Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | trypanothione reductase | 0.0051 | 0.2225 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0064 | 0.3087 | 0.1581 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0065 | 0.3157 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0117 | 0.6775 | 0.8342 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0223 | 0.0081 |
Plasmodium falciparum | thioredoxin reductase | 0.0051 | 0.2225 | 0.5 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0025 | 0.0366 | 0.0739 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.013 | 0.7679 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0117 | 0.6775 | 0.8342 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0117 | 0.6775 | 0.8342 |
Brugia malayi | glutathione reductase | 0.0051 | 0.2225 | 0.4467 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.013 | 0.7679 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0065 | 0.3157 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0117 | 0.6775 | 0.8342 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.3087 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0051 | 0.2225 | 0.5583 |
Brugia malayi | Bromodomain containing protein | 0.0082 | 0.4307 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0051 | 0.2225 | 0.5583 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0039 | 0.1372 | 0.4076 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.3087 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0064 | 0.3087 | 0.9766 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0025 | 0.0366 | 0.0226 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0064 | 0.3087 | 0.9766 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0117 | 0.6775 | 0.8342 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.013 | 0.7679 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0051 | 0.2225 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.013 | 0.7679 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1876 | 0.4709 |
Schistosoma mansoni | bromodomain containing protein | 0.0069 | 0.3426 | 0.3331 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.3087 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0051 | 0.2225 | 0.4467 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0064 | 0.3087 | 0.2986 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0022 | 0.0223 | 0.0559 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1555 | 0.3902 |
Brugia malayi | Bromodomain containing protein | 0.0042 | 0.155 | 0.2673 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0025 | 0.0366 | 0.0739 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0051 | 0.2225 | 0.6906 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0051 | 0.2225 | 0.6906 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0064 | 0.3087 | 0.2986 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0064 | 0.3087 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.3985 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0051 | 0.2225 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0039 | 0.1372 | 0.4076 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0064 | 0.3087 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0051 | 0.2225 | 0.5 |
Mycobacterium tuberculosis | Probable reductase | 0.0117 | 0.6775 | 0.8342 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.1733 | 0.4348 |
Plasmodium falciparum | glutathione reductase | 0.0051 | 0.2225 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.