Detailed information for compound 65380

Basic information

Technical information
  • TDR Targets ID: 65380
  • Name: 4-(4-cyanoanilino)-4-oxo-3-[(2,2,2-trifluoroa cetyl)amino]butanoic acid
  • MW: 329.231 | Formula: C13H10F3N3O4
  • H donors: 3 H acceptors: 5 LogP: 0.81 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccc(cc1)NC(=O)C(NC(=O)C(F)(F)F)CC(=O)O
  • InChi: 1S/C13H10F3N3O4/c14-13(15,16)12(23)19-9(5-10(20)21)11(22)18-8-3-1-7(6-17)2-4-8/h1-4,9H,5H2,(H,18,22)(H,19,23)(H,20,21)
  • InChiKey: KIGAPXNVLOREBY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(4-cyanoanilino)-4-oxo-3-[(2,2,2-trifluoro-1-oxoethyl)amino]butanoic acid
  • 4-[(4-cyanophenyl)amino]-4-oxo-3-(2,2,2-trifluoroethanoylamino)butanoic acid
  • 4-(4-cyanoanilino)-4-keto-3-[(2,2,2-trifluoroacetyl)amino]butyric acid
  • 4-[(4-cyanophenyl)amino]-4-oxo-3-[(2,2,2-trifluoroacetyl)amino]butanoic acid
  • 4-[(4-cyanophenyl)amino]-4-oxo-3-[(2,2,2-trifluoro-1-oxoethyl)amino]butanoic acid
  • 4-[(4-cyanophenyl)amino]-4-keto-3-[(2,2,2-trifluoroacetyl)amino]butyric acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0256 0.0142
Echinococcus multilocularis somatostatin receptor 0.0019 0.0256 0.0142
Echinococcus multilocularis orexin receptor type 2 0.0019 0.0256 0.0142
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0078 0.3989 0.4162
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0256 0.0142
Echinococcus granulosus Protein kinase C brain isozyme 0.0109 0.5972 0.6297
Schistosoma mansoni neuropeptide F-like receptor 0.0019 0.0256 0.0142
Brugia malayi hypothetical protein 0.0019 0.0256 0.0256
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0019 0.0256 0.0256
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0019 0.0256 0.0142
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0256
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0124 0.0025
Schistosoma mansoni neuropeptide receptor 0.0019 0.0256 0.0142
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0019 0.0256 0.0142
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0019 0.0256 0.0142
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0256 0.0142
Schistosoma mansoni adenoreceptor 0.0019 0.0256 0.0142
Brugia malayi neuropeptide F receptor 0.0019 0.0256 0.0256
Brugia malayi Dopamine receptor protein 1 0.0019 0.0256 0.0256
Toxoplasma gondii AGC kinase 0.0017 0.0124 0.5
Loa Loa (eye worm) hypothetical protein 0.0172 1 1
Echinococcus granulosus neuropeptide Y receptor 0.0019 0.0256 0.0142
Schistosoma mansoni biogenic amine (5HT) receptor 0.0019 0.0256 0.0142
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0256 0.0142
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0109 0.5972 0.6297
Brugia malayi Tachykinin-like peptides receptor 99D 0.0019 0.0256 0.0256
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0124 0.0025
Brugia malayi Hr1 repeat family protein 0.0017 0.0124 0.0124
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0019 0.0256 0.0256
Echinococcus granulosus allatostatin A receptor 0.0019 0.0256 0.0142
Schistosoma mansoni hypothetical protein 0.0019 0.0256 0.0142
Onchocerca volvulus NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial homolog 0.0087 0.4606 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0256 0.0142
Echinococcus granulosus peptide allatostatin:somatostatin 0.0019 0.0256 0.0142
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0019 0.0256 0.0142
Schistosoma mansoni aryl hydrocarbon receptor 0.0051 0.2317 0.2361
Schistosoma mansoni opsin-like receptor 0.0019 0.0256 0.0142
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0256 0.0142
Echinococcus granulosus biogenic amine 5HT receptor 0.0019 0.0256 0.0142
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0256 0.0142
Echinococcus granulosus g protein coupled receptor 0.0019 0.0256 0.0142
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0256 0.0142
Schistosoma mansoni biogenic amine (5HT) receptor 0.0019 0.0256 0.0142
Echinococcus granulosus intermediate filament protein 0.0028 0.082 0.0749
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0256
Echinococcus multilocularis transfer RNA-Lys 0.0038 0.1469 0.1448
Schistosoma mansoni single-minded 0.0051 0.2317 0.2361
Echinococcus multilocularis serotonin receptor 0.0019 0.0256 0.0142
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0256
Brugia malayi neuropeptide F receptor 0.0019 0.0256 0.0256
Brugia malayi Melatonin receptor type 1A 0.0019 0.0256 0.0256
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0017 0.0124 0.0124
Loa Loa (eye worm) neuropeptide F receptor 0.0019 0.0256 0.0256
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0019 0.0256 0.0142
Echinococcus multilocularis neuropeptide receptor A26 0.0019 0.0256 0.0142
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0256 0.0142
Echinococcus granulosus alpha 1A adrenergic receptor 0.0019 0.0256 0.0142
Echinococcus multilocularis lamin dm0 0.0028 0.082 0.0749
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0019 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0078 0.3989 0.3989
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0019 0.0256 0.0142
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0256 0.0142
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0019 0.0256 0.0142
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0256 0.0142
Schistosoma mansoni alpha-1 adrenergic receptor 0.0019 0.0256 0.0142
Echinococcus multilocularis fmrfamide receptor 0.0019 0.0256 0.0142
Schistosoma mansoni amine GPCR 0.0019 0.0256 0.0142
Schistosoma mansoni neuropeptide f receptor 76f 0.0019 0.0256 0.0142
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0256
Brugia malayi Cytochrome P450 family protein 0.0024 0.0571 0.0571
Schistosoma mansoni myosin xvIII 0.0019 0.0256 0.0142
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0256 0.0142
Brugia malayi Protein kinase domain containing protein 0.0017 0.0124 0.0124
Mycobacterium ulcerans NADH dehydrogenase I subunit F 0.0163 0.9411 1
Loa Loa (eye worm) neuropeptide F receptor 0.0019 0.0256 0.0256
Echinococcus multilocularis neuropeptide Y receptor 0.0019 0.0256 0.0142
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0256
Echinococcus multilocularis serine threonine protein kinase 0.0097 0.5216 0.5483
Brugia malayi G-protein coupled receptor 0.0019 0.0256 0.0256
Echinococcus multilocularis neuropeptide Y receptor 0.0019 0.0256 0.0142
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0256
Schistosoma mansoni neuropeptide receptor 0.0019 0.0256 0.0142
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.008 0.4169 0.4169
Wolbachia endosymbiont of Brugia malayi NADH dehydrogenase I subunit F 0.0163 0.9411 0.5
Trypanosoma brucei NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial 0.0163 0.9411 1
Entamoeba histolytica protein kinase, putative 0.0017 0.0124 0.5
Schistosoma mansoni growth hormone secretagogue receptor 0.0019 0.0256 0.0142
Entamoeba histolytica protein kinase, putative 0.0017 0.0124 0.5
Brugia malayi hypothetical protein 0.0019 0.0256 0.0256
Echinococcus multilocularis NADH dehydrogenase (ubiquinone) flavoprotein 1 0.0163 0.9411 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0256
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0019 0.0256 0.0142
Brugia malayi hypothetical protein 0.0019 0.0256 0.0256
Schistosoma mansoni intermediate filament proteins 0.0028 0.082 0.0749
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0019 0.0256 0.0142
Loa Loa (eye worm) melatonin receptor type 1A 0.0019 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0256
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0019 0.0256 0.0142
Loa Loa (eye worm) AGC/AKT protein kinase 0.0017 0.0124 0.0124
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0256 0.0142
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0256
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0019 0.0256 0.0142
Echinococcus granulosus tachykinin peptides receptor 99D 0.0019 0.0256 0.0142
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0256 0.0142
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0256
Echinococcus granulosus G protein coupled receptor 139 0.0019 0.0256 0.0142
Echinococcus granulosus g protein coupled receptor 0.0019 0.0256 0.0142
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0019 0.0256 0.0142
Echinococcus granulosus neuropeptide receptor 0.0019 0.0256 0.0142
Loa Loa (eye worm) AGC/NDR protein kinase 0.0017 0.0124 0.0124
Echinococcus granulosus lamin 0.0028 0.082 0.0749
Echinococcus multilocularis fmrfamide receptor 0.0019 0.0256 0.0142
Echinococcus multilocularis neuropeptides capa receptor 0.0019 0.0256 0.0142
Echinococcus granulosus single minded 2 0.0038 0.1469 0.1448
Brugia malayi hypothetical protein 0.0019 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0256
Echinococcus granulosus g-protein coupled receptor 0.0019 0.0256 0.0142
Brugia malayi PAS domain containing protein 0.0051 0.2317 0.2317
Brugia malayi hypothetical protein 0.0019 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0256
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0124 0.0025
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0256
Schistosoma mansoni amine GPCR 0.0019 0.0256 0.0142
Echinococcus granulosus dro:myosuppressin receptor 0.0019 0.0256 0.0142
Echinococcus granulosus serotonin receptor 0.0019 0.0256 0.0142
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0256
Echinococcus granulosus fmrfamide receptor 0.0019 0.0256 0.0142
Echinococcus multilocularis protein kinase c epsilon type 0.0031 0.1038 0.0984
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.082 0.082
Brugia malayi G protein-coupled receptor F59B2.13 0.0019 0.0256 0.0256
Echinococcus granulosus NADH dehydrogenase ubiquinone flavoprotein 1 0.0163 0.9411 1
Brugia malayi putative neuropeptide receptor NPR1 0.0019 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0256
Loa Loa (eye worm) AGC/PKN protein kinase 0.0017 0.0124 0.0124
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0017 0.0124 0.0124
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0256 0.0142
Echinococcus multilocularis RNA directed DNA polymerase 0.0078 0.3989 0.4162
Echinococcus granulosus neuropeptides capa receptor 0.0019 0.0256 0.0142
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.082 0.082
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0124 0.0025
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0256 0.0142
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0019 0.0256 0.0142
Echinococcus granulosus hypothetical protein 0.0019 0.0256 0.0142
Loa Loa (eye worm) hypothetical protein 0.0089 0.4745 0.4745
Loa Loa (eye worm) intermediate filament protein 0.0028 0.082 0.082
Brugia malayi RE15519p 0.0019 0.0256 0.0256
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0256 0.0142
Echinococcus multilocularis G protein coupled receptor 139 0.0019 0.0256 0.0142
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0031 0.1038 0.1038
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0019 0.0256 0.0142
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0256 0.0142
Brugia malayi larval opioid receptor 0.0019 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0256
Echinococcus multilocularis lamin 0.0028 0.082 0.0749
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0256 0.0142
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0019 0.0256 0.0142
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0256
Trypanosoma brucei NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial, putative 0.0163 0.9411 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0019 0.0256 0.0142
Schistosoma mansoni lamin 0.0028 0.082 0.0749
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.5972 0.6297
Trichomonas vaginalis NADH-ubiquinone oxidoreductase flavoprotein, putative 0.0163 0.9411 1
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0124 0.0025
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0019 0.0256 0.0142
Echinococcus granulosus protein kinase c iota type 0.0029 0.0881 0.0815
Loa Loa (eye worm) G-protein coupled receptor 0.0019 0.0256 0.0256
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0256 0.0142
Schistosoma mansoni hypothetical protein 0.0019 0.0256 0.0142
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0019 0.0256 0.0256
Brugia malayi G protein-coupled receptor 0.0019 0.0256 0.0256
Schistosoma mansoni NADH-ubiquinone oxidoreductase 0.0163 0.9411 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0019 0.0256 0.0142
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0256
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0019 0.0256 0.0142
Echinococcus multilocularis serotonin receptor 0.0019 0.0256 0.0142
Schistosoma mansoni biogenic amine receptor 0.0019 0.0256 0.0142
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0256
Echinococcus granulosus g protein coupled receptor 0.0019 0.0256 0.0142
Brugia malayi ORL1-like opioid receptor 0.0019 0.0256 0.0256
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0124 0.0025
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0019 0.0256 0.0256
Schistosoma mansoni amine GPCR 0.0019 0.0256 0.0142
Brugia malayi bHLH-PAS transcription factor 0.0038 0.1469 0.1469
Echinococcus granulosus neuropeptide receptor A26 0.0019 0.0256 0.0142
Brugia malayi Protein kinase domain containing protein 0.0017 0.0124 0.0124
Schistosoma mansoni atypical protein kinase C 0.0029 0.0881 0.0815
Brugia malayi sulfakinin receptor protein 0.0019 0.0256 0.0256
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0256 0.0142
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0124 0.0025
Echinococcus multilocularis G-protein coupled receptor, putative 0.0019 0.0256 0.0142
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0256 0.0142
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0124 0.0025
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0019 0.0256 0.0256
Mycobacterium ulcerans putative regulatory protein 0.0038 0.1469 0.0132
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0256
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0124 0.0025
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0256
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0019 0.0256 0.0256
Brugia malayi Serotonin receptor 0.0019 0.0256 0.0256
Schistosoma mansoni opsin-like receptor 0.0019 0.0256 0.0142
Echinococcus granulosus neuropeptide receptor 0.0019 0.0256 0.0142
Entamoeba histolytica protein kinase, putative 0.0017 0.0124 0.5
Brugia malayi Serotonin receptor 0.0019 0.0256 0.0256
Schistosoma mansoni hypothetical protein 0.0019 0.0256 0.0142
Echinococcus multilocularis neuropeptide s receptor 0.0019 0.0256 0.0142
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0256
Echinococcus multilocularis g-protein coupled receptor 0.0019 0.0256 0.0142
Brugia malayi GnHR receptor homolog 0.0019 0.0256 0.0256
Echinococcus multilocularis sex peptide receptor 0.0019 0.0256 0.0142
Schistosoma mansoni hypothetical protein 0.0019 0.0256 0.0142
Brugia malayi intermediate filament protein 0.0028 0.082 0.082
Trichomonas vaginalis NADH-ubiquinone oxidoreductase flavoprotein, putative 0.0163 0.9411 1
Brugia malayi hypoxia-induced factor 1 0.0159 0.9152 0.9152
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0256 0.0142
Echinococcus multilocularis dro:myosuppressin receptor 0.0019 0.0256 0.0142
Trypanosoma cruzi NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.0163 0.9411 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.1038 0.0984
Schistosoma mansoni neuropeptide receptor 0.0019 0.0256 0.0142
Echinococcus granulosus 7tm_1 domain containing protein 0.0019 0.0256 0.0142
Brugia malayi hypothetical protein 0.0019 0.0256 0.0256
Echinococcus granulosus biogenic amine 5HT receptor 0.0019 0.0256 0.0142
Echinococcus multilocularis musashi 0.0028 0.082 0.0749
Echinococcus multilocularis neuropeptide FF receptor 2 0.0019 0.0256 0.0142
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0256
Treponema pallidum nitrogen fixation protein (rnfC) 0.0036 0.1363 0.5
Echinococcus granulosus somatostatin receptor 0.0019 0.0256 0.0142
Leishmania major NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.0163 0.9411 0.5
Echinococcus multilocularis allatostatin A receptor 0.0019 0.0256 0.0142
Echinococcus granulosus neuropeptides capa receptor 0.0019 0.0256 0.0142
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0019 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0028 0.082 0.082
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0256
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0019 0.0256 0.0142
Brugia malayi Dopamine receptor 0.0019 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0256
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0256 0.0142
Brugia malayi Protein kinase c protein 2 0.0092 0.4926 0.4926
Brugia malayi hypothetical protein 0.0019 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0256
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0017 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0256
Echinococcus granulosus 7TM GPCR rhodopsin 0.0019 0.0256 0.0142
Brugia malayi hypothetical protein 0.0019 0.0256 0.0256
Loa Loa (eye worm) G-protein coupled receptor 0.0019 0.0256 0.0256
Brugia malayi follicle stimulating hormone receptor 0.0019 0.0256 0.0256
Schistosoma mansoni lamin 0.0028 0.082 0.0749
Echinococcus granulosus orexin receptor type 2 0.0019 0.0256 0.0142
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0019 0.0256 0.0142
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0256 0.0142
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0019 0.0256 0.0142
Schistosoma mansoni biogenic amine receptor 0.0019 0.0256 0.0142
Schistosoma mansoni opsin-like receptor 0.0019 0.0256 0.0142
Echinococcus granulosus RNA directed DNA polymerase 0.0078 0.3989 0.4162
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0019 0.0256 0.0142
Schistosoma mansoni amine GPCR 0.0019 0.0256 0.0142
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0256
Echinococcus multilocularis neuropeptides capa receptor 0.0019 0.0256 0.0142
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0017 0.0124 0.0124
Brugia malayi putative neuropeptide receptor 0.0019 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0256
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0019 0.0256 0.0142
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0256 0.0142
Echinococcus granulosus neuropeptide FF receptor 2 0.0019 0.0256 0.0142
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0256
Echinococcus multilocularis neuropeptide receptor 0.0019 0.0256 0.0142
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0256
Schistosoma mansoni histamine h1 receptor 0.0019 0.0256 0.0142
Onchocerca volvulus 0.0028 0.082 0.1295
Onchocerca volvulus 0.0028 0.082 0.1295
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0256
Brugia malayi protein kinase C II. 0.0031 0.1038 0.1038
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0019 0.0256 0.0256
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0571 0.0571
Brugia malayi Dopamine receptor protein 2 0.0019 0.0256 0.0256
Brugia malayi G-protein coupled receptor 0.0019 0.0256 0.0256
Echinococcus granulosus neuropeptide Y receptor 0.0019 0.0256 0.0142
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0256 0.0142
Brugia malayi NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial precursor 0.0163 0.9411 0.9411
Echinococcus granulosus protein kinase c epsilon type 0.0031 0.1038 0.0984
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0256
Loa Loa (eye worm) NADH-ubiquinone oxidoreductase 51 kDa subunit 0.0163 0.9411 0.9411
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0256
Brugia malayi p70 ribosomal S6 kinase beta 0.0017 0.0124 0.0124
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0019 0.0256 0.0142
Brugia malayi Protein kinase domain containing protein 0.0017 0.0124 0.0124
Entamoeba histolytica protein kinase, putative 0.0017 0.0124 0.5
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0019 0.0256 0.0142
Echinococcus granulosus sex peptide receptor 0.0019 0.0256 0.0142
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0256
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0256 0.0142
Schistosoma mansoni neuropeptide F-like receptor 0.0019 0.0256 0.0142
Brugia malayi hypothetical protein 0.0019 0.0256 0.0256
Echinococcus granulosus protein kinase C gamma type 0.0097 0.5216 0.5483
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0256 0.0142
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0019 0.0256 0.0142
Loa Loa (eye worm) TYRA-2 protein 0.0019 0.0256 0.0256
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0019 0.0256 0.0256
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0124 0.0025
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0256 0.0142
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0124 0.0025
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.5972 0.6297
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0256 0.0142
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0256 0.0142
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0256
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0256 0.0142
Trypanosoma cruzi NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.0163 0.9411 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0256 0.0142
Onchocerca volvulus 0.0038 0.1469 0.2788
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0017 0.0124 0.0124
Echinococcus granulosus neuropeptide s receptor 0.0019 0.0256 0.0142
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0256 0.0142
Mycobacterium tuberculosis Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F) 0.0163 0.9411 1
Echinococcus granulosus lamin dm0 0.0028 0.082 0.0749
Brugia malayi hypothetical protein 0.0019 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0256
Schistosoma mansoni neuropeptide receptor 0.0019 0.0256 0.0142
Echinococcus multilocularis protein kinase c iota type 0.0029 0.0881 0.0815
Loa Loa (eye worm) hypothetical protein 0.0027 0.0787 0.0787
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0256 0.0142
Schistosoma mansoni biogenic amine receptor 0.0019 0.0256 0.0142
Echinococcus multilocularis neuropeptide receptor 0.0019 0.0256 0.0142
Brugia malayi AKH receptor 0.0019 0.0256 0.0256
Loa Loa (eye worm) hypoxia-induced factor 1 0.0159 0.9152 0.9152
Schistosoma mansoni amine GPCR 0.0019 0.0256 0.0142
Loa Loa (eye worm) hypothetical protein 0.0019 0.0256 0.0256

Activities

Activity type Activity value Assay description Source Reference
Taste (functional) = 0 Compound was evaluated for the potency of sweet taste when sweetness of sucrose is taken as 1 on a weight basis; Not sweet ChEMBL. 7069717
Taste (binding) = 3000 Value represents the number of times the compound was as sweet as sucrose ChEMBL. 6502596

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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