Detailed information for compound 653399

Basic information

Technical information
  • TDR Targets ID: 653399
  • Name: 2-[2-[(4-dimethylaminophenyl)methylidene]hydr azinyl]-1,3-thiazol-4-one
  • MW: 262.331 | Formula: C12H14N4OS
  • H donors: 1 H acceptors: 1 LogP: 1.9 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(c1ccc(cc1)/C=N/NC1=NC(=O)CS1)C
  • InChi: 1S/C12H14N4OS/c1-16(2)10-5-3-9(4-6-10)7-13-15-12-14-11(17)8-18-12/h3-7H,8H2,1-2H3,(H,14,15,17)/b13-7+
  • InChiKey: AOFVYOCIKCHIBD-NTUHNPAUSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(2E)-2-[(4-dimethylaminophenyl)methylidene]hydrazinyl]-1,3-thiazol-4-one
  • 2-[N'-[(4-dimethylaminophenyl)methylene]hydrazino]thiazol-4-one
  • 2-[(N'E)-N'-[(4-dimethylaminophenyl)methylene]hydrazino]thiazol-4-one
  • 2-[N'-[(4-dimethylaminophenyl)methylene]hydrazino]-4-thiazolone
  • 2-[(N'E)-N'-[(4-dimethylaminophenyl)methylene]hydrazino]-4-thiazolone
  • 2-[N'-(4-dimethylaminobenzylidene)hydrazino]thiazol-4-one
  • 2-[(N'E)-N'-(4-dimethylaminobenzylidene)hydrazino]thiazol-4-one
  • 4-(Dimethylamino)benzaldehyde (4-oxo-4,5-dihydro-1,3-thiazol-2-yl)hydrazone
  • Benzaldehyde, 4-dimethylamino-, (4-oxo-2-thiazolin-2-yl)hydrazone
  • 2-[N'-(4-Dimethylamino-benzylidene)-hydrazino]-thiazol-4-one
  • BAS 00194050
  • T0400-0577

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0215 0.0215
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0215 0.0557
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0846 0.3686
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.00000000011292 0.00000000049196
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0348 0.0348
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0138 0.5
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0223 0.0315
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0764 0.3329
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.2666 0.8837
Echinococcus granulosus bloom syndrome protein 0.0024 0.0348 0.0348
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0223 0.0223
Echinococcus multilocularis chromobox protein 1 0.0069 0.161 0.161
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0024 0.0362 0.1577
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0215 0.0935
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.00000000011292 0.00000000049196
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0018 0.0025
Schistosoma mansoni survival motor neuron protein 0.0054 0.1193 0.3096
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.2324 0.2324
Trypanosoma cruzi hypothetical protein, conserved 0.0211 0.5564 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.1115 0.1115
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0223 0.0579
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0223 0.0315
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0992 0.0992
Trypanosoma brucei hypothetical protein, conserved 0.0211 0.5564 1
Brugia malayi glutathione reductase 0.0047 0.0992 0.1401
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0133 0.1346
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0215 0.0303
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0138 0.0178
Echinococcus multilocularis chromobox protein 1 0.0069 0.161 0.161
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0114 0.0114
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0491 0.0693
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.161 0.2275
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0209 0.0542
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0215 0.0303
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.00000000011292 0.00000000011292
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.2295 0.4084
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0114 0.0161
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0491 0.4947
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.2295 0.3243
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.00000000011292 0.00000000049196
Trichomonas vaginalis chromobox protein, putative 0.0069 0.161 0.7015
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0215 0.0215
Echinococcus granulosus survival motor neuron protein 1 0.0265 0.7078 0.7078
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0138 0.0178
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0977 0.4257
Loa Loa (eye worm) hypothetical protein 0.0015 0.0114 0.0161
Plasmodium falciparum glutathione reductase 0.0047 0.0992 1
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0764 0.3329
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0114 0.0161
Schistosoma mansoni jumonji domain containing protein 0.0075 0.1781 0.4624
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.1115 0.1115
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0215 0.0303
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0992 0.0992
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.066 0.1714
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0215 0.0557
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0128 0.1292
Mycobacterium tuberculosis Conserved protein 0.0024 0.0362 0.0784
Plasmodium falciparum thioredoxin reductase 0.0016 0.0138 0.1389
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.2295 0.4084
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.00000000011292 0.00000000049196
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0806 0.0806
Giardia lamblia Kinase, PLK 0.0093 0.2295 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0138 0.0178
Loa Loa (eye worm) hypothetical protein 0.0019 0.0215 0.0303
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.00000000011292 0.00000000049196
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0114 0.0114
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.1115 0.2894
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0215 0.0215
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0223 0.0315
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0362 0.0584
Plasmodium falciparum thioredoxin reductase 0.0047 0.0992 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0215 0.0935
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0268 0.27
Echinococcus granulosus GPCR family 2 0.0015 0.0114 0.0114
Brugia malayi chromobox protein homolog 3 0.0039 0.0764 0.108
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0846 0.3686
Loa Loa (eye worm) hypothetical protein 0.003 0.0531 0.075
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.00000000011292 0.00000000049196
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.2998 1
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0215 0.0557
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0138 0.0178
Schistosoma mansoni kinase 0.0048 0.1012 0.2626
Trypanosoma cruzi hypothetical protein, conserved 0.0211 0.5564 1
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0024 0.0362 0.0784
Entamoeba histolytica hypothetical protein 0.0019 0.0215 0.0935
Brugia malayi Heterochromatin protein 1 0.0069 0.161 0.2275
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0215 0.0215
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.2324 0.2324
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0138 0.0357
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0215 0.0935
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0215 0.0935
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0215 0.0215
Loa Loa (eye worm) glutathione reductase 0.0047 0.0992 0.1401
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.2295 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.2998 1
Echinococcus granulosus jumonji domain containing protein 0.004 0.0806 0.0806
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.104 0.147
Loa Loa (eye worm) hypothetical protein 0.0019 0.0215 0.0303
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0265 0.7078 1
Echinococcus granulosus citrate lyase subunit beta protein 0.0024 0.0362 0.0362
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0215 0.0215
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0215 0.0935
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.00000000011292 0.00000000049196
Loa Loa (eye worm) hypothetical protein 0.0019 0.0215 0.0303
Loa Loa (eye worm) hypothetical protein 0.0019 0.0215 0.0303
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0215 0.0303
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.00000000011292 0.00000000029313
Plasmodium falciparum phd finger protein, putative 0.0029 0.0491 0.4947
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0018 0.0025
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.1115 0.1115
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0992 0.1724
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0992 0.1401
Brugia malayi CHD4 protein 0.0011 0.00000000011292 0.00000000015954
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.2295 1
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0449 0.1956
Brugia malayi Bromodomain containing protein 0.0029 0.0491 0.0693
Trypanosoma brucei polo-like protein kinase 0.0093 0.2295 0.4084
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0491 0.1273
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.2295 0.4084
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0611 0.0864
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0138 0.0178
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0138 0.1389
Plasmodium vivax glutathione reductase, putative 0.0047 0.0992 1
Schistosoma mansoni hypothetical protein 0.0011 0.00000000011292 0.00000000029313
Mycobacterium ulcerans hypothetical protein 0.0024 0.0362 1
Echinococcus granulosus Chromo domain 0.0011 0.00000000011292 0.00000000011292
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.1115 0.1115
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.104 0.147
Onchocerca volvulus 0.003 0.0531 0.2313
Schistosoma mansoni hypothetical protein 0.0015 0.0114 0.0295
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0215 0.0215
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.00000000011292 0.00000000049196
Loa Loa (eye worm) hypothetical protein 0.0029 0.0491 0.0693
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.2295 0.2295
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0215 0.0215
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0138 0.0178
Schistosoma mansoni hypothetical protein 0.0015 0.0114 0.0295
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0215 0.0303
Brugia malayi PXA domain containing protein 0.0019 0.0215 0.0303
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0114 0.0114
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.2295 0.5958
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0138 0.0195
Echinococcus multilocularis peregrin 0.0029 0.0491 0.0491
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0138 0.1389
Echinococcus multilocularis expressed protein 0.0369 1 1
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0215 0.0215
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.2666 0.8837
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0138 0.0138
Schistosoma mansoni hypothetical protein 0.0033 0.0611 0.1587
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0215 0.0303
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0348 0.0492
Loa Loa (eye worm) CHromoDomain protein family member 0.0011 0.00000000011292 0.00000000015954
Loa Loa (eye worm) RecQ helicase 0.0024 0.0348 0.0492
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.00000000011292 0.00000000049196
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0138 0.1389
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0138 0.1389
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0215 0.0557
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.00000000011292 0.00000000049196
Giardia lamblia PHD finger protein 15 0.0029 0.0491 0.1635
Loa Loa (eye worm) hypothetical protein 0.0033 0.0611 0.0864
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0362 1
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.2295 1
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0011 0.00000000011292 0.00000000011292
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.2666 0.8837
Entamoeba histolytica hypothetical protein 0.0019 0.0215 0.0935
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0138 0.06
Mycobacterium tuberculosis Probable reductase 0.0107 0.2666 0.8837
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.00000000011292 0.00000000049196
Leishmania major trypanothione reductase 0.0047 0.0992 0.1724
Echinococcus granulosus chromobox protein 1 0.0069 0.161 0.161
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.1115 0.2894
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0223 0.0223
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0348 0.1517
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0215 0.0557
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0138 0.0178
Schistosoma mansoni hypothetical protein 0.0054 0.1193 0.3096
Echinococcus multilocularis survival motor neuron protein 1 0.0265 0.7078 0.7078
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0977 0.4257
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0223 0.0579
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.2295 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.1066 0.1506
Plasmodium vivax hypothetical protein, conserved 0.0011 0.00000000011292 0.0000000011388
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.00000000011292 0.00000000049196
Brugia malayi jmjC domain containing protein 0.0095 0.2324 0.3283
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0491 0.4947
Loa Loa (eye worm) hypothetical protein 0.0011 0.00000000011292 0.00000000015954
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.066 0.066
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0215 0.0557
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.2998 1
Mycobacterium ulcerans hypothetical protein 0.0024 0.0362 1
Brugia malayi PXA domain containing protein 0.0019 0.0215 0.0303
Echinococcus multilocularis GPCR, family 2 0.0015 0.0114 0.0114
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.00000000011292 0.00000000049196
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0138 0.0178
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0215 0.0215
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0138 0.0178
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.2295 1
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0215 0.0303
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0011 0.00000000011292 0.00000000011292
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0348 0.1517
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0011 0.00000000011292 0.0000000011388
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0215 0.0557
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0846 0.3686
Leishmania major hypothetical protein, conserved 0.0211 0.5564 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0215 0.0303
Loa Loa (eye worm) hypothetical protein 0.0019 0.0215 0.0303
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0215 0.0215
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0039 0.0171
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.00000000011292 0.00000000015954
Loa Loa (eye worm) hypothetical protein 0.012 0.3024 0.4273
Schistosoma mansoni chromobox protein 0.0069 0.161 0.418
Loa Loa (eye worm) hypothetical protein 0.0039 0.0764 0.108
Toxoplasma gondii thioredoxin reductase 0.0047 0.0992 1
Echinococcus granulosus chromobox protein 1 0.0069 0.161 0.161
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0138 0.0178
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.1115 0.1575
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0138 0.1389
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0138 0.0178
Trichomonas vaginalis chromobox protein, putative 0.0069 0.161 0.7015
Onchocerca volvulus 0.0054 0.1193 0.5197
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0215 0.0215
Schistosoma mansoni hypothetical protein 0.0029 0.0491 0.1273
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0992 0.2985
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.00000000011292 0.00000000029313
Onchocerca volvulus Alhambra homolog 0.0029 0.0491 0.2137
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0138 0.06
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0011 0.00000000011292 0.0000000011388
Trypanosoma brucei trypanothione reductase 0.0047 0.0992 0.1724
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0491 0.4947
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0223 0.0579
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.066 0.066
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0362 0.0584
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.066 0.1714
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0138 0.5
Entamoeba histolytica hypothetical protein 0.0019 0.0215 0.0935
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0215 0.0557
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.2295 0.3243
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0114 0.0114
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0215 0.0215
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0114 0.0161
Schistosoma mansoni hypothetical protein 0.0015 0.0114 0.0295
Brugia malayi hypothetical protein 0.0019 0.0215 0.0303
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.00000000011292 0.00000000011292
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0138 0.1389
Brugia malayi Thioredoxin reductase 0.0047 0.0992 0.1401
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0138 0.0178
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.1348 0.1905
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.2295 1
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0215 0.0215
Brugia malayi jmjC domain containing protein 0.0035 0.066 0.0933
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0138 0.0178
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.066 0.0933
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.1193 0.1685
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0215 0.0935
Entamoeba histolytica hypothetical protein 0.0011 0.00000000011292 0.00000000049196
Plasmodium falciparum glutathione reductase 0.0016 0.0138 0.1389
Loa Loa (eye worm) hypothetical protein 0.0049 0.104 0.147
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.2295 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.00000000011292 0.00000000049196
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.2666 0.8837
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.00000000011292 0.00000000049196
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0215 0.0215
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.1115 0.1575
Schistosoma mansoni hypothetical protein 0.0015 0.0114 0.0295
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0449 0.1956
Echinococcus multilocularis citrate lyase subunit beta protein 0.0024 0.0362 0.0362
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.2666 0.8837
Brugia malayi hypothetical protein 0.0265 0.7078 1
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0215 0.0215
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.2998 1
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.2295 1
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0215 0.0303
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0215 0.0557
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.00000000011292 0.00000000049196
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0138 0.5
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0362 0.0584
Treponema pallidum NADH oxidase 0.0016 0.0138 0.5
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0362 1
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0215 0.0557
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.1115 0.2894
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0138 0.0178
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0215 0.0557
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0491 0.0491
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0024 0.0362 1
Echinococcus multilocularis Chromo domain 0.0011 0.00000000011292 0.00000000011292
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.104 0.147
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0992 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0764 0.3329
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0138 0.0178
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.00000000011292 0.00000000015954
Brugia malayi PHD-finger family protein 0.0029 0.0491 0.0693
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0138 0.0178
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.2295 1
Schistosoma mansoni chromobox protein 0.0069 0.161 0.418
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0138 0.0178
Echinococcus granulosus peregrin 0.0029 0.0491 0.0491
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0491 0.0491
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0039 0.0171
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0138 0.0138
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0215 0.0935
Brugia malayi hypothetical protein 0.0019 0.0215 0.0303
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.2295 0.2295

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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