHFFFAOYSA-N  


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Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi glutamate synthase 0.0024 0.0007 0.0015
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0657 0.2274 0.4447
Schistosoma mansoni Smad4 0.0091 0.0246 0.0826
Schistosoma mansoni smad 0.0041 0.0067 0.0224
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0024 0.0007 0.0033
Loa Loa (eye worm) hypothetical protein 0.0042 0.0073 0.0157
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0166 0.0354
Echinococcus multilocularis ferritin 0.0105 0.0299 0.0299
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0024 0.0007 0.0052
Schistosoma mansoni hypothetical protein 0.0049 0.0096 0.0322
Echinococcus multilocularis Smad4 0.0091 0.0246 0.0246
Plasmodium falciparum ataxin-2 like protein, putative 0.0205 0.0656 0.302
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0024 0.0007 0.0052
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.009 0.0243 0.0793
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.009 0.0243 0.3096
Mycobacterium tuberculosis Probable lipase LipD 0.0227 0.0734 0.1436
Trichomonas vaginalis apoptosis inducing factor, putative 0.0024 0.0007 0.0017
Echinococcus granulosus dihydrofolate reductase 0.0855 0.2983 0.2983
Mycobacterium ulcerans bacterioferritin BfrA 0.0105 0.0299 0.1003
Mycobacterium leprae Probable lipase LipE 0.0227 0.0734 0.2444
Mycobacterium tuberculosis Probable lipase LipE 0.0227 0.0734 0.1436
Brugia malayi Bromodomain containing protein 0.0078 0.0201 0.0429
Schistosoma mansoni glutamate synthase 0.0024 0.0007 0.0024
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0657 0.2274 0.7617
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0166 0.0555
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0166 0.0555
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0024 0.0007 0.0017
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0096 0.0096
Echinococcus multilocularis thioredoxin glutathione reductase 0.0259 0.0849 0.0849
Brugia malayi Serotonin receptor 0.0526 0.1805 0.3854
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0024 0.0007 0.0024
Loa Loa (eye worm) programmed cell death 8 0.0024 0.0007 0.0015
Schistosoma mansoni hypothetical protein 0.0024 0.0007 0.0024
Trichomonas vaginalis glutamate synthase, putative 0.0024 0.0007 0.0017
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0024 0.0007 0.0015
Echinococcus granulosus ferritin 0.0105 0.0299 0.0299
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0237 0.077 0.2563
Brugia malayi Thioredoxin reductase 0.0259 0.0849 0.1813
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0092 0.0251 0.0251
Mycobacterium tuberculosis Possible penicillin-binding protein 0.145 0.5113 1
Loa Loa (eye worm) hypothetical protein 0.0227 0.0734 0.1568
Schistosoma mansoni ferritin 0.0105 0.0299 0.1003
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0145 0.0442 0.0442
Trypanosoma brucei trypanothione reductase 0.0259 0.0849 0.3942
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0024 0.0007 0.0033
Schistosoma mansoni transcription factor LCR-F1 0.0409 0.1385 0.4645
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0024 0.0007 0.0007
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0237 0.077 0.2563
Loa Loa (eye worm) MH1 domain-containing protein 0.0041 0.0067 0.0143
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0166 0.0555
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0024 0.0007 0.0014
Loa Loa (eye worm) dihydrofolate reductase 0.0855 0.2983 0.6368
Brugia malayi MH2 domain containing protein 0.0091 0.0246 0.0526
Schistosoma mansoni hypothetical protein 0.0092 0.0251 0.0841
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0227 0.0734 0.1568
Loa Loa (eye worm) hypothetical protein 0.005 0.0101 0.0216
Brugia malayi beta-lactamase family protein 0.0227 0.0734 0.1568
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0024 0.0007 0.0033
Mycobacterium ulcerans beta-lactamase 0.0227 0.0734 0.2462
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0105 0.0299 0.3827
Onchocerca volvulus 0.0227 0.0734 0.1732
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0024 0.0007 0.0014
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0237 0.077 0.2583
Schistosoma mansoni glutamate synthase 0.0024 0.0007 0.0024
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.009 0.0243 0.11
Loa Loa (eye worm) hypothetical protein 0.0024 0.0007 0.0015
Trichomonas vaginalis glutathione reductase, putative 0.009 0.0243 0.0578
Plasmodium vivax hypothetical protein, conserved 0.0227 0.0734 0.3387
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0024 0.0007 0.0007
Echinococcus granulosus thymidylate synthase 0.0237 0.077 0.077
Toxoplasma gondii hypothetical protein 0.0082 0.0214 0.0963
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0227 0.0734 0.1436
Trichomonas vaginalis glutamate synthase, putative 0.0024 0.0007 0.0017
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0024 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0154 0.0472 0.1008
Brugia malayi glutathione reductase 0.0259 0.0849 0.1813
Echinococcus multilocularis muscleblind protein 1 0.0298 0.0988 0.0988
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0024 0.0007 0.0014
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0091 0.0246 0.0246
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.009 0.0243 0.1129
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0024 0.0007 0.0007
Leishmania major hypothetical protein, conserved 0.0024 0.0007 0.0033
Echinococcus granulosus Smad4 0.0091 0.0246 0.0246
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0409 0.1385 0.1385
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0259 0.0849 0.1661
Brugia malayi thymidylate synthase 0.0237 0.077 0.1645
Mycobacterium ulcerans esterase/lipase LipP 0.0227 0.0734 0.2462
Entamoeba histolytica hypothetical protein 0.0409 0.1385 1
Schistosoma mansoni dihydrofolate reductase 0.0855 0.2983 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.009 0.0243 0.0243
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.009 0.0243 0.0816
Echinococcus granulosus glutamate synthase 0.0024 0.0007 0.0007
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0006 0.0019
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0066 0.0158 0.0337
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0105 0.0299 0.0585
Schistosoma mansoni hypothetical protein 0.0049 0.0096 0.0322
Trypanosoma cruzi PAB1-binding protein , putative 0.0205 0.0656 0.3043
Toxoplasma gondii LsmAD domain-containing protein 0.0205 0.0656 0.302
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1052 0.3686 0.7871
Loa Loa (eye worm) MH2 domain-containing protein 0.0041 0.0067 0.0143
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0237 0.077 0.3552
Schistosoma mansoni hypothetical protein 0.0135 0.0406 0.1363
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.009 0.0243 0.11
Brugia malayi beta-lactamase 0.0227 0.0734 0.1568
Schistosoma mansoni voltage-gated potassium channel 0.008 0.0207 0.0694
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0024 0.0007 0.0015
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0024 0.0007 0.0024
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0151 0.0462 0.1548
Loa Loa (eye worm) RNA binding protein 0.0068 0.0166 0.0354
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0024 0.0007 0.0007
Schistosoma mansoni apoferritin-2 0.0105 0.0299 0.1003
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0024 0.0007 0.0007
Echinococcus granulosus mothers against decapentaplegic 2 0.0041 0.0067 0.0067
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0068 0.0166 0.0394
Loa Loa (eye worm) hypothetical protein 0.0105 0.0298 0.0636
Entamoeba histolytica hypothetical protein 0.0409 0.1385 1
Mycobacterium ulcerans bacterioferritin BfrB 0.0105 0.0299 0.1003
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0169 0.0525 0.0525
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0855 0.2983 1
Brugia malayi MH2 domain containing protein 0.133 0.4684 1
Echinococcus multilocularis dihydrofolate reductase 0.0855 0.2983 0.2983
Onchocerca volvulus 0.0227 0.0734 0.1732
Trypanosoma cruzi PAB1-binding protein , putative 0.0205 0.0656 0.3043
Mycobacterium ulcerans glutamate synthase subunit beta 0.0024 0.0007 0.0024
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.009 0.0243 0.1129
Loa Loa (eye worm) glutathione reductase 0.0259 0.0849 0.1813
Treponema pallidum NADH oxidase 0.009 0.0243 0.3096
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0155 0.0478 0.1581
Brugia malayi Dihydrofolate reductase 0.0855 0.2983 0.6368
Toxoplasma gondii NADPH-glutathione reductase 0.009 0.0243 0.11
Onchocerca volvulus 0.0412 0.1397 0.331
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0024 0.0007 0.0052
Leishmania major trypanothione reductase 0.0259 0.0849 0.3942
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0073 0.0183 0.0391
Schistosoma mansoni smad 0.0091 0.0246 0.0826
Onchocerca volvulus 0.0171 0.0534 0.1254
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0024 0.0007 0.0014
Echinococcus multilocularis muscleblind protein 0.0298 0.0988 0.0988
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0024 0.0007 0.0017
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0227 0.0734 0.2462
Loa Loa (eye worm) hypothetical protein 0.004 0.0065 0.0138
Schistosoma mansoni hypothetical protein 0.0049 0.0096 0.0322
Toxoplasma gondii ABC1 family protein 0.0227 0.0734 0.3387
Echinococcus multilocularis mothers against decapentaplegic 5 0.0091 0.0246 0.0246
Schistosoma mansoni glutamate synthase 0.0024 0.0007 0.0024
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0624 0.2154 1
Echinococcus granulosus expressed protein 0.0105 0.0299 0.0299
Loa Loa (eye worm) hypothetical protein 0.0298 0.0988 0.211
Schistosoma mansoni ferritin light chain 0.0105 0.0299 0.1003
Mycobacterium ulcerans thymidylate synthase 0.0237 0.077 0.2583
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0056 0.0056
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0024 0.0007 0.0052
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.009 0.0243 0.1129
Brugia malayi TAR-binding protein 0.0068 0.0166 0.0354
Leishmania major hypothetical protein, conserved 0.0205 0.0656 0.3043
Echinococcus granulosus mothers against decapentaplegic 6 0.0041 0.0067 0.0067
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.009 0.0243 0.1129
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.009 0.0243 0.1129
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0155 0.0478 0.0934
Leishmania major acetoin dehydrogenase e3 component-like protein 0.009 0.0243 0.1129
Echinococcus multilocularis mothers against decapentaplegic 2 0.0041 0.0067 0.0067
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0591 0.2038 0.3985
Brugia malayi hypothetical protein 0.0132 0.0396 0.0845
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0056 0.0056
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0113 0.0326 0.1511
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0151 0.0462 0.2117
Loa Loa (eye worm) hypothetical protein 0.0412 0.1397 0.2983
Brugia malayi hypothetical protein 0.0171 0.0534 0.114
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0144 0.0144
Echinococcus granulosus mothers against decapentaplegic 5 0.0091 0.0246 0.0246
Loa Loa (eye worm) hypothetical protein 0.0063 0.0149 0.0317
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.009 0.0243 0.0816
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0227 0.0734 0.1568
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0024 0.0007 0.0007
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0024 0.0007 0.0017
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0096 0.0096
Trypanosoma cruzi hypothetical protein, conserved 0.0227 0.0734 0.3409
Brugia malayi MH1 domain containing protein 0.0091 0.0246 0.0526
Entamoeba histolytica hypothetical protein 0.0409 0.1385 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0591 0.2038 0.3985
Echinococcus multilocularis glutamate synthase 0.0024 0.0007 0.0007
Schistosoma mansoni Smad4 0.0041 0.0067 0.0224
Schistosoma mansoni smad1 5 8 and 0.0091 0.0246 0.0826
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0166 0.0354
Trichomonas vaginalis D-aminoacylase, putative 0.0227 0.0734 0.1746
Schistosoma mansoni voltage-gated potassium channel 0.008 0.0207 0.0694
Loa Loa (eye worm) Smad1 0.0091 0.0246 0.0526
Mycobacterium ulcerans lipase LipD 0.0227 0.0734 0.2462
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0237 0.077 0.3552
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0068 0.0166 0.0394
Echinococcus granulosus thioredoxin glutathione reductase 0.0259 0.0849 0.0849
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0172
Brugia malayi Bromodomain containing protein 0.004 0.0064 0.0137
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0096 0.0205
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0166 0.0555
Loa Loa (eye worm) hypothetical protein 0.0205 0.0656 0.14
Trypanosoma brucei hypothetical protein, conserved 0.0227 0.0734 0.3409
Schistosoma mansoni ferritin 0.0105 0.0299 0.1003
Brugia malayi Smad1 0.0091 0.0246 0.0526
Leishmania major hypothetical protein, conserved 0.0024 0.0007 0.0033
Brugia malayi PHD-finger family protein 0.0026 0.0015 0.0031
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0144 0.0144
Plasmodium vivax thioredoxin reductase, putative 0.0259 0.0849 0.3922
Schistosoma mansoni ferritin 0.0105 0.0299 0.1003
Schistosoma mansoni smad1 5 8 and 0.0091 0.0246 0.0826
Schistosoma mansoni sulfide quinone reductase 0.0024 0.0007 0.0024
Mycobacterium tuberculosis Conserved protein 0.0227 0.0734 0.1436
Trypanosoma cruzi NADH dehydrogenase, putative 0.0024 0.0007 0.0033
Trichomonas vaginalis D-aminoacylase, putative 0.0227 0.0734 0.1746
Loa Loa (eye worm) hypothetical protein 0.0041 0.0067 0.0143
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0624 0.2154 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.009 0.0243 0.1129
Schistosoma mansoni hypothetical protein 0.0166 0.0515 0.1726
Brugia malayi mothers against decapentaplegic homolog 3 0.0041 0.0067 0.0143
Brugia malayi latrophilin 2 splice variant baaae 0.0105 0.0298 0.0636
Entamoeba histolytica hypothetical protein 0.0409 0.1385 1
Trypanosoma cruzi hypothetical protein, conserved 0.0227 0.0734 0.3409
Giardia lamblia NADH oxidase lateral transfer candidate 0.009 0.0243 1
Brugia malayi MH2 domain containing protein 0.0041 0.0067 0.0143
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0024 0.0007 0.0007
Echinococcus granulosus muscleblind protein 0.0298 0.0988 0.0988
Echinococcus multilocularis expressed protein 0.0105 0.0299 0.0299
Loa Loa (eye worm) hypothetical protein 0.0171 0.0534 0.114
Entamoeba histolytica thioredoxin reductase, putative 0.0024 0.0007 0.0052
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.009 0.0243 0.1129
Echinococcus granulosus GPCR family 2 0.0049 0.0096 0.0096
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0237 0.077 0.3552
Brugia malayi Pre-SET motif family protein 0.1052 0.3686 0.7871
Loa Loa (eye worm) hypothetical protein 0.0237 0.077 0.1644
Schistosoma mansoni thyroid hormone receptor 0.0146 0.0445 0.1493
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0024 0.0007 0.0017
Trichomonas vaginalis ferritin, putative 0.0105 0.0299 0.0711
Plasmodium vivax glutathione reductase, putative 0.0259 0.0849 0.3922
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0024 0.0007 0.0033
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0007 0.0033
Mycobacterium ulcerans ferredoxin reductase 0.0024 0.0007 0.0024
Trichomonas vaginalis set domain proteins, putative 0.1197 0.4207 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0657 0.2274 0.4447
Loa Loa (eye worm) hypothetical protein 0.0298 0.0988 0.211
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.009 0.0243 0.0816
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0082 0.0214 0.0963
Echinococcus granulosus histone lysine methyltransferase setb 0.0169 0.0525 0.0525
Brugia malayi hypothetical protein 0.0205 0.0656 0.14
Schistosoma mansoni hypothetical protein 0.0409 0.1385 0.4645
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0105 0.0299 0.0981
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0096 0.0096
Trichomonas vaginalis penicillin-binding protein, putative 0.0227 0.0734 0.1746
Plasmodium vivax SET domain protein, putative 0.0151 0.0462 0.2117
Echinococcus granulosus beta LACTamase domain containing family member 0.0227 0.0734 0.0734
Chlamydia trachomatis dihydrofolate reductase 0.0855 0.2983 1
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0024 0.0007 0.0033
Schistosoma mansoni smad1 5 8 and 0.0091 0.0246 0.0826
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0024 0.0007 0.0033
Trypanosoma brucei PAB1-binding protein , putative 0.0205 0.0656 0.3043
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.009 0.0243 0.11
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0024 0.0007 0.0007
Loa Loa (eye worm) thymidylate synthase 0.0237 0.077 0.1645
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0024 0.0007 0.0017
Echinococcus granulosus geminin 0.0166 0.0515 0.0515
Schistosoma mansoni apoferritin-2 0.0105 0.0299 0.1003
Leishmania major NADH dehydrogenase, putative 0.0024 0.0007 0.0033
Brugia malayi Probable ClpP-like protease 0.0237 0.077 0.1644
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0024 0.0007 0.0033
Trichomonas vaginalis D-aminoacylase, putative 0.0227 0.0734 0.1746
Brugia malayi Calcitonin receptor-like protein seb-1 0.0154 0.0472 0.1008
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0155 0.0478 0.0934
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0006 0.0006
Toxoplasma gondii thioredoxin reductase 0.0259 0.0849 0.3922
Loa Loa (eye worm) hypothetical protein 0.0049 0.0096 0.0205
Trypanosoma cruzi trypanothione reductase, putative 0.009 0.0243 0.1129
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.009 0.0243 0.11
Trypanosoma cruzi NADH dehydrogenase, putative 0.0024 0.0007 0.0033
Echinococcus multilocularis geminin 0.0166 0.0515 0.0515
Loa Loa (eye worm) MH1 domain-containing protein 0.0091 0.0246 0.0526
Giardia lamblia Glutamate synthase 0.0024 0.0007 0.0294
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0591 0.2038 0.3985
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0073 0.0183 0.0183
Onchocerca volvulus 0.0237 0.077 0.1817
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0024 0.0007 0.0015
Schistosoma mansoni cellular tumor antigen P53 0.0412 0.1397 0.4684
Loa Loa (eye worm) hypothetical protein 0.0227 0.0734 0.1568
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.009 0.0243 0.0519
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.009 0.0243 0.1129
Schistosoma mansoni ferritin light chain 0.0105 0.0299 0.1003
Mycobacterium ulcerans dehydrogenase 0.0024 0.0007 0.0024
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0227 0.0734 0.2462
Echinococcus multilocularis thymidylate synthase 0.0237 0.077 0.077
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0096 0.0205
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0024 0.0007 0.0017
Plasmodium falciparum ataxin-2 like protein, putative 0.0205 0.0656 0.302
Plasmodium falciparum thioredoxin reductase 0.0259 0.0849 0.3922
Brugia malayi hypothetical protein 0.0409 0.1385 0.2958
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0007 0.0033
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.009 0.0243 0.1129
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0237 0.077 0.3552
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0237 0.077 0.1507
Plasmodium falciparum glutathione reductase 0.009 0.0243 0.11
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0024 0.0007 0.0033
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0166 0.0166
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0237 0.077 0.2565
Brugia malayi MH1 domain containing protein 0.0091 0.0246 0.0526
Loa Loa (eye worm) transcription factor SMAD2 0.133 0.4684 1
Schistosoma mansoni ferritin 0.0105 0.0299 0.1003
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0024 0.0007 0.0017
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0024 0.0007 0.0017
Brugia malayi MH1 domain containing protein 0.005 0.0101 0.0216
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0409 0.1385 0.1385
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0024 0.0007 0.0052
Leishmania major dihydrolipoamide dehydrogenase, putative 0.009 0.0243 0.1129
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0624 0.2154 1
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0024 0.0007 0.0015
Onchocerca volvulus 0.0227 0.0734 0.1732
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0096 0.0096
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0024 0.0007 0.0024
Plasmodium falciparum thioredoxin reductase 0.009 0.0243 0.11
Schistosoma mansoni disulfide oxidoreductase 0.0024 0.0007 0.0024
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0041 0.0067 0.0142
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.009 0.0243 0.0243
Schistosoma mansoni hypothetical protein 0.0049 0.0096 0.0322
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0237 0.077 1
Echinococcus multilocularis smad 0.0091 0.0246 0.0246
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0024 0.0007 0.0017
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0092 0.0251 0.0251
Brugia malayi beta-lactamase family protein 0.0227 0.0734 0.1568
Mycobacterium tuberculosis Probable dehydrogenase 0.0591 0.2038 0.3985
Trichomonas vaginalis penicillin-binding protein, putative 0.0227 0.0734 0.1746
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0591 0.2038 0.3985
Echinococcus multilocularis beta LACTamase domain containing family member 0.0227 0.0734 0.0734
Mycobacterium tuberculosis Probable esterase LipL 0.0227 0.0734 0.1436
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0166 0.0555
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0624 0.2154 1
Schistosoma mansoni Smad4 0.0041 0.0067 0.0224
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0237 0.077 0.077
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.009 0.0243 0.0476
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0237 0.077 1
Loa Loa (eye worm) thioredoxin reductase 0.0259 0.0849 0.1813
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0227 0.0734 0.1436
Trichomonas vaginalis mercuric reductase, putative 0.009 0.0243 0.0578
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0151 0.0462 0.0462
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0007 0.0033
Schistosoma mansoni hypothetical protein 0.0166 0.0515 0.1726
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0151 0.0462 0.1548
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0082 0.0214 0.2712
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0135 0.0406 0.0406
Loa Loa (eye worm) MH2 domain-containing protein 0.133 0.4684 1
Trichomonas vaginalis esterase, putative 0.0227 0.0734 0.1746
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0154 0.0472 0.1008
Echinococcus multilocularis GPCR, family 2 0.0049 0.0096 0.0096
Echinococcus granulosus peptidase Clp S14 family 0.0155 0.0478 0.0478
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0024 0.0007 0.0014
Plasmodium falciparum glutathione reductase 0.0259 0.0849 0.3922
Onchocerca volvulus 0.0151 0.0462 0.1083
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0237 0.077 0.2581
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0024 0.0007 0.0007
Giardia lamblia Thioredoxin reductase 0.0024 0.0007 0.0294
Brugia malayi dihydrofolate reductase family protein 0.0855 0.2983 0.6368
Mycobacterium ulcerans hypothetical protein 0.0024 0.0007 0.0024
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0624 0.2154 1
Mycobacterium tuberculosis Hypothetical protein 0.0113 0.0326 0.0637
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0237 0.077 0.077
Loa Loa (eye worm) hypothetical protein 0.0169 0.0525 0.1121
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0024 0.0007 0.0007
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0024 0.0007 0.0017
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0169 0.0525 0.1761
Loa Loa (eye worm) MH2 domain-containing protein 0.0091 0.0246 0.0526
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0657 0.2274 0.4447
Schistosoma mansoni hypothetical protein 0.0105 0.0298 0.0999
Brugia malayi Muscleblind-like protein 0.0298 0.0988 0.211
Trichomonas vaginalis conserved hypothetical protein 0.0113 0.0326 0.0774
Loa Loa (eye worm) hypothetical protein 0.0227 0.0734 0.1568
Onchocerca volvulus 0.1197 0.4207 1
Echinococcus granulosus smad 0.0091 0.0246 0.0246
Schistosoma mansoni peptidase Clp (S14 family) 0.0237 0.077 0.2581
Leishmania major hypothetical protein, conserved 0.0024 0.0007 0.0033
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0066 0.0158 0.0337
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0135 0.0406 0.0406
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0855 0.2983 0.5834
Schistosoma mansoni bromodomain containing protein 0.0066 0.0157 0.0527
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0082 0.0214 0.0695
Mycobacterium ulcerans monoxygenase 0.0024 0.0007 0.0024
Schistosoma mansoni sulfide quinone reductase 0.0024 0.0007 0.0024
Loa Loa (eye worm) nuclear factor I 0.005 0.0101 0.0216
Mycobacterium ulcerans hypothetical protein 0.0227 0.0734 0.2462
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0237 0.077 0.2581
Loa Loa (eye worm) hypothetical protein 0.0227 0.0734 0.1568
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.009 0.0243 0.1129
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0169 0.0525 0.1761
Plasmodium vivax ataxin-2 like protein, putative 0.0205 0.0656 0.302
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0024 0.0007 0.0024
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0818 0.285 0.285
Brugia malayi hypothetical protein 0.0113 0.0326 0.0695
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0073 0.0183 0.0391
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0024 0.0007 0.0033
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0024 0.0007 0.0294
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0024 0.0007 0.0024
Mycobacterium ulcerans NADH dehydrogenase 0.0024 0.0007 0.0024
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0591 0.2038 0.6824
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0227 0.0734 0.1436
Mycobacterium leprae conserved hypothetical protein 0.0227 0.0734 0.2444
Loa Loa (eye worm) beta-lactamase 0.0227 0.0734 0.1568
Echinococcus multilocularis mothers against decapentaplegic 6 0.0041 0.0067 0.0067
Leishmania major dihydrolipoamide dehydrogenase, putative 0.009 0.0243 0.1129
Treponema pallidum bacterioferrin (TpF1) 0.0105 0.0299 0.3827
Brugia malayi MH2 domain containing protein 0.0091 0.0246 0.0526
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0006 0.0006
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.009 0.0243 0.1129
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0073 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0227 0.0734 0.1568
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0082 0.0214 0.0963
Mycobacterium tuberculosis Probable hydrolase 0.0227 0.0734 0.1436
Schistosoma mansoni thyroid hormone receptor 0.0146 0.0445 0.1493
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0227 0.0734 0.2462
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0166 0.0354
Brugia malayi MH1 domain containing protein 0.005 0.0101 0.0216
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.009 0.0243 0.1129
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0855 0.2983 1
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0024 0.0007 0.0033
Entamoeba histolytica disulphide oxidoreductase, putative 0.0024 0.0007 0.0052
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.009 0.0243 0.3096
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0105 0.0299 0.0585
Echinococcus multilocularis tumor protein p63 0.2815 1 1
Mycobacterium tuberculosis Conserved protein 0.0227 0.0734 0.1436
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0096 0.0205
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0091 0.0246 0.0826
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0024 0.0007 0.0033
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0624 0.2154 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.009 0.0243 0.11
Echinococcus multilocularis thyroid hormone receptor alpha 0.0146 0.0445 0.0445
Brugia malayi Pre-SET motif family protein 0.0151 0.0462 0.0986
Mycobacterium ulcerans flavoprotein disulfide reductase 0.009 0.0243 0.0816
Echinococcus granulosus TGF beta signal transducer SmadC 0.0091 0.0246 0.0246
Brugia malayi RNA binding protein 0.0068 0.0166 0.0354
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0154 0.0472 0.1008
Mycobacterium tuberculosis Probable reductase 0.0591 0.2038 0.3985
Mycobacterium tuberculosis Conserved protein 0.0227 0.0734 0.1436
Echinococcus granulosus tar DNA binding protein 0.0068 0.0166 0.0166
Echinococcus multilocularis peptidase Clp (S14 family) 0.0155 0.0478 0.0478
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0024 0.0007 0.0007
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0024 0.0007 0.0024
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.009 0.0243 0.1129
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0024 0.0007 0.0024
Loa Loa (eye worm) hypothetical protein 0.0227 0.0734 0.1568
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0237 0.077 0.2563
Trypanosoma brucei NADH dehydrogenase 0.0024 0.0007 0.0033
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0024 0.0007 0.0014
Trypanosoma cruzi trypanothione reductase, putative 0.0259 0.0849 0.3942
Loa Loa (eye worm) hypothetical protein 0.0073 0.0185 0.0395
Leishmania major hypothetical protein, conserved 0.0227 0.0734 0.3409

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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