Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0638 | 0.5 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.0638 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 1 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0638 | 0.0638 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.0638 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0638 | 0.0638 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0638 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.7163 | 0.7163 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0638 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0638 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.0638 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.3848 | 0.3848 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.7163 | 0.7163 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0638 | 0.0638 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0638 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.0638 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.7163 | 0.7163 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.0638 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.0638 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.7163 | 0.7163 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0638 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0638 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 1 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0638 | 0.0638 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.3848 | 0.3848 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 1 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0638 | 0.0638 |
Brugia malayi | TAR-binding protein | 0.0062 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.3848 | 0.3848 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.0638 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.0638 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0638 | 0.0638 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.