Detailed information for compound 65372

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 840.851 | Formula: C37H37FN6O12S2
  • H donors: 4 H acceptors: 13 LogP: -2.06 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 3
  • SMILES: CS(=O)(=O)O.CS(=O)(=O)O.Fc1cnc2c(c1)cc1c3c2cccc3c(=O)n(c1=O)[C@@H](CNCCNC[C@H](n1c(=O)c2cccc3c2c(c1=O)cc(c3)[N+](=O)[O-])C)C
  • InChi: 1S/C35H29FN6O6.2CH4O3S/c1-18(40-32(43)25-7-3-5-20-12-23(42(47)48)14-28(29(20)25)35(40)46)15-37-9-10-38-16-19(2)41-33(44)26-8-4-6-24-30(26)27(34(41)45)13-21-11-22(36)17-39-31(21)24;2*1-5(2,3)4/h3-8,11-14,17-19,37-38H,9-10,15-16H2,1-2H3;2*1H3,(H,2,3,4)/t18-,19-;;/m1../s1
  • InChiKey: TUTWZQAJCYMJRG-BAMQSBMESA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.008 0.0259
Echinococcus multilocularis beta adrenergic receptor kinase 0.0022 0.0152 0.015
Echinococcus multilocularis lysosomal alpha glucosidase 0.0187 0.2044 0.2043
Brugia malayi hypothetical protein 0.0075 0.0758 0.0998
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0012 0.003
Echinococcus multilocularis musashi 0.0061 0.0602 0.06
Brugia malayi small heat shock protein 0.0662 0.7494 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0126 0.0471
Toxoplasma gondii DNA-directed RNA polymerase III RPC2 0.0013 0.005 0.0436
Trypanosoma brucei calpain-like protein, putative 0.0243 0.2685 1
Mycobacterium ulcerans bacterioferritin BfrA 0.001 0.0014 0.0002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0117 0.0145
Echinococcus granulosus jun protein 0.0095 0.0991 0.099
Echinococcus multilocularis DNA directed RNA polymerase II subunit RPB2 0.0013 0.005 0.0048
Brugia malayi PXA domain containing protein 0.0021 0.0148 0.0184
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0189 0.0236
Echinococcus granulosus ferritin 0.001 0.0014 0.0012
Brugia malayi Glycosyl hydrolases family 31 protein 0.0041 0.0378 0.0491
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0148 0.0146
Onchocerca volvulus UPF0528 protein homolog 0.0045 0.0424 0.1408
Trypanosoma brucei glycosyl hydrolase-like protein 0.0015 0.008 0.0266
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0148 0.0146
Echinococcus granulosus 6 phosphofructokinase 0.0114 0.1215 0.1214
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0663 0.7509 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0126 0.0441
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0378 0.1407
Schistosoma mansoni ferritin light chain 0.001 0.0014 0.0012
Schistosoma mansoni ferritin 0.001 0.0014 0.0012
Brugia malayi regulator of G-protein signaling egl-10 0.0021 0.0148 0.0184
Loa Loa (eye worm) hypothetical protein 0.0028 0.0227 0.0293
Trypanosoma brucei calpain, putative 0.0243 0.2685 1
Trypanosoma cruzi cytochrome P450, putative 0.0017 0.0093 0.0347
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.1144 0.3885
Mycobacterium ulcerans arylamine N-acetyltransferase Nat 0.0618 0.699 0.9308
Chlamydia trachomatis DNA-directed RNA polymerase subunit beta 0.0249 0.2759 0.3575
Onchocerca volvulus 0.003 0.0244 0.0793
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0148 0.0146
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0126 0.0158
Loa Loa (eye worm) hypothetical protein 0.0025 0.0189 0.0241
Loa Loa (eye worm) hypothetical protein 0.0021 0.0148 0.0186
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0022 0.0152 0.0192
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0378 0.1274
Giardia lamblia Kinase, PLK 0.0108 0.1144 1
Schistosoma mansoni alpha-glucosidase 0.0161 0.1746 0.1744
Mycobacterium ulcerans DNA-directed RNA polymerase subunit beta 0.0249 0.2759 0.3665
Plasmodium falciparum DNA-directed RNA polymerase III subunit RPC2, putative 0.0013 0.005 0.0055
Loa Loa (eye worm) hypothetical protein 0.0029 0.024 0.031
Brugia malayi A-kinase anchor protein 10, precursor 0.0021 0.0148 0.0184
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0189 0.0637
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.008 0.0259
Brugia malayi Cytochrome P450 family protein 0.0027 0.0214 0.0273
Schistosoma mansoni intermediate filament proteins 0.0061 0.0602 0.06
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0663 0.7509 1
Echinococcus granulosus RUN 0.0021 0.0141 0.0139
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0636 0.0832
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.027 0.0269
Trichomonas vaginalis ferritin, putative 0.001 0.0014 0.0035
Trichomonas vaginalis bromodomain-containing protein, putative 0.0092 0.0962 0.3266
Brugia malayi Pre-SET motif family protein 0.0034 0.0292 0.0376
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0243 0.2685 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.0093 0.0113
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0012 0.003
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0663 0.7509 1
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0126 0.0155
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0092 0.0962 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0141 0.0139
Brugia malayi DNA-directed RNA polymerase III subunit 127.6 kDa polypeptide 0.0013 0.005 0.0053
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0257 0.0332
Plasmodium vivax DNA-directed RNA polymerase III subunit, putative 0.0013 0.005 0.0055
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0378 0.1274
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0257 0.019
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0141 0.0176
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0148 0.0146
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0189 0.0236
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0012 0.003
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.1215 0.4128
Echinococcus granulosus neutral alpha glucosidase AB 0.0041 0.0378 0.0376
Schistosoma mansoni bromodomain containing protein 0.0009 0.001 0.0009
Onchocerca volvulus 0.0075 0.0758 0.2546
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0126 0.0157
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0148 0.0146
Schistosoma mansoni DNA-directed RNA polymerase I subunit 0.0009 0.0008 0.0007
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0148 0.0146
Mycobacterium ulcerans bacterioferritin BfrB 0.001 0.0014 0.0002
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0148 0.0146
Loa Loa (eye worm) hypothetical protein 0.0025 0.0189 0.0241
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0148 0.0491
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0148 0.0146
Treponema pallidum DNA-directed RNA polymerase subunit beta 0.0249 0.2759 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0108 0.1144 0.1517
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0243 0.2685 1
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.1215 0.1214
Trypanosoma cruzi polo-like protein kinase, putative 0.0108 0.1144 0.4261
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0021 0.0148 0.0491
Onchocerca volvulus 0.0034 0.0292 0.0955
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0041 0.0378 0.3872
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0061 0.0602 0.0793
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0148 0.0491
Entamoeba histolytica hypothetical protein 0.0021 0.0148 0.0839
Loa Loa (eye worm) hypothetical protein 0.0009 0.001 0.0003
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0257 0.0864
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.0517 0.1749
Echinococcus multilocularis expressed protein 0.0416 0.4676 0.4675
Echinococcus multilocularis lamin 0.0061 0.0602 0.06
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0378 0.1274
Echinococcus granulosus beta-adrenergic receptor kinase 0.0022 0.0152 0.015
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0114 0.1215 0.1605
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0064 0.0636 0.0832
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0141 0.0139
Echinococcus multilocularis DNA directed RNA polymerase I subunit RPA2 0.0013 0.005 0.0048
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0257 0.0864
Schistosoma mansoni apoferritin-2 0.001 0.0014 0.0012
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0148 0.0146
Leishmania major DNA-directed RNA polymerase polypeptide, putative 0.0013 0.005 0.0155
Loa Loa (eye worm) RNA polymerase III 128kD subunit-PA 0.0013 0.005 0.0056
Loa Loa (eye worm) hypothetical protein 0.0092 0.0962 0.1273
Schistosoma mansoni hypothetical protein 0.088 1 1
Loa Loa (eye worm) RGS-3 protein 0.0021 0.0148 0.0186
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0064 0.0636 0.0635
Plasmodium falciparum histone acetyltransferase GCN5 0.0085 0.0874 0.1154
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0292 0.029
Schistosoma mansoni rab6-interacting 0.0021 0.0141 0.0139
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0141 0.0139
Echinococcus granulosus expressed protein 0.0416 0.4676 0.4675
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0148 0.0146
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.001 0.0014 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0012 0.003
Echinococcus multilocularis 6 phosphofructokinase 0.0114 0.1215 0.1214
Echinococcus granulosus lamin 0.0061 0.0602 0.06
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0378 0.1274
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0126 0.0152
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0012 0.003
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0314 0.3506 0.3505
Brugia malayi Pre-SET motif family protein 0.0233 0.2571 0.3422
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0012 0.003
Entamoeba histolytica fatty acid elongase, putative 0.0086 0.089 0.7212
Echinococcus multilocularis regulator of G protein signaling 0.0021 0.0148 0.0146
Trichomonas vaginalis maltase-glucoamylase, putative 0.0015 0.008 0.0259
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0189 0.1193
Toxoplasma gondii exonuclease III APE 0.002 0.0126 0.1237
Schistosoma mansoni rab6-interacting 0.0021 0.0141 0.0139
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0189 0.0236
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0012 0.003
Schistosoma mansoni lipoxygenase 0.0021 0.0141 0.0139
Onchocerca volvulus 0.0012 0.0036 0.0081
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0152 0.015
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.0093 0.0113
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0243 0.2685 1
Trypanosoma cruzi cytochrome P450, putative 0.0017 0.0093 0.0347
Plasmodium falciparum DNA-directed RNA polymerase II subunit RPB2, putative 0.0013 0.005 0.0055
Plasmodium vivax SET domain containing protein 0.001 0.0012 0.0005
Entamoeba histolytica fatty acid elongase, putative 0.0086 0.089 0.7212
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0126 0.0409
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0378 0.1274
Echinococcus granulosus lamin dm0 0.0061 0.0602 0.06
Trichomonas vaginalis DNA-directed RNA polymerase III subunit, putative 0.0013 0.005 0.0158
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0117 0.0139
Schistosoma mansoni jun-related protein 0.0077 0.0787 0.0786
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0243 0.2685 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0017 0.0093 0.0108
Brugia malayi hypothetical protein 0.0021 0.0141 0.0174
Schistosoma mansoni lamin 0.0061 0.0602 0.06
Schistosoma mansoni alpha-glucosidase 0.0161 0.1746 0.1744
Schistosoma mansoni loxhd1 0.0021 0.0141 0.0139
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0378 0.1274
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0642 0.064
Trypanosoma brucei polo-like protein kinase 0.0108 0.1144 0.4243
Giardia lamblia Hypothetical protein 0.001 0.0012 0.0035
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0189 0.0239
Brugia malayi Sulfatase family protein 0.001 0.0012 0.0003
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0189 0.0236
Echinococcus granulosus histone acetyltransferase KAT2B 0.0305 0.3405 0.3404
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0114 0.1215 0.4376
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0092 0.0962 0.3266
Mycobacterium tuberculosis Bacterioferritin BfrB 0.001 0.0014 0.0002
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.1215 0.1613
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0257 0.0864
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0148 0.0146
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0105 0.0123
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0257 0.0864
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0012 0.003
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0009 0.001 0.0009
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.008 0.0259
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0041 0.0378 0.0494
Schistosoma mansoni lipoxygenase 0.0058 0.0569 0.0568
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0012 0.003
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0012 0.003
Schistosoma mansoni hypothetical protein 0.0077 0.0787 0.0786
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0126 0.0656
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0148 0.0146
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0257 0.0864
Echinococcus multilocularis Regulator of G protein signaling 20 0.0021 0.0148 0.0146
Plasmodium vivax DNA-directed RNA polymerase II subunit RPB2, putative 0.0013 0.005 0.0055
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0152 0.015
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0012 0.003
Echinococcus multilocularis jun protein 0.0095 0.0991 0.099
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0005
Leishmania major glycosyl hydrolase-like protein 0.0015 0.008 0.0266
Loa Loa (eye worm) hypothetical protein 0.0061 0.0602 0.0793
Brugia malayi hypothetical protein 0.001 0.0012 0.0003
Loa Loa (eye worm) hypothetical protein 0.0019 0.0117 0.0145
Loa Loa (eye worm) hypothetical protein 0.0021 0.0141 0.0177
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0189 0.1193
Brugia malayi hypothetical protein 0.0021 0.0148 0.0184
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0189 0.0675
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.008 0.0259
Trichomonas vaginalis sucrase-isomaltase, putative 0.0041 0.0378 0.1274
Loa Loa (eye worm) hypothetical protein 0.0019 0.0117 0.0145
Toxoplasma gondii DNA-directed RNA polymerase II RPB2 0.0013 0.005 0.0436
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.1144 0.3885
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0148 0.0491
Loa Loa (eye worm) CYP4Cod1 0.0017 0.0093 0.0113
Onchocerca volvulus 0.0061 0.0602 0.2014
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0187 0.2044 0.2719
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0148 0.0184
Echinococcus multilocularis lamin dm0 0.0061 0.0602 0.06
Schistosoma mansoni z-protein (S1r protein) 0.0021 0.0148 0.0146
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0148 0.0146
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0244 0.0315
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0105 0.0123
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0126 0.0125
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0021 0.0148 0.0146
Echinococcus multilocularis DNA directed RNA polymerase III subunit RPC2 0.0013 0.005 0.0048
Trypanosoma brucei DNA-directed RNA polymerase II subunit 2, putative 0.0013 0.005 0.0155
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0189 0.0236
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0378 0.2813
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0033 0.0277 0.0359
Brugia malayi 6-phosphofructokinase 0.0114 0.1215 0.161
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0148 0.0491
Schistosoma mansoni ferritin light chain 0.001 0.0014 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0012 0.003
Brugia malayi Intermediate filament tail domain containing protein 0.0061 0.0602 0.079
Echinococcus multilocularis neutral alpha glucosidase AB 0.0041 0.0378 0.0376
Entamoeba histolytica fatty acid elongase, putative 0.0086 0.089 0.7212
Echinococcus multilocularis zinc finger protein 0.0009 0.001 0.0009
Brugia malayi acetyltransferase, GNAT family protein 0.0314 0.3506 0.4672
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0021 0.0014
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0292 0.029
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0257 0.0332
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0257 0.019
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0257 0.1779
Brugia malayi cytoplasmic intermediate filament protein 0.0033 0.0277 0.0357
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0012 0.003
Loa Loa (eye worm) hypothetical protein 0.0021 0.0141 0.0177
Schistosoma mansoni ferritin 0.001 0.0014 0.0012
Echinococcus multilocularis dnaJ subfamily B 0.088 1 1
Loa Loa (eye worm) DNA-directed RNA polymerase 0.0011 0.0024 0.0021
Brugia malayi NC domain containing protein 0.0045 0.0424 0.0553
Echinococcus granulosus zinc finger protein 0.0009 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0354 0.3959 0.5278
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0012 0.003
Loa Loa (eye worm) hypothetical protein 0.0019 0.0117 0.0145
Entamoeba histolytica fatty acid elongase, putative 0.0086 0.089 0.7212
Loa Loa (eye worm) hypothetical protein 0.0034 0.0292 0.0379
Echinococcus multilocularis microtubule associated protein 2 0.078 0.8849 0.8849
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0092 0.0962 0.1272
Toxoplasma gondii hypothetical protein 0.0045 0.0424 0.4361
Schistosoma mansoni DNA-directed RNA polymerase III subunit 0.0013 0.005 0.0048
Loa Loa (eye worm) hypothetical protein 0.0021 0.0148 0.0186
Mycobacterium ulcerans hypothetical protein 0.0025 0.0189 0.0236
Entamoeba histolytica hypothetical protein 0.0021 0.0148 0.0839
Brugia malayi Cytochrome P450 family protein 0.0017 0.0093 0.011
Brugia malayi phosphofructokinase 0.0114 0.1215 0.161
Loa Loa (eye worm) DNA-directed RNA polymerase II second largest subunit 0.0013 0.005 0.0056
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0189 0.0236
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.1144 0.3885
Trypanosoma brucei glucosidase, putative 0.0041 0.0378 0.138
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.1144 0.3885
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0378 0.1407
Schistosoma mansoni ferritin 0.001 0.0014 0.0012
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0015 0.008 0.0254
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0126 0.0152
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0126 0.015
Schistosoma mansoni cpg binding protein 0.0031 0.0264 0.0262
Mycobacterium ulcerans 6-phosphofructokinase 0.0114 0.1215 0.1605
Brugia malayi Doublecortin family protein 0.0021 0.0141 0.0174
Onchocerca volvulus 0.0025 0.0189 0.0603
Brugia malayi hypothetical protein 0.0136 0.1459 0.1936
Brugia malayi 6-phosphofructokinase 0.0114 0.1215 0.161
Trichomonas vaginalis set domain proteins, putative 0.0265 0.2939 1
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0012 0.003
Loa Loa (eye worm) hypothetical protein 0.0025 0.0189 0.0241
Brugia malayi intermediate filament protein 0.0061 0.0602 0.079
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0257 0.2192
Onchocerca volvulus 0.0021 0.0141 0.0439
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.1215 1
Mycobacterium leprae DNA-DIRECTED RNA POLYMERASE (BETA CHAIN) RPOB (TRANSCRIPTASE BETA CHAIN) (RNA POLYMERASE BETA SUBUNIT) 0.0249 0.2759 1
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.1215 1
Loa Loa (eye worm) acetyltransferase 0.0314 0.3506 0.4673
Trichomonas vaginalis DNA-directed RNA polymerase I subunit, putative 0.0013 0.005 0.0158
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0012 0.003
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0141 0.0139
Onchocerca volvulus 0.0061 0.0602 0.2014
Schistosoma mansoni ap endonuclease 0.002 0.0126 0.0125
Brugia malayi Cytochrome P450 family protein 0.0017 0.0093 0.011
Brugia malayi regulator of G-protein signaling rgs-7 0.0021 0.0148 0.0184
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0058 0.0569 0.0568
Schistosoma mansoni polycystin 1-related 0.0021 0.0141 0.0139
Schistosoma mansoni bromodomain containing protein 0.0009 0.001 0.0009
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0257 0.0864
Schistosoma mansoni hypothetical protein 0.0194 0.213 0.2128
Loa Loa (eye worm) hypothetical protein 0.0015 0.008 0.0095
Loa Loa (eye worm) histone methyltransferase 0.001 0.0022 0.0019
Loa Loa (eye worm) hypothetical protein 0.0045 0.0424 0.0556
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.1215 0.4509
Echinococcus multilocularis RUN 0.0021 0.0141 0.0139
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0233 0.2571 0.3424
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0148 0.0146
Schistosoma mansoni apoferritin-2 0.001 0.0014 0.0012
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0148 0.0146
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0105 0.0123
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0257 0.2609
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0663 0.7509 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.1215 0.1613
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0189 0.1193
Loa Loa (eye worm) hypothetical protein 0.0021 0.0148 0.0186
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0005
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0189 0.0236
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0189 0.0236
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0021 0.0148 0.0186
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0243 0.2685 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.0636 0.0635
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.1144 0.3885
Schistosoma mansoni hypothetical protein 0.0021 0.0141 0.0139
Loa Loa (eye worm) hypothetical protein 0.0009 0.001 0.0003
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0148 0.0146
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0243 0.2685 1
Trichomonas vaginalis mucin-desulfating sulfatase, putative 0.001 0.0012 0.003
Echinococcus granulosus histone acetyltransferase KAT2B 0.0092 0.0962 0.0961
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0257 0.0864
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0021 0.0148 0.0146
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0029 0.024 0.0239
Loa Loa (eye worm) hypothetical protein 0.0021 0.0148 0.0186
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0189 0.0675
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0126 0.0125
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0126 0.0471
Brugia malayi PXA domain containing protein 0.0021 0.0148 0.0184
Trypanosoma brucei cytochrome P450, putative 0.0017 0.0093 0.0316
Loa Loa (eye worm) PXA domain-containing protein 0.0021 0.0148 0.0186
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0117 0.0139
Echinococcus granulosus lysosomal alpha glucosidase 0.0187 0.2044 0.2043
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0243 0.2685 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0058 0.0569 0.0568
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.1215 0.4128
Toxoplasma gondii histone lysine methyltransferase SET1 0.0065 0.0652 0.675
Schistosoma mansoni ap endonuclease 0.002 0.0126 0.0125
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.1215 0.4128
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0141 0.0139
Brugia malayi Glycosyl hydrolases family 31 protein 0.0015 0.008 0.0092
Brugia malayi follicle stimulating hormone receptor 0.0501 0.5649 0.7535
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.1215 1
Schistosoma mansoni ferritin 0.001 0.0014 0.0012
Schistosoma mansoni alpha glucosidase 0.0041 0.0378 0.0376
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0189 0.0239
Leishmania major ATP-dependent phosphofructokinase 0.0114 0.1215 0.4509
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0148 0.0146
Echinococcus granulosus DNA directed RNA polymerase II subunit RPB2 0.0013 0.005 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0012 0.003
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0243 0.2685 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0117 0.0145
Onchocerca volvulus 0.0265 0.2939 1
Schistosoma mansoni hypothetical protein 0.0194 0.213 0.2128
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0148 0.0146
Echinococcus multilocularis cpg binding protein 0.0031 0.0264 0.0262
Loa Loa (eye worm) hypothetical protein 0.0021 0.0148 0.0186
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0015 0.008 0.023
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0108 0.1144 0.1143
Trypanosoma brucei DNA-directed RNA polymerase III, putative 0.0013 0.005 0.0155
Onchocerca volvulus 0.0021 0.0141 0.0439
Schistosoma mansoni cpg binding protein 0.003 0.0244 0.0243
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0012 0.003
Trichomonas vaginalis Phosphoglycerol transferase I, putative 0.001 0.0012 0.003
Trypanosoma cruzi RNA polymerase I second largest subunit, putative 0.0009 0.0008 0.0031
Echinococcus granulosus expressed protein 0.001 0.0014 0.0012
Leishmania major alpha glucosidase II subunit, putative 0.0041 0.0378 0.138
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0189 0.0637
Echinococcus multilocularis lysosomal alpha glucosidase 0.0187 0.2044 0.2043
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.008 0.0259
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.008 0.0259
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0012 0.003
Schistosoma mansoni DNA-directed RNA polymerase III subunit 0.0013 0.005 0.0048
Loa Loa (eye worm) hypothetical protein 0.0021 0.0148 0.0186
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0064 0.0636 0.0836
Brugia malayi hypothetical protein 0.0021 0.0141 0.0174
Echinococcus granulosus geminin 0.0194 0.213 0.2128
Brugia malayi CXXC zinc finger family protein 0.003 0.0244 0.0313
Brugia malayi DNA-directed RNA polymerase, beta subunit family protein 0.0013 0.005 0.0053
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0189 0.0236
Brugia malayi hypothetical protein 0.0021 0.0148 0.0184
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0009 0.001 0.0009
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0022 0.0152 0.0189
Loa Loa (eye worm) hypothetical protein 0.0028 0.0227 0.0293
Trypanosoma cruzi DNA-directed RNA polymerase III, putative 0.0013 0.005 0.0186
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0292 0.029
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.008 0.0259
Schistosoma mansoni DNA-directed rna polymerase II subunit 0.0013 0.005 0.0048
Entamoeba histolytica hypothetical protein 0.0021 0.0148 0.0839
Echinococcus multilocularis expressed protein 0.001 0.0014 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0148 0.0491
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0012 0.003
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0243 0.2685 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0257 0.0332
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0148 0.0146
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.1215 0.4526
Trypanosoma brucei hypothetical protein 0.0243 0.2685 1
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0243 0.2685 1
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.1144 0.1143
Entamoeba histolytica fatty acid elongase, putative 0.0086 0.089 0.7212
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.008 0.0297
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.008 0.0297
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0022 0.0152 0.0192
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0126 0.0418
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0292 0.029
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0064 0.0636 0.2346
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0141 0.0139
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0148 0.0146
Giardia lamblia DNA-directed RNA polymerase RPB2 0.0013 0.005 0.0366
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0012 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0148 0.0491
Echinococcus granulosus microtubule associated protein 2 0.078 0.8849 0.8849
Loa Loa (eye worm) intermediate filament protein 0.0061 0.0602 0.0793
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0114 0.1215 0.4376
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0378 0.2813
Schistosoma mansoni cpg binding protein 0.0031 0.0264 0.0262
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0243 0.2685 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0589 0.0776
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.1215 0.1214
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0152 0.015
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0292 0.029
Mycobacterium tuberculosis DNA-directed RNA polymerase (beta chain) RpoB (transcriptase beta chain) (RNA polymerase beta subunit) 0.0061 0.0601 0.0785
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0378 0.1274
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0663 0.7509 1
Echinococcus granulosus Regulator of G protein signaling 20 0.0021 0.0148 0.0146
Leishmania major cytochrome p450-like protein 0.0017 0.0093 0.0316
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0092 0.0962 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0126 0.0441
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0189 0.0239
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0587 0.0773
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0012 0.003
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0501 0.5649 0.7536
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0636 0.0832
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0012 0.003
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.1215 0.4128
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0314 0.3506 0.3505
Schistosoma mansoni kinase 0.0055 0.0534 0.0532
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0243 0.2685 1
Echinococcus multilocularis ferritin 0.001 0.0014 0.0012
Giardia lamblia Histone acetyltransferase GCN5 0.0085 0.0874 0.7623
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0243 0.2685 1
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0012 0.003
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0243 0.2685 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0214 0.0275
Trypanosoma cruzi polo-like protein kinase, putative 0.0108 0.1144 0.4261
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0257 0.2609
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.0257 0.0886
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0022 0.0021
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0095 0.0991 0.099
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0108 0.1144 0.4243
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0148 0.0146
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0257 0.0332
Loa Loa (eye worm) phosphofructokinase 0.0114 0.1215 0.1613
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0148 0.0184
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0243 0.2685 1
Brugia malayi DNA-directed RNA polymerase II second largest subunit, putative 0.0013 0.005 0.0053
Trichomonas vaginalis maltase-glucoamylase, putative 0.0041 0.0378 0.1274
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0012 0.003
Schistosoma mansoni microtubule-associated protein tau 0.078 0.8849 0.8849
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.0517 0.1749
Plasmodium vivax SET domain protein, putative 0.0034 0.0292 0.0378
Wolbachia endosymbiont of Brugia malayi DNA-directed RNA polymerase subunit beta/beta' 0.0249 0.2759 0.3663
Entamoeba histolytica serine/threonine protein kinase, putative 0.0108 0.1144 0.9388
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0292 0.029
Trichomonas vaginalis DNA-directed RNA polymerase I subunit, putative 0.0013 0.005 0.0158
Echinococcus granulosus intermediate filament protein 0.0061 0.0602 0.06
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0141 0.0177
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0029 0.024 0.0239
Giardia lamblia Hypothetical protein 0.001 0.0012 0.0035
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0095 0.0991 0.099
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0117 0.0144
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0117 0.0144
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0663 0.7509 1
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0257 0.2609
Echinococcus granulosus cpg binding protein 0.0031 0.0264 0.0262
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0105 0.0123
Mycobacterium tuberculosis Arylamine N-acetyltransferase Nat (arylamine acetylase) 0.0618 0.699 0.9308
Brugia malayi bZIP transcription factor family protein 0.0095 0.0991 0.1311
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0663 0.7509 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0292 0.029
Giardia lamblia DNA-directed RNA polymerase subunit B 0.0013 0.005 0.0366
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0126 0.0157
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0126 0.1039
Schistosoma mansoni lamin 0.0061 0.0602 0.06
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0292 0.2971
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.0636 0.0635
Plasmodium falciparum DNA-directed RNA polymerase subunit beta, putative 0.0068 0.0679 0.0894
Onchocerca volvulus 0.0108 0.1141 0.3856
Echinococcus granulosus DNA directed RNA polymerase III subunit RPC2 0.0013 0.005 0.0048
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.1144 0.3885
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0108 0.1144 0.1143
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0012 0.003
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0189 0.0675
Schistosoma mansoni zinc finger protein 0.0009 0.001 0.0009
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.1144 0.3885
Onchocerca volvulus Serine\/threonine kinase homolog 0.0108 0.1144 0.3867
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0126 0.0418
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0022 0.0021
Echinococcus multilocularis geminin 0.0194 0.213 0.2128
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0141 0.0176
Brugia malayi serine/threonine-protein kinase plk-2 0.0108 0.1144 0.1515
Loa Loa (eye worm) hypothetical protein 0.0662 0.7494 1
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0663 0.7509 1
Echinococcus granulosus DNA directed RNA polymerase I subunit RPA2 0.0013 0.005 0.0048
Brugia malayi Glycosyl hydrolases family 31 protein 0.0187 0.2044 0.2717
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0021 0.0148 0.0146
Entamoeba histolytica acetyltransferase, GNAT family 0.0085 0.0874 0.7072

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.059 uM In vitro DNA poly-dGdC binding by ethidium bromide displacement ChEMBL. No reference
IC50 (functional) = 0.064 uM Compound was evaluated in vitro for the 50% inhibitory activity against L1210 murine leukemia ChEMBL. No reference
IC50 (functional) = 0.064 uM Compound was evaluated in vitro for the 50% inhibitory activity against L1210 murine leukemia ChEMBL. No reference
IC50 (binding) = 1.42 uM In vitro DNA poly-dAdT binding by ethidium bromide displacement ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.