Detailed information for compound 653177

Basic information

Technical information
  • TDR Targets ID: 653177
  • Name: 4-ethoxy-N-[3-[(4-fluorobenzoyl)amino]phenyl] benzamide
  • MW: 378.396 | Formula: C22H19FN2O3
  • H donors: 2 H acceptors: 2 LogP: 4.03 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)C(=O)Nc1cccc(c1)NC(=O)c1ccc(cc1)F
  • InChi: 1S/C22H19FN2O3/c1-2-28-20-12-8-16(9-13-20)22(27)25-19-5-3-4-18(14-19)24-21(26)15-6-10-17(23)11-7-15/h3-14H,2H2,1H3,(H,24,26)(H,25,27)
  • InChiKey: XRHGEBZQKWKJLE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-ethoxy-N-[3-[[(4-fluorophenyl)-oxomethyl]amino]phenyl]benzamide
  • 4-ethoxy-N-[3-[(4-fluorophenyl)carbonylamino]phenyl]benzamide
  • ZINC01195204
  • CBMicro_005581
  • BIM-0005646.P001
  • Oprea1_216808

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis geminin 0.0172 0.5057 0.505
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0114 0.01
Loa Loa (eye worm) DR-78 0.0005 0.0014 0.0013
Entamoeba histolytica hypothetical protein 0.0037 0.0992 0.8395
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0032 0.0031
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0185 0.0184
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0185 0.0184
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0446 0.0444
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0079 0.2259 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.1294 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0335 1 1
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.1433 0.1421
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0185 0.0171
Schistosoma mansoni coup transcription factor 0.0011 0.0185 0.0185
Plasmodium vivax importin-beta 2, putative 0.003 0.0767 0.3391
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.1175 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0013
Brugia malayi RNA, U transporter 1 0.0085 0.2437 0.2436
Loa Loa (eye worm) hypothetical protein 0.0006 0.0032 0.0031
Loa Loa (eye worm) hypothetical protein 0.0006 0.0036 0.0035
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0024 0.0598 0.4946
Loa Loa (eye worm) acetyltransferase 0.0161 0.4734 0.4734
Brugia malayi nuclear receptor RXR 0.0006 0.0032 0.0031
Leishmania major T-complex protein 1, beta subunit, putative 0.0024 0.0598 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0185 0.0171
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.032 0.9532 0.9532
Trichomonas vaginalis ran, putative 0.0022 0.0528 0.3926
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.008 0.0376
Brugia malayi MH2 domain containing protein 0.0008 0.0114 0.0113
Schistosoma mansoni ap endonuclease 0.0019 0.0446 0.0446
Loa Loa (eye worm) histone methyltransferase 0.001 0.016 0.0159
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0013
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.0032 0.0032
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0185 0.0171
Brugia malayi Nuclear hormone receptor E75 0.0005 0.0014 0.0013
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0161 0.4734 0.4727
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0013
Schistosoma mansoni smad 0.0008 0.0114 0.0114
Echinococcus multilocularis transportin 1 0.0006 0.0033 0.0019
Loa Loa (eye worm) hypothetical protein 0.0011 0.0185 0.0184
Loa Loa (eye worm) importin-beta domain-containing protein 0.0006 0.0033 0.0032
Schistosoma mansoni ap endonuclease 0.0019 0.0446 0.0446
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0185 0.0184
Loa Loa (eye worm) kap beta 3 protein 0.0006 0.0033 0.0032
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0446 0.1854
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0446 0.1965
Brugia malayi nuclear hormone receptor family member odr-7 0.0005 0.0014 0.0013
Brugia malayi Importin beta-1 subunit 0.003 0.0767 0.0766
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0005 0.0014 0.0013
Schistosoma mansoni tar DNA-binding protein 0.0335 1 1
Schistosoma mansoni bromodomain containing protein 0.0006 0.0036 0.0036
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0185 0.0171
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.008 0.0376
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.008 0.0376
Schistosoma mansoni tar DNA-binding protein 0.0335 1 1
Brugia malayi Probable ClpP-like protease 0.0079 0.2259 0.2258
Brugia malayi steroid hormone receptor 0.0011 0.0185 0.0184
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.1294 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0079 0.2259 0.2248
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0688 0.2941
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0992 0.0979
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.016 0.0146
Echinococcus granulosus smad 0.0008 0.0114 0.01
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.1433 0.4744
Onchocerca volvulus 0.0011 0.0185 0.2103
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.2259 1
Echinococcus multilocularis translational activator gcn1 0.0006 0.0033 0.0019
Schistosoma mansoni hypothetical protein 0.0037 0.0992 0.0992
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0528 0.0515
Brugia malayi MH1 domain containing protein 0.0008 0.0114 0.0113
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0598 0.0598
Brugia malayi CXXC zinc finger family protein 0.0032 0.0827 0.0826
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0006 0.0032 0.0018
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0185 0.0171
Entamoeba histolytica hypothetical protein 0.0024 0.0596 0.4931
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0598 0.0597
Brugia malayi hypothetical protein 0.0005 0.0014 0.0013
Toxoplasma gondii hypothetical protein 0.0027 0.0688 0.2941
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0185 0.0171
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0528 0.2225
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0185 0.0184
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0185 0.2103
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0098 0.2836 0.2835
Brugia malayi Nuclear hormone receptor E75 0.0005 0.0014 0.0013
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0101 0.0087
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.008 0.0376
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.008 0.0376
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0185 0.0184
Brugia malayi Bromodomain containing protein 0.0006 0.0036 0.0035
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0446 0.3272
Brugia malayi conserved hypotetical protein 0.0005 0.0014 0.0013
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0185 0.0185
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.2259 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0013
Schistosoma mansoni Smad4 0.0008 0.0114 0.0114
Onchocerca volvulus 0.0032 0.0827 1
Brugia malayi nuclear receptor NHR-88 0.0011 0.0185 0.0184
Echinococcus granulosus histone acetyltransferase KAT2B 0.0157 0.4598 0.459
Brugia malayi ecdysone receptor 0.0005 0.0014 0.0013
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0114 0.0114
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0024 0.0598 0.0584
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0014 0.0014
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0598 0.0598
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.181 0.7983
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.1175 0.513
Brugia malayi nuclear hormone receptor 0.0011 0.0185 0.0184
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0114 0.01
Echinococcus multilocularis importin 5 0.0006 0.0033 0.0019
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0079 0.2259 1
Echinococcus granulosus snurportin 1 0.032 0.9532 0.9531
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0185 0.0171
Echinococcus granulosus transportin 1 0.0006 0.0033 0.0019
Loa Loa (eye worm) hypothetical protein 0.0006 0.0032 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.008 0.0376
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.1433 0.1421
Schistosoma mansoni ran 0.0022 0.0528 0.0528
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0446 0.0432
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0185 0.0184
Echinococcus granulosus geminin 0.0172 0.5057 0.505
Echinococcus multilocularis tar DNA binding protein 0.0335 1 1
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0185 0.0184
Loa Loa (eye worm) hypothetical protein 0.0079 0.2259 0.2258
Schistosoma mansoni tar DNA-binding protein 0.0335 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0185 0.0171
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0185 0.0185
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.0032 0.0032
Brugia malayi nuclear hormone receptor family member nhr-6 0.0005 0.0014 0.0013
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0528 0.0527
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0114 0.01
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0528 0.2331
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.1433 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0185 0.0185
Brugia malayi MH1 domain containing protein 0.0008 0.0114 0.0113
Schistosoma mansoni nuclear receptor nhr-48 0.0005 0.0014 0.0014
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0596 0.4464
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0446 0.3272
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0185 0.0184
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0013
Schistosoma mansoni zinc finger protein 0.0006 0.0036 0.0036
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0992 0.0979
Brugia malayi hypothetical protein 0.0006 0.0032 0.0031
Loa Loa (eye worm) hypothetical protein 0.003 0.0767 0.0766
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0013
Brugia malayi hypothetical protein 0.0006 0.0032 0.0031
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0688 0.3037
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0114 0.0113
Loa Loa (eye worm) hypothetical protein 0.0006 0.0032 0.0031
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0024 0.0598 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.2836 0.2826
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.016 0.0146
Brugia malayi nuclear receptor RXR 0.0005 0.0014 0.0013
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0024 0.0598 0.7692
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.2259 1
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0156 0.0155
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0596 0.4464
Brugia malayi nuclear receptor NHR-88 0.0005 0.0014 0.0013
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.008 0.0376
Brugia malayi tailless protein 0.0005 0.0014 0.0013
Brugia malayi ecdysteroid receptor 0.0011 0.0185 0.0184
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0185 0.0184
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0079 0.2259 1
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0185 0.0185
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0185 0.0184
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0185 0.0171
Schistosoma mansoni importin beta-1 0.003 0.0767 0.0767
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.008 0.0376
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0101 0.0087
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0446 0.0432
Leishmania major GTP-binding protein, putative 0.0022 0.0528 0.8768
Schistosoma mansoni hypothetical protein 0.032 0.9532 0.9532
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0185 0.0184
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0688 0.1334
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0185 0.0184
Loa Loa (eye worm) nuclear hormone receptor 0.0005 0.0014 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0185 0.0184
Echinococcus granulosus zinc finger protein 0.0006 0.0036 0.0022
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.2259 0.5
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0446 0.3614
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.1909 0.1909
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.008 0.0376
Brugia malayi acetyltransferase, GNAT family protein 0.0161 0.4734 0.4734
Brugia malayi TAR-binding protein 0.0335 1 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0185 0.0171
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.1433 1
Brugia malayi hypothetical protein 0.0037 0.0992 0.0991
Schistosoma mansoni tar DNA-binding protein 0.0335 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0185 0.0184
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0013
Brugia malayi MH2 domain containing protein 0.0008 0.0114 0.0113
Echinococcus multilocularis cpg binding protein 0.0034 0.0882 0.0869
Toxoplasma gondii exonuclease III APE 0.0019 0.0446 0.1854
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0185 0.0184
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.2259 1
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0185 0.0171
Brugia malayi orphan nuclear receptor NR2E1 0.0005 0.0014 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.008 0.0376
Leishmania major importin beta-1 subunit, putative 0.0024 0.0596 0.9968
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.2259 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0185 0.0171
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0013
Brugia malayi MH2 domain containing protein 0.0123 0.3569 0.3569
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.008 0.0376
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0005 0.0014 0.0013
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0114 0.01
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0596 0.9882
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.2836 0.2836
Schistosoma mansoni nuclear receptor 0.0005 0.0014 0.0014
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0079 0.2259 1
Brugia malayi nuclear receptor NHR-67 0.0005 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.0006 0.0036 0.0035
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0101 0.0087
Schistosoma mansoni bromodomain containing protein 0.0006 0.0036 0.0036
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0767 0.3299
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0185 0.0171
Brugia malayi RNA recognition motif domain containing protein 0.0335 1 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.008 0.0376
Schistosoma mansoni cpg binding protein 0.0032 0.0827 0.0827
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0079 0.2259 0.2248
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.1294 0.5667
Plasmodium falciparum importin beta, putative 0.003 0.0767 0.3299
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.008 0.0376
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0013
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0827 0.0826
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0024 0.0598 0.0584
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0446 0.562
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0185 0.0171
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0114 0.0113
Echinococcus granulosus Smad4 0.0008 0.0114 0.01
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0079 0.2259 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0528 0.5425
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0098 0.2836 0.2835
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0185 0.0171
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0006 0.0032 0.0018
Echinococcus granulosus importin subunit beta 1 0.003 0.0767 0.0754
Brugia malayi Smad1 0.0008 0.0114 0.0113
Schistosoma mansoni importin-beta 2 0.0006 0.0033 0.0033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0185 0.0184
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0185 0.2103
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0014 0.0014
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.1294 0.1282
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0185 0.0171
Entamoeba histolytica hypothetical protein 0.0037 0.0992 0.8395
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0446 0.0444
Loa Loa (eye worm) hypothetical protein 0.0011 0.0185 0.0184
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0446 0.7306
Trichomonas vaginalis helicase, putative 0.0007 0.008 0.0376
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0005 0.0014 0.0014
Echinococcus multilocularis importin subunit beta 1 0.003 0.0767 0.0754
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0767 1
Trichomonas vaginalis chaperonin, putative 0.0024 0.0598 0.4478
Brugia malayi kap beta 3 protein 0.0006 0.0033 0.0032
Loa Loa (eye worm) hypothetical protein 0.0011 0.0185 0.0184
Loa Loa (eye worm) hypothetical protein 0.0006 0.0032 0.0031
Echinococcus multilocularis snurportin 1 0.032 0.9532 0.9531
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0005 0.0014 0.0014
Schistosoma mansoni peptidase Clp (S14 family) 0.0079 0.2259 0.2259
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0185 0.0185
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0185 0.0185
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0992 0.0992
Echinococcus granulosus tar DNA binding protein 0.0335 1 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0528 0.5425
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0185 0.0184
Loa Loa (eye worm) hypothetical protein 0.0011 0.0185 0.0184
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0185 0.0185
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0161 0.4734 0.4734
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.3569 0.3569
Schistosoma mansoni tar DNA-binding protein 0.0335 1 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0185 0.2103
Entamoeba histolytica hypothetical protein 0.0037 0.0992 0.8395
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0185 0.0184
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0767 1
Brugia malayi hypothetical protein 0.0005 0.0014 0.0013
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0528 0.0515
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0185 0.0185
Loa Loa (eye worm) TAR-binding protein 0.0335 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0185 0.0184
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.1175 1
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0185 0.0185
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0185 0.0185
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0185 0.0184
Loa Loa (eye worm) hypothetical protein 0.0011 0.0185 0.0184
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0185 0.0185
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0032 0.0031
Echinococcus granulosus cpg binding protein 0.0034 0.0882 0.0869
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.008 0.0376
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.1294 0.5726
Schistosoma mansoni cpg binding protein 0.0034 0.0882 0.0882
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.008 0.0376
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0528 0.2225
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0528 0.6744
Plasmodium falciparum T-complex protein 1 subunit beta 0.0024 0.0598 0.2538
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0013
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.0032 0.0031
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.2836 0.2826
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0596 0.4464
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0185 0.0171
Echinococcus multilocularis smad 0.0008 0.0114 0.01
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.2836 0.2836
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0598 0.0597
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.2836 0.2826
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.008 0.0376
Brugia malayi nuclear hormone receptor 0.0005 0.0014 0.0013
Schistosoma mansoni cpg binding protein 0.0034 0.0882 0.0882
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0013
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0528 0.0527
Entamoeba histolytica hypothetical protein 0.0037 0.0992 0.8395
Echinococcus granulosus translational activator gcn1 0.0006 0.0033 0.0019
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.1294 0.5667
Schistosoma mansoni smad1 5 8 and 0.0008 0.0114 0.0114
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0024 0.0598 0.4478
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0185 0.0184
Plasmodium vivax transportin, putative 0.0006 0.0033 0.0137
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0598 0.0598
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.2836 0.2826
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0185 0.0184
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0185 0.0185
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.008 0.0376
Echinococcus multilocularis zinc finger protein 0.0006 0.0036 0.0022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0185 0.0184
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.3569 0.3569
Schistosoma mansoni smad1 5 8 and 0.0008 0.0114 0.0114
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0185 0.0184
Schistosoma mansoni zinc finger protein 0.0005 0.0014 0.0014
Echinococcus multilocularis Smad4 0.0008 0.0114 0.01
Loa Loa (eye worm) T-complex protein 1 0.0024 0.0598 0.0597
Loa Loa (eye worm) RNA binding protein 0.0335 1 1
Loa Loa (eye worm) Smad1 0.0008 0.0114 0.0113
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0185 0.0184
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0101 0.0101
Schistosoma mansoni nuclear receptor 0.0005 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.0172 0.5057 0.5057
Schistosoma mansoni ran 0.0022 0.0528 0.0528
Brugia malayi PHD-finger family protein 0.0006 0.0036 0.0035
Loa Loa (eye worm) hypothetical protein 0.0006 0.0032 0.0031
Toxoplasma gondii t-complex protein beta subunit 0.0024 0.0598 0.2538
Loa Loa (eye worm) hypothetical protein 0.0011 0.0185 0.0184
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0006 0.0036 0.0022
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0101 0.0087
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0528 0.1132
Schistosoma mansoni smad1 5 8 and 0.0008 0.0114 0.0114
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0185 0.0171
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0006 0.0036 0.0022
Loa Loa (eye worm) nuclear receptor NHR-67 0.0005 0.0014 0.0013
Entamoeba histolytica Ran family GTPase 0.0022 0.0528 0.4337
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.2836 0.2836
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0024 0.0598 0.264
Giardia lamblia TCP-1 chaperonin subunit beta 0.0024 0.0598 0.2087
Loa Loa (eye worm) hypothetical protein 0.0011 0.0185 0.0184
Schistosoma mansoni hypothetical protein 0.0172 0.5057 0.5057
Echinococcus granulosus importin 5 0.0006 0.0033 0.0019

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.