TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 272.342 | Formula: C16H20N2O2
H donors: 1 H acceptors: 3 LogP: 4.24 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: C/C(=C\CCCCCc1cccc2n1cnc2)/C(=O)O
InChi: 1S/C16H20N2O2/c1-13(16(19)20)7-4-2-3-5-8-14-9-6-10-15-11-17-12-18(14)15/h6-7,9-12H,2-5,8H2,1H3,(H,19,20)/b13-7+
InChiKey: HWCVRXHBDLCDEV-NTUHNPAUSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	thromboxane A synthase 1 (platelet)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	cytochrome P450, putative	thromboxane A synthase 1 (platelet)	534 aa	498 aa	21.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	methionine synthase reductase	0.0083	0.127	0.3469
Giardia lamblia	Synaptic glycoprotein SC2	0.011	0.197	0.5646
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0058	0.0641	0.0773
Brugia malayi	flavodoxin family protein	0.0051	0.0476	0.0901
Plasmodium vivax	NADPH-cytochrome p450 reductase, putative	0.0134	0.2562	0.7557
Trichomonas vaginalis	spcc417.12 protein, putative	0.0058	0.0641	0.0773
Trypanosoma cruzi	Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative	0.0051	0.0476	0.0443
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0094	0.1551	0.4239
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0094	0.1551	0.2938
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0051	0.0476	0.0443
Giardia lamblia	Nitric oxide synthase, inducible	0.0118	0.2178	0.6322
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0127	0.2403	0.4551
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.0134	0.2562	0.4593
Trichomonas vaginalis	conserved hypothetical protein	0.011	0.197	0.3415
Loa Loa (eye worm)	hypothetical protein	0.011	0.197	0.3731
Trypanosoma brucei	S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative	0.0051	0.0476	0.0443
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0147	0.2896	0.5483
Plasmodium vivax	prenyltransferase alpha subunit, putative	0.0163	0.3308	1
Entamoeba histolytica	type A flavoprotein, putative	0.0051	0.0476	0.0771
Schistosoma mansoni	synaptic glycoprotein sc2 related	0.011	0.197	0.197
Giardia lamblia	Rab geranylgeranyltransferase	0.0163	0.3308	1
Brugia malayi	Carboxylesterase family protein	0.0058	0.0641	0.1215
Schistosoma mansoni	6-phosphofructokinase	0.007	0.0964	0.0964
Entamoeba histolytica	type A flavoprotein, putative	0.0051	0.0476	0.0771
Schistosoma mansoni	hypothetical protein	0.0035	0.0074	0.0074
Echinococcus multilocularis	transfer RNA-Lys	0.0035	0.0071	0.0194
Toxoplasma gondii	flavodoxin domain-containing protein	0.0066	0.086	0.1207
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.0042	0.0234	0.0307
Loa Loa (eye worm)	hypothetical protein	0.0163	0.3308	0.6265
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0058	0.0641	0.1753
Brugia malayi	hypothetical protein	0.0058	0.0641	0.1215
Echinococcus granulosus	3 oxo 5 alpha steroid 4 dehydrogenase C terminal	0.011	0.197	0.5383
Plasmodium falciparum	NADPH--cytochrome P450 reductase, putative	0.0051	0.0476	0.073
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0058	0.0641	0.0641
Brugia malayi	Carboxylesterase family protein	0.0171	0.3507	0.6642
Echinococcus granulosus	hydroxymethylglutaryl coenzyme A reductase	0.0138	0.2664	0.728
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0057	0.0616	0.1167
Trypanosoma brucei	carbonic anhydrase-like protein	0.0127	0.2403	0.4277
Onchocerca volvulus		0.0042	0.0253	0.0957
Echinococcus granulosus	6 phosphofructo 2 kinase:fructose 2	0.007	0.0964	0.2635
Schistosoma mansoni	diflavin oxidoreductase	0.0066	0.086	0.086
Schistosoma mansoni	hypothetical protein	0.0177	0.366	0.366
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0163	0.3308	0.6077
Trypanosoma brucei	NADPH-cytochrome p450 reductase, putative	0.0134	0.2562	0.4593
Schistosoma mansoni	aryl hydrocarbon receptor	0.0047	0.0383	0.0383
Loa Loa (eye worm)	hypothetical protein	0.007	0.0948	0.1795
Mycobacterium ulcerans	hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase	0.0138	0.2664	0.3516
Echinococcus granulosus	synaptic glycoprotein sc2	0.011	0.197	0.5383
Brugia malayi	CHE-14 protein	0.0057	0.0616	0.1167
Echinococcus granulosus	BC026374 protein S09 family	0.0058	0.0641	0.1753
Toxoplasma gondii	3-oxo-5-alpha-steroid 4-dehydrogenase	0.0241	0.5281	1
Echinococcus granulosus	para nitrobenzyl esterase	0.0058	0.0641	0.1753
Brugia malayi	latrophilin 2 splice variant baaae	0.007	0.0948	0.1795
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0163	0.3308	0.6077
Echinococcus multilocularis	geminin	0.0177	0.366	1
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0241	0.5281	1
Loa Loa (eye worm)	FAD binding domain-containing protein	0.0083	0.127	0.2404
Brugia malayi	Synaptic glycoprotein SC2	0.011	0.197	0.3731
Brugia malayi	hypothetical protein	0.0035	0.0074	0.0141
Trichomonas vaginalis	sulfite reductase, putative	0.0134	0.2562	0.4593
Echinococcus granulosus	neuroligin	0.0058	0.0641	0.1753
Schistosoma mansoni	hypothetical protein	0.007	0.0948	0.0948
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.007	0.0964	0.1415
Loa Loa (eye worm)	hypothetical protein	0.0241	0.5281	1
Loa Loa (eye worm)	carbonic anhydrase 3	0.0127	0.2403	0.4551
Echinococcus multilocularis	para nitrobenzyl esterase	0.0058	0.0641	0.1753
Schistosoma mansoni	5-methyl tetrahydrofolate-homocysteine methyltransferase reductase	0.0083	0.127	0.127
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0641	0.1215
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0051	0.0476	0.0443
Schistosoma mansoni	single-minded	0.0047	0.0383	0.0383
Trypanosoma cruzi	NADPH-dependent FMN/FAD containing oxidoreductase, putative	0.0134	0.2562	0.4593
Leishmania major	hypothetical protein, conserved	0.0051	0.0476	0.0443
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0163	0.3308	0.6265
Echinococcus multilocularis	NADPH cytochrome P450 reductase	0.0134	0.2562	0.7001
Trichomonas vaginalis	NADPH fad oxidoreductase, putative	0.0118	0.2178	0.3829
Brugia malayi	hypothetical protein	0.0159	0.3207	0.6074
Trypanosoma cruzi	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0241	0.5281	1
Echinococcus granulosus	single minded 2	0.0035	0.0071	0.0194
Loa Loa (eye worm)	FAD binding domain-containing protein	0.0134	0.2562	0.4852
Trypanosoma cruzi	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.011	0.197	0.3415
Onchocerca volvulus		0.0058	0.0641	0.3003
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase	0.0138	0.2664	0.4796
Leishmania major	3-hydroxy-3-methylglutaryl-CoA reductase	0.0138	0.2664	0.4796
Echinococcus multilocularis	synaptic glycoprotein sc2	0.011	0.197	0.5383
Echinococcus multilocularis	protein dispatched 1	0.0057	0.0616	0.1684
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0094	0.1551	0.4239
Plasmodium falciparum	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.011	0.197	0.562
Echinococcus multilocularis	sterol regulatory element binding protein	0.0057	0.0616	0.1684
Plasmodium vivax	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.011	0.197	0.562
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0127	0.2403	0.4551
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0042	0.0253	0.0253
Trichomonas vaginalis	conserved hypothetical protein	0.011	0.197	0.3415
Brugia malayi	FAD binding domain containing protein	0.0083	0.127	0.2404
Schistosoma mansoni	acetylcholinesterase	0.0058	0.0641	0.0641
Brugia malayi	Carboxylesterase family protein	0.0058	0.0641	0.1215
Mycobacterium ulcerans	formate dehydrogenase H FdhF	0.0134	0.2562	0.3378
Brugia malayi	hypoxia-induced factor 1	0.0147	0.2896	0.5483
Loa Loa (eye worm)	hypothetical protein	0.0134	0.2562	0.4852
Schistosoma mansoni	hypothetical protein	0.0177	0.366	0.366
Treponema pallidum	flavodoxin	0.0051	0.0476	0.5
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0127	0.2403	0.2403
Loa Loa (eye worm)	carboxylesterase	0.0058	0.0641	0.1215
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0616	0.0723
Loa Loa (eye worm)	hypothetical protein	0.0138	0.2664	0.5045
Mycobacterium ulcerans	carboxylesterase, LipT	0.0327	0.7446	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0094	0.1551	0.1551
Mycobacterium ulcerans	hypothetical protein	0.0241	0.5281	0.7064
Schistosoma mansoni	BC026374 protein (S09 family)	0.0058	0.0641	0.0641
Onchocerca volvulus		0.011	0.197	1
Plasmodium vivax	polyprenol reductase, putative	0.011	0.197	0.562
Loa Loa (eye worm)	acetylcholinesterase 1	0.0171	0.3507	0.6642
Trypanosoma brucei	NADPH-dependent diflavin oxidoreductase 1	0.0134	0.2562	0.4593
Echinococcus granulosus	protein farnesyltransferase alpha subunit	0.0163	0.3308	0.904
Brugia malayi	Carboxylesterase family protein	0.0171	0.3507	0.6642
Plasmodium vivax	hypothetical protein, conserved	0.0051	0.0476	0.073
Echinococcus granulosus	Protein patched homolog 1	0.0057	0.0616	0.1684
Entamoeba histolytica	type A flavoprotein, putative	0.0051	0.0476	0.0771
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.007	0.0964	0.1415
Mycobacterium ulcerans	fructose-2,6-bisphosphatase GpmB	0.0042	0.0234	0.0221
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0065	0.0816	0.1121
Giardia lamblia	Rab geranylgeranyltransferase	0.0042	0.0253	0.006
Trichomonas vaginalis	synaptic glycoprotein sc2, putative	0.011	0.197	0.3415
Leishmania major	p450 reductase, putative	0.0134	0.2562	0.4593
Echinococcus granulosus	NADPH dependent diflavin oxidoreductase 1	0.0134	0.2562	0.7001
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0094	0.1551	0.4239
Echinococcus granulosus	geranylgeranyl transferase type 2 subunit alpha	0.0042	0.0253	0.0691
Echinococcus multilocularis	carboxylesterase 5A	0.0171	0.3507	0.9584
Brugia malayi	Carboxylesterase family protein	0.0058	0.0641	0.1215
Onchocerca volvulus		0.0058	0.0641	0.3003
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0074	0.0203
Entamoeba histolytica	type A flavoprotein, putative	0.0051	0.0476	0.0771
Onchocerca volvulus		0.0058	0.0641	0.3003
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0163	0.3308	0.6265
Trichomonas vaginalis	synaptic glycoprotein sc2, putative	0.011	0.197	0.3415
Echinococcus granulosus	protein prenyltransferase alpha subunit	0.0042	0.0253	0.0691
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0094	0.1551	0.1551
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0102	0.1764	0.3341
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0641	0.1215
Echinococcus multilocularis	3 oxo 5 alpha steroid 4 dehydrogenase, C terminal	0.011	0.197	0.5383
Brugia malayi	PAS domain containing protein	0.0047	0.0383	0.0725
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0171	0.3507	0.3507
Entamoeba histolytica	trans-2,3-enoyl-CoA reductase, putative	0.011	0.197	0.3641
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0327	0.7446	1
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0042	0.0253	0.0479
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0058	0.0641	0.0641
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0051	0.0476	0.0443
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0641	0.1215
Loa Loa (eye worm)	hypothetical protein	0.0171	0.3507	0.6642
Loa Loa (eye worm)	hypothetical protein	0.0102	0.1764	0.3341
Echinococcus granulosus	carboxylesterase 5A	0.0171	0.3507	0.9584
Entamoeba histolytica	3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein	0.011	0.197	0.3641
Toxoplasma gondii	3-oxo-5-alpha-steroid 4-dehydrogenase	0.011	0.197	0.3415
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0616	0.1167
Entamoeba histolytica	type A flavoprotein, putative	0.0051	0.0476	0.0771
Echinococcus granulosus	carbonic anhydrase II	0.0127	0.2403	0.6567
Trichomonas vaginalis	synaptic glycoprotein sc2, putative	0.011	0.197	0.3415
Giardia lamblia	Hypothetical protein	0.0118	0.2178	0.6322
Brugia malayi	bHLH-PAS transcription factor	0.0035	0.0071	0.0135
Trypanosoma brucei	6-phosphofructo-2-kinase 2	0.0069	0.0934	0.1355
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.007	0.0964	0.1415
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0241	0.5281	1
Echinococcus granulosus	acetylcholinesterase	0.0171	0.3507	0.9584
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0641	0.1215
Echinococcus multilocularis	NADPH dependent diflavin oxidoreductase 1	0.0134	0.2562	0.7001
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0934	0.1769
Echinococcus multilocularis	6 phosphofructo 2 kinase:fructose 2	0.007	0.0964	0.2635
Loa Loa (eye worm)	carboxylesterase	0.0171	0.3507	0.6642
Trypanosoma cruzi	NADPH--cytochrome P450 reductase, putative	0.0051	0.0476	0.0443
Schistosoma mansoni	gliotactin	0.0058	0.0641	0.0641
Trypanosoma brucei	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.0138	0.2664	0.4796
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0094	0.1551	0.2938
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0641	0.1215
Trypanosoma cruzi	Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative	0.0051	0.0476	0.0443
Brugia malayi	3-oxo-5-alpha-steroid 4-dehydrogenase 1	0.0241	0.5281	1
Leishmania major	NADPH-cytochrome p450 reductase-like protein	0.0134	0.2562	0.4593
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0641	0.1215
Leishmania major	3-oxo-5-alpha-steroid 4-dehydrogenase-like protein	0.0241	0.5281	1
Onchocerca volvulus		0.0058	0.0641	0.3003
Trypanosoma cruzi	6-phosphofructo-2-kinase 1	0.0069	0.0934	0.1355
Echinococcus multilocularis	neuroligin	0.0058	0.0641	0.1753
Loa Loa (eye worm)	carboxylesterase	0.0058	0.0641	0.1215
Trypanosoma brucei	3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative	0.0241	0.5281	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0102	0.1764	0.3341
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0065	0.0816	0.1121
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0065	0.0816	0.1121
Brugia malayi	Carboxylesterase family protein	0.0058	0.0641	0.1215
Plasmodium falciparum	nitric oxide synthase, putative	0.0134	0.2562	0.7557
Toxoplasma gondii	hypothetical protein	0.0121	0.2239	0.395
Brugia malayi	flavodoxin family protein	0.0134	0.2562	0.4852
Loa Loa (eye worm)	flavodoxin family protein	0.0051	0.0476	0.0901
Loa Loa (eye worm)	hypothetical protein	0.011	0.197	0.3731
Echinococcus granulosus	Niemann Pick C1 protein	0.0057	0.0616	0.1684
Trypanosoma brucei	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.011	0.197	0.3415
Plasmodium falciparum	protein farnesyltransferase subunit alpha	0.0163	0.3308	1
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	0.0163	0.3308	0.6212
Plasmodium falciparum	polyprenol reductase, putative	0.011	0.197	0.562
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0102	0.1764	0.3341
Echinococcus multilocularis	acetylcholinesterase	0.0171	0.3507	0.9584
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0127	0.2403	0.4277
Brugia malayi	FAD binding domain containing protein	0.0134	0.2562	0.4852
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.0134	0.2562	0.4593
Toxoplasma gondii	3-oxo-5-alpha-steroid 4-dehydrogenase	0.011	0.197	0.3415
Brugia malayi	Hydroxymethylglutaryl-coenzyme A reductase family protein	0.0138	0.2664	0.5045
Echinococcus granulosus	acetylcholinesterase	0.0171	0.3507	0.9584
Schistosoma mansoni	synaptic glycoprotein sc2 related	0.011	0.197	0.197
Entamoeba histolytica	Rab geranylgeranyltransferase alpha subunit, putative	0.0042	0.0253	0.0343
Trypanosoma brucei	NADPH--cytochrome P450 reductase, putative	0.0134	0.2562	0.4593
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0163	0.3308	0.6077
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0074	0.0074
Leishmania major	cytochrome P450 reductase, putative	0.0118	0.2178	0.3829
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0127	0.2403	0.4551
Loa Loa (eye worm)	hypothetical protein	0.004	0.0204	0.0387
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0127	0.2403	0.4277
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0051	0.0476	0.0443
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0241	0.5281	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.0057	0.0616	0.1684
Schistosoma mansoni	patched 1	0.0057	0.0616	0.0616
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	0.0163	0.3308	0.904
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0121	0.2239	0.395
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0094	0.1551	0.4239
Echinococcus multilocularis	geranylgeranyl transferase type 2 subunit alpha	0.0042	0.0253	0.0691
Schistosoma mansoni	protein farnesyltransferase alpha subunit	0.0163	0.3308	0.3308
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0042	0.0253	0.0479
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0058	0.0641	0.0641
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.011	0.197	0.3415
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0127	0.2403	0.2403
Loa Loa (eye worm)	hypothetical protein	0.007	0.0964	0.1826
Trypanosoma cruzi	p450 reductase, putative	0.0134	0.2562	0.4593
Chlamydia trachomatis	sulfite reductase	0.0083	0.127	0.5
Onchocerca volvulus		0.0058	0.0641	0.3003
Giardia lamblia	3-hydroxy-3-methylglutaryl-coenzyme A reductase	0.0065	0.0816	0.1893
Echinococcus granulosus	NADPH cytochrome P450 reductase	0.0134	0.2562	0.7001
Mycobacterium ulcerans	hypothetical protein	0.0042	0.0234	0.0221
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.0069	0.0934	0.1355
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0094	0.1551	0.1551
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0058	0.0641	0.1753
Plasmodium vivax	flavodoxin domain containing protein	0.0118	0.2178	0.63
Echinococcus granulosus	geminin	0.0177	0.366	1
Plasmodium falciparum	S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative	0.0051	0.0476	0.073
Echinococcus multilocularis	methionine synthase reductase	0.0083	0.127	0.3469
Leishmania major	carbonic anhydrase-like protein	0.0127	0.2403	0.4277
Toxoplasma gondii	flavodoxin domain-containing protein	0.0066	0.086	0.1207
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0057	0.0616	0.0616
Entamoeba histolytica	steroid 5-alpha reductase, putative	0.0241	0.5281	1
Loa Loa (eye worm)	hypothetical protein	0.0171	0.3507	0.6642
Schistosoma mansoni	hydroxymethylglutaryl-CoA reductase (NADPH)	0.0138	0.2664	0.2664
Trypanosoma cruzi	6-phosphofructo-2-kinase 1	0.0069	0.0934	0.1355
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.007	0.0964	0.1415
Echinococcus multilocularis	hydroxymethylglutaryl coenzyme A reductase	0.0138	0.2664	0.728
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0058	0.0641	0.0641
Onchocerca volvulus		0.007	0.0964	0.4703
Echinococcus multilocularis	protein prenyltransferase alpha subunit	0.0042	0.0253	0.0691
Echinococcus multilocularis	carbonic anhydrase II	0.0127	0.2403	0.6567
Trypanosoma cruzi	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0241	0.5281	1
Trypanosoma brucei	NADPH--cytochrome P450 reductase, putative	0.0134	0.2562	0.4593
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0641	0.1215
Echinococcus granulosus	sterol regulatory element binding protein	0.0057	0.0616	0.1684
Schistosoma mansoni	cytochrome P450 reductase	0.0134	0.2562	0.2562
Echinococcus multilocularis	acetylcholinesterase	0.0171	0.3507	0.9584
Schistosoma mansoni	NADPH flavin oxidoreductase	0.0067	0.0886	0.0886
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0058	0.0641	0.1753
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3207	0.6074
Entamoeba histolytica	hypothetical protein	0.011	0.197	0.3641
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0074	0.0203
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.0138	0.2664	0.4796
Echinococcus multilocularis	protein patched	0.0057	0.0616	0.1684

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 19 nM	In vitro inhibition of thromboxane A2 synthetase from human platelets.	ChEMBL.	3918169
IC50 (binding)	= 19 nM	In vitro inhibition of thromboxane A2 synthetase from human platelets.	ChEMBL.	3918169

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 65476