Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.7536 | 0.9446 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4087 | 0.4413 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0024 | 0.0947 | 0.1257 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0022 | 0.0618 | 0.0667 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0066 | 0.7536 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.7536 | 0.9446 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0066 | 0.7536 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0066 | 0.7536 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0024 | 0.0947 | 0.1257 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.7536 | 0.5 |
Schistosoma mansoni | bromodomain containing protein | 0.0068 | 0.7978 | 1 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0019 | 0.0106 | 0.0114 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.3266 | 0.4094 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.4881 | 0.527 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0066 | 0.7536 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.3266 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0065 | 0.736 | 0.9766 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.7536 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.3266 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0066 | 0.7536 | 1 |
Echinococcus granulosus | zinc finger protein | 0.0021 | 0.0435 | 0.0578 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.7536 | 0.5 |
Echinococcus multilocularis | zinc finger protein | 0.0021 | 0.0435 | 0.0578 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.3266 | 0.4334 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0039 | 0.3258 | 0.4323 |
Brugia malayi | Bromodomain containing protein | 0.0041 | 0.3667 | 0.2673 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.2405 | 0.2597 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.4881 | 0.4078 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4417 | 0.4769 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.4881 | 0.4078 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.3266 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.4881 | 0.527 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.9262 | 1 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0024 | 0.0947 | 0.1188 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.3679 | 0.3972 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.2405 | 0.3015 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.3266 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0618 | 0.0774 |
Schistosoma mansoni | zinc finger protein | 0.0021 | 0.0435 | 0.0546 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.3266 | 0.4094 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0039 | 0.3258 | 0.4323 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0065 | 0.736 | 0.9766 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.3266 | 0.4334 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.2405 | 0.1214 |
Brugia malayi | hypothetical protein | 0.0039 | 0.3266 | 0.2209 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.