Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0021 | 0.0558 | 0.1144 |
Brugia malayi | nuclear receptor NHR-88 | 0.0021 | 0.0558 | 0.1144 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0021 | 0.0558 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0558 | 0.1107 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0021 | 0.0558 | 0.0558 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0021 | 0.0558 | 0.0558 |
Echinococcus granulosus | protein arginine N methyltransferase 8 | 0.0033 | 0.2247 | 0.2247 |
Loa Loa (eye worm) | protein arginine N-methyltransferase | 0.0019 | 0.0206 | 0.0382 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0021 | 0.0558 | 0.0558 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.3645 | 0.7358 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0021 | 0.0558 | 0.0558 |
Brugia malayi | hypothetical protein | 0.0052 | 0.488 | 1 |
Toxoplasma gondii | histone arginine methyltransferase PRMT1 | 0.0033 | 0.2247 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0021 | 0.0558 | 0.0558 |
Trichomonas vaginalis | protein arginine N-methyltransferase, putative | 0.0033 | 0.2247 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0021 | 0.0558 | 0.1144 |
Plasmodium falciparum | protein arginine N-methyltransferase 1 | 0.0033 | 0.2247 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0021 | 0.0558 | 0.1107 |
Brugia malayi | Carm1-pending protein | 0.0019 | 0.0206 | 0.0423 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0021 | 0.0558 | 0.1144 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0021 | 0.0558 | 0.1532 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0021 | 0.0558 | 0.1107 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0021 | 0.0558 | 0.1107 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.3645 | 0.3645 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.488 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0021 | 0.0558 | 0.1144 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0021 | 0.0558 | 0.1144 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0021 | 0.0558 | 0.1144 |
Schistosoma mansoni | protein arginine n-methyltransferase | 0.0019 | 0.0206 | 0.0566 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0021 | 0.0558 | 0.1107 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0021 | 0.0558 | 0.1144 |
Schistosoma mansoni | protein arginine N-methyltransferase 1 | 0.0033 | 0.2247 | 0.6166 |
Brugia malayi | hypothetical protein | 0.0043 | 0.3645 | 0.7469 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.3645 | 1 |
Entamoeba histolytica | arginine N-methyltransferase protein, putative | 0.0052 | 0.488 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0558 | 0.1107 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.3645 | 0.7358 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0021 | 0.0558 | 0.1107 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0021 | 0.0558 | 0.0558 |
Onchocerca volvulus | 0.0021 | 0.0558 | 0.5 | |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0021 | 0.0558 | 0.0558 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0021 | 0.0558 | 0.1532 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0021 | 0.0558 | 0.1144 |
Trypanosoma cruzi | arginine N-methyltransferase, putative | 0.0052 | 0.488 | 1 |
Trichomonas vaginalis | protein arginine N-methyltransferase, putative | 0.0033 | 0.2247 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0021 | 0.0558 | 0.1107 |
Plasmodium vivax | protein arginine N-methyltransferase 1, putative | 0.0033 | 0.2247 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.3645 | 1 |
Echinococcus multilocularis | protein arginine N methyltransferase 8 | 0.0033 | 0.2247 | 0.2247 |
Trypanosoma brucei | Protein arginine N-methyltransferase 1 catalytic subunit | 0.0052 | 0.488 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0021 | 0.0558 | 0.1144 |
Schistosoma mansoni | protein arginine N-methyltransferase 1 | 0.0033 | 0.2247 | 0.6166 |
Echinococcus granulosus | histone arginine methyltransferase CARMER | 0.0019 | 0.0206 | 0.0206 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.3645 | 0.7358 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0558 | 0.1107 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0021 | 0.0558 | 0.1144 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0021 | 0.0558 | 0.1532 |
Schistosoma mansoni | thyroid hormone receptor | 0.0021 | 0.0558 | 0.1532 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0021 | 0.0558 | 0.1144 |
Echinococcus multilocularis | protein arginine N methyltransferase 7 | 0.0019 | 0.0206 | 0.0206 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0021 | 0.0558 | 0.0558 |
Schistosoma mansoni | coup transcription factor | 0.0021 | 0.0558 | 0.1532 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.3645 | 0.3645 |
Schistosoma mansoni | thyroid hormone receptor | 0.0021 | 0.0558 | 0.1532 |
Echinococcus granulosus | methyltransferase protein 5 | 0.0019 | 0.0206 | 0.0206 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0021 | 0.0558 | 0.0558 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0021 | 0.0558 | 0.1144 |
Echinococcus granulosus | protein arginine N methyltransferase 7 | 0.0019 | 0.0206 | 0.0206 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0558 | 0.1107 |
Echinococcus granulosus | protein arginine methyltransferase | 0.0033 | 0.2247 | 0.2247 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0206 | 0.0566 |
Trichomonas vaginalis | protein arginine N-methyltransferase, putative | 0.0033 | 0.2247 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0021 | 0.0558 | 0.1532 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0021 | 0.0558 | 0.1144 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0021 | 0.0558 | 0.0558 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0021 | 0.0558 | 0.1532 |
Echinococcus granulosus | Ankyrin | 0.0017 | 0.0021 | 0.0021 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0088 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0558 | 0.1107 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0021 | 0.0558 | 0.5 |
Schistosoma mansoni | protein arginine N-methyltransferase 1 | 0.0033 | 0.2247 | 0.6166 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0021 | 0.0558 | 0.1107 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0021 | 0.0558 | 0.1144 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0558 | 0.1107 |
Loa Loa (eye worm) | Carm1-pending protein | 0.0019 | 0.0206 | 0.0382 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0021 | 0.0558 | 0.0558 |
Brugia malayi | Protein arginine N-methyltransferase | 0.0019 | 0.0206 | 0.0423 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0021 | 0.0558 | 0.1107 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0021 | 0.0558 | 0.0558 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0017 | 0.0021 | 0.0057 |
Echinococcus granulosus | FTZ F1 alpha | 0.0021 | 0.0558 | 0.0558 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0558 | 0.1107 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0021 | 0.0558 | 0.0558 |
Entamoeba histolytica | hypothetical protein | 0.0052 | 0.488 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.3645 | 0.7358 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0021 | 0.0558 | 0.0558 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0021 | 0.0558 | 0.1144 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0021 | 0.0558 | 0.0558 |
Schistosoma mansoni | nuclear hormone receptor | 0.0021 | 0.0558 | 0.1532 |
Brugia malayi | ecdysteroid receptor | 0.0021 | 0.0558 | 0.1144 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0021 | 0.0558 | 0.1144 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0021 | 0.0558 | 0.1532 |
Brugia malayi | steroid hormone receptor | 0.0021 | 0.0558 | 0.1144 |
Leishmania major | arginine N-methyltransferase-like protein | 0.0033 | 0.2247 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0021 | 0.0558 | 0.0558 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0021 | 0.0558 | 0.1532 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0021 | 0.0558 | 0.1532 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0021 | 0.0558 | 0.1532 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0558 | 0.1107 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0021 | 0.0558 | 0.1144 |
Echinococcus multilocularis | protein arginine methyltransferase | 0.0033 | 0.2247 | 0.2247 |
Echinococcus multilocularis | histone arginine methyltransferase CARMER | 0.0019 | 0.0206 | 0.0206 |
Trypanosoma cruzi | arginine N-methyltransferase, putative | 0.0052 | 0.488 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0021 | 0.0558 | 0.0558 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0021 | 0.0558 | 0.5 |
Echinococcus multilocularis | Ankyrin | 0.0017 | 0.0021 | 0.0021 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Reduction (functional) | = 66 % | Percent reduction in paw volume (right primary lesion, days 9-18) by 33 mg/kg p.o. in rats. | ChEMBL. | No reference |
Reduction (functional) | = 75 % | Improvement in joint mobility at 33 mg/kg p.o. in rat model of arthritis. | ChEMBL. | No reference |
Reduction (functional) | = 79 % | Percent reduction in paw volume (left primary lesion, days 9-18) by 33 mg/kg p.o. in rats. | ChEMBL. | No reference |
Reduction (functional) | = 80 % | Percent reduction in paw volume (right primary lesion, days 0-8) by 33 mg/kg p.o. in rats. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.