Detailed information for compound 654336

Basic information

Technical information
  • TDR Targets ID: 654336
  • Name: N-[(2-methoxyphenyl)methylideneamino]furan-2- carboxamide
  • MW: 244.246 | Formula: C13H12N2O3
  • H donors: 1 H acceptors: 1 LogP: 2.2 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1C=NNC(=O)c1ccco1
  • InChi: 1S/C13H12N2O3/c1-17-11-6-3-2-5-10(11)9-14-15-13(16)12-7-4-8-18-12/h2-9H,1H3,(H,15,16)/b14-9+
  • InChiKey: JSUBUGTXTQIFKP-NTEUORMPSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(2-methoxyphenyl)methyleneamino]furan-2-carboxamide
  • N-[(2-methoxyphenyl)methyleneamino]-2-furancarboxamide
  • N-[(2-methoxybenzylidene)amino]-2-furamide
  • STK199232
  • NSC106735

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.0001 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0127 0.0778 0.0778
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.0001 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0093 0.0093
Echinococcus granulosus excitatory amino acid transporter 2 0.1171 1 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0245 0.1823 0.1823
Echinococcus multilocularis Excitatory amino acid transporter 0.1171 1 1
Echinococcus multilocularis muscleblind protein 0.0161 0.1083 0.1083
Schistosoma mansoni alpha-glucosidase 0.0152 0.0995 0.0995
Schistosoma mansoni aldehyde dehydrogenase 0.0127 0.0778 0.0778
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0093 0.0093
Echinococcus multilocularis lysosomal alpha glucosidase 0.0176 0.1212 0.1212
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0001 1
Brugia malayi Muscleblind-like protein 0.0161 0.1083 0.1083
Echinococcus granulosus neutral amino acid transporter A 0.1171 1 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0249 0.1853 0.1853
Echinococcus multilocularis neutral amino acid transporter A 0.1171 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0093 0.0093
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0519 0.4241 0.4241
Loa Loa (eye worm) hypothetical protein 0.0161 0.1083 0.1083
Mycobacterium leprae Probable lipase LipE 0.0039 0 0.5
Trypanosoma brucei glucosidase, putative 0.0039 0.0001 1
Schistosoma mansoni alpha glucosidase 0.0039 0.0001 0.0001
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.1171 1 0.5
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0519 0.4241 0.4241
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0519 0.4241 0.4241
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.0001 0.0018
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.1171 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0001 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.0001 0.0001
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0127 0.0778 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0127 0.0778 1
Echinococcus granulosus sodium:dicarboxylate symporter 0.1171 1 1
Chlamydia trachomatis glutamate symporter 0.1171 1 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0001 0.5
Echinococcus multilocularis neutral amino acid transporter A 0.1171 1 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0001 1
Schistosoma mansoni alpha-glucosidase 0.0152 0.0995 0.0995
Treponema pallidum glutamate/aspartate transporter 0.0519 0.4241 0.5
Echinococcus granulosus neutral amino acid transporter 0.1171 1 1
Brugia malayi follicle stimulating hormone receptor 0.025 0.1868 0.1868
Echinococcus multilocularis sodium:dicarboxylate symporter 0.1171 1 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.0001 0.0001
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0127 0.0778 0.0778
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0001 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0176 0.1212 0.1212
Echinococcus multilocularis Excitatory amino acid transporter 0.1171 1 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0176 0.1212 0.1212
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0093 0.0093
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0001 1
Echinococcus granulosus muscleblind protein 0.0161 0.1083 0.1083
Brugia malayi Glycosyl hydrolases family 31 protein 0.0176 0.1212 0.1212
Loa Loa (eye worm) transcription factor SMAD2 0.0245 0.1823 0.1823
Echinococcus granulosus excitatory amino acid transporter 2 0.1171 1 1
Schistosoma mansoni aldehyde dehydrogenase 0.0127 0.0778 0.0778
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.1171 1 1
Echinococcus multilocularis excitatory amino acid transporter 2 0.1171 1 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.025 0.1868 0.1868
Echinococcus granulosus excitatory amino acid transporter 3 0.1171 1 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.0001 0.0001
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0001 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.0001 0.0001
Onchocerca volvulus Excitatory amino acid transporter homolog 0.1171 1 1
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.0001 0.0018
Echinococcus granulosus Excitatory amino acid transporter 0.1171 1 1
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0519 0.4241 0.4241
Mycobacterium ulcerans aldehyde dehydrogenase 0.0127 0.0778 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0093 0.0093
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0093 0.0093
Echinococcus multilocularis neutral amino acid transporter A 0.1171 1 1
Toxoplasma gondii aldehyde dehydrogenase 0.0127 0.0778 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0001 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0001 0.5
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0001 1
Onchocerca volvulus 0.0102 0.0556 0.0556
Echinococcus multilocularis lysosomal alpha glucosidase 0.0176 0.1212 0.1212
Echinococcus multilocularis muscleblind protein 1 0.0161 0.1083 0.1083
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0001 1
Treponema pallidum glutamate transporter 0.0519 0.4241 0.5
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0127 0.0778 0.0778
Brugia malayi MH2 domain containing protein 0.0245 0.1823 0.1823
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0093 0.0093
Echinococcus multilocularis excitatory amino acid transporter 3 0.1171 1 1
Plasmodium vivax hypothetical protein, conserved 0.0039 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0161 0.1083 0.1083
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0093 0.0093
Echinococcus granulosus Excitatory amino acid transporter 0.1171 1 1
Echinococcus granulosus neutral amino acid transporter A 0.1171 1 1
Loa Loa (eye worm) excitatory amino acid transporter 0.1171 1 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0093 0.0093
Mycobacterium leprae conserved hypothetical protein 0.0039 0 0.5
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.1171 1 1
Echinococcus multilocularis excitatory amino acid transporter 2 0.1171 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0127 0.0778 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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