Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Trypanosoma cruzi | trypanothione reductase, putative | Starlite/ChEMBL | References |
Trypanosoma brucei gambiense | trypanothione reductase, putative | References | |
Trypanosoma brucei | trypanothione reductase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | trypanothione reductase, putative | 492 aa | 548 aa | 21.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | NADH oxidase | 0.0079 | 0 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0228 | 1 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0228 | 1 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0228 | 1 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0228 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0079 | 0 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0228 | 1 | 1 |
Leishmania major | trypanothione reductase | 0.0228 | 1 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0079 | 0 | 0.5 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0079 | 0 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0228 | 1 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0228 | 1 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0228 | 1 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0228 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0079 | 0 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0228 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0228 | 1 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0228 | 1 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0079 | 0 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0079 | 0 | 0.5 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0079 | 0 | 0.5 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0079 | 0 | 0.5 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0079 | 0 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0079 | 0 | 0.5 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0228 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 40 uM | Antitrypanosomal activity against blood stream form Trypanosoma brucei brucei by resazurin fluorescence-based viability assay | ChEMBL. | 21851087 |
IC50 (binding) | = 6.8 uM | Inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by DTNB-coupled spectrophotometric assay | ChEMBL. | 21851087 |
IC50 (binding) | = 19 uM | Inhibition of trypanothione reductase from Trypanosoma cruzi by DTNB-coupled spectrophotometric assay | ChEMBL. | 21851087 |
IC50 (binding) | > 100 uM | Inhibition of human glutathione reductase | ChEMBL. | 21851087 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.