Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | thymidylate synthase | 0.041 | 0.0975 | 0.0717 |
Onchocerca volvulus | 0.041 | 0.0975 | 0.5 | |
Echinococcus granulosus | thymidylate synthase | 0.041 | 0.0975 | 0.0717 |
Brugia malayi | thymidylate synthase | 0.041 | 0.0975 | 0.0861 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.041 | 0.0975 | 0.0861 |
Schistosoma mansoni | dihydrofolate reductase | 0.2692 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.041 | 0.0975 | 0.0975 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.2692 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.2692 | 1 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.2692 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.2692 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.2692 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.2692 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1613 | 0.5734 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.2692 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1613 | 0.5734 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0195 | 0.0125 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1613 | 0.5734 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1613 | 0.5734 | 1 |
Brugia malayi | Serotonin receptor | 0.0484 | 0.1268 | 0.1158 |
Schistosoma mansoni | lipoxygenase | 0.0234 | 0.0278 | 0.0278 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1613 | 0.5734 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.2692 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1613 | 0.5734 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.