Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Nitric-oxide synthase, brain | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.76 uM | Inhibitory activity against Neuronal Nitric Oxide Synthase (nNOS) | ChEMBL. | 12699384 |
Ki (binding) | = 0.76 uM | Inhibitory activity against Neuronal Nitric Oxide Synthase (nNOS) | ChEMBL. | 12699384 |
Ki (binding) | = 193 uM | Inhibitory activity against endothelial nitric oxide synthase (eNOS) | ChEMBL. | 12699384 |
Ki (binding) | = 193 uM | Inhibitory activity against endothelial nitric oxide synthase (eNOS) | ChEMBL. | 12699384 |
Ki (binding) | = 395 uM | Inhibitory activity against Inducible nitric oxide synthase (iNOS) | ChEMBL. | 12699384 |
Ki (binding) | = 395 uM | Inhibitory activity against Inducible nitric oxide synthase (iNOS) | ChEMBL. | 12699384 |
Selectivity (binding) | = 56 | Selectivity ratio of Ki value of eNOS to nNOS | ChEMBL. | 12699384 |
Selectivity (binding) | = 520 | Selectivity ratio of Ki value of iNOS to nNOS | ChEMBL. | 12699384 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.