Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.5222 | 0.9008 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0607 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.0607 | 0.5 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.0607 | 0.5 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0607 | 0.1047 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.0607 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0607 | 0.1047 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0607 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.0607 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.0607 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0607 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0607 | 0.1047 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.5222 | 0.4913 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0607 | 0.5 |
Mycobacterium leprae | PROBABLE BACTERIOFERRITIN BFRA | 0.0017 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.5797 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.5797 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.5797 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.5797 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.5797 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.5797 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0607 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.5797 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.0607 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.5797 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0607 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0607 | 0.1047 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.0607 | 0.5 |
Brugia malayi | hypothetical protein | 0.0036 | 0.5797 | 0.5526 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.5222 | 0.4913 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0607 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.